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1. 发明授权

US09493465B2 3-hydroxypyrrolidine inhibitors of 5′-methylthioadenosine phosphorylase and nucleosidase 有权
标题翻译： 3'-羟基吡咯烷抑制剂的5'-甲硫基腺苷磷酸化酶和核苷酶
公开(公告)号：US09493465B2
公开(公告)日：2016-11-15
申请号：US13383772
申请日：2010-07-16
申请人： Gary Brian Evans , Alistair Ian Longshaw , Vern L. Schramm , Peter Charles Tyler
发明人： Gary Brian Evans , Alistair Ian Longshaw , Vern L. Schramm , Peter Charles Tyler
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00 , A61P31/04
CPC分类号： C07D487/04
摘要： The present invention relates to 3-hydroxypyrrolidine compounds of the general formula (I) which are inhibitors of 5′-methylthioadenosine phosphorylase or 5′-methylthioadenosine nucleosidase. The invention also relates to the use of these compounds in the treatment of diseases or conditions in which it is desirable to inhibit 5′-methylthioadenosine phosphorylase or 5′-methylthioadenosine nucleosidase including cancer, and to pharmaceutical compositions containing the compounds.
摘要翻译：本发明涉及作为5'-甲硫基腺苷磷酸化酶或5'-甲硫基腺苷核苷酶抑制剂的通式（I）的3-羟基吡咯烷化合物。本发明还涉及这些化合物在治疗期望抑制5'-甲硫基腺苷磷酸化酶或包括癌症的5'-甲基硫代腺苷核苷酸酶的疾病或病症的用途，以及含有该化合物的药物组合物。

2. 发明授权

US09290501B2 Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase 有权
标题翻译：通过抑制甲硫噻糖磷酸化酶治疗细菌感染的方法，测定和化合物
公开(公告)号：US09290501B2
公开(公告)日：2016-03-22
申请号：US13884298
申请日：2011-11-28
申请人： Vern L. Schramm , Keith Clinch , Peter Charles Tyler , Gary Brian Evans , Richard Hubert Furneaux
发明人： Vern L. Schramm , Keith Clinch , Peter Charles Tyler , Gary Brian Evans , Richard Hubert Furneaux
IPC分类号： A01N43/04 , A61K31/70 , C07D487/04 , A61K31/7076 , A61K31/7064 , A61K31/7042 , A61K31/7052 , A61K31/708 , A61K31/706 , A61K31/00 , A61K31/519 , A61K31/7068 , A61K45/06 , C12Q1/48
CPC分类号： C07D487/04 , A61K31/00 , A61K31/519 , A61K31/7042 , A61K31/7052 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7076 , A61K31/708 , A61K45/06 , C12Q1/48
摘要： The present invention discloses methods for treating bacterial infections in a subject comprising administering to the subject a sub-growth inhibiting amount of a 5′-methylthioinosine phosphorylase (MTIP) inhibitor, as well as assays for identifying such inhibitors, and compounds and pharmaceutical compositions comprising the inhibitors.
摘要翻译：本发明公开了一种用于治疗受试者细菌感染的方法，其包括对受试者施用次生长抑制量的5'-甲硫基肌苷磷酸化酶（MTIP）抑制剂以及用于鉴定此类抑制剂的测定法，以及包含抑制剂。

