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1. 发明申请

US20210204808A1 SYSTEMS, METHODS, AND DEVICES FOR OPTICAL COHERENCE TOMOGRAPHY MULTIPLE ENFACE ANGIOGRAPHY AVERAGING 有权
公开(公告)号：US20210204808A1
公开(公告)日：2021-07-08
申请号：US17145872
申请日：2021-01-11
申请人： Doheny Eye Institute
发明人： SriniVas R. Sadda , Akihito Uji
IPC分类号： A61B3/10 , A61B3/12 , A61B3/00 , G06T7/30 , G06T7/00 , G06T7/33 , G06T5/50 , G06T5/00
摘要： The disclosure herein provides methods, systems, and devices for improving optical coherence tomography machine outputs through multiple enface optical coherence tomography angiography averaging techniques. The embodiments disclosed herein can be utilized in ophthalmology for employing optical coherence tomography (OCT) for in vivo visualization of blood vessels and the flow of blood in an eye of a patient, which is also known generally as optical coherence tomography angiography (OCTA). The embodiments disclosed herein can use linear registration, affine registration and/or elastic registration to align a plurality of optical coherence tomography angiography images or videos at corresponding superficial vascular layers having well-defined features or landmarks, and to apply the same linear registration, affine registration and/or elastic registration settings and/or data to corresponding deeper tissue layers, such as the choriocapillaris, which generally do not have well-defined features or landmarks, in order to align a plurality of corresponding deeper tissue layers for the purpose of averaging the images or video to produce a clearer and more accurate image or video of the tissue structure at deeper tissue layers.

2. 发明授权

US10918274B2 Systems, methods, and devices for optical coherence tomography multiple enface angiography averaging 有权
公开(公告)号：US10918274B2
公开(公告)日：2021-02-16
申请号：US16575212
申请日：2019-09-18
申请人： Doheny Eye Institute
发明人： SriniVas R. Sadda , Akihito Uji
IPC分类号： G06K9/00 , A61B3/10 , A61B3/12 , A61B3/00 , G06T7/30 , G06T7/00 , G06T7/33 , G06T5/50 , G06T5/00
摘要： The disclosure herein provides methods, systems, and devices for improving optical coherence tomography machine outputs through multiple enface optical coherence tomography angiography averaging techniques. The embodiments disclosed herein can be utilized in ophthalmology for employing optical coherence tomography (OCT) for in vivo visualization of blood vessels and the flow of blood in an eye of a patient, which is also known generally as optical coherence tomography angiography (OCTA). The embodiments disclosed herein can use linear registration, affine registration and/or elastic registration to align a plurality of optical coherence tomography angiography images or videos at corresponding superficial vascular layers having well-defined features or landmarks, and to apply the same linear registration, affine registration and/or elastic registration settings and/or data to corresponding deeper tissue layers, such as the choriocapillaris, which generally do not have well-defined features or landmarks, in order to align a plurality of corresponding deeper tissue layers for the purpose of averaging the images or video to produce a clearer and more accurate image or video of the tissue structure at deeper tissue layers.

3. 发明授权

US10165941B2 Optical coherence tomography-based ophthalmic testing methods, devices and systems 有权
公开(公告)号：US10165941B2
公开(公告)日：2019-01-01
申请号：US15349970
申请日：2016-11-11
申请人： DOHENY EYE INSTITUTE
发明人： Alexander C. Walsh , Paul G. Updike , Srinivas R. Sadda
IPC分类号： A61B3/10 , A61B3/117 , A61B5/00 , A61B3/00 , A61B3/113 , A61B3/08 , A61B3/028 , A61B3/18
摘要： In accordance with one aspect of the present invention, an optical coherence tomography-based ophthalmic testing center system includes an optical coherence tomography instrument comprising an eyepiece for receiving at least one eye of a user or subject; a light source that outputs light that is directed through the eyepiece into the user's or subject's eye, an interferometer configured to produce optical interference using light reflected from the user's/subject's eye, an optical detector disposed so as to detect said optical interference; and a processing unit coupled to the detector. The ophthalmic testing center system can be configured to perform a multitude of self-administered functional and/or structural ophthalmic tests and output the test data.

4. 发明授权

US10070934B2 Sterile surgical tray 有权
公开(公告)号：US10070934B2
公开(公告)日：2018-09-11
申请号：US15284156
申请日：2016-10-03
申请人： Doheny Eye Institute
发明人： Ralph Kerns , Mark Humayun , Matthew T. McCormick , Trent Spencer Wells , Lawrence Chong , Jaw Chyng Lue
IPC分类号： A61B17/00 , A61B50/33 , A61B90/30 , A61M1/00 , A61M3/02 , A61F9/007 , A61B90/50 , A61B50/20
CPC分类号： A61B50/33 , A61B50/20 , A61B90/30 , A61B90/50 , A61B2017/00221 , A61B2017/00225 , A61B2017/00398 , A61B2017/00477 , A61B2017/00734 , A61B2217/005 , A61B2217/007 , A61F9/007 , A61F9/00736 , A61M1/0001 , A61M3/0254 , A61M2205/7536
摘要： A surgical apparatus for use by a surgeon can include a tray and a plurality of surgical instruments. The tray can have a plurality of structures located on an upper side of the tray for receiving the plurality of surgical instruments. The tray can receive a separate control unit. The tray can also have a fluid reservoir receiver for receiving a bottle or container of fluid, such as balanced salt solution. The fluid reservoir receiver can include one or more features, including, a spike, an air vent, and a light. A separate container can be used to place the bottle or container of fluid into the fluid reservoir receiver on the tray. This separate container can include a collapsible section.

