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1. 发明专利

JP2008081464A Fibrinolysis-enhancing agent and food having fibrinolysis-enhancing effect 审中-公开
标题翻译：纤维蛋白溶解增强剂和具有纤维蛋白溶解增强作用的食物
公开(公告)号：JP2008081464A
公开(公告)日：2008-04-10
申请号：JP2006265427
申请日：2006-09-28
申请人： Honda Trading Corp , Hiroyuki Sumi , 株式会社ホンダトレーディング , 洋行須見
发明人： SUMI HIROYUKI
IPC分类号： A61K31/7048 , A23L1/30 , A61P3/06 , A61P3/14 , A61P7/02 , A61P15/12 , A61P19/00 , C07H17/07
摘要： PROBLEM TO BE SOLVED: To confirm a fibrinolysis-enhancing effect of a soybean component. SOLUTION: Genistein or its homolog exhibits the fibrinolysis-enhancing effect by increasing the amount of plasminogen activator in a body by several folds on taking it orally. Also, the genistein or its homolog is expected to show an effect of preventing aging such as roughness, dullness, wrinkles, etc., of skin, which become problems mainly in women. Further, the effects of moderating menopausal syndromes (hot flush, etc.) occurring at around 50 years old, and improving hyperlipemia and a poor bone metabolism marker occurring at or after climacterium can be expected. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：确认大豆组分的纤维蛋白溶解增强作用。解决方案：染料木黄酮或其同系物通过口服将体内纤溶酶原激活物的量增加数倍，显示纤维蛋白溶解增强作用。此外，染料木素或其同系物预期会显示出防止皮肤老化的效果，如老化，这些问题主要在女性中成为问题。此外，可以预期发生在约50岁时缓解更年期综合征（热冲洗等），改善高脂血症和在高原期间或之后发生的不良骨代谢标记的作用。版权所有（C）2008，JPO＆INPIT

2. 发明专利

JP2008106064A T-pa accelerating material and its manufacturing method 审中-公开
标题翻译： T-PA加速材料及其制造方法
公开(公告)号：JP2008106064A
公开(公告)日：2008-05-08
申请号：JP2007255042
申请日：2007-09-28
申请人： Honda Trading Corp , Hiroyuki Sumi , 株式会社ホンダトレーディング , 洋行須見
发明人： SUMI HIROYUKI
IPC分类号： A61K35/74 , A23L1/30 , A61K31/7076 , A61K31/708 , A61P7/02 , A61P43/00 , C07G99/00 , C12P1/04
摘要： PROBLEM TO BE SOLVED: To provide an effective thrombolytic active material (t-PA accelerating material) except natto kinase, and its manufacturing method.
SOLUTION: Existence of a material which accelerates the t-PA production capacity in a cell is confirmed using a natto fungus cultivation liquid and the fungus itself, of which natto kinase, an enzyme, has been deactivated by heat-treatment, and adding it to a human cell. It means this t-PA acceleration material is prepared by the heat treatment of a natto fungus cultivation liquid or the natto fungus itself.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供除纳豆激酶以外的有效的溶栓活性物质（t-PA加速物质）及其制造方法。解决方案：使用纳豆真菌培养液和真菌本身证实了加速细胞中t-PA产生能力的物质，其中纳豆激酶，酶已经通过热处理而失活，以及将其加入人体细胞。这意味着这种t-PA加速材料是通过纳豆真菌培养液或纳豆真菌本身的热处理制备的。版权所有（C）2008，JPO＆INPIT

3. 发明专利

JP2005323596A Method for producing vitamin k by culture of unnan sl-001 strain 有权
标题翻译：通过UNNAN SL-001菌株培养生产维生素K的方法
公开(公告)号：JP2005323596A
公开(公告)日：2005-11-24
申请号：JP2005142065
申请日：2005-05-16
申请人： Honda Trading Corp , Hiroyuki Sumi , 株式会社ホンダトレーディング , 洋行須見
发明人： SUMI HIROYUKI
IPC分类号： A23K1/16 , A23L1/302 , A61K35/74 , A61P3/02 , A61P7/04 , A61P19/10 , C12P7/66
摘要： PROBLEM TO BE SOLVED: To provide a method for efficiently producing a vitamin K derivative, especially menaquinone-7 (vitamin K2) derivative. SOLUTION: This method for producing the vitamin K2 in the first embodiment comprises culturing an Unnan SL-001 strain as one kind of Bacillus natto, and a step for obtaining the vitamin K derivative by Soxhlet extraction from the cultured biomass and/or culture liquid and precipitation by acidification. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种有效生产维生素K衍生物，特别是甲醛醌-7（维生素K2）衍生物的方法。解决方案：在第一实施方式中，这种维生素K2的制造方法包括：将Unnan SL-001菌株作为一种纳豆芽孢杆菌进行培养，以及通过从培养的生物质提取索氏提取得到维生素K衍生物的步骤和/或培养液和酸化沉淀。版权所有（C）2006，JPO＆NCIPI

