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1. 发明申请

US20100222872A1 Methods, Compositions and Devices for Treating Lesioned Sites Using Bioabsorbable Carriers 审中-公开
标题翻译：用生物可吸收载体处理病变部位的方法，组成和装置
公开(公告)号：US20100222872A1
公开(公告)日：2010-09-02
申请号：US12782656
申请日：2010-05-18
申请人： Lothar W. Kleiner , Syed Hossainy , Irina Astafieva , Stephen Pacetti , Thierry Glauser , Jessica Desnoyer , Florian N. Ludwig
发明人： Lothar W. Kleiner , Syed Hossainy , Irina Astafieva , Stephen Pacetti , Thierry Glauser , Jessica Desnoyer , Florian N. Ludwig
IPC分类号： A61F2/82 , A61F2/00
CPC分类号： A61K9/143 , A61K9/0019 , A61K9/1611 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/00 , C08L67/04
摘要： Methods and compositions for the sustained release of treatment agents to treat an occluded blood vessel and affected tissue and/or organs are disclosed. Porous or non-porous bioabsorbable glass, metal or ceramic bead, rod or fiber particles can be loaded with a treatment agent, and optionally an image-enhancing agent, and coated with a sustained-release coating for delivery to an occluded blood vessel and affected tissue and/or organs by a delivery device. Implantable medical devices manufactured with coatings including the particles or embedded within the medical device are additionally disclosed.
摘要翻译：公开了用于持续释放治疗剂以治疗闭塞的血管和受影响的组织和/或器官的方法和组合物。多孔或无孔生物可吸收玻璃，金属或陶瓷珠，棒或纤维颗粒可以加载处理剂和任选的图像增强剂，并涂覆有持续释放的涂层以递送至闭塞的血管并受影响组织和/或器官。另外公开了用包括颗粒的涂层制造的植入式医疗装置或嵌入在医疗装置内的植入式医疗装置。

2. 发明申请

US20080051335A1 METHODS, COMPOSITIONS AND DEVICES FOR TREATING LESIONED SITES USING BIOABSORBABLE CARRIERS 审中-公开
标题翻译：方法，组合物和使用生物可降解载体处理裂解位点的装置
公开(公告)号：US20080051335A1
公开(公告)日：2008-02-28
申请号：US11614047
申请日：2006-12-20
申请人： Lothar Kleiner , Syed Hossainy , Irina Astafieva , Stephen Pacetti , Thierry Glauser , Jessica DesNoyer , Florian Ludwig
发明人： Lothar Kleiner , Syed Hossainy , Irina Astafieva , Stephen Pacetti , Thierry Glauser , Jessica DesNoyer , Florian Ludwig
IPC分类号： A61K48/00 , A61K38/18
CPC分类号： A61K9/143 , A61K9/0019 , A61K9/1611 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/00 , C08L67/04
摘要： Methods and compositions for the sustained release of treatment agents to treat an occluded blood vessel and affected tissue and/or organs are disclosed. Porous or non-porous bioabsorbable glass, metal or ceramic bead, rod or fiber particles can be loaded with a treatment agent, and optionally an image-enhancing agent, and coated with a sustained-release coating for delivery to an occluded blood vessel and affected tissue and/or organs by a delivery device. Implantable medical devices manufactured with coatings including the particles or embedded within the medical device are additionally disclosed.
摘要翻译：公开了用于持续释放治疗剂以治疗闭塞的血管和受影响的组织和/或器官的方法和组合物。多孔或无孔生物可吸收玻璃，金属或陶瓷珠，棒或纤维颗粒可以加载处理剂和任选的图像增强剂，并涂覆有持续释放的涂层以递送至闭塞的血管并受影响组织和/或器官。另外公开了用包括颗粒的涂层制造的植入式医疗装置或嵌入在医疗装置内的植入式医疗装置。

