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1. 发明授权

US09044444B2 Method for improving skin appearance and reducing hair loss 有权
标题翻译：改善皮肤外观和减少脱发的方法
公开(公告)号：US09044444B2
公开(公告)日：2015-06-02
申请号：US13527984
申请日：2012-06-20
申请人： Horng-Jyh Harn , Shinn-Zong Lin , Tzyy-Wen Chiou , Po-Cheng Lin , Hen-Yi Chu
发明人： Horng-Jyh Harn , Shinn-Zong Lin , Tzyy-Wen Chiou , Po-Cheng Lin , Hen-Yi Chu
IPC分类号： A01N63/00 , A61K38/20 , A61K38/19
CPC分类号： A61K38/202 , A61K8/983 , A61K31/728 , A61K35/15 , A61K38/18 , A61K38/19 , A61K38/193 , A61K38/39 , A61K39/0005 , A61K2039/5154 , A61K2039/54 , A61K2800/91 , A61Q7/00 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61K2300/00
摘要： A method for improving skin appearance and/or reducing hair loss in a subject is provided. The method comprises administrating to the subject an effective amount of peripheral monocytes, wherein the peripheral monocytes are induced by granulocyte colony stimulating factor (GCSF) or a combination of GCSF and an interleukin relative to GCSF.
摘要翻译：提供了一种用于改善受试者的皮肤外观和/或减少脱发的方法。该方法包括向受试者施用有效量的外周单核细胞，其中通过粒细胞集落刺激因子（GCSF）或相对于GCSF的GCSF和白细胞介素的组合诱导外周单核细胞。

2. 发明申请

US20130287717A1 METHOD FOR IMPROVING SKIN APPEARANCE AND REDUCING HAIR LOSS 有权
标题翻译：改善皮肤外观和减少头发损失的方法
公开(公告)号：US20130287717A1
公开(公告)日：2013-10-31
申请号：US13527984
申请日：2012-06-20
申请人： Horng-Jyh HARN , Shinn-Zong LIN , Tzyy-Wen CHIOU , Po-Cheng LIN , Hen-Yi CHU
发明人： Horng-Jyh HARN , Shinn-Zong LIN , Tzyy-Wen CHIOU , Po-Cheng LIN , Hen-Yi CHU
IPC分类号： A61K8/98 , A61K35/28 , A61Q19/02 , A61Q19/00 , A61P17/14 , A61Q19/08 , A61K35/12 , A61K35/14
CPC分类号： A61K38/202 , A61K8/983 , A61K31/728 , A61K35/15 , A61K38/18 , A61K38/19 , A61K38/193 , A61K38/39 , A61K39/0005 , A61K2039/5154 , A61K2039/54 , A61K2800/91 , A61Q7/00 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61K2300/00
摘要： A method for improving skin appearance and/or reducing hair loss in a subject is provided. The method comprises administrating to the subject an effective amount of peripheral monocytes, wherein the peripheral monocytes are induced by granulocyte colony stimulating factor (GCSF) or a combination of GCSF and an interleukin relative to GCSF.
摘要翻译：提供了一种用于改善受试者的皮肤外观和/或减少脱发的方法。该方法包括向受试者施用有效量的外周单核细胞，其中通过粒细胞集落刺激因子（GCSF）或相对于GCSF的GCSF和白细胞介素的组合诱导外周单核细胞。

