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1. 发明申请

WO1997022574A1 PROCESS FOR PRODUCING CATECHOL DERIVATIVES 审中-公开
标题翻译：生产CATECHOL衍生物的方法
公开(公告)号：WO1997022574A1
公开(公告)日：1997-06-26
申请号：PCT/JP1996003650
申请日：1996-12-13
申请人： DAISO CO., LTD. , FURUKAWA, Yoshiro , TAKENAKA, Keishi
发明人： DAISO CO., LTD.
IPC分类号： C07C43/23
CPC分类号： C07C45/71 , C07C41/26 , C07C45/55 , C07C45/68 , Y02P20/55 , C07C47/565 , C07C47/575 , C07C43/23
摘要： An improved process for producing catechol derivatives (1) useful as intermediates for compounds useful as drugs or agricultural chemicals, which comprises the reaction steps shown above. In said process (I), R represents alkyl, cycloalkyl, aralkyl, alkoxy, halogeno, allyl or aryl, and R represents a hydroxy-protecting group. The process is characterized in that formylation as the first step is conducted in the presence of a tin catalyst in two stages, first at 60 to 85 DEG C to a conversion of 30 to 80 % and then at 95 to 105 DEG C to completion, to thereby obtain a salicylaldehyde (3) in a high yield with a high selectivity. The objective catechol derivatives (1) having a high purity are hence obtained in a high yield.
摘要翻译：一种用于制备可用作药物或农药的化合物的中间体的儿茶酚衍生物（1）的改进方法，其包括上述反应步骤。在所述方法（I）中，R表示烷基，环烷基，芳烷基，烷氧基，卤代，烯丙基或芳基，R 1表示羟基保护基。该方法的特征在于，作为第一步的甲酰化在锡催化剂存在下分两个阶段进行，首先在60至85℃下转化30至80％，然后在95至105℃完成，从而以高产率以高选择性获得水杨醛（3）。因此以高产率获得具有高纯度的目标儿茶酚衍生物（1）。

2. 发明申请

WO1996036603A1 IMPROVED PROCESS FOR PRODUCING 4-HYDROXY-2-PYRROLIDONE 审中-公开
标题翻译：改进4-羟基-2-吡咯烷酮的方法
公开(公告)号：WO1996036603A1
公开(公告)日：1996-11-21
申请号：PCT/JP1996001259
申请日：1996-05-14
申请人： DAISO CO., LTD. , FURUKAWA, Yoshiro , SHIOMI, Yutaka , NAGAO, Kenichi
发明人： DAISO CO., LTD.
IPC分类号： C07D207/273
CPC分类号： C07D207/273
摘要： An improved process for producing 4-hydroxy-2-pyrrolidone represented by formula (1), which is useful as an intermediate for synthesizing medicines, agricultural chemicals and so forth, by synthesizing a 4-azido-3-hydroxybutanoic ester by the reaction of a 4-halogeno-3-hydroxybutanoic ester with an alkali metal or alkaline earth metal azide followed by the catalytic reduction of the azido group of the ester and cyclization.
摘要翻译：一种制备式（1）表示的4-羟基-2-吡咯烷酮的改进方法，其可用作合成药物，农药等的中间体，通过将4-叠氮基-3-羟基丁酸酯通过一种带有碱金属或碱土金属叠氮化物的4-卤代-3-羟基丁酸酯，然后催化还原酯的叠氮基并环化。