5. 发明授权

US09919140B2 Implantable oxygenator with self-contained electrolyte 有权
公开(公告)号：US09919140B2
公开(公告)日：2018-03-20
申请号：US14433583
申请日：2013-10-07
申请人： UNIVERSITY OF SOUTHERN CALIFORNIA , DOHENY EYE INSTITUTE , CALIFORNIA INSTITUTE OF TECHNOLOGY
发明人： Mark S. Humayun , Karthik Murali , Ramiro Magalhaes Ribeiro , Yu-chong Tai , Nicholas Scianmarello
IPC分类号： A61M37/00 , A61F9/00 , C25B1/02 , C25B9/08 , A61M5/142
CPC分类号： A61M37/00 , A61F9/0017 , A61M5/14276 , A61M2005/14204 , A61M2205/3334 , A61M2210/0612 , C25B1/02 , C25B9/08
摘要： An implantable oxygenator may have a configuration that is suitable for implantation within a human body be implanted within a human body, such as within a human eye. The implantable oxygenator may include an electrolyte reservoir having a configuration suitable for storing electrolyte and an electrolysis system having a configuration that performs electrolysis on a portion of the electrolyte, thereby producing oxygen in the region of the electrolysis system.

6. 发明申请

US20170348147A1 IMPLANTABLE OXYGEN GENERATOR AND TRANSPORTER 审中-公开
公开(公告)号：US20170348147A1
公开(公告)日：2017-12-07
申请号：US15685353
申请日：2017-08-24
申请人： California Institute of Technology , University of Southern California , Doheny Eye Institute
发明人： Yu-Chong Tai , Nicholas E. Scianmarello , Karthik Murali , Mark S. Humayun , Ramiro Magalhaes Ribeiro
IPC分类号： A61F9/00 , A61N1/378 , A61N1/05 , A61M5/142 , A61M37/00 , A61N1/20
CPC分类号： A61F9/0017 , A61M5/14276 , A61M37/00 , A61M2005/14204 , A61M2205/04 , A61M2210/0612 , A61N1/0543 , A61N1/20 , A61N1/3787 , C25B1/04 , C25B9/00 , C25B15/02 , C25B15/08
摘要： An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule generator includes an electrolyte reservoir and a set of electrodes. A first portion of the electrolyte reservoir is impermeable to a predetermined class of small molecules. A second portion of the electrolyte reservoir is permeable to the small molecules. The set of electrodes is disposed inside the electrolyte reservoir and is configured to facilitate electrolysis of the small molecules based on an electric power application to the set of electrodes and on presence of electrolyte inside the electrolyte reservoir. At least a portion of the small molecule diffusor is permeable to the small molecules.

7. 发明申请

US20170071785A1 IMPLANTABLE OXYGEN GENERATOR AND TRANSPORTER 有权
标题翻译：可植入氧气发生器和运输机
公开(公告)号：US20170071785A1
公开(公告)日：2017-03-16
申请号：US15261435
申请日：2016-09-09
申请人： California Institute of Technology , University of Southern California , Doheny Eye Institute
发明人： Yu-Chong Tai , Nicholas E. Scianmarello , Karthik Murali , Mark S. Humayun , Ramiro Magalhaes Ribeiro
IPC分类号： A61F9/00 , A61N1/05 , A61M5/142 , A61M37/00
CPC分类号： A61F9/0017 , A61M5/14276 , A61M37/00 , A61M2005/14204 , A61M2205/04 , A61M2210/0612 , A61N1/0543 , A61N1/20 , A61N1/3787
摘要： An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule generator includes an electrolyte reservoir and a set of electrodes. A first portion of the electrolyte reservoir is impermeable to a predetermined class of small molecules. A second portion of the electrolyte reservoir is permeable to the small molecules. The set of electrodes is disposed inside the electrolyte reservoir and is configured to facilitate electrolysis of the small molecules based on an electric power application to the set of electrodes and on presence of electrolyte inside the electrolyte reservoir. At least a portion of the small molecule diffusor is permeable to the small molecules.
摘要翻译：描述了可植入医疗装置。可植入医疗装置包括小分子发生器，小分子扩散器和连接两者的插管。小分子发生器包括电解质储存器和一组电极。电解质储存器的第一部分对于预定类别的小分子是不可渗透的。电解液储存器的第二部分对小分子是可渗透的。该组电极设置在电解质储存器的内部，并且构造成基于对该组电极的电力施加和电解质储存器内的电解质的存在来促进小分子的电解。至少一部分小分子扩散剂对小分子是可渗透的。

