专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007095398A8 XYLANASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译： XYLANASES，核酸编码它们及其制备和使用方法
公开(公告)号：WO2007095398A8
公开(公告)日：2008-04-10
申请号：PCT/US2007004429
申请日：2007-02-14
申请人： VERENIUM CORP , DAVID WEINER , DAVID BLUM
发明人： DAVID WEINER , DAVID BLUM
IPC分类号： C12N9/42 , D06L4/40 , D06L4/70
CPC分类号： C12N9/248 , A23K10/12 , A23K20/163 , A23L29/30 , A23V2002/00 , C12N9/2405 , C12N9/2437 , C12N9/2482 , C12N9/2488 , C12N9/2494 , C12P19/02 , C12P19/14 , C12Y302/01008 , D06L4/40 , D06L4/70 , D21C3/003 , D21C9/10 , D21H17/005 , Y02E50/16
摘要： The invention relates to enzymes having xylanase, mannanase and/or glucanase activity, e.g., catalyzing hydrolysis of internal ß-l,4-xylosidic linkages or endo- ß-1,4- ghicanase linkages; and/or degrading a linear polysaccharide beta-l ,4-xylan into xylose. Thus, the invention provides methods and processes for breaking down hemicellulose, which is a major component of the cell wall of plants, including methods and processes for hydrolyzing hemicelluloses in any plant or wood or wood product, wood waste, paper pulp, paper product or paper waste or byproduct. In addition, methods of designing new xylanases, mannanases and/or glucanases and methods of use thereof are also provided. The xylanases, mannanases and/or glucanases have increased activity and stability at increased pH and temperature.
摘要翻译：本发明涉及具有木聚糖酶，甘露聚糖酶和/或葡聚糖酶活性的酶，例如催化内部β-1,4-木糖苷键或内切-β-1,4-羟基化酶键的水解; 和/或将线性多糖β-1,4-木聚糖降解成木糖。因此，本发明提供了分解作为植物细胞壁的主要成分的半纤维素的方法和方法，包括在任何植物或木材或木制品，木材废料，纸浆，纸制品中水解半纤维素的方法和方法，废纸或副产品。此外，还提供了设计新的木聚糖酶，甘露聚糖酶和/或葡聚糖酶的方法及其使用方法。木聚糖酶，甘露聚糖酶和/或葡聚糖酶在增加的pH和温度下具有增加的活性和稳定性。

2. 发明申请

WO2007095398A2 XYLANASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译： XYLANASES，核酸编码它们及其制备和使用方法
公开(公告)号：WO2007095398A2
公开(公告)日：2007-08-23
申请号：PCT/US2007/004429
申请日：2007-02-14
申请人： DIVERSA CORPORATION , DAVID, Weiner , DAVID, Blum
发明人： DAVID, Weiner , DAVID, Blum
IPC分类号： D06L4/40 , D06L4/70
CPC分类号： C12N9/248 , A23K10/12 , A23K20/163 , A23L5/00 , A23L7/00 , A23L29/30 , A23L31/00 , A23L31/10 , A23L33/125 , A23V2002/00 , C12N9/2405 , C12N9/2437 , C12N9/2482 , C12N9/2488 , C12N9/2494 , C12P19/02 , C12P19/14 , C12Y302/01008 , D06L4/40 , D06L4/70 , D21C3/003 , D21C9/10 , D21H17/005 , Y02E50/16
摘要： The invention relates to enzymes having xylanase, mannanase and/or glucanase activity, e.g., catalyzing hydrolysis of internal β-l,4-xylosidic linkages or endo- β-1,4- ghicanase linkages; and/or degrading a linear polysaccharide beta-l ,4-xylan into xylose. Thus, the invention provides methods and processes for breaking down hemicellulose, which is a major component of the cell wall of plants, including methods and processes for hydrolyzing hemicelluloses in any plant or wood or wood product, wood waste, paper pulp, paper product or paper waste or byproduct. In addition, methods of designing new xylanases, mannanases and/or glucanases and methods of use thereof are also provided. The xylanases, mannanases and/or glucanases have increased activity and stability at increased pH and temperature.
摘要翻译：本发明涉及具有木聚糖酶，甘露聚糖酶和/或葡聚糖酶活性的酶，例如催化内部β-1,4-木糖苷键或内切-β-1,4-羟基化酶键的水解; 和/或将线性多糖β-1,4-木聚糖降解成木糖。因此，本发明提供了分解作为植物细胞壁的主要成分的半纤维素的方法和方法，包括在任何植物或木材或木制品，木材废料，纸浆，纸制品中水解半纤维素的方法和方法，废纸或副产品。此外，还提供了设计新的木聚糖酶，甘露聚糖酶和/或葡聚糖酶的方法及其使用方法。木聚糖酶，甘露聚糖酶和/或葡聚糖酶在增加的pH和温度下具有增加的活性和稳定性。