4. 发明专利

JP2004067538A Oral fibrinolytic enzyme (nattokinase) preparation 审中-公开
公开(公告)号：JP2004067538A
公开(公告)日：2004-03-04
申请号：JP2002226274
申请日：2002-08-02
申请人： Honda Trading Corp , Hiroyuki Sumi , 株式会社ホンダトレーディング , 須見洋行
发明人： SUMI HIROYUKI
IPC分类号： A61K35/74 , A61P7/02
摘要： PROBLEM TO BE SOLVED: To provide an oral fibrinolytic enzyme (nattokinase) preparation which has the highest fibrinolytic activity per molecule, is originated from a food, has high safety, can orally be administered, and is effective for thrombolysis. SOLUTION: This oral fibrinolytic enzyme (nattokinase) preparation is characterized by containing viable Bacillus natto. The oral fibrinolytic enzyme preparation is characterized by containing the Bacillus natto as a main ingredient. COPYRIGHT: (C)2004,JPO

5. 发明专利

JP2001000175A CULTURE OF BACILLUS SUBTILIS, CULTURED PRODUCT OF MICROORGANISM THEREBY, WATER-SOLUBLE VITAMIN K DERIVATIVE DERIVED FROM THE SAME CULTURED PRODUCT, AND FOOD, DRINK AND FEED WHICH COMPRISE CULTURED PRODUCT OF MICROORGANISM OF VITAMIN K DERIVATIVE 失效
公开(公告)号：JP2001000175A
公开(公告)日：2001-01-09
申请号：JP13418599
申请日：1999-05-14
申请人： SUMI HIROYUKI , HONDA TRADING CORP
发明人： SUMI HIROYUKI
IPC分类号： A23K10/12 , A23K20/00 , A23K20/174 , A23L33/135 , A23L33/15 , A61K31/00 , A61K31/12 , A61K31/122 , A61K35/74 , A61K35/742 , A61P3/00 , A61P3/02 , C12N1/20 , C12P1/04 , A23K1/16 , A23L1/302
摘要： PROBLEM TO BE SOLVED: To obtain a cultured product excellent in safety and useful for foods, drinks, feed, or the like, on the basis of the cultivation of Bacillus subtilis, by cultivating Bacillus subtilis and then by recovering microbial cells before vitamin K produced in the microbial cells is released outside the microbial cells. SOLUTION: A strain of Bacillus subtilis such as Bacillus subtilis natto is cultivated and the microbial cells before vitamin K (e.g. a vitamin K2 derivative such as a menaquinone-7 derivative) produced in the microbial cells is released outside the microbial cells are recovered. The microbial cells preferably are recovered during a period from the logarithmic phase to the stationary phase in cell number and also before natto kinase is produced. A water-soluble vitamin K derivative is fractionated preferably by the Soxhlet extraction of cultured cell bodies of Bacillus subtilis to extract the vitamin K derivative and then by acidifying the culture solution of Bacillus subtilis to further precipitate the vitamin K derivative.

6. 发明专利

JP2004290114A Highly functional food material, and food and drink using the same 审中-公开
公开(公告)号：JP2004290114A
公开(公告)日：2004-10-21
申请号：JP2003088980
申请日：2003-03-27
申请人： Honda Trading Corp , Hiroyuki Sumi , 株式会社ホンダトレーディング , 洋行須見
发明人： SUMI HIROYUKI
IPC分类号： A23L2/52 , A23L1/30 , A23L1/305
摘要： PROBLEM TO BE SOLVED: To provide a highly functional food material containing plenty of amino acids such as γ-aminobutyric acid; and to provide a food and drink using the functional food material. SOLUTION: The food material is obtained by fermenting a cooked buckwheat by the action of malted rice, and removing volatile components consisting essentially of an alcohol. The material (the food material) can be obtained as the lees of Shochu (white distilled liquor) of the buckwheat from a production process of the Shochu of the buckwheat. The method for effectively utilizing the lees of the Shochu, and the method for inexpensively mass-producing the amino acids such as the γ-aminobutyric acid (GABA) are also provided. COPYRIGHT: (C)2005,JPO&NCIPI

7. 发明专利

JP2008081457A t-PA PRODUCTION-ACCELERATING MATERIAL AND METHOD FOR PRODUCING THE SAME 审中-公开
标题翻译： t-PA生产加速材料及其制造方法
公开(公告)号：JP2008081457A
公开(公告)日：2008-04-10
申请号：JP2006264583
申请日：2006-09-28
申请人： Honda Trading Corp , Hiroyuki Sumi , 株式会社ホンダトレーディング , 洋行須見
发明人： SUMI HIROYUKI
IPC分类号： C07G99/00 , A23L1/30 , A61K35/74 , A61P7/02 , A61P43/00 , C12P1/04
摘要： PROBLEM TO BE SOLVED: To provide an effective thrombolysis-active substance [t-PA (tissue plasminogen activator) production-accelerating material], except nattokinase, and a method for producing the thrombolysis-active substance. SOLUTION: The presence of a substance accelerating the t-PA-producing ability in a cell has been confirmed by using a Bacillus natto-fermented solution and biomass itself, deactivating the nattokinase of an enzyme by heat treatment, and adding the resulting product to a human cell. The t-PA production-accelerating material according to the present invention is produced by subjecting the Bacillus natto-fermented solution and the biomass itself to the heat treatment. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供除纳豆激酶以外的有效的溶栓活性物质[t-PA（组织纤维蛋白溶酶原激活剂）生产促进物质）和制造溶栓活性物质的方法。解决方案：通过使用纳豆芽孢杆菌发酵溶液和生物质本身，通过热处理使酶的纳豆激酶失活，并加入所得到的产物，证实了加速细胞中t-PA产生能力的物质的存在产品到人体细胞。根据本发明的t-PA生产加速材料是通过对纳豆芽孢杆菌发酵的溶液和生物质本身进行热处理而制得的。版权所有（C）2008，JPO＆INPIT