8. 发明申请

US20160015563A1 SYSTEMS, METHODS, AND DEVICES FOR CANNULA INSERTION 有权
标题翻译：用于肛门插入的系统，方法和装置
公开(公告)号：US20160015563A1
公开(公告)日：2016-01-21
申请号：US14793980
申请日：2015-07-08
申请人： Doheny Eye Institute
发明人： Mark Humayun , Jaw-Chyng Lormen Lue
IPC分类号： A61F9/007 , A61B17/34
CPC分类号： A61F9/00736 , A61B17/3403 , A61B17/3421 , A61B2017/3409 , A61F9/007
摘要： A cannula insertion system configured to divide a cannula insertion process into a two-step process. The first step advances a needle portion a first distance and the second step advances the needle portion a second distance. The first step and the second step may be at different angles. At least one of the angles may be less than 90°. At least one of the steps may be mechanically assisted.
摘要翻译：套管插入系统，其配置成将套管插入过程分成两步过程。第一步使针部分进行第一距离，并且第二步骤使针部分前进第二距离。第一步和第二步可以是不同的角度。角度中的至少一个可以小于90°。可以机械辅助至少一个步骤。

9. 发明授权

US09149182B2 Optical coherence tomography device, method, and system 有权
标题翻译：光学相干断层扫描装置，方法和系统
公开(公告)号：US09149182B2
公开(公告)日：2015-10-06
申请号：US13717508
申请日：2012-12-17
申请人： Doheny Eye Institute
发明人： Alexander C. Walsh , Paul G. Updike , Srinivas R. Sadda
IPC分类号： A61B3/14 , A61B3/10 , A61B5/00 , A61B3/00 , A61B3/11
CPC分类号： A61B3/102 , A61B3/0008 , A61B3/0025 , A61B3/0033 , A61B3/1005 , A61B3/111 , A61B3/1225 , A61B5/0022 , A61B5/7275 , G06F19/00
摘要： In accordance with one aspect of the present invention, an optical coherence tomography instrument comprises an eyepiece for receiving at least one eye of a user is provided; a light source that outputs light that is directed through the eyepiece into the user's eye; an interferometer configured to produce optical interference using light reflected from the user's eye; an optical detector disposed so as to detect said optical interference; and electronics coupled to the detector. The electronics can be configured to perform a risk assessment analysis based on optical coherence tomography measurements obtained using the interferometer. An output device can be electrically coupled to the electronics, and may be configured to output the risk assessment to the user through the output device. The optical coherence tomography instrument can be self-administered, and the eyepiece can be a monocular system or a binocular system.
摘要翻译：根据本发明的一个方面，提供了一种光学相干断层摄影仪器，其包括用于接收用户的至少一只眼睛的目镜; 将通过目镜引导的光输出到用户的眼睛中的光源; 干涉仪，被配置为使用从用户的眼睛反射的光产生光学干涉; 设置为检测所述光学干涉的光学检测器; 和耦合到检测器的电子装置。电子设备可以被配置为基于使用干涉仪获得的光学相干断层扫描测量来执行风险评估分析。输出设备可以电耦合到电子设备，并且可以被配置为通过输出设备向用户输出风险评估。光学相干断层扫描仪可以自我管理，目镜可以是单目系统或双目系统。

10. 发明申请

US20150105864A1 Biocompatible Implants and Methods of Making and Attaching the Same 审中-公开
标题翻译：生物相容性植入物及其制造和附着方法
公开(公告)号：US20150105864A1
公开(公告)日：2015-04-16
申请号：US14499192
申请日：2014-09-28
申请人： Doheny Eye Institute
发明人： Adrian P. Rowley , Lucien D. Laude , Mark S. Humayun , James D. Weiland , Atoosa Lotfi , Francis S. Markland, Jr.
IPC分类号： A61L27/34 , A61L27/50
CPC分类号： A61F2/148 , A61L27/34 , A61L27/50 , A61L2400/18 , A61N1/0543 , A61N1/36 , A61N1/36046 , C08L89/00
摘要： The invention provides a biocompatible silicone implant that can be securely affixed to living tissue through interaction with integral membrane proteins (integrins). A silicone article containing a laser-activated surface is utilized to make the implant. One example is an implantable prosthesis to treat blindness caused by outer retinal degenerative diseases. The device bypasses damaged photoreceptors and electrically stimulates the undamaged neurons of the retina. Electrical stimulation is achieved using a silicone microelectrode array (MEA). A safe, protein adhesive is used in attaching the MEA to the retinal surface and assist in alleviating focal pressure effects. Methods of making and attaching such implants are also provided.
摘要翻译：本发明提供了一种生物相容的硅氧烷植入物，其通过与整合的蛋白质（整联蛋白）的相互作用可靠地固定在生物体组织上。使用含有激光激活表面的硅胶制品来制造植入物。一个例子是用于治疗由视网膜外变性疾病引起的失明的可植入假体。该装置绕过受损的光感受器并电刺激视网膜的未损伤的神经元。使用硅微电极阵列（MEA）实现电刺激。使用安全的蛋白质粘合剂将MEA附着到视网膜表面并有助于减轻焦点压力的影响。还提供了制造和附接这种植入物的方法。

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