3. 发明申请

US20160311891A1 DNA Antibody Constructs And Method Of Using Same 审中-公开
标题翻译： DNA抗体构建体及其使用方法
公开(公告)号：US20160311891A1
公开(公告)日：2016-10-27
申请号：US15103970
申请日：2014-12-13
申请人： David Weiner , Karuppiah Mathumani , Seleeke Flingai , Niranjan Sardesai
发明人： David Weiner , Karuppiah Mathumani , Seleeke Flingai , Niranjan Sardesai
IPC分类号： C07K16/10 , A61N1/32 , A61M37/00 , C07K16/32 , C12N7/00
CPC分类号： C07K16/1081 , A61K48/005 , A61K2039/505 , A61K2039/53 , A61K2039/54 , A61M2037/0007 , C07K16/10 , C07K16/1063 , C07K16/32 , C07K2317/10 , C07K2317/51 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/56 , C07K2317/60 , C07K2317/76 , C07K2319/00 , C12N7/00 , C12N2740/16032 , C12N2740/16111 , C12N2740/16122 , C12N2770/24111 , C12N2770/24122 , C12N2770/24133 , C12N2770/24171 , C12N2770/36111 , C12N2770/36122 , C12N2770/36133 , C12N2770/36171 , Y02A50/383 , Y02A50/386
摘要： Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
摘要翻译：本文公开了包含编码抗体的重组核酸序列的组合物。本文还公开了通过将所述组合物施用于受试者来在受试者中产生合成抗体的方法。本公开还提供了使用所述组合物和产生方法预防和/或治疗受试者的疾病的方法。

4. 发明申请

US20160175427A1 Influenza Nucleic Acid Molecules And Vaccines Made Therefrom 审中-公开
标题翻译：流感核酸分子和疫苗
公开(公告)号：US20160175427A1
公开(公告)日：2016-06-23
申请号：US14910136
申请日：2014-08-04
申请人： David WEINER , Jian YAN , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , INOVIO PHARMACEUTICALS, INC.
发明人： David B. Weiner , Jian Yan
IPC分类号： A61K39/145 , C12N7/00 , C07K14/005
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N2760/16122 , C12N2760/16134
摘要： Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HA Influenza A of serotype H7N9 alone and in combination with HA hemagglutinin and/or influenza B hemagglutinin, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against one or more influenza A serotypes and/or influenza B serotypes, or combinations thereof, using the vaccines that are provided.
摘要翻译：本文提供了编码单独的血清型H7N9的HA流感A与HA血凝素和/或乙型流感血凝素以及表达序列的遗传构建体/载体和疫苗的新型共有氨基酸序列的核酸序列。本文还提供了使用提供的疫苗产生针对一种或多种甲型流感血清型和/或流感乙型血清型或其组合的免疫应答的方法。

5. 发明申请

US20160067334A1 Vaccines With Biomolecular Adjuvants 审中-公开
标题翻译：生物分子佐剂疫苗
公开(公告)号：US20160067334A1
公开(公告)日：2016-03-10
申请号：US14774428
申请日：2014-03-14
申请人： David WEINER , Karuppiah MUTHUMANI
发明人： David B. Weiner , Karuppiah Muthumani
IPC分类号： A61K39/39 , C07K14/52 , A61K41/00 , C07K14/47 , A61K39/21 , C12N7/00
CPC分类号： A61K39/39 , A61K39/12 , A61K39/21 , A61K41/0047 , A61K2039/53 , A61K2039/55516 , A61K2039/55522 , C07K14/4702 , C07K14/52 , C12N7/00 , C12N2740/16034 , C12N2740/16134 , C12N2740/16171 , C12N2740/16234 , C12N2740/16271 , Y02A50/412
摘要： Disclosed herein is a vaccine comprising an antigen and one or more bimolecular adjuvant. Also disclosed herein are methods for increasing an immune response in a subject. The methods may comprise administering the vaccine to the subject in need thereof.
摘要翻译：本文公开了包含抗原和一种或多种双分子佐剂的疫苗。本文还公开了增加受试者的免疫应答的方法。所述方法可以包括向有需要的受试者施用疫苗。