8. 发明专利

JP2008072966A Method for producing nattokinase and vitamin k2 审中-公开
标题翻译：生产天冬氨酸蛋白酶和维生素K2的方法
公开(公告)号：JP2008072966A
公开(公告)日：2008-04-03
申请号：JP2006256322
申请日：2006-09-21
申请人： Honda Trading Corp , Hiroyuki Sumi , 株式会社ホンダトレーディング , 洋行須見
发明人： SUMI HIROYUKI
IPC分类号： C12N9/56 , C12P7/66
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide a method for efficiently producing Nattokinase and a method for efficiently producing vitamin K 2 . SOLUTION: The method for producing the Nattokinase comprises adding dipicolinic acid to a culture solution of Bacillus natto. The method for producing the vitamin K 2 comprises adding the dipicolinic acid to the culture solution of the Bacillus natto. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供一种有效生产纳豆激酶的方法和一种有效生产维生素K 2 的方法。解决方案：纳豆激酶的制造方法包括将吡啶二酸加入纳豆芽孢杆菌的培养液中。生产维生素K 2 的方法包括将dipicolinic酸加入到纳豆芽孢杆菌的培养溶液中。版权所有（C）2008，JPO＆INPIT

9. 发明专利

JP2004275075A Method for producing dipicolinic acid 审中-公开
标题翻译：生产双酚A酸的方法
公开(公告)号：JP2004275075A
公开(公告)日：2004-10-07
申请号：JP2003070837
申请日：2003-03-14
申请人： Honda Trading Corp , 株式会社ホンダトレーディング
发明人： SAITO JOSUKE
IPC分类号： C12P17/12 , C12R1/125
摘要： PROBLEM TO BE SOLVED: To provide a method for mass-producing dipicolinic acid at low cost.
SOLUTION: The method for highly efficiently producing dipicolinic acid from a sort of most inexpensive so-called industrial wastes comprises the following steps: (1) Koji and yeast are made to act on a steamed plant material to effect fermentation, and alcohol-based volatiles are removed from the resultant plant material at normal or reduced pressures to prepare medium substrate, (2) the medium substrate is inoculated with bacillus natto to make a fermented product, and (3) from the fermented product, the objective dipicolinic acid is refined. Specifically, in this method, distillation tailings produced in e.g. manufacturing Sho-chu( low-grade distilled spirits ) are used as the medium substrate.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供以低成本批量生产吡啶二酸的方法。解决方案：从一种最廉价的所谓工业废物中高效地生产二吡啶酸的方法包括以下步骤：（1）使Koji和酵母作用于蒸的植物材料上进行发酵，并且酒精在正常或减压下从所得植物材料中除去挥发物以制备培养基质，（2）用纳豆芽孢杆菌接种培养基质以制备发酵产物，和（3）从发酵产物中将目标吡啶二羧酸精致具体地说，在该方法中，制造Sho-chu（低级蒸馏酒）用作介质基质。版权所有（C）2005，JPO＆NCIPI

10. 发明专利

JP2004065047A Method for extracting bacillus natto kinase and extracted bacillus natto kinase 审中-公开
公开(公告)号：JP2004065047A
公开(公告)日：2004-03-04
申请号：JP2002226273
申请日：2002-08-02
申请人： Honda Trading Corp , Hiroyuki Sumi , 株式会社ホンダトレーディング , 須見洋行
发明人： SUMI HIROYUKI
IPC分类号： C12N9/56
摘要： PROBLEM TO BE SOLVED: To provide a new method for extracting Bacillus natto kinase.
SOLUTION: This method for extracting a plasmin (Bacillus natto kinase) contained in Bacillus natto is characterized by (1) extracting the Bacillus natto with water, (2) preliminarily treating the Bacillus natto with an organic solvent such as acetone, toluene or hexane and then extracting the pretreated Bacillus natto, (3) treating the Bacillus natto with an alkali at pH 11.0 and then extracting the Bacillus natto kinase, or (4) leaving the Bacillus natto at low temperature of 4°C for one day or more to cause the autolysis of the Bacillus natto cell and then extracting the Bacillus natto kinase. A strong fibrinolytic activity (plating method) or an amide-degrading activity against H-D-Val-Leu-Lys-pNA and Suc-Ala-Ala-Pro-Phe-pNA is recognized for any one of the obtained extraction fractions.
COPYRIGHT: (C)2004,JPO

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