3. 发明申请

US20130231555A1 IMAGE GUIDED SURGERY APPARATUS AND SYSTEM 审中-公开
标题翻译：图像指导手术设备和系统
公开(公告)号：US20130231555A1
公开(公告)日：2013-09-05
申请号：US13615610
申请日：2012-09-14
申请人： Shinn-Zong LIN , Jin-Chern CHIOU , Horng-Jyh HARN , Jeng-Ren DUANN , Yung-Jiun LIN
发明人： Shinn-Zong LIN , Jin-Chern CHIOU , Horng-Jyh HARN , Jeng-Ren DUANN , Yung-Jiun LIN
IPC分类号： A61M25/095
CPC分类号： A61B34/20 , A61B18/1492 , A61B90/11 , A61B90/50 , A61B2090/306 , A61B2090/3614 , A61B2090/374
摘要： An image guided surgery apparatus and system are provided. The image guided surgery system includes an image capturing system, an image scanner, a navigator, a surgical catheter and a surgical probe. The image capturing system has an elongated and flexible working tube for capturing a surface image, a structure image or a dynamic structure image of a tissue during the surgical catheter moving forward to the surgical part, thus determining the type and the structure of the tissue in the front-end of the surgical catheter. Therefore, whether a moving path of the surgical catheter is to at the correct position can be confirmed for reaching a correct surgical site. The surgical catheter assists the surgical probe directly reaching the optimal surgical site for performing a precise positioning surgery.
摘要翻译：提供了图像引导手术装置和系统。图像引导手术系统包括图像捕获系统，图像扫描仪，导航仪，手术导管和手术探针。图像捕获系统具有细长且灵活的工作管，用于在手术导管向前移动到手术部分时捕获组织的表面图像，结构图像或动态结构图像，从而确定组织的类型和结构手术导管的前端。因此，可以确认手术导管的移动路径是否处于正确的位置以到达正确的手术部位。手术导管帮助手术探针直接到达最佳手术部位进行精确的定位手术。

4. 发明申请

US20110178171A1 COMPOUNDS FOR CANCER THERAPY 审中-公开
标题翻译：癌症治疗的化合物
公开(公告)号：US20110178171A1
公开(公告)日：2011-07-21
申请号：US13008597
申请日：2011-01-18
申请人： Yi-Lin CHEN , Horng-Jyh Harn , Shinn-Zong Lin , Tzyy-Wen Chiou , Cheng-Tung Lin
发明人： Yi-Lin CHEN , Horng-Jyh Harn , Shinn-Zong Lin , Tzyy-Wen Chiou , Cheng-Tung Lin
IPC分类号： A61K31/365 , A61P35/00
CPC分类号： A61K31/365
摘要： A method of inhibiting the cellular proliferation of at least one selected from the group consisting of androgen dependent prostate cancer cells, androgen independent prostate cancer cells, oral cancer cells, liver cancer cells (hepatoma), and gastric cancer cells in a subject is provided, wherein the method comprises administrating to the subject an effective amount of an active component selected from the group consisting of Z form isochaihulactone (Z-K8) of the following formula (I), E form isochaihulactone (E-K8) of the following formula (II), a pharmaceutically acceptable salt of Z-K8 or E-K8, a pharmaceutically acceptable ester of Z-K8 or E-K8, and combinations thereof: and R is H, alkoxy, or aryl. Also provided is a method for manufacturing Z-K8 and E-K8.
摘要翻译：提供一种抑制受试者中选自雄激素依赖性前列腺癌细胞，雄激素依赖性前列腺癌细胞，口腔癌细胞，肝癌细胞（肝癌）和胃癌细胞的至少一种的细胞增殖的方法，其中所述方法包括向受试者施用有效量的选自下式（I）的Z型异黄酮（Z-K8），下式的E型异黄酮（E-K8）（ II），Z-K8或E-K8的药学上可接受的盐，Z-K8或E-K8的药学上可接受的酯及其组合：R为H，烷氧基或芳基。还提供了制造Z-K8和E-K8的方法。

