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1. 发明申请

US20070221835A1 Combined Spectroscopic Method for Rapid Differentiation of Biological Samples 审中-公开
标题翻译：用于生物样品快速分化的组合光谱法
公开(公告)号：US20070221835A1
公开(公告)日：2007-09-27
申请号：US11682408
申请日：2007-03-06
申请人： Daniel Raftery , Huanwen Chen , Zhengzheng Pan
发明人： Daniel Raftery , Huanwen Chen , Zhengzheng Pan
IPC分类号： B01D59/44
CPC分类号： H01J49/0036 , G01R33/465 , H01J49/145 , H01J49/165
摘要： A method for differentiating complex biological samples, each sample having one or more metabolite species. The method comprises producing a mass spectrum by subjecting the sample to a mass spectrometry analysis, the mass spectrum containing individual spectral peaks representative of the one or more metabolite species contained within the sample; subjecting the individual spectral peaks of the mass spectrum to a statistical pattern recognition analysis; identifying the one or more metabolite species contained within the sample by analyzing the individual spectral peaks of the mass spectrum; and assigning the sample into a defined sample class.
摘要翻译：用于区分复杂生物样品的方法，每个样品具有一种或多种代谢物种。该方法包括通过对样品进行质谱分析来产生质谱，所述质谱包含代表样品中所含的一种或多种代谢物种类的各个光谱峰; 对质谱的各个光谱峰进行统计模式识别分析; 通过分析质谱的各个光谱峰来识别样品中所含的一种或多种代谢物; 并将样本分配到定义的样本类中。

2. 发明授权

US08380445B2 NMR method for differentiating complex mixtures 有权
标题翻译：用于区分复杂混合物的NMR方法
公开(公告)号：US08380445B2
公开(公告)日：2013-02-19
申请号：US13039136
申请日：2011-03-02
申请人： Daniel Raftery , Peter Sandusky
发明人： Daniel Raftery , Peter Sandusky
IPC分类号： G01N31/00 , G01N33/48 , G06G7/48 , G06G7/58
CPC分类号： G01R33/465 , G01N24/08 , G01R33/4625
摘要： A method for differentiating complex mixtures each having one or more chemical species is provided. The method comprises producing a sample NMR spectrum by subjecting a mixture to a selective spectroscopy process, wherein the NMR spectrum has individual spectral peaks representative of the one or more chemical species within the mixture. The one or more chemical species within the mixture are identified by analyzing the individual spectral peaks, and the individual spectral peaks are then subjected to a multivariate statistical analysis.
摘要翻译：提供了一种用于区分各自具有一种或多种化学物质的复杂混合物的方法。该方法包括通过使混合物进行选择性光谱法制备样品NMR光谱，其中NMR光谱具有表示混合物内一种或多种化学物质的单个光谱峰。混合物中的一种或多种化学物质通过分析各个光谱峰进行鉴定，然后对各个光谱峰进行多变量统计分析。

3. 发明申请

US20120142542A1 Metabolite Biomarkers for the Detection of Esophageal Cancer Using NMR 有权
标题翻译：使用NMR检测食管癌的代谢物生物标志物
公开(公告)号：US20120142542A1
公开(公告)日：2012-06-07
申请号：US13226256
申请日：2011-09-06
申请人： M. Daniel Raftery , Jian Zhang , Zane Hammoud
发明人： M. Daniel Raftery , Jian Zhang , Zane Hammoud
IPC分类号： C40B30/00 , C40B40/12 , C40B40/04
CPC分类号： G01N27/74 , G01N33/57488 , G01N2570/00
摘要： Methods for the detection and screening of esophageal adenocarcinoma (EAC) patients and for the monitoring of EAC treatment using a panel or panels of small molecule metabolite biomarkers are disclosed. In other aspects, methods for detection and screening for the progression of high-risk conditions (BE and HOD) to EAC and to monitoring treatment using a panel or panels of small molecule metabolite biomarkers are disclosed. The biomarkers are sensitive and specific for the detection of EAC, and can also be used to classify Barrett's esophagus (BE) and high-grade dysplasia (HOD), which are widely regarded as precursors of EAC.
摘要翻译：公开了使用小分子代谢物生物标志物的小组或小组检测和筛选食管腺癌（EAC）患者和用于监测EAC治疗的方法。在其他方面，公开了用于检测和筛选高危条件（BE和HOD）进展到EAC的方法以及使用小分子代谢物生物标志物的小组或小组监测治疗的方法。生物标志物对EAC的检测敏感且特异，也可用于对Barrett食管（BE）和高度发育异常（HOD）进行分类，被广泛认为是EAC的前体。