3. 发明授权

US08711734B2 Method and system for fail-safe call survival 有权
标题翻译：故障安全呼叫生存的方法和系统
公开(公告)号：US08711734B2
公开(公告)日：2014-04-29
申请号：US13162701
申请日：2011-06-17
申请人： Rajan Iyengar , Gabriel Bourque , Brian Evans , Jason McCarthy , James Terhune
发明人： Rajan Iyengar , Gabriel Bourque , Brian Evans , Jason McCarthy , James Terhune
IPC分类号： H04L12/16
CPC分类号： H04L65/1069 , H04L65/1006 , H04L65/80 , H04L69/40
摘要： The present invention provides a system and method for fail-safe call survival by detecting failure of an active call serving component and switching the service over to a standby component. The system and method will prevent an existing call, whether established or to be established, from being dropped due to a single point of failure within a Voice over Internet Protocol system. The continuation of the call is based on the failed component as opposed to relying on communication endpoints to re-initiate or re-route the failed call. Call recovery is initiated independent from the call path of a call. The detection of a condition or need for call recovery and the determination to initiate call recovery procedures are made without involving endpoints or intermediate points of the call. The availability and sanity of all components are continuously monitored and are tailored specifically for the duties of each component.
摘要翻译：本发明通过检测主动呼叫服务组件的故障并将业务切换到备用组件来提供用于故障安全呼叫生存的系统和方法。该系统和方法将阻止由于因特网协议系统中的单一故障点而导致的已建立或未建立的呼叫被丢弃。呼叫的继续是基于故障组件，而不是依靠通信端点重新启动或重新路由失败的呼叫。呼叫恢复与呼叫的呼叫路径无关。在不涉及呼叫的端点或中间点的情况下进行呼叫恢复的状况或需要的检测以及发起呼叫恢复过程的确定。所有组件的可用性和完整性都将不断监控，并针对每个组件的职责量身定做。

4. 发明申请

US20130274220A1 METHODS, ASSAYS AND COMPOUNDS FOR TREATING BACTERIAL INFECTIONS BY INHIBITING METHYLTHIOINOSINE PHOSPHORYLASE 有权
标题翻译：通过抑制甲硫氨酸磷酸酶处理细菌感染的方法，测定和化合物
公开(公告)号：US20130274220A1
公开(公告)日：2013-10-17
申请号：US13884298
申请日：2011-11-28
申请人： Vern L. Schramm , Keith Clinch , Peter Charles Tyler , Gary Brian Evans , Richard Hubert Furneaux
发明人： Vern L. Schramm , Keith Clinch , Peter Charles Tyler , Gary Brian Evans , Richard Hubert Furneaux
IPC分类号： C07D487/04 , A61K45/06 , A61K31/519 , C12Q1/48
CPC分类号： C07D487/04 , A61K31/00 , A61K31/519 , A61K31/7042 , A61K31/7052 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7076 , A61K31/708 , A61K45/06 , C12Q1/48
摘要： The present invention discloses methods for treating bacterial infections in a subject comprising administering to the subject a sub-growth inhibiting amount of a 5′-methylthioinosine phosphorylase (MTIP) inhibitor, as well as assays for identifying such inhibitors, and compounds and pharmaceutical compositions comprising the inhibitors.
摘要翻译：本发明公开了一种用于治疗受试者细菌感染的方法，其包括对受试者施用次生长抑制量的5'-甲硫基肌苷磷酸化酶（MTIP）抑制剂以及用于鉴定此类抑制剂的测定法，以及包含抑制剂。

5. 发明授权

US07553839B2 5h-pyrrolo[3,2-D] pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases 有权
标题翻译： 5'-吡咯并[3,2-D]嘧啶抑制剂的核苷磷酸化酶和核苷酸酶
公开(公告)号：US07553839B2
公开(公告)日：2009-06-30
申请号：US10524995
申请日：2003-08-21
申请人： Gary Brian Evans , Richard Hubert Furneaux , Dirk Henning Lenz , Vern L. Schramm , Peter Charles Tyler , Olga Vladimirovna Zubkova
发明人： Gary Brian Evans , Richard Hubert Furneaux , Dirk Henning Lenz , Vern L. Schramm , Peter Charles Tyler , Olga Vladimirovna Zubkova
IPC分类号： C07D487/04 , A61K31/519 , A61P35/04 , A61P31/04 , A61P37/06 , A61P33/02
CPC分类号： C07D473/30 , C07D473/34 , C07H19/23
摘要： The present invention relates to compounds of the general formula (I) which are inhibitors of purine muclioside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT), 5′-methylthioadenosine phosphorylases (MTAP), 5′-methylthioadenosine mucliosidases (MTAN) and/or nucleoside hydrolases (NH). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds.
摘要翻译：本发明涉及作为嘌呤粘蛋白磷酸化酶（PNP），嘌呤磷酸核糖基转移酶（PPRT），5'-甲硫基腺苷磷酸化酶（MTAP），5'-甲硫基腺苷粘蛋白酶（MTAN）和/或核苷水解酶（NH）。本发明还涉及这些化合物在治疗包括癌症，细菌感染，原生动物感染和T细胞介导的疾病的疾病和感染中的用途以及含有该化合物的药物组合物。

