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1. 发明专利

BR0111757A 未知
公开(公告)号：BR0111757A
公开(公告)日：2004-07-06
申请号：BR0111757
申请日：2001-06-07
申请人： HAO ZHANG
发明人： ZHANG JUNSHOU
IPC分类号： A61K9/20 , A61K9/28 , A61K9/48 , A61K31/606 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/32 , A61K47/36 , A61K47/42 , A61K47/44 , A61P29/00
摘要： The present invention relates to an oral medicament for specific delivery in colon and methods for preparation thereof.

2. 发明专利

AU7231401A Oral formulations for localized colonic release and the method of preparation thereof 未知
公开(公告)号：AU7231401A
公开(公告)日：2002-05-27
申请号：AU7231401
申请日：2001-06-07
申请人： HAO ZHANG
发明人： ZHANG JUNSHOU
IPC分类号： A61K9/20 , A61K9/28 , A61K9/48 , A61K31/606 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/32 , A61K47/36 , A61K47/42 , A61K47/44 , A61P29/00
摘要： The present invention relates to an oral medicament for specific delivery in colon and methods for preparation thereof.

3. 发明专利

AU8952101A Biologically active oral preparation that can be site-specific released in colon 未知
公开(公告)号：AU8952101A
公开(公告)日：2002-03-22
申请号：AU8952101
申请日：2001-06-07
申请人： HAO ZHANG
发明人： ZHANG JUNSHOU
IPC分类号： A61K9/48 , A61K38/28
摘要： The invention is directed to an oral biological preparation for specific delivery in colon, especially an oral insulin preparation for specific delivery in colon.

4. 发明专利

AU6638696A Apparatus and methods for improved noninvasive dermal administration of pharmaceuticals 未知
公开(公告)号：AU6638696A
公开(公告)日：1997-02-26
申请号：AU6638696
申请日：1996-07-26
申请人： JIE ZHANG , HAO ZHANG
发明人： ZHANG JIE , ZHANG HAO
IPC分类号： A61M37/00 , A61F7/02 , A61F7/03 , A61F13/00 , A61K9/70 , A61K31/167 , A61K31/245 , A61L15/42 , A61L15/44 , A61P23/00
摘要： An apparatus, product formulation, and method for improved dermal permeation of pharmaceuticals wherein the apparatus includes a thin drug formulation reservoir and a heat-generating chamber separated by a first non-permeable wall, wherein the reservoir and chamber are formed in or supported by a housing. The drug formulation reservoir houses or is capable of housing a predetermined amount of a formulation containing pharmaceutically-active agent(s). The heat-generating/temperature-regulating chamber includes a medium for generating controlled heat, preferably a chemical composition made of carbon, iron, water and/or salt which is activated upon contact with air (oxygen). The function of the heat-gencrating,/tcmpcrature-rcgulating clement is to heat the user's skin, rapidly bring the skin temperature to a desired and elevated narrow range and keep it in this range for sufficient time to obtain more rapid, enhanced and less variable dermal absorption of selected pharmaceutically-active agents and to obtain improved clinical effects. Structure for controlling the generation of heat is also disclosed. The apparatus may optionally include a spacing or standoff structure which spans the drug formulation reservoir between the non-permeable wall and the user's skin surface for maintaining a predetermined thickness of the drug formulation on the user's skin surface. Also, a novel product formulation which can be used with the apparatus which uses high percentage of eutectic mixture of local anesthetics to reduce the overall degradation rate of the local anesthetic compound(s) in formulations which are subject to hydrolysis.

5. 发明授权

US11499686B1 X-axis curvable LED lighting system and method of use 有权
公开(公告)号：US11499686B1
公开(公告)日：2022-11-15
申请号：US17479736
申请日：2021-09-20
申请人： Daniel Machlis , Eva Lu , Hao Zhang
发明人： Daniel Machlis , Eva Lu , Hao Zhang
IPC分类号： F21S4/28 , F21V5/04 , F21Y103/10 , F21Y115/10
摘要： An x-axis curvable LED lighting system includes an elongated notched x-axis curved channel enclosed in a casing which can be freely bent without a machine having a bottom portion and one or more walls extending therefrom; an elongated lens to secure over a top of the elongated curved channel; and a flexible light strip, having a mounting strip to secure to one of the one or more walls of the elongated curved channel; LED lights attached to the mounting strip by an extension such that the LED lights are positioned within the elongated curved channel along the bottom portion; the LED lights emit light through the elongated lens.

