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    • 3. 发明申请
    • SUNSCREEN COMPOSITIONS AND COMPOUNDS FOR USE THEREIN
    • SUNSCREEN组合物及其使用的化合物
    • WO1988002251A1
    • 1988-04-07
    • PCT/AU1987000330
    • 1987-09-25
    • ICI AUSTRALIA OPERATIONS PROPRIETARY LIMITEDAUSTRALIAN INSTITUTE OF MARINE SCIENCEBIRD, GrahamFITZMAURICE, NeilDUNLAP, Walter, ClarkCHALKER, Bruce, EdwardBANDARANAYAKE, Wickramasinghe, Mudiyanselage
    • ICI AUSTRALIA OPERATIONS PROPRIETARY LIMITEDAUSTRALIAN INSTITUTE OF MARINE SCIENCE
    • A61K07/42
    • C07D221/20A61K8/4926A61Q17/04C07D211/70C07D215/20
    • Certain compounds of formula (I) and sunscreen compositions comprising as an effective component at least one compound of formula (I), wherein R is selected from alkyl, alkenyl, alkynyl, substituted alkyl, substituted alkenyl, phenyl, substituted phenyl, substituted benzyl, cycloalkyl, cycloalkenyl, substituted cycloalkyl, substituted cycloalkenyl and polymeric groups; R is selected from hydrogen, alkyl and alkoxy; and wherein R and R may form a carbocyclic ring which may be substituted; R is selected from alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, phenyl, benzoyl, substituted phenyl, substituted benzyl, substituted benzoyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, alkanoyl, substituted alkanoyl, polymeric groups, the group OROROR wherein R is a bivalent hydrocarbon radical and R is alkyl, alkenyl, phenyl, benzyl, substituted phenyl, substituted benzyl; R is alkyl or alkoxy; n is an integer from 0 to 4; and R and R are independently selected from alkyl, alkoxy, alkanoyl, alkanoyl substituted by hydroxyl or alkoxycarbonyl and R and R may form a spiro carbocyclic ring which may be substituted with alkyl.
    • 某些式(I)化合物和防晒组合物,其包含至少一种式(I)化合物作为有效成分,其中R 1选自烷基,烯基,炔基,取代的烷基,取代的烯基,苯基,取代的苯基, 取代的苄基,环烷基,环烯基,取代的环烷基,取代的环烯基和聚合基团; R 2选自氢,烷基和烷氧基; 并且其中R 1和R 2可以形成可被取代的碳环; R 3选自烷基,取代的烷基,烯基,取代的烯基,炔基,苯基,苯甲酰基,取代的苯基,取代的苄基,取代的苯甲酰基,环烷基,取代的环烷基,环烯基,取代的环烯基,烷酰基,取代的烷酰基,聚合基团, OROROR 9,其中R是二价烃基,R 9是烷基,烯基,苯基,苄基,取代的苯基,取代的苄基; R 4是烷基或烷氧基; n为0〜4的整数; R 5和R 6独立地选自被羟基或烷氧基羰基取代的烷酰基,烷酰基,链烷酰基,R 5和R 6可以形成可被烷基取代的螺环碳环。
    • 6. 发明申请
    • PREPARATION OF AN EPOXIDE
    • 环氧化物的制备
    • WO1989010350A1
    • 1989-11-02
    • PCT/AU1989000176
    • 1989-04-21
    • ICI AUSTRALIA OPERATIONS PROPRIETARY LIMITEDBIRD, GrahamWATSON, KeithGOUNTZOS, HelenTHANG, San
    • ICI AUSTRALIA OPERATIONS PROPRIETARY LIMITED
    • C07C143/68
    • C07D303/48C07C309/39C07D301/02
    • Accordingly we provide a stereoselective process for preparation of an epoxide of formula (I), wherein Ar is selected from the group consisting of aryl, heteroaryl, substituted aryl and substituted heteroaryl, and R is a carboxylic acid group or ester or a group capable of being converted to a carboxylic acid group or ester; the process comprising reacting a diol of formula (III) with a sulfonating agent of formula (IV) to from a compound of formula (V) and eliminating the sulfonyloxy group form the compound of formula (V) to form the epoxide of formula (I), wherein in the compound of formula (IV), L is a leaving group and in the compounds of formula (IV and V), the group X, which may be different when there is more than one X, is selected from the group consisting of C1 to C6 alkyl and halogen, and n is an integer from 1 to 5.
    • 因此,我们提供了制备式(I)的环氧化物的立体选择性方法,其中Ar选自芳基,杂芳基,取代的芳基和取代的杂芳基,R是羧酸基或酯或能够 转化为羧酸基或酯; 该方法包括使式(III)的二醇与式(Ⅳ)的磺化剂反应从式(Ⅴ)化合物中除去磺酰氧基,形成式(Ⅴ)化合物,形成式(Ⅳ)的环氧化物 ),其中在式(IV)的化合物中,L是离去基团,在式(IV和V)的化合物中,当存在多于一个X时可能不同的基团X选自 由C1至C6烷基和卤素组成,n为1至5的整数。