5. 发明授权

US07902255B2 γ-butyrolactone compound and pharmaceutical composition thereof 有权
标题翻译： γ-丁内酯化合物及其药物组合物
公开(公告)号：US07902255B2
公开(公告)日：2011-03-08
申请号：US12378504
申请日：2009-02-17
申请人： Shinn-Zong Lin , Horng-Jyh Harn
发明人： Shinn-Zong Lin , Horng-Jyh Harn
IPC分类号： A61K31/341 , A61K31/343
CPC分类号： A61K36/23
摘要： A γ-butyrolactone compound as shown in Formula (I) and pharmaceutical composition thereof: wherein X═N, O, S, Se; and A and B are selected from substituents having the following formula: wherein R1, R2, R3, R4, and R5 are selected from a hydrogen atom, a halogen atom, a hydroxyl group, a mercapto group, an amino group, an alkoxy group, and a nitro group. The γ-butyrolactone compound and pharmaceutical composition thereof butyrolactone have inhibitory effects on hepatoma, ovarian cancer, breast cancer, lung cancer, malignant glioblastoma or colorectal carcinoma, and are cytotoxic with high specificity to inhibit Paclitaxel-resistant tumor cells at later stage of chemotherapy without any damage on normal cells.
摘要翻译：式（I）所示的γ-丁内酯化合物及其药物组合物：其中X = N，O，S，Se; A和B选自具有下式的取代基：其中R1，R2，R3，R4和R5选自氢原子，卤素原子，羟基，巯基，氨基，烷氧基和硝基。 γ-丁内酯化合物及其药物组合物丁内酯对肝癌，卵巢癌，乳腺癌，肺癌，恶性胶质母细胞瘤或结肠直肠癌具有抑制作用，具有高度特异性的细胞毒性，可在化疗后期抑制紫杉醇耐药肿瘤细胞，无对正常细胞的任何损伤。

6. 发明授权

US07348032B2 Method for extracting antineoplastic components from Bupleurum scorzonerifolium 有权
标题翻译：从柴胡提取抗肿瘤成分的方法
公开(公告)号：US07348032B2
公开(公告)日：2008-03-25
申请号：US10690992
申请日：2003-10-21
申请人： Shinn-Zong Lin , Horng-Jyh Harn
发明人： Shinn-Zong Lin , Horng-Jyh Harn
IPC分类号： A61K36/00 , A61K9/00
CPC分类号： A61K36/23
摘要： A method for extracting antineoplastic component from Bupleurum scorzonerifolium applicable in treating cell proliferative disorder is proposed. The antineoplastic components of Bupleurum scorzonerifolium include at least a Y-butyolactone centred heterocyclic compound with a Z configuration or E configuration at its carbon 2(5) position, and molecules, such as Chaihulactone, Isochaihulactone, Chaihulactone analogues or derivatives containing in the heterocyclic compound. From results of cell and molecular biological studies, in vivo animal test, and histological study, it is found that antineoplastic components extracted from Bupleurum scorzonerifolium are effective in suppressing a variety of cancer cell growths, inhibiting telomerase activity, as well as effective in killing with high specificity Taxol-resistant tumor cells at later stage of chemical therapy, making the components a new choice for anti-cancer agent, anti-HIV agent, or synergistic agent.
摘要翻译：提出了一种从适用于治疗细胞增殖性疾病的柴胡中提取抗肿瘤成分的方法。柴胡的抗肿瘤成分至少包含在其碳2（5）位置具有Z构型或E构型的Y-丁内酯中心杂环化合物，以及分子，例如柴胡内酯，异丁内酯，柴胡内酯类似物或含有杂环化合物的衍生物。从细胞和分子生物学研究，体内动物试验和组织学研究结果可以看出，从柴胡提取的抗肿瘤成分有效抑制多种癌细胞生长，抑制端粒酶活性，并有效杀死高特异性抗紫杉醇抗肿瘤细胞在化学治疗的后期，使得这些成分成为抗癌剂，抗HIV药剂或协同剂的新选择。

7. 发明申请

US20070134351A1 ANGELICAE SINENSIS EXTRACTS USEFUL FOR TREATMENT OF CANCERS 有权
标题翻译： ANGELICAE SINENSIS提取物可用于治疗癌症
公开(公告)号：US20070134351A1
公开(公告)日：2007-06-14
申请号：US11561713
申请日：2006-11-20
申请人： Jiann-Kuan LUO , Horng-Jyh HARN , Wen-Liang CHANG , Shinn-Zong LIN , Yeung-Leung CHENG , Nu-Man TSAI
发明人： Jiann-Kuan LUO , Horng-Jyh HARN , Wen-Liang CHANG , Shinn-Zong LIN , Yeung-Leung CHENG , Nu-Man TSAI
IPC分类号： A61K36/232
CPC分类号： A61K31/34 , A61K36/232
摘要： The invention provides an acetone extract, chloroform extract or hexane extract of Angelicae sinensis and/or the active components purified therefrom, such as n-butylidenephthalide, which are effective in treating cancers.
摘要翻译：本发明提供了一种丙酮提取物，氯仿提取物或当归的己烷提取物和/或其纯化的活性成分，如正丁基苯酞，其有效治疗癌症。