6. 发明申请

US20220017886A1 Linoleic Acid Isomerase and its Application in Production of Conjugated Linoleic Acid 有权
公开(公告)号：US20220017886A1
公开(公告)日：2022-01-20
申请号：US17497963
申请日：2021-10-10
申请人： Haiqin Chen , Bo Yang , He Gao , Jianxin Zhao , Yongquan Chen , Hao Zhang , Wei Chen
发明人： Haiqin Chen , Bo Yang , He Gao , Jianxin Zhao , Yongquan Chen , Hao Zhang , Wei Chen
IPC分类号： C12N9/90 , C12P7/64
摘要： Disclosed is linoleic acid isomerases and their application in production of conjugated linoleic acid, which belongs to the technical fields of protein engineering and microbial engineering. The linoleic acid isomerase derived from Bifidobacterium is used to produce the conjugated linoleic acid. The recombinant E. coli containing the linoleic acid isomerase of the invention is added into a reaction system containing linoleic acid and react for 3 h to produce conjugated linoleic acids. The conversion rate of the conjugated linoleic acid of the invented method ranges from 12.1% to 42.1%, and the percentage of cis9, trans11-CLA in the conjugated linoleic acid can reach 84.3% to 89.1%. The invention provides a method for using microorganisms to produce conjugated linoleic acids with high safety and yield where cis9, trans11-CLA isomer is the major form in the conjugated linoleic acid products.

7. 发明申请

US20210403884A1 Diacylglycerol Acyltransferase 1 and Application Thereof in Production of Triacylglycerol 有权
公开(公告)号：US20210403884A1
公开(公告)日：2021-12-30
申请号：US17469899
申请日：2021-09-09
申请人： Haiqin Chen , Wei Chen , Xin Tang , Jun Cao , Jianxin Zhao , Yongquan Chen , Hao Zhang
发明人： Haiqin Chen , Wei Chen , Xin Tang , Jun Cao , Jianxin Zhao , Yongquan Chen , Hao Zhang
IPC分类号： C12N9/10 , C12P7/64
摘要： Disclosed is a diacylglycerol acyltransferase 1, a recombinant Saccharomyces cerevisiae containing the diacylglycerol acyltransferase 1, and application thereof in production of triacylglycerol. The diacylglycerol acyltransferase 1 of the invention has a function of catalyzing synthesis of triacylglycerol. After the recombinant Saccharomyces cerevisiae containing the diacylglycerol acyltransferase 1 of the invention is subjected to induction culture for 48 h, the content of total fatty acid and triacylglycerol in the recombinant Saccharomyces cerevisiae containing the diacylglycerol acyltransferase 1 can be respectively increased by 1.94 folds and 12.09 folds as compared with those of Saccharomyces cerevisiae without the recombinant diacylglycerol acyltransferase 1. The instant invention provides a method for improving the ability of microorganisms to produce polyunsaturated fatty acids (PUFAs) by means of genetic engineering.

8. 发明申请

US20190235109A1 GENERATING A HIGH-RESOLUTION LITHOLOGY MODEL FOR SUBSURFACE FORMATION EVALUATION 审中-公开
公开(公告)号：US20190235109A1
公开(公告)日：2019-08-01
申请号：US15883817
申请日：2018-01-30
申请人： Hao Zhang , Alberto Mezzatesta
发明人： Hao Zhang , Alberto Mezzatesta
IPC分类号： G01V1/30 , E21B7/06 , G01V1/50 , C09K8/62 , E21B49/00 , G01V1/28 , G01V5/10 , G01V3/08 , G01V99/00
摘要： Examples of techniques for generating a high-resolution lithology model for subsurface formation evaluation are disclosed. In one example implementation according to aspects of the present disclosure, a computer-implemented method includes determining, by a processing device, a low-resolution lithology volumetric model. The method further includes comparing, by the processing device, the low-resolution lithology volumetric model to a high-resolution imaging log. The method further includes calculating, by the processing device, a dynamic boundary curve for each of a plurality of moving windows. The method further includes generating, by the processing device, the high-resolution lithology model based at least in part on the calculated dynamic boundary curve for each of the plurality of moving windows. The method further includes controlling a drilling operation based at least in part on the high-resolution lithology model.