6. 发明申请

US20070049570A1 Quinoline derivatives as phosphodiesterase inhibitors 审中-公开
标题翻译：喹啉衍生物作为磷酸二酯酶抑制剂
公开(公告)号：US20070049570A1
公开(公告)日：2007-03-01
申请号：US11349701
申请日：2006-02-08
申请人： Anthony Dean , Brian Evans , Sharon Gough , Christopher Lunniss , Alison Redgrave
发明人： Anthony Dean , Brian Evans , Sharon Gough , Christopher Lunniss , Alison Redgrave
IPC分类号： A61K31/56
CPC分类号： C07D401/12 , C07D215/54 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D453/02
摘要： There are provided according to the invention novel compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R19, R20, and R34 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
摘要翻译：根据本发明提供新的式（I）化合物或其药学上可接受的盐，其中R1，R2，R19，R20和R34如说明书中所述，其制备方法，含有它们的制剂及其在治疗炎症性疾病。

7. 发明授权

US07129355B2 Process for preparing kifunensine intermediate and kifunensine therefrom 有权
标题翻译：制备奎宁宁中间体和奎司宁的方法
公开(公告)号：US07129355B2
公开(公告)日：2006-10-31
申请号：US10615044
申请日：2003-07-08
申请人： Paul Andrew Benjes , Ashley Nicholas Jarvis , Gary Brian Evans , Gavin Frank Painter , John Adrian Dickison , Anthony Mitchell , Keith Clinch
发明人： Paul Andrew Benjes , Ashley Nicholas Jarvis , Gary Brian Evans , Gavin Frank Painter , John Adrian Dickison , Anthony Mitchell , Keith Clinch
IPC分类号： C07D471/02 , C07D319/12 , C07D317/00
CPC分类号： C07D407/04 , Y02P20/55
摘要： A novel method for the preparation of a compound of formula (I) from an N—protected-D-mannosamine. A compound of formula (I) is a useful intermediate for the preparation of kiftnensine, a potent and selective mannosidase inhibitor. The method includes protecting the hydroxyl group at the C-6 position of an N—protected-D-mannosamine, to give a 6—O—protected—N—protected-D-mannosamine; reducing the C-1 anomeric carbon atom of the 6—O—protected—N—protected-D-mannosamine to give a 6—O—protected—N—protected-D-mannitol; protecting the four hydroxyl groups of the 6—O—protected—N—protected-D-mannitol; and removing the nitrogen atom protecting group and optionally removing the C-6 oxygen atom protecting group to give the compound of formula (I): where R1 and R2 are each independently protecting groups which, together with the oxygen atoms to which they are attached, form a 5-, 6-, 7- or 8-membered ring; and R3 is hydrogen or a protecting group.
摘要翻译：一种从N-保护的D-甘露糖胺制备式（I）化合物的新方法。式（I）化合物是用于制备功能性和选择性甘露糖苷酶抑制剂的kiftnensine的有用中间体。该方法包括保护N-保护的D-甘露糖胺C-6位的羟基，得到6-O-保护的N-保护的D-甘露糖胺; 还原6-O-保护的N-保护的D-甘露糖胺的C-1端基异构体碳原子，得到6-O-保护的N-保护的D-甘露糖醇; 保护6-O-保护的N-保护的D-甘露糖醇的四个羟基; 除去氮原子保护基，任选地除去C-6氧原子保护基，得到式（I）化合物：其中R 1和R 2各自为独立地保护与它们所连接的氧原子一起形成5-，6-，7-或8-元环的基团; R 3是氢或保护基。