8. 发明授权

US08927601B2 Uses of N-butylidenephthalide in treating a liver injury and improving liver function 有权
标题翻译：用于治疗肝损伤和改善肝功能的N-丁基肾上腺素
公开(公告)号：US08927601B2
公开(公告)日：2015-01-06
申请号：US13331059
申请日：2011-12-20
申请人： Tzyy-Wen Chiou , Horng-Jyh Harn , Shinn-Zong Lin
发明人： Tzyy-Wen Chiou , Horng-Jyh Harn , Shinn-Zong Lin
IPC分类号： A61K31/343
CPC分类号： A61K31/343
摘要： Provided is a method for treating a liver injury such as fibrosis, cirrhosis and hepatitis as well as a method for restoring liver function in a subject, which includes administrating to the subject a therapeutically effective amount of n-butylidenephthalide having the formula (I) as an active ingredient, or a pharmaceutically acceptable salt of ester thereof: wherein R is ═CHCH2CH2CH3, and n-butylidenephthalide (I) is E form, Z form or a mixture thereof.
摘要翻译：本发明提供一种治疗肝损伤如纤维化，肝硬化和肝炎的方法以及恢复受试者的肝功能的方法，其包括向受试者施用治疗有效量的具有式（I）的正丁基联苯醚作为活性成分或其药学上可接受的酯：其中R为= CHCH2CH2CH3，正丁基苯酞（I）为E型，Z型或其混合物。

9. 发明申请

US20110165201A1 ANTICANCER FORMULATION 审中-公开
标题翻译：抗原配方
公开(公告)号：US20110165201A1
公开(公告)日：2011-07-07
申请号：US12984042
申请日：2011-01-04
申请人： Tzyy-Wen Chiou , Horng-Jyh Harn , Shinn-Zong Lin
发明人： Tzyy-Wen Chiou , Horng-Jyh Harn , Shinn-Zong Lin
IPC分类号： A61K31/343 , A61K9/00 , A61P35/00
CPC分类号： A61K31/343 , A61K9/0024 , A61K47/34
摘要： This invention relates to a pharmaceutical formulation containing z-butylidenephthalide and a polymer, e.g., a polyanhydride. Also disclosed is use of this formulation to treat tumor.
摘要翻译：本发明涉及含有叔丁基肾上腺素和聚合物例如聚酐的药物制剂。还公开了该制剂的用途来治疗肿瘤。

10. 发明申请

US20090111870A1 Angelicae Sinensis Extracts Useful for Treatment of Cancers 审中-公开
标题翻译：当归提取物可用于治疗癌症
公开(公告)号：US20090111870A1
公开(公告)日：2009-04-30
申请号：US12260723
申请日：2008-10-29
申请人： Jiann-Kuan Luo , Horng-Jyh Harn , Wen-Liang Chang , Shinn-Zong Lin , Yeung-Leung Cheng , Nu-Man Tsai
发明人： Jiann-Kuan Luo , Horng-Jyh Harn , Wen-Liang Chang , Shinn-Zong Lin , Yeung-Leung Cheng , Nu-Man Tsai
IPC分类号： A61K31/34 , A61P35/00 , A61P35/02
CPC分类号： A61K31/34 , A61K36/232
摘要： An acetone extract, chloroform extract or hexane extract of Angelicae sinensis and/or the active components purified therefrom, such as n-butylidenephthalide, are administered alone or in combination with one or more chemotherapy drugs and are effective in treating cancers.
摘要翻译：丙酮提取物，氯仿提取物或当归的己烷提取物和/或其纯化的活性成分如正丁基肾上皮素单独或与一种或多种化疗药物组合施用，并且有效治疗癌症。

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