9. 发明授权

US09924563B2 Method, system and media gateway for realizing mobile switch center pool 有权
公开(公告)号：US09924563B2
公开(公告)日：2018-03-20
申请号：US12356438
申请日：2009-01-20
申请人： Sihai Ye , Xiaochun Cui , Bei Wang , Zhenhua Liu , Hualin Luo , Hao Zhang , Fudong Zeng
发明人： Sihai Ye , Xiaochun Cui , Bei Wang , Zhenhua Liu , Hualin Luo , Hao Zhang , Fudong Zeng
IPC分类号： H04L12/28 , H04W88/14 , H04W24/04 , H04W48/18
CPC分类号： H04W88/14 , H04W24/04 , H04W48/18
摘要： The disclosure provides a method for realizing a Mobile Switch Center (MSC) pool, a system for realizing an MSC pool and a Media Gateway (MGW). The method for realizing an MSC pool includes: connecting with a Base Station Controllers (BSC)/Radio Network Controller (RNC), by a Media Gateway (MGW) through the use of a common signaling point; and upon receipt of a message whose destination signaling point is the common signaling point from the BSC/RNC, determining, by the MGW, a destination MSC server of the message according to ID information carried in the message, and sending the received message to the destination MSC server. According to the present invention, the networking scheme for an MSC pool may be implemented without upgrading any BSC/RNC. The flexibility of the networking scheme for mobile communication systems may be improved, and the traffic load of the subscribers may be shared.

10. 发明授权

US09320766B2 Protective effects and application of a lactobacillus plantarum on the alleviation of lead toxicity 有权
标题翻译：植物乳杆菌的保护作用和应用对铅毒性的缓解
公开(公告)号：US09320766B2
公开(公告)日：2016-04-26
申请号：US14118867
申请日：2012-07-18
申请人： Fengwei Tian , Wei Chen , Qixiao Zhai , Hao Zhang , Jianxin Zhao , Gang Wang , Yuanda Song , Qiuxiang Zhang , Xiaoming Liu , Min Guo , Daming Fan
发明人： Fengwei Tian , Wei Chen , Qixiao Zhai , Hao Zhang , Jianxin Zhao , Gang Wang , Yuanda Song , Qiuxiang Zhang , Xiaoming Liu , Min Guo , Daming Fan
IPC分类号： A61K35/747 , C12R1/25 , A23L1/30 , A23C13/16 , A23C19/032 , A23C9/123 , A23C11/10 , C12N1/20 , A23L2/38 , A23L1/212
CPC分类号： A61K35/747 , A23C9/1234 , A23C11/106 , A23C13/16 , A23C19/032 , A23L2/382 , A23L19/00 , A23L33/135 , A23V2002/00 , A23Y2220/67 , C12N1/20 , C12R1/25
摘要： The Lactobacillus plantarum CCFM8661 is tolerant to acid and lead ions in vitro which can tolerate lead ions solution with the initial concentration of 150 mg/L, and has a strong capability of binding lead ions, which can reduce the lead level in mice blood, liver, kidney and stomach, significantly improve antioxidant indicators and alleviate pathological symptoms of lead exposed mice.
摘要翻译：植物乳杆菌CCFM8661在体外耐受酸和铅离子，可以耐受初始浓度为150 mg / L的铅离子溶液，并具有较强的结合铅离子的能力，可以降低小鼠血液，肝脏的铅水平，肾，胃，显着改善抗氧化指标，减轻铅暴露小鼠的病理症状。

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