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1. 发明申请

US20100206731A1 DEVICES AND METHODS FOR OPTOELECTRONIC MANIPULATION OF SMALL PARTICLES 有权
标题翻译：用于光电子操作小颗粒的装置和方法
公开(公告)号：US20100206731A1
公开(公告)日：2010-08-19
申请号：US12702137
申请日：2010-02-08
申请人： Aldrich N.K. Lau , Joon Mo Yang , Huan L. Phan , Steven W. Sherwood , Hans A. Fuernkranz
发明人： Aldrich N.K. Lau , Joon Mo Yang , Huan L. Phan , Steven W. Sherwood , Hans A. Fuernkranz
IPC分类号： B03C11/00
CPC分类号： B03C5/026 , B03C5/005 , B03C5/028 , C07K1/26 , G01N27/305
摘要： A method for sorting cells in a biological sample comprising a first type of cells and a second type of cells may comprise introducing the biological sample into a chamber comprising a first surface and a second surface, wherein the first surface is associated with a transparent electrode and the second surface is associated with a photoconductive portion of an electrode. The method may further comprise moving incident light and the photoconductive portion relative to one another so as to illuminate regions of the photoconductive portion and modulate an electric field in the chamber in proximity to the illuminated regions. The method may further comprise separating the first type of cells from the second type of cells in the chamber via dielectrophoretic movement of the first type of cells and the second type of cells caused by the modulated electric field, wherein a dielectrophoretic characteristic of at least one of the first type of cells and the second type of cells has been modified.
摘要翻译：用于分选生物样品中包含第一类型细胞和第二类型细胞的细胞的方法可以包括将生物样品引入包含第一表面和第二表面的室中，其中第一表面与透明电极相关联，第二表面与电极的光电导部分相关联。该方法还可以包括相对于彼此移动入射光和光电导部分，以照射光电导部分的区域并且调制在邻近照明区域的室中的电场。该方法还可以包括通过由调制电场引起的第一类型的细胞和第二类型的细胞的介电电泳运动，将第一类型的细胞与腔室中的第二类型的细胞分离，其中至少一种的介电电泳特性的第一类型的细胞和第二类型的细胞已被修改。

2. 发明申请

US20090233327A1 Surface Modification in a Manipulation Chamber 审中-公开
标题翻译：操纵室中的表面改性
公开(公告)号：US20090233327A1
公开(公告)日：2009-09-17
申请号：US12398140
申请日：2009-03-04
申请人： Aldrich N.K. Lau , Huan L. Phan
发明人： Aldrich N.K. Lau , Huan L. Phan
IPC分类号： C12Q1/02 , B05D5/12 , B05D3/00
CPC分类号： G01N27/305 , B03C11/00 , C07K1/26
摘要： A device for manipulating biological material, the device including at least one electrode and a photoconductive material configured to receive the biological material; and a light source configured to illuminate the photoconductive material so as to modulate an electric field, wherein the electric field is configured to manipulate the biological material; wherein a surface of the at least one electrode and/or the photoconductive material is modified with at least one of a carboxylic moiety, an amino moiety, a poly(ethylene glycol) moiety, a polymer of (poly(ethylene oxide) methyl ether) acrylate, a poly(2-hydroxyethyl (meth)acrylate), a poly(N-vinylpyrrolidone), a poly(N-vinylformamide), a poly(N-vinylformamide) derivative, a poly((meth)acrylamide), and a poly((meth)acrylamide) derivative. Methods for manipulating biological material are also disclosed.
摘要翻译：一种用于操纵生物材料的装置，该装置包括至少一个电极和被配置为容纳生物材料的光导材料; 以及光源，被配置为照亮所述光电导材料以调制电场，其中所述电场被配置为操纵所述生物材料; 其中所述至少一个电极和/或光电导材料的表面用羧基部分，氨基部分，聚（乙二醇）部分，（聚（环氧乙烷）甲基醚）的聚合物，丙烯酸酯，聚（甲基）丙烯酸2-羟乙酯），聚（N-乙烯基吡咯烷酮），聚（N-乙烯基甲酰胺），聚（N-乙烯基甲酰胺）衍生物，聚（（甲基）丙烯酰胺）聚（（甲基）丙烯酰胺）衍生物。还公开了用于操作生物材料的方法。

3. 发明授权

US07419784B2 Methods, systems and apparatus for separation and isolation of one or more sample components of a sample biological material 有权
标题翻译：用于分离和分离样品生物材料的一种或多种样品组分的方法，系统和装置
公开(公告)号：US07419784B2
公开(公告)日：2008-09-02
申请号：US10401110
申请日：2003-03-27
申请人： Robert S. Dubrow , Luc J. Bousse , Huan L. Phan
发明人： Robert S. Dubrow , Luc J. Bousse , Huan L. Phan
IPC分类号： G01N33/53
CPC分类号： B01L3/50273 , B01L3/502715 , B01L3/502753 , B01L3/502784 , B01L2200/0605 , B01L2200/0631 , B01L2200/10 , B01L2300/0816 , B01L2400/0421 , B01L2400/0487 , G01N27/44791 , Y10T436/25
摘要： Devices, systems and methods for use in separating sample materials into different sample components and then isolating one or more of the sample components for further processing or analysis are disclosed. Devices employ configurations that optionally allow a sample material to be electrophoretically separated into sample components in a separation matrix within a separation conduit. The sample components may then be detected in a detection zone in the separation conduit, and then selected components shunted to a component collection conduit within the device downstream of the detection zone for further processing or analysis based on information received at the detection zone. Methods of using these devices, and systems that incorporate these devices are also envisioned.
摘要翻译：公开了用于将样品材料分离成不同样品组分，然后分离一个或多个样品组分用于进一步处理或分析的装置，系统和方法。设备采用可选地允许样品材料在分离管道内的分离基质中电泳分离成样品组分的构型。然后可以在分离管道中的检测区域中检测样品组分，然后根据在检测区域接收的信息，将选定的组分分流到检测区域下游装置内的组件收集管道进一步处理或分析。也可以设想使用这些装置的方法以及包含这些装置的系统。

4. 发明授权

US07055695B2 Container providing a controlled hydrated environment 有权
公开(公告)号：US07055695B2
公开(公告)日：2006-06-06
申请号：US10449517
申请日：2003-06-02
申请人： Michael Greenstein , Colin B Kennedy , Huan L Phan , Stephan Bianchi , Jonathan R Harris , Daren W Hebold , Robert A Howard , Andrew L Zee
发明人： Michael Greenstein , Colin B Kennedy , Huan L Phan , Stephan Bianchi , Jonathan R Harris , Daren W Hebold , Robert A Howard , Andrew L Zee
IPC分类号： B65D85/00
CPC分类号： B01L9/527 , B01L2200/025 , B01L2200/0689 , B01L2200/185 , B01L2300/041 , B65D85/70
摘要： A container is provided for shipping and storing a pre-wetted and pre-conditioned microfluidic “sipper” chip. The container contains both dry compartments and wet compartments. A base contains a fluid-filled reservoir configured to house the capillaries. The opening of the reservoir is sealed with an O-ring. The plastic mount of the chip rests on the base in a dry compartment. The upper surface of the chip contains several wells containing fluid. A gasket is provided with plugs configured to be disposed within and seal the wells. Alternatively, the wells are first sealed with a foil film adhered to the well openings with an adhesive and a gasket is disposed between the foil and a cover, which is removably attached to the base. When the cover is closed, the gasket and O-ring seal the wet compartments to prevent leakage and to slow evaporation.

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