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1. 发明授权

US09739745B2 System and method for measuring an analyte in a sample 有权
公开(公告)号：US09739745B2
公开(公告)日：2017-08-22
申请号：US13620448
申请日：2012-09-14
申请人： Alastair M. Hodges , Ronald C. Chatelier
发明人： Alastair M. Hodges , Ronald C. Chatelier
IPC分类号： G01N27/327
摘要： Methods for calculating an analyte concentration of a sample are provided. In one exemplary embodiment the method includes steps that are directed toward accounting for inaccuracies that occur as a result of temperature variations in a sample, a meter, or the surrounding environment. In another exemplary embodiment the method includes steps that are directed toward determining whether an adequate sample is provided in a meter because insufficient samples can result in inaccuracies. The methods that are provided can be incorporated into a variety of mechanisms, but they are primarily directed toward glucose meters for blood samples and toward meters for controls solutions.

2. 发明授权

US08877034B2 Systems, devices, and methods for measuring whole blood hematocrit based on initial fill velocity 有权
标题翻译：基于初始填充速度测量全血血细胞比容的系统，装置和方法
公开(公告)号：US08877034B2
公开(公告)日：2014-11-04
申请号：US12649509
申请日：2009-12-30
申请人： Ronald C. Chatelier , Dennis Rylatt , Linda Raineri , Alastair M. Hodges
发明人： Ronald C. Chatelier , Dennis Rylatt , Linda Raineri , Alastair M. Hodges
IPC分类号： G01N33/49 , G01N33/80 , G01N33/48 , G01N27/48
CPC分类号： G01N27/3272 , G01N27/3273 , G01N27/3274 , G01N27/48 , G01N33/49 , G01N33/80 , G01N2333/4737
摘要： Methods for determining the hematocrit of a blood sample, and devices and systems used in conjunction with the same. The hematocrit value can be determined on its own, and further, it can be further used to determine a concentration of an analyte in a sample. In one exemplary embodiment of a method for determining the hematocrit value in a blood sample, a volume of blood is provided in a sample analyzing device having a working and a counter electrode. An electric potential is applied between the electrodes and an initial fill velocity of the sample into the device is calculated. The hematocrit of the blood, as well as a concentration of an analyte in view of the initial fill velocity can then be determined. Systems and devices that take advantage of the use of an initial fill velocity to determine hematocrit levels and make analyte concentration determinations are also provided.
摘要翻译：用于确定血液样本的血细胞比容的方法，以及与之一起使用的装置和系统。血细胞比容值可以单独测定，而且还可以用于确定样品中分析物的浓度。在用于确定血液样品中的血细胞比容值的方法的一个示例性实施方案中，在具有工作和对电极的样品分析装置中提供体积的血液。在电极之间施加电位，并计算样品进入器件的初始填充速度。然后可以确定血液的血细胞比容，以及考虑到初始填充速度的分析物的浓度。还提供利用初始填充速度来确定血细胞比容水平并进行分析物浓度测定的系统和装置。

3. 发明申请

US20130306493A1 SYSTEMS AND METHODS FOR HIGH ACCURACY ANALYTE MEASUREMENT 有权
标题翻译：用于高精度分析测量的系统和方法
公开(公告)号：US20130306493A1
公开(公告)日：2013-11-21
申请号：US13824308
申请日：2010-12-31
申请人： Ronald C. Chatelier , Alastair M. Hodges
发明人： Ronald C. Chatelier , Alastair M. Hodges
IPC分类号： G01N27/327
CPC分类号： G01N27/4163 , C12Q1/006 , C12Q1/025 , G01N27/30 , G01N27/327 , G01N27/3272 , G01N27/3274 , G01N27/413 , G01N33/49
摘要： Methods for determining a concentration of an analyte in a sample, and the devices and systems used in conjunction with the same, are provided herein. In one exemplary embodiment of a method for determining a concentration of an analyte in a sample, a sample including an analyte is provided in a sample analyzing device having a working and a counter electrode. An electric potential is applied between the electrodes and a first analyte concentration is determined. A second analyte concentration value is calculated from the first analyte concentration value and corrected for temperature effects, fill time and capacitance to provide for a final analyte concentration value.
摘要翻译：本文提供了用于确定样品中分析物浓度的方法以及与其一起使用的装置和系统。在用于确定样品中分析物浓度的方法的一个示例性实施方案中，在具有工作电极和对电极的样品分析装置中提供包括分析物的样品。在电极之间施加电位，并确定第一分析物浓度。根据第一分析物浓度值计算第二分析物浓度值，并对温度影响，填充时间和电容进行校正以提供最终分析物浓度值。