3. 发明申请

WO2004039795A3 AMIDE COMPOUNDS FOR THE TREATMENT OF HYPERLIPIDEMIA 审中-公开
标题翻译：用于治疗高磷脂酰胆碱的化合物
公开(公告)号：WO2004039795A3
公开(公告)日：2005-03-24
申请号：PCT/JP0313683
申请日：2003-10-27
申请人： FUJISAWA PHARMACEUTICAL CO , DAISO CO LTD , INOUE YOSHIKAZU , TERASAWA TAKESHI , TAKASUGI HISASHI , NAGAYOSHI AKIRA , UESHIMA KOJI , SAWADA MASAE , FURUKAWA YOSHIRO , MIKAMI MASAFUMI , HINOUE KAZUMASA , FUKUMOTO DAISUKE
发明人： INOUE YOSHIKAZU , TERASAWA TAKESHI , TAKASUGI HISASHI , NAGAYOSHI AKIRA , UESHIMA KOJI , SAWADA MASAE , FURUKAWA YOSHIRO , MIKAMI MASAFUMI , HINOUE KAZUMASA , FUKUMOTO DAISUKE
IPC分类号： A61P3/06 , C07D207/32 , C07D207/325 , C07D209/08 , C07D213/30 , C07D213/38 , C07D213/40 , C07D213/56 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D231/38 , C07D249/08 , C07D277/40 , C07D277/48 , C07D295/155 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14
CPC分类号： C07D207/325 , C07D209/08 , C07D213/30 , C07D213/38 , C07D213/40 , C07D213/56 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D231/38 , C07D249/08 , C07D277/40 , C07D277/48 , C07D295/155 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14
摘要： A compound of the formula (I) Wherein R is hydrogen, lower alkyl, lower alkenyl, halo(lower)alkyl, cyclo(lower)alkyl, lower alkoxy, lower alkylthio, acyl, optionally substituted aryl or NR R ; R is hydrogen; or aryl or heteroaryl, each of which may be substituted; X is direct bond or bivalent residue derived from piperazine; Y is -(A )n-(A )m-, wherein n and m are independently 0 or 1) ; (II) is bivalent residue derived from arene or heteroarene; and (III) is bivalent residue derived from arene or heteroarene, or a salt thereof. The compound of the present invention and a salt thereof inhibit apolipoprotein B (Apo B) secretion and are useful as a medicament for prophylactic and treatment of diseases or conditions resulting from elevated circulating levels of Apo B.
摘要翻译：式（I）的化合物，其中R 1是氢，低级烷基，低级烯基，卤代（低级）烷基，环（低级）烷基，低级烷氧基，低级烷硫基，酰基，任选取代的芳基或NR 3 [R <4>; R 2是氢; 或芳基或杂芳基，其各自可以被取代; X是衍生自哌嗪的直接键或二价残基; Y是 - （A 1）n - （A 2）m - ，其中n和m独立地为0或1）; （II）是衍生自芳烃或杂芳烃的二价残基; 和（III）是衍生自芳烃或杂芳烃的二价残基或其盐。本发明化合物及其盐抑制载脂蛋白B（Apo B）分泌，可用作预防和治疗由ApoB升高的循环水平引起的疾病或病症的药物。

4. 发明申请

WO1996030360A1 PROCESS FOR PRODUCING 1,4-BENZODIOXANE DERIVATIVES 审中-公开
标题翻译：生产1,4-苯二酮衍生物的方法
公开(公告)号：WO1996030360A1
公开(公告)日：1996-10-03
申请号：PCT/JP1996000727
申请日：1996-03-21
申请人： DAISO CO., LTD. , FURUKAWA, Yoshiro , KITAORI, Kazuhiro , TAKENAKA, Keishi
发明人： DAISO CO., LTD.
IPC分类号： C07D319/20
CPC分类号： C07D319/20 , Y02P20/55
摘要： A novel process for producing 1,4-benzodioxane derivatives represented by general formula (1), which are useful as intermediates in the production of remedies for circulatory diseases and psychoneurotic diseases, comprising sulfonating a phenoxypropanediol compound by reacting with a sulfonyl halide compound, eliminating the protecting group, treating with a base to thereby subject to a ring closure reaction followed by, if required, further sulfonation. In said formula R represents H or RSO2 (wherein R represents alkyl or optionally alkyl-substituted phenyl); and R , R and R represent each H, halogeno, OH, NO2, CN, formyl, COOH, alkoxycarbonyloxy, alkyl, alkoxy, haloalkyl, N,N-dialkylamino, alkylcarbonyl, alkoxycarbonyl, optionally alkyl-substituted phenyl, etc.
摘要翻译：一种用于生产由通式（1）表示的1,4-苯并二恶烷衍生物的新方法，其可用作生产循环系统疾病和精神神经病疾病的药物的中间体，包括通过与磺酰卤化合物反应来磺化苯氧基丙二醇化合物，消除保护基团，用碱处理，从而进行闭环反应，随后如果需要，进一步磺化。在所述式中，R 1表示H或RSO 2（其中R表示烷基或任选被烷基取代的苯基）; R 2，R 3和R 4分别表示H，卤代，OH，NO 2，CN，甲酰基，COOH，烷氧基羰基氧基，烷基，烷氧基，卤代烷基，N，N-二烷基氨基，烷基羰基，烷基取代的苯基等

