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1. 发明授权

US06561980B1 Automatic segmentation of prostate, rectum and urethra in ultrasound imaging 失效
标题翻译：超声成像中前列腺，直肠和尿道的自动分割
公开(公告)号：US06561980B1
公开(公告)日：2003-05-13
申请号：US09621867
申请日：2000-07-21
申请人： Gang Gheng , Haisong Liu , Yan Yu
发明人： Gang Gheng , Haisong Liu , Yan Yu
IPC分类号： A61B800
CPC分类号： G06T5/008 , A61B8/12 , G01S7/52036 , G06T5/002 , G06T5/20 , G06T7/0012 , G06T7/12 , G06T2207/10132 , G06T2207/20012 , G06T2207/20081 , G06T2207/20192 , G06T2207/30028 , G06T2207/30081
摘要： An ultrasound image of a transverse cross-sectional outline of the prostate gland is acquired. For three-dimensional imaging, a series of images can be taken, one of each slice of the prostate. The initial ultrasound images are pre-processed to remove the noise and increase the contrast. The rectum edge is located from the bottom of the images. The key points on the prostate boundaries are located and connected under the iterative training of a knowledge-based model until the shape of the boundary reaches a stable state. The urethra is segmented near the center of the prostate.
摘要翻译：获取前列腺横截面轮廓的超声图像。对于三维成像，可以拍摄一系列图像，每个前列腺切片之一。初始超声图像被预处理以去除噪声并增加对比度。直肠边缘位于图像的底部。在基于知识的模型的迭代训练下，前列腺边界的关键点位于并连接，直到边界的形状达到稳定状态。尿道在前列腺的中心附近分段。

2. 发明申请

US20100093090A1 METHOD AND KIT FOR EFFICIENT REPROGRAMMING OF SOMATIC CELLS 审中-公开
标题翻译：方法和工具，用于高效地代谢细胞
公开(公告)号：US20100093090A1
公开(公告)日：2010-04-15
申请号：US12568634
申请日：2009-09-28
申请人： HONGKUI DENG , YANG ZHAO , XIAOLEI YIN , QIANG ZHANG , FANGFANG ZHU , HAISONG LIU , WEIFENG YANG , CHENGANG XIANG , HAN QIN
发明人： HONGKUI DENG , YANG ZHAO , XIAOLEI YIN , QIANG ZHANG , FANGFANG ZHU , HAISONG LIU , WEIFENG YANG , CHENGANG XIANG , HAN QIN
IPC分类号： C12N5/071 , C12N5/00
CPC分类号： C12N15/113 , C12N5/0696 , C12N15/111 , C12N2501/065 , C12N2501/40 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2510/00 , C12N2799/027 , C12N2810/6081
摘要： The present invention relates to method or kit for efficient reprogramming of somatic cells.
摘要翻译：本发明涉及用于有效重编程体细胞的方法或试剂盒。

3. 发明授权

US06438401B1 Indentification and quantification of needle displacement departures from treatment plan 有权
标题翻译：针位置的识别和量化偏离治疗计划
公开(公告)号：US06438401B1
公开(公告)日：2002-08-20
申请号：US09636551
申请日：2000-08-11
申请人： Gang Cheng , Haisong Liu , Yan Yu
发明人： Gang Cheng , Haisong Liu , Yan Yu
IPC分类号： A61B505
CPC分类号： A61N5/103 , A61B8/0833 , A61B8/0841 , A61B2034/2051 , A61B2034/2055 , A61B2034/2059 , A61N5/1027 , A61N2005/1011
摘要： A placement plan is developed for the placement of radioactive seeds in a prostrate for brachytherapy. The placement plan is made available to an intraoperative tracking interface which also shows a live ultrasound image of the needle or catheter placement in the prostate. The difference in the x-y plane between the planned and actual locations of the needle or catheter is calculated, and from that difference, the error in position of each seed is calculated. The seeds are moved, or the operator changes the number of seeds, and the dose is recalculated. A small column of ultrasound images is taken, and each seed located in the column of images is given a confidence level. If the confidence level exceeds a threshold set by the operator, the dosimetry is recalculated. Periodically throughout the seed placement, fluoroscopic x-rays are taken, and the seed coordinates are matched to the x-ray image. Seed locations with low confidence levels are adjusted based on the x-ray locations, and the dosimetry is recalculated.
摘要翻译：开发了放射性种子放置在近距离放射治疗的前列腺中的放置计划。放置计划可用于术中跟踪界面，其还显示针或导管放置在前列腺中的活超声图像。计算针或导管的计划和实际位置之间的x-y平面的差异，并从该差异计算每个种子的位置误差。移动种子，或者操作者改变种子数，并重新计算剂量。拍摄一小列超声波图像，并将位于图像列中的每个种子置于置信水平。如果置信水平超过操作者设定的阈值，则重新计算剂量测定。在整个种子放置期间，采取荧光X射线，种子坐标与X射线图像相匹配。基于x射线位置调整低置信水平的种子位置，并重新计算剂量测定。

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