3. 发明申请

US20070259101A1 Microporous coating on medical devices 审中-公开
标题翻译：医疗器械上的微孔涂层
公开(公告)号：US20070259101A1
公开(公告)日：2007-11-08
申请号：US11447829
申请日：2006-06-05
申请人： Lothar W. Kleiner , Syed Faiyaz Ahmed Hossainy , Irina Astafieva , Stephen D. Pacetti , Thierry Glauser , Jessica DesNoyer
发明人： Lothar W. Kleiner , Syed Faiyaz Ahmed Hossainy , Irina Astafieva , Stephen D. Pacetti , Thierry Glauser , Jessica DesNoyer
IPC分类号： A61L33/00 , B05D3/00
CPC分类号： A61L27/30 , A61L27/54 , A61L27/56 , A61L31/082 , A61L31/088 , A61L31/146 , A61L31/16 , A61L2300/606 , A61L2300/608 , C23C4/18 , C23C26/00 , C23C28/00 , C23C28/322 , C23C28/3225 , C23C28/345 , C23C28/36
摘要： Microporous ceramic, metallic or glassy coating on a medical device comprising a bioactive agent for controlled release of the agent and methods of making and using the same are provided.
摘要翻译：提供了一种医疗装置上的微孔陶瓷，金属或玻璃状涂层，其包含用于药剂控制释放的生物活性剂及其制备和使用方法。

4. 发明申请

US20060074191A1 Blends of poly(ester amide) polymers 有权
标题翻译：聚（酯酰胺）聚合物的共混物
公开(公告)号：US20060074191A1
公开(公告)日：2006-04-06
申请号：US10960381
申请日：2004-10-06
申请人： Jessica DesNoyer , Stephen Pacetti , Lothar Kleiner
发明人： Jessica DesNoyer , Stephen Pacetti , Lothar Kleiner
IPC分类号： C08L77/00 , C08G69/48
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/606 , C08L77/12 , C08L2666/14
摘要： Provided herein is a poly(ester amide) (PEA) polymer blend and a polymeric coating containing the PEA polymer blend. The PEA polymer blend has a Tg above the Tg of poly(ester amide benzyl ester) (PEA-Bz) or the Tg of poly(ester amide TEMPO). The PEA polymer blend can form a coating on an implantable device, one example of which is a stent. The coating can optionally include a biobeneficial material and/or optionally with a bioactive agent. The implantable device can be used to treat or prevent a disorder such as one of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
摘要翻译：本文提供了聚（酯酰胺）（PEA）聚合物共混物和含有PEA聚合物共混物的聚合物涂层。 PEA聚合物共混物在聚（酯酰胺苄酯）（PEA-Bz）或T N g N T T上方具有T N' 的聚（酯酰胺TEMPO）。 PEA聚合物共混物可以在可植入装置上形成涂层，其一个实例是支架。涂层可任选地包括生物有益材料和/或任选地含有生物活性剂。可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔之一，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍导管阻塞，输尿管阻塞，肿瘤阻塞及其组合。

5. 发明申请

US20050288481A1 Design of poly(ester amides) for the control of agent-release from polymeric compositions 审中-公开
标题翻译：聚（酯酰胺）的设计，用于控制聚合物组合物释放的药剂
公开(公告)号：US20050288481A1
公开(公告)日：2005-12-29
申请号：US11187467
申请日：2005-07-22
申请人： Jessica DesNoyer , Stephen Pacetti , Lothar Kleiner , Syed Hossainy , Yung-Ming Chen , Gordon Stewart , Gina Zhang
发明人： Jessica DesNoyer , Stephen Pacetti , Lothar Kleiner , Syed Hossainy , Yung-Ming Chen , Gordon Stewart , Gina Zhang
IPC分类号： A61L2/00 , A61L31/10 , A61L31/16
CPC分类号： A61L31/10 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/16 , A61L2300/416 , A61L2300/604 , C08L77/12
摘要： The present invention generally encompasses a medical article, such as a medical device or coating comprising an agent or combination of agents, wherein the agent is distributed throughout a polymeric matrix. The polymeric matrix comprises an agent and a poly(ester amide) having a design that was preselected to provide a predetermined release rate of the combination of agents from the medical article.
摘要翻译：本发明通常包括医疗制品，例如包含试剂或试剂组合的医疗装置或涂层，其中所述试剂分布在整个聚合物基质中。聚合物基质包含试剂和聚（酯酰胺），该聚（酯酰胺）具有预设以提供来自医药制品的试剂组合的预定释放速率的设计。