5. 发明申请

WO1998025990A1 COPOLYETHER AND SOLID POLYMER ELECTROLYTE 审中-公开
标题翻译：聚合物和固体聚合物电解质
公开(公告)号：WO1998025990A1
公开(公告)日：1998-06-18
申请号：PCT/JP1997004499
申请日：1997-12-08
申请人： DAISO CO., LTD. , WATANABE, Masayoshi , MIURA, Katsuhito , YANAGIDA, Masanori , HIGOBASHI, Hiroki , ENDO, Takahiro
发明人： DAISO CO., LTD.
IPC分类号： C08G65/22
CPC分类号： H01G9/025 , C08G59/145 , C08G59/22 , C08G65/14 , C08G65/22 , C08G65/223 , C08G65/24 , C08K5/0008 , C08L71/02 , H01M6/181 , H01M10/052 , H01M10/0565 , C08L71/00
摘要： A solid polymer electrolyte prepared by blending (1) copolyether comprising a main chain derived from ethylene oxide molecules and a side chain having two oligooxyethylene groups with (2) an electrolytic salt and, if necessary, (3) a plasticizer selected from among aprotic organic solvents, derivatives and metal salts of polyalkylene glycols having a number-average molecular weight of 200 to 5000, and metal salts of the derivatives is superior to the solid electrolytes of the prior art in ionic conductivity and excellent in processability, moldability and mechanical strenghts. Secondary batteries can be produced by combining the solid polymer electrolyte with a negative electrode of metallic lithium and a positive electrode of cobalt lithium.
摘要翻译：一种固体聚合物电解质，其通过将（1）包含衍生自环氧乙烷分子的主链和具有两个低聚氧乙烯基团的侧链的共聚醚与（2）电解质盐共混（如果需要）（3）选自非质子有机数均分子量为200〜5000的聚亚烷基二醇的溶剂，衍生物和金属盐，以及衍生物的金属盐优于现有技术的离子导电性的固体电解质，加工性，成型性和机械强度优异。可以通过将固体聚合物电解质与金属锂的负极和钴锂的正极组合来制造二次电池。

6. 发明申请

WO1998012186A1 PROCESS FOR THE PREPARATION OF GLYCIDYL ETHERS 审中-公开
标题翻译：制备甘油三酯的方法
公开(公告)号：WO1998012186A1
公开(公告)日：1998-03-26
申请号：PCT/JP1997003221
申请日：1997-09-12
申请人： DAISO CO., LTD. , FURUKAWA, Yoshiro , KITAORI, Kazuhiro , YANAGIMOTO, Tetsuya , MIKAMI, Masafumi , YOSHIMOTO, Hiroshi , OTERA, Junzo
发明人： DAISO CO., LTD.
IPC分类号： C07D301/00
CPC分类号： C07D303/22 , C07D301/28
摘要： A process for the preparation of glycidyl ethers, characterized by reacting an epoxy compound represented by general formula (1) with an alcohol in the presence of a fluorine salt, wherein X is halogeno or sulfonyloxy. The process makes it possible to prepare glycidyl ethers and optical isomers thereof useful as internediates for the synthesis of drugs by easy and simple means in high yields, and the optical isomers prepared by the process have a high optical purity.
摘要翻译：一种制备缩水甘油醚的方法，其特征在于在氟盐存在下使通式（1）表示的环氧化合物与醇反应，其中X为卤代或磺酰氧基。该方法可以通过简单和简单的方法制备用作药物合成的内分子的缩水甘油醚和其旋光异构体，并且通过该方法制备的光学异构体具有高的光学纯度。

7. 发明申请

WO1998011088A1 PROCESS FOR PREPARING 1,3-DIOXOLANE-4-METHANOL COMPOUNDS 审中-公开
标题翻译：制备1,3-二氧杂环戊烷-4-甲醇化合物的方法
公开(公告)号：WO1998011088A1
公开(公告)日：1998-03-19
申请号：PCT/JP1997003166
申请日：1997-09-09
申请人： DAISO CO., LTD. , HINOUE, Kazumasa , FURUKAWA, Yoshiro
发明人： DAISO CO., LTD.
IPC分类号： C07D317/22
CPC分类号： C07D317/20
摘要： A process for preparing 1,3-dioxolane-4-methanol compounds in a racemic modification form and an optically active form having a high purity in a high yield in a simple and cost-effective manner. The process comprises reacting a 3-halogeno-1,2-propanediol (1a) (wherein X represents a halogen atom) or a glycidol with an alcohol in the presence of a base, acetalating the resultant 3-alkoxy-1,2-propanediol in the presence of an acid catalyst, and further conducting hydrogenation in the presence of a reduction catalyst to prepare a 1,3-dioxolane-4-methanol compound (5) (wherein R and R represent each hydrogen, an alkyl group having 1 to 4 carbon atoms, or a phenyl group, or R and R together with the adjacent carbon atom may form a three- to six-membered ring).
摘要翻译：以简单且成本有效的方式以高产率制备外消旋体形式的1,3-二氧戊环-4-甲醇化合物和具有高纯度的光学活性形式的方法。该方法包括在碱的存在下使3-卤代-1,2-丙二醇（1a）（其中X表示卤素原子）或缩水甘油与醇反应，缩合所得3-烷氧基-1,2-丙二醇在酸催化剂的存在下，在还原催化剂的存在下进一步进行氢化以制备1,3-二氧戊环-4-甲醇化合物（5）（其中R 1和R 2各自代表氢，具有1至4个碳原子的烷基或苯基，或R 1和R 2与相邻碳原子一起可以形成三至六元环）。