6. 发明授权

US08557551B2 Compositions and methods for making and modifying oils 有权
标题翻译：用于制造和改性油的组合物和方法
公开(公告)号：US08557551B2
公开(公告)日：2013-10-15
申请号：US11575066
申请日：2005-09-09
申请人： David Lam , David Weiner , Timothy Hitchman , Nelson R. Barton , Jonathan Lyon
发明人： David Lam , David Weiner , Timothy Hitchman , Nelson R. Barton , Jonathan Lyon
IPC分类号： C12P7/64
CPC分类号： C12P7/6418 , C12P7/6427 , C12P7/6445 , C12P7/6454 , C12P7/6472 , C12P7/6481 , C12P7/649 , Y02E50/13
摘要： The invention provides novel methods for making or modifying oils, e.g., plant, animal or microbial oils, such as vegetable oils or related compounds, that are low in a particular fatty acid(s), for example, low linoleic oils, low linolenic oils, low palmitic oils, low stearic oils or oils low in a combination thereof.
摘要翻译：本发明提供用于制备或改性油的新方法，例如植物油，动物油或微生物油，例如植物油或相关化合物，其在特定的脂肪酸中是低的，例如低亚麻油，低亚麻油，低棕榈油，低硬脂油或其组合低的油。

7. 发明授权

US08298799B2 Hydrolases, nucleic acids encoding them and methods for making and using them 有权
标题翻译：水解酶，编码它们的核酸和制备和使用它们的方法
公开(公告)号：US08298799B2
公开(公告)日：2012-10-30
申请号：US10547956
申请日：2004-03-08
申请人： Uwe T. Bornscheuer , David Weiner , Tim Hitchman , Jonathan Lyon , Sirirung Wongsakul
发明人： Uwe T. Bornscheuer , David Weiner , Tim Hitchman , Jonathan Lyon , Sirirung Wongsakul
IPC分类号： C12N9/14
CPC分类号： C12N9/20 , A23C9/20 , A23C19/05 , A23C19/063 , A23K10/14 , A23K20/189 , A23L29/06 , A23V2002/00 , A61K8/0216 , A61K8/375 , A61K8/606 , A61K8/66 , A61K38/465 , A61K2800/86 , A61Q5/06 , A61Q11/00 , A61Q19/00 , C10M129/70 , C10M129/76 , C10M2207/281 , C10M2207/289 , C10M2207/40 , C11C3/08 , C11D3/386 , C11D3/38627 , C11D3/38636 , C12C1/047 , C12C5/004 , C12C11/003 , C12N9/14 , C12N9/16 , C12N9/18 , C12P7/6418 , C12Q1/34 , C12Y301/01003 , D06M16/003 , D06M2200/12 , D06M2200/30 , D06M2200/50 , G01N33/573 , G01N2500/02
摘要： The invention provides hydrolases, polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides, e.g., enzymes, having a hydrolase activity, e.g., an esterase, acylase, lipase, phospholipase (e.g., phosphlipase A, B, C and D activity, patatin activity, lipid acyl hydrolase (LAH) activity) or protease activity, including thermostable and thermotolerant hydrolase activity, and polynucleotides encoding these enzyme, and making and using these polynucleotides and polypeptides. The hydrolase activities of the polypeptides and peptides of the invention include esterase activity, lipase activity (hydrolysis of lipids), acidolysis reactions (to replace an esterified fatty acid with a free fatty acid), transesterification reactions (exchange of fatty acids between triglycerides), ester synthesis, ester interchange reactions, phospholipase activity and protease activity (hydrolysis of peptide bonds). The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts, including the manufacture of cosmetics and nutraceuticals. In another aspect, the polypeptides of the invention are used to synthesize enantiomerically pure chiral products.
摘要翻译：本发明提供水解酶，编码它们的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。一方面，本发明涉及具有水解酶活性的多肽，例如酯酶，酰基转移酶，脂肪酶，磷脂酶（例如，磷脂酶A，B，C和D活性，patatin活性，脂质酰基水解酶（ LAH）活性）或蛋白酶活性，包括热稳定和耐热水解酶活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。本发明的多肽和肽的水解酶活性包括酯酶活性，脂肪酶活性（脂质水解），酸解反应（用游离脂肪酸代替酯化脂肪酸），酯交换反应（甘油三酸酯之间的脂肪酸交换），酯合成，酯交换反应，磷脂酶活性和蛋白酶活性（肽键的水解）。本发明的多肽可用于各种药物，农业和工业环境中，包括制造化妆品和营养品。另一方面，本发明的多肽用于合成对映体纯的手性产物。