4. 发明申请

US20130098763A1 SYSTEM AND METHOD FOR MEASURING AN ANALYTE IN A SAMPLE 有权
公开(公告)号：US20130098763A1
公开(公告)日：2013-04-25
申请号：US13619241
申请日：2012-09-14
申请人： Ronald C. Chatelier , Alastair M. Hodges , Santhanagopalan Nandagopalan
发明人： Ronald C. Chatelier , Alastair M. Hodges , Santhanagopalan Nandagopalan
IPC分类号： C12Q1/00
CPC分类号： G01N27/4163 , C12Q1/006 , G01N27/3274
摘要： Methods of determining a corrected analyte concentration in view of some error source are provided herein. The methods can be utilized for the determination of various analytes and/or various sources of error. In one example, the method can be configured to determine a corrected glucose concentration in view of an extreme level of hematocrit found within the sample. In other embodiments, methods are provided for identifying various system errors and/or defects. For example, such errors can include partial-fill or double-fill situations, high track resistance, and/or sample leakage. Systems are also provided for determining a corrected analyte concentration and/or detecting some system error.

5. 发明申请

US20130008804A1 SYSTEM AND METHOD FOR MEASURING AN ANALYTE IN A SAMPLE 有权
公开(公告)号：US20130008804A1
公开(公告)日：2013-01-10
申请号：US13620448
申请日：2012-09-14
申请人： Alastair M. Hodges , Ronald C. Chatelier
发明人： Alastair M. Hodges , Ronald C. Chatelier
IPC分类号： G01N27/26
CPC分类号： G01N27/3274
摘要： Methods for calculating an analyte concentration of a sample are provided. In one exemplary embodiment the method includes steps that are directed toward accounting for inaccuracies that occur as a result of temperature variations in a sample, a meter, or the surrounding environment. In another exemplary embodiment the method includes steps that are directed toward determining whether an adequate sample is provided in a meter because insufficient samples can result in inaccuracies. The methods that are provided can be incorporated into a variety of mechanisms, but they are primarily directed toward glucose meters for blood samples and toward meters for controls solutions.

6. 发明申请

US20110155584A1 Systems, Devices, and Methods for Measuring Whole Blood Hematocrit Based on Initial Fill Velocity 有权
标题翻译：基于初始填充速度测量全血血细胞比容的系统，设备和方法
公开(公告)号：US20110155584A1
公开(公告)日：2011-06-30
申请号：US12649509
申请日：2009-12-30
申请人： Ronald C. Chatelier , Dennis Rylatt , Linda Raineri , Alastair M. Hodges
发明人： Ronald C. Chatelier , Dennis Rylatt , Linda Raineri , Alastair M. Hodges
IPC分类号： G01N27/26
CPC分类号： G01N27/3272 , G01N27/3273 , G01N27/3274 , G01N27/48 , G01N33/49 , G01N33/80 , G01N2333/4737
摘要： Methods for determining the hematocrit of a blood sample, and devices and systems used in conjunction with the same. The hematocrit value can be determined on its own, and further, it can be further used to determine a concentration of an analyte in a sample. In one exemplary embodiment of a method for determining the hematocrit value in a blood sample, a volume of blood is provided in a sample analyzing device having a working and a counter electrode. An electric potential is applied between the electrodes and an initial fill velocity of the sample into the device is calculated. The hematocrit of the blood, as well as a concentration of an analyte in view of the initial fill velocity can then be determined. Systems and devices that take advantage of the use of an initial fill velocity to determine hematocrit levels and make analyte concentration determinations are also provided.
摘要翻译：用于确定血液样本的血细胞比容的方法，以及与之一起使用的装置和系统。血细胞比容值可以单独测定，而且还可以用于确定样品中分析物的浓度。在用于确定血液样品中的血细胞比容值的方法的一个示例性实施方案中，在具有工作和对电极的样品分析装置中提供体积的血液。在电极之间施加电位，并计算样品进入器件的初始填充速度。然后可以确定血液的血细胞比容，以及考虑到初始填充速度的分析物的浓度。还提供利用初始填充速度来确定血细胞比容水平并进行分析物浓度测定的系统和装置。

7. 发明申请

US20090301899A1 SYSTEM AND METHOD FOR MEASURING AN ANALYTE IN A SAMPLE 有权
标题翻译：用于测量样品中分析物的系统和方法
公开(公告)号：US20090301899A1
公开(公告)日：2009-12-10
申请号：US12464935
申请日：2009-05-13
申请人： Alastair M. Hodges , Ronald C. Chatelier
发明人： Alastair M. Hodges , Ronald C. Chatelier
IPC分类号： G01N27/26
CPC分类号： G01N27/3274
摘要： Methods for calculating an analyte concentration of a sample are provided. In one exemplary embodiment the method includes steps that are directed toward accounting for inaccuracies that occur as a result of temperature variations in a sample, a meter, or the surrounding environment. In another exemplary embodiment the method includes steps that are directed toward determining whether an adequate sample is provided in a meter because insufficient samples can result in inaccuracies. The methods that are provided can be incorporated into a variety of mechanisms, but they are primarily directed toward glucose meters for blood samples and toward meters for controls solutions.
摘要翻译：提供了用于计算样品的分析物浓度的方法。在一个示例性实施例中，该方法包括针对由于样品，仪表或周围环境中的温度变化而发生的不准确性的步骤。在另一示例性实施例中，该方法包括以下步骤：针对确定在仪表中是否提供了足够的样品，因为不足的样品可导致不准确。所提供的方法可以并入多种机制中，但是它们主要针对血液样品的血糖仪和用于对照溶液的米。