8. 发明申请

WO1998007772A1 SOLID POLYELECTROLYTE 审中-公开
标题翻译：固体聚电解质
公开(公告)号：WO1998007772A1
公开(公告)日：1998-02-26
申请号：PCT/JP1997002854
申请日：1997-08-19
申请人： DAISO CO., LTD. , MIURA, Katsuhito , SHOJI, Shigeru , SAKASHITA, Takahiro , MATOBA, Yasuo
发明人： DAISO CO., LTD.
IPC分类号： C08G65/22
CPC分类号： H01M10/0568 , C08G65/22 , H01B1/122 , H01G11/56 , H01M4/525 , H01M6/181 , H01M10/052 , H01M10/0565 , Y02E60/13
摘要： A solid polyelectrolyte prepared by mixing (1) a polyether copolymer having a backbone derived from ethylene oxide and a side chain of oligo-oxyethylene, (2) an electrolyte salt compound, and (3) an aprotic organic solvent, or a plasticizer consisting of a derivative or a metal salt of a polyalkylene glycol having a number average molecular weight of 200 to 5000 or a metal salt of the derivative, has ion conductivity superior to the conventional solid electrolytes and, at the same time, has excellent workability, moldability, and mechanical strength. The polyelectrolyte is combined with an anode of a lithium metal and a cathode of lithium cobaltate to constitute a rechargeable battery.
摘要翻译：通过混合（1）具有衍生自环氧乙烷的主链和低聚氧乙烯侧链的聚醚共聚物，（2）电解质盐化合物和（3）非质子有机溶剂或由下列组成的增塑剂组成的固体聚电解质数均分子量为200〜5000的聚亚烷基二醇的衍生物或金属盐或衍生物的金属盐具有优于常规固体电解质的离子传导性，同时具有优异的可加工性，成型性，和机械强度。聚电解质与锂金属的阳极和钴酸锂的阴极组合以构成可充电电池。

9. 发明申请

WO1997034952A1 NOVEL MELAMINE RESIN COMPOSITION AND USE THEREOF 审中-公开
标题翻译：新型甲酚树脂组合物及其用途
公开(公告)号：WO1997034952A1
公开(公告)日：1997-09-25
申请号：PCT/JP1997000886
申请日：1997-03-19
申请人： DAISO CO., LTD. , NAKAMURA, Seiji , SHIMIZU, Yasumi , AOKI, Koji , OHTSUKA, Takayuki , YANAGIMOTO, Tetsuya
发明人： DAISO CO., LTD.
IPC分类号： C08L61/28
CPC分类号： C08L61/28 , B32B21/08
摘要： A melamine resin composition comprising a melamine resin solution and 0.2 to 30 parts by weight on a solid basis, based on 100 parts by weight of the melamine resin of the solution, of a copolymer microgel emulsion of a vinyl compound comprising diallyl phthalate as an indispensable component, and providing decorative sheets having good gloss.
摘要翻译：包含三聚氰胺树脂溶液的三聚氰胺树脂组合物和基于100重量份的该溶液的三聚氰胺树脂为基础的0.2-30重量份的包含邻苯二甲酸二烯丙酯作为不可或缺的乙烯基化合物的共聚物微凝胶乳液并提供具有良好光泽度的装饰片材。

10. 发明申请

WO1997026254A1 PROCESS FOR PRODUCING GLYCIDYL SULFONATE DERIVATIVES 审中-公开
标题翻译：生产甘氨酸磺酸酯衍生物的方法
公开(公告)号：WO1997026254A1
公开(公告)日：1997-07-24
申请号：PCT/JP1997000075
申请日：1997-01-17
申请人： DAISO CO., LTD. , SAKATA, Midori , FURUKAWA, Yoshiro , TAKENAKA, Keishi
发明人： DAISO CO., LTD.
IPC分类号： C07D303/34
CPC分类号： C07D303/16 , C07D301/00
摘要： A process for producing high-purity glycidyl sulfonate derivatives in high yields which comprises reacting glycidol, in particular a reaction mixture containing glycidol and obtained by reacting 3-chloro-1,2-propanediol in an aqueous medium under basic conditions, with a sulfonyl halide in a two-phase solvent comprising an organic solvent and water in the presence of bases comprising a specific inorganic base and either a tertiary amine or a pyridine derivative.
摘要翻译：一种以高产率生产高纯度缩水甘油磺酸酯衍生物的方法，其包括使缩水甘油，特别是含有缩水甘油的反应混合物并通过在碱性条件下在水性介质中与3-磺酰卤反应得到的反应混合物在包含特定无机碱和叔胺或吡啶衍生物的碱的存在下，在包含有机溶剂和水的两相溶剂中进行。

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