8. 发明申请

US20120010104A1 GROWTH SELECTION METHOD 审中-公开
标题翻译：生长选择方法
公开(公告)号：US20120010104A1
公开(公告)日：2012-01-12
申请号：US13165663
申请日：2011-06-21
申请人： David Weiner , Tim Hitchman , Lishan Zhao , Mark J. Burk , Grace Desantis , Sarah Richardson Hanson , Aileen Milan , Toby Richardson , Patti Kretz , William Greenberg
发明人： David Weiner , Tim Hitchman , Lishan Zhao , Mark J. Burk , Grace Desantis , Sarah Richardson Hanson , Aileen Milan , Toby Richardson , Patti Kretz , William Greenberg
IPC分类号： C40B30/06
CPC分类号： C12N15/1086 , C12P41/006
摘要： The invention provides growth selection methods for screening an environmental or a mixed population library of nucleic acids comprising uncharacterized nucleic acids for the presence of a nucleic acid encoding an enzyme of interest. In one aspect, methods for screening and identification of enzymes, e.g., transaminases, nitrilases, aldolases, epoxide hydrolases are provided. Methods for the production and screening of gene libraries generated from nucleic acids isolated from more than one organism for enzymes of interest, e.g., transaminases, nitrilases, aldolases, epoxide hydrolases, are also provided.
摘要翻译：本发明提供用于筛选包含未表征的核酸的核酸的环境或混合群体文库以用于存在编码目的酶的核酸的生长选择方法。在一个方面，提供了用于筛选和鉴定酶的方法，例如转氨酶，腈水解酶，醛缩酶，环氧化物水解酶。还提供了从多于一种生物体分离的核酸产生的基因文库的产生和筛选的方法，所述生物体用于所关心的酶，例如转氨酶，腈水解酶，醛缩酶，环氧化物水解酶。

9. 发明申请

US20120009634A1 ALDOLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 有权
标题翻译：阿尔法，核酸编码方法及其使用方法
公开(公告)号：US20120009634A1
公开(公告)日：2012-01-12
申请号：US13235107
申请日：2011-09-16
申请人： Ellen BURKE , Steven John Gort , Paula M. Hicks , Peter Luginbuhl , Sara C. McFarlan , Toby Richardson , Christopher Solheid , David Weiner , Lishan Zhao
发明人： Ellen BURKE , Steven John Gort , Paula M. Hicks , Peter Luginbuhl , Sara C. McFarlan , Toby Richardson , Christopher Solheid , David Weiner , Lishan Zhao
IPC分类号： C12P17/10
CPC分类号： C12P17/10 , C12N9/88 , C12P13/001 , Y02P20/52
摘要： This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S, R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R,R and S,R configurations, and salts thereof.
摘要翻译：本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。在一些实施方案中，本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，包括耐热和耐热活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。根据本发明的多肽可以用于各种药物，农业和工业环境。在一些实施方案中，本发明提供了可用于制备R-2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸（R-MP）和莫纳甜的某些立体异构体的多肽和生物合成途径，例如R ，R和S，R莫纳甜及其盐，以及莫纳甜衍生物的某些立体异构体，例如R，R和S，R构型及其盐。

10. 发明授权

US08034595B2 Nitrilases and methods for making and using them 有权
标题翻译：腈水解酶及其制备和使用方法
公开(公告)号：US08034595B2
公开(公告)日：2011-10-11
申请号：US11868909
申请日：2007-10-08
申请人： Mark Madden , David Weiner , Jennifer Ann Chaplin
发明人： Mark Madden , David Weiner , Jennifer Ann Chaplin
IPC分类号： C12N9/14 , C12P13/04 , C07H21/04
CPC分类号： C12N9/78 , C12N15/00 , C12P7/42 , C12P13/002 , C12P13/04 , C12P41/006 , C12Y305/05001 , Y02P20/52
摘要： The invention provides nitrilases and methods for making and using them, and in one aspect, provides methods for producing enantiomerically pure α-substituted carboxylic acids, such as, for example, α-amino acids and α-hydroxy acids. In one aspect, methods of the invention combine an aldehyde or ketone with a cyanide and ammonia or an ammonium salt or an amine, in the presence of a nitrilase or a polypeptide having nitrilase activity, to stereoselectively hydrolyze the amino nitrile or cyanohydrin intermediate under conditions sufficient to produce the carboxylic acid.
摘要翻译：本发明提供腈水解酶及其制备和使用方法，一方面，提供了制备对映体纯的α-取代羧酸的方法，例如α-氨基酸和α-羟基酸。在一个方面，本发明的方法在腈水解酶或具有腈水解酶活性的多肽的存在下，将醛或酮与氰化物和氨或铵盐或胺组合，在条件下立体选择性水解氨基腈或氰醇中间体足以产生羧酸。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式