8. 发明授权

US09863931B2 On-board control detection 有权
公开(公告)号：US09863931B2
公开(公告)日：2018-01-09
申请号：US13264926
申请日：2010-04-16
申请人： Peter Michael Newman , Alastair M. Hodges
发明人： Peter Michael Newman , Alastair M. Hodges
IPC分类号： G01N33/50 , G01N33/49 , C12Q1/00 , G01N33/543
CPC分类号： G01N33/4905 , C12Q1/006 , G01N33/5438 , Y10T436/144444
摘要： Embodiments disclosed herein relate to a sensor comprising an on-board control system and a testing system. The on-board system can determine viability of the control system or the testing system. Also disclosed are methods of using such a sensor.

9. 发明授权

US08932445B2 Systems and methods for improved stability of electrochemical sensors 有权
标题翻译：用于改善电化学传感器稳定性的系统和方法
公开(公告)号：US08932445B2
公开(公告)日：2015-01-13
申请号：US12895168
申请日：2010-09-30
申请人： Ronald C. Chatelier , Alastair M. Hodges
发明人： Ronald C. Chatelier , Alastair M. Hodges
IPC分类号： G01N33/487 , G01N33/543 , C12Q1/00 , C12Q1/54 , G01N27/327
CPC分类号： G01N27/3274 , C12Q1/001 , C12Q1/54 , G01N27/3272 , G01N27/3273 , G01N33/5438
摘要： Methods for determining a concentration of an analyte in a sample, and the devices and systems used in conjunction with the same, are provided herein. In one exemplary embodiment of a method for determining a concentration of an analyte in a sample, a sample including an analyte is provided in a sample analyzing device having a working and a counter electrode. An electric potential is applied between the electrodes and a measurement of a parameter correlating to changes in a physical property of the sample analyzing device is calculated. A concentration of the analyte in view of the parameter correlating to a change in the physical property can then be determined Systems and devices that take advantage of the parameter correlating to changes in a physical property to make analyte concentration determinations are also provided.
摘要翻译：本文提供了用于确定样品中分析物浓度的方法以及与其一起使用的装置和系统。在用于确定样品中分析物浓度的方法的一个示例性实施方案中，在具有工作电极和对电极的样品分析装置中提供包括分析物的样品。在电极之间施加电位，并且计算与样品分析装置的物理性质的变化相关的参数的测量。然后可以确定鉴于与物理性质的变化相关的参数的分析物的浓度。还提供利用与物理性质的变化相关的参数的优点的系统和装置，以进行分析物浓度测定。

10. 发明授权

US08617370B2 Systems and methods of discriminating between a control sample and a test fluid using capacitance 有权
标题翻译：使用电容来区分对照样品和测试流体的系统和方法
公开(公告)号：US08617370B2
公开(公告)日：2013-12-31
申请号：US12895067
申请日：2010-09-30
申请人： Ronald C. Chatelier , Alastair M. Hodges
发明人： Ronald C. Chatelier , Alastair M. Hodges
IPC分类号： G01N27/327
CPC分类号： G01N27/28 , C12Q1/005 , G01N27/3274 , G01N33/48707
摘要： Methods for distinguishing between an aqueous non-blood sample (e.g., a control solution) and a blood sample are provided herein. In one aspect, the method includes using a test strip in which multiple current transients are measured by a meter electrically connected to an electrochemical test strip. The current transients are used to determine if a sample is a blood sample or an aqueous non-blood sample based on characteristics of the sample (e.g., amount of interferent present, reaction kinetics, and/or capacitance). The method can also include calculating a discrimination criteria based upon these characteristics. Various aspects of a system for distinguishing between a blood sample and an aqueous non-blood sample are also provided herein.
摘要翻译：本文提供了用于区分水中非血液样品（例如对照溶液）和血液样品的方法。在一个方面，该方法包括使用测试条，其中通过电连接到电化学测试条的仪表测量多个电流瞬变。根据样品的特征（例如，存在的干扰物量，反应动力学和/或电容），使用电流瞬变来确定样品是血液样品还是水性非血液样品。该方法还可以包括基于这些特征来计算鉴别标准。本文还提供了用于区分血液样品和水性非血液样品的系统的各个方面。

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