4. 发明申请

US20120107955A1 METABOLITE BIOMARKERS FOR THE DETECTION OF ESOPHAGEAL CANCER USING MS 审中-公开
标题翻译：使用MS检测食管癌的代谢生物标志物
公开(公告)号：US20120107955A1
公开(公告)日：2012-05-03
申请号：US13226236
申请日：2011-09-06
申请人： M. Daniel Raftery , Danijel Djukovic , Zane Hammoud
发明人： M. Daniel Raftery , Danijel Djukovic , Zane Hammoud
IPC分类号： G01N33/574 , C07H19/067 , G01N21/00 , C07H19/167
CPC分类号： G01N33/57407
摘要： Results of studies of nucleosides in biofluid specimens from patients with esophageal adenocarcinoma and related disorders have identified five biomarkers of the conditions: 1-methyladenosine, N2,N2-dimethylguanosine, N2-methylguanosine, cytidine and uridine. In certain embodiments, methods of measuring these biomarkers and kits for measuring these biomarkers are provided.
摘要翻译：食管腺癌和相关疾病患者生物流体标本中核苷的研究结果已经确定了5个生物标志物：1-甲基腺苷，N2，N2-二甲基鸟苷，N2-甲基鸟苷，胞苷和尿苷。在某些实施方案中，提供了测量这些生物标志物和用于测量这些生物标志物的试剂盒的方法。

5. 发明申请

US20110123976A1 Biomarkers and identification methods for the early detection and recurrence prediction of breast cancer using NMR 审中-公开
标题翻译：使用NMR的乳腺癌早期检测和复发预测的生物标志物和鉴定方法
公开(公告)号：US20110123976A1
公开(公告)日：2011-05-26
申请号：US12925054
申请日：2010-10-13
申请人： M. Daniel Raftery , Vincent Asiago
发明人： M. Daniel Raftery , Vincent Asiago
IPC分类号： C12Q1/00 , C07C53/06 , C07D233/64 , C07C229/36 , C07D233/88 , C07C229/08 , C07H3/02 , C07C229/22 , C07C279/14 , C07C229/26 , C07C323/58 , C07C229/24 , C07D207/16 , C07C59/01 , G01N33/68 , G01R33/44 , G01N33/487 , G06F17/18 , G06F19/00
CPC分类号： G01N33/57415 , G01N33/68 , G01N33/6842 , G01N2570/00 , G01R33/4625 , G01R33/465
摘要： A method is provided for the parallel identification of one or more metabolite species within a biological sample. The method comprises analyzing the sample to produce a spectrum containing individual spectral peaks representative of the one or more metabolite species contained within the sample; subjecting each of the individual spectral peaks to a statistical pattern recognition analysis to identify the one or more metabolite species contained within the sample; and identifying the one or more metabolite species contained within the sample by analyzing the individual spectral peaks of the spectra.
摘要翻译：提供了用于平行鉴定生物样品中一种或多种代谢物种的方法。该方法包括分析样品以产生含有代表样品中所含的一种或多种代谢物种类的各个光谱峰的光谱; 使每个单个光谱峰进行统计模式识别分析，以鉴定样品中所含的一种或多种代谢物种; 并通过分析光谱的各个光谱峰来鉴定样品中包含的一种或多种代谢物种类。

6. 发明申请

US20070055456A1 NMR method for differentiating complex mixtures 审中-公开
标题翻译：用于区分复杂混合物的NMR方法
公开(公告)号：US20070055456A1
公开(公告)日：2007-03-08
申请号：US11514031
申请日：2006-08-31
申请人： Daniel Raftery , Peter Sandusky
发明人： Daniel Raftery , Peter Sandusky
IPC分类号： G06F19/00
CPC分类号： G01R33/465 , G01N24/08 , G01R33/4625
摘要： A method for differentiating complex mixtures each having one or more chemical species is provided. The method comprises producing a sample NMR spectrum by subjecting a mixture to a selective spectroscopy process, wherein the NMR spectrum has individual spectral peaks representative of the one or more chemical species within the mixture. The one or more chemical species within the mixture are identified by analyzing the individual spectral peaks, and the individual spectral peaks are then subjected to a multivariate statistical analysis.
摘要翻译：提供了一种用于区分各自具有一种或多种化学物质的复杂混合物的方法。该方法包括通过使混合物进行选择性光谱法制备样品NMR光谱，其中NMR光谱具有表示混合物内一种或多种化学物质的单个光谱峰。混合物中的一种或多种化学物质通过分析各个光谱峰进行鉴定，然后对各个光谱峰进行多变量统计分析。

7. 发明授权

US07187173B1 Multi-coil NMR probe with nonmagnetic diodes 失效
标题翻译：具有非磁性二极管的多线圈NMR探头
公开(公告)号：US07187173B1
公开(公告)日：2007-03-06
申请号：US10825856
申请日：2004-04-15
申请人： Daniel Raftery , Robert E. Santini , Megan A. Macnaughtan
发明人： Daniel Raftery , Robert E. Santini , Megan A. Macnaughtan
IPC分类号： G01V3/00
CPC分类号： G01R33/30 , G01R33/302 , G01R33/34092
摘要： A multi-coil NMR probe using nonmagnetic diodes as switches located in close proximity to the radio-frequency circuit of the sample coils within the probe.
摘要翻译：使用非磁性二极管作为开关的多线圈NMR探针位于探针附近的样品线圈的射频电路附近。