8. 发明申请

US20060235801A1 Licensing content for use on portable device 有权
标题翻译：用于便携式设备的许可内容
公开(公告)号：US20060235801A1
公开(公告)日：2006-10-19
申请号：US11108038
申请日：2005-04-14
申请人： Clifford Strom , Michael Siu , Brian Evans
发明人： Clifford Strom , Michael Siu , Brian Evans
IPC分类号： H04L9/00
CPC分类号： H04L63/0442 , G06F21/10 , G06F2221/2129 , H04L9/0825 , H04L9/083 , H04L63/0823 , H04L2209/603
摘要： A computing device has encrypted content and a corresponding license having a decryption key for decrypting the content. The license allows the computing device to render the content thereon. The computing device may issue a sub-license based on the license to a portable device. The sub-license allows the portable device to render the content thereon and has the decryption key. The portable device has a digital device certificate including information thereon. The computing device receives from the portable device the device certificate thereof, and determines based on rules in the license and the information on the portable device in the device certificate whether the computing device can issue the sub-license to the portable device. If so, the computing device constructs such sub-license to include the decryption key (KD) and transmits the constructed sub-license to the portable device.
摘要翻译：计算设备具有加密内容和具有用于解密内容的解密密钥的相应许可证。许可证允许计算设备在其上呈现内容。计算设备可以基于许可证向便携式设备发布子许可证。子许可证允许便携式设备在其上呈现内容并具有解密密钥。便携式设备具有包括其上的信息的数字设备证书。计算设备从便携式设备接收其设备证书，并且基于许可证中的规则和设备证书中的便携式设备上的信息来确定计算设备是否可以向便携式设备发布子许可证。如果是这样，则计算设备构造这样的子许可证以包括解密密钥（KD），并将构造的子许可证发送到便携式设备。

9. 发明申请

US20060235799A1 Playlist burning in rights-management context 失效
标题翻译：播放列表刻录在权限管理上下文中
公开(公告)号：US20060235799A1
公开(公告)日：2006-10-19
申请号：US11107709
申请日：2005-04-14
申请人： Brian Evans , Clifford Strom , Geoffrey Dunbar , Richard Prologo
发明人： Brian Evans , Clifford Strom , Geoffrey Dunbar , Richard Prologo
IPC分类号： G06F17/60
CPC分类号： G06F21/10
摘要： A method is provided for a computing device to copy (burn) a playlist of tracks to a portable medium, where each track corresponds to a piece of digital content. At least one of the pieces of content is rights-management (RM) protected and accordingly is burned to the portable medium only in accordance with a corresponding digital license.
摘要翻译：提供了一种用于计算设备将轨道播放列表复制（刻录）到便携式介质的方法，其中每个轨道对应于一段数字内容。至少有一件内容是权限管理（RM）受保护的，因此仅根据相应的数字许可证将其烧录到便携式介质。

10. 发明申请

US20060232449A1 Retention of information about digital-media rights in transformed digital media content 有权
公开(公告)号：US20060232449A1
公开(公告)日：2006-10-19
申请号：US11108327
申请日：2005-04-18
申请人： Amit Jain , Benjamin Cutter , Brian Evans , Clifford Strom
发明人： Amit Jain , Benjamin Cutter , Brian Evans , Clifford Strom
IPC分类号： H03M7/00
CPC分类号： H04N21/440263 , G06F21/10 , G11B20/00224 , G11B20/0071 , G11B20/00731 , G11B20/00797 , G11B20/0084 , H04N21/4126 , H04N21/440218 , H04N21/4627 , H04N21/8355
摘要： Described herein are one or more implementations for transforming (e.g., transcoding) DRM-protected digital media content while retaining associated DRM-information (e.g., a user license its related information).

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