8. 发明授权

US06685889B1 Photochemical catalysts and methods for their manufacture and use 失效
标题翻译：光化学催化剂及其制造和使用方法
公开(公告)号：US06685889B1
公开(公告)日：2004-02-03
申请号：US09736516
申请日：2000-12-13
申请人： Daniel Raftery , Ajit R. Pradhan , Megan A. Macnaughtan
发明人： Daniel Raftery , Ajit R. Pradhan , Megan A. Macnaughtan
IPC分类号： B01J1908
CPC分类号： B01J37/0246 , B01J19/127 , B01J29/084 , B01J35/004 , B01J35/06 , B01J37/0217 , B01J2219/0892
摘要： Photochemical catalysts and methods for their manufacture and use are provided. In one aspect of the invention, a photochemical catalyst includes an optical microfiber coated with a catalytic amount of a molecular sieve, such as a zeolite. In one preferred form, at least a portion of the outer surface of the optical microfiber is cladding-free to allow radial transmission of light to the molecular sieve coating. In another aspect of the invention, a method of making a photochemical catalyst is provided that includes depositing a catalytic amount of a molecular sieve onto an outer surface of an optical microfiber, wherein the optical microfiber is configured to transmit light to the molecular sieve. A method of photocatalysis utilizing the above-described photocatalysts includes exposing the photocatalyst and a reactant to a light source to photocatalytically react the reactant.
摘要翻译：提供了光化学催化剂及其制造和使用方法。在本发明的一个方面，光化学催化剂包括涂覆有催化量的分子筛如沸石的光学超细纤维。在一种优选形式中，光学超细纤维的外表面的至少一部分是无包层的，以允许将光径向透射到分子筛涂层。在本发明的另一方面，提供一种制备光化学催化剂的方法，其包括将催化量的分子筛沉积在光学超细纤维的外表面上，其中所述光学超细纤维被配置为将光透射到分子筛。使用上述光催化剂的光催化剂的方法包括将光催化剂和反应物暴露于光源以使反应物光催化反应。

9. 发明授权

US08653006B2 Metabolite biomarkers for the detection of esophageal cancer using NMR 有权
标题翻译：使用NMR检测食管癌的代谢物生物标志物
公开(公告)号：US08653006B2
公开(公告)日：2014-02-18
申请号：US13226256
申请日：2011-09-06
申请人： M. Daniel Raftery , Jian Zhang , Zane Hammoud
发明人： M. Daniel Raftery , Jian Zhang , Zane Hammoud
IPC分类号： C40B30/00 , C40B40/12 , C40B40/04
CPC分类号： G01N27/74 , G01N33/57488 , G01N2570/00
摘要： Methods for the detection and screening of esophageal adenocarcinoma (EAC) patients and for the monitoring of EAC treatment using a panel or panels of small molecule metabolite biomarkers are disclosed. In other aspects, methods for detection and screening for the progression of high-risk conditions (BE and HGD) to EAC and to monitoring treatment using a panel or panels of small molecule metabolite biomarkers are disclosed. The biomarkers are sensitive and specific for the detection of EAC, and can also be used to classify Barrett's esophagus (BE) and high-grade dysplasia (HGD), which are widely regarded as precursors of EAC.
摘要翻译：公开了使用小分子代谢物生物标志物的小组或小组检测和筛选食管腺癌（EAC）患者和用于监测EAC治疗的方法。在其他方面，公开了用于检测和筛选高危条件（BE和HGD）进展到EAC以及使用小分子代谢物生物标志物的小组或小组进行监测的方法。生物标志物对EAC的检测敏感且特异，也可用于对Barrett食管（BE）和高度发育异常（HGD）进行分类，被广泛认为是EAC的前体。

10. 发明申请

US20110202285A1 NMR METHOD FOR DIFFERENTIATING COMPLEX MIXTURES 有权
标题翻译：用于分解复合混合物的NMR方法
公开(公告)号：US20110202285A1
公开(公告)日：2011-08-18
申请号：US13039136
申请日：2011-03-02
申请人： Daniel Raftery , Peter Sandusky
发明人： Daniel Raftery , Peter Sandusky
IPC分类号： G06F19/00 , G01R33/44
CPC分类号： G01R33/465 , G01N24/08 , G01R33/4625
摘要： A method for differentiating complex mixtures each having one or more chemical species is provided. The method comprises producing a sample NMR spectrum by subjecting a mixture to a selective spectroscopy process, wherein the NMR spectrum has individual spectral peaks representative of the one or more chemical species within the mixture. The one or more chemical species within the mixture are identified by analyzing the individual spectral peaks, and the individual spectral peaks are then subjected to a multivariate statistical analysis.
摘要翻译：提供了一种用于区分各自具有一种或多种化学物质的复杂混合物的方法。该方法包括通过使混合物进行选择性光谱法制备样品NMR光谱，其中NMR光谱具有表示混合物内一种或多种化学物质的单个光谱峰。混合物中的一种或多种化学物质通过分析各个光谱峰进行鉴定，然后对各个光谱峰进行多变量统计分析。

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