6. 发明授权

US09242005B1 Pro-healing agent formulation compositions, methods and treatments 有权
标题翻译：预愈合剂配方组合物，方法和治疗
公开(公告)号：US09242005B1
公开(公告)日：2016-01-26
申请号：US11507860
申请日：2006-08-21
申请人： Syed Hossainy , Florian Niklas Ludwig , Stephen Pacetti , Paul Consigny , Fozan El-Nounou , Thierry Glauser , Jessica DesNoyer
发明人： Syed Hossainy , Florian Niklas Ludwig , Stephen Pacetti , Paul Consigny , Fozan El-Nounou , Thierry Glauser , Jessica DesNoyer
IPC分类号： A61M31/00 , A61K47/42 , A61K47/48 , A61M5/178
CPC分类号： A61K47/42 , A61K9/0019 , A61K9/1075 , A61K9/127 , A61K9/1273 , A61M5/178 , A61M25/104 , A61M31/00 , A61M2025/0087 , A61M2025/105 , A61M2025/1052
摘要： Pro-healing agent formulation compositions, methods and treatments for enhancing vascular healing are disclosed herein. In some embodiments, a pro-healing agent is encapsulated, suspended, disposed within or loaded into a biodegradable carrier for sustained-release delivery to a denuded or damaged endothelium treatment area in a blood vessel. In some applications, the pro-healing agent can accelerate re-endothelialization of a denuded vascular region. In some applications, the pro-healing agent can assist in the regaining of endothelium functionality. The formulation can be delivered by a delivery assembly such as an infusion catheter, a porous balloon catheter, a needle injection catheter, a double balloon catheter or the like.
摘要翻译：本文公开了用于增强血管愈合的预愈合剂制剂组合物，方法和治疗。在一些实施方案中，将前修复剂包封，悬浮，置于生物降解载体内或装载到可生物降解的载体中，以缓释递送至血管内的裸露或损伤的内皮治疗区域。在一些应用中，预愈合剂可以加速裸露的血管区域的再内皮化。在一些应用中，前修复剂可以帮助恢复内皮功能。制剂可以通过输送组件例如输注导管，多孔气囊导管，针注射导管，双气囊导管等来递送。

7. 发明授权

US08846069B2 Coatings for implantable devices comprising polymers of lactic acid and methods for fabricating the same 有权
标题翻译：用于包含乳酸聚合物的可植入装置的涂层及其制造方法
公开(公告)号：US08846069B2
公开(公告)日：2014-09-30
申请号：US12762718
申请日：2010-04-19
申请人： Syed F.A. Hossainy , Yiwen Tang , Eugene T. Michal , Thierry Glauser , Stephen D. Pacetti , Jessica DesNoyer
发明人： Syed F.A. Hossainy , Yiwen Tang , Eugene T. Michal , Thierry Glauser , Stephen D. Pacetti , Jessica DesNoyer
IPC分类号： A61F13/00 , A61L31/10 , A61L31/14 , A61L31/16
CPC分类号： A61L31/10 , A61F2250/0067 , A61L27/28 , A61L27/34 , A61L29/08 , A61L29/085 , A61L31/08 , A61L31/148 , A61L31/16 , A61L2420/00 , A61L2420/02 , A61L2420/06 , C08L67/04
摘要： Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising polymers of lactic acid.
摘要翻译：公开了用于可植入医疗装置的涂层及其制造方法，所述涂层包含乳酸聚合物。

8. 发明申请

US20070249801A1 Biologically absorbable coatings for implantable devices based on poly(ester amides) and methods for fabricating the same 有权
标题翻译：基于聚（酯酰胺）的可植入装置的生物可吸收涂层及其制造方法
公开(公告)号：US20070249801A1
公开(公告)日：2007-10-25
申请号：US11728209
申请日：2007-03-22
申请人： Stephen Pacetti , Jessica DesNoyer
发明人： Stephen Pacetti , Jessica DesNoyer
IPC分类号： C08G69/44
CPC分类号： A61L31/10 , Y10T428/31725 , Y10T428/31768 , C08L77/12
摘要： Coatings for an implantable medical devices such as stents and methods of fabricating thereof are disclosed. The coatings comprise a biologically absorbable poly(ester amide), which is a polymeric product of a reaction between a diol-diamine and a dicarboxylic acid.
摘要翻译：公开了用于诸如支架的可植入医疗装置的涂层及其制造方法。涂层包含生物可吸收的聚（酯酰胺），其是二醇 - 二胺和二羧酸之间的反应的聚合产物。

9. 发明申请

US20060136048A1 Abluminal, multilayer coating constructs for drug-delivery stents 有权
公开(公告)号：US20060136048A1
公开(公告)日：2006-06-22
申请号：US11015313
申请日：2004-12-16
申请人： Stephen Pacetti , Jessica DesNoyer , Yung-Ming Chen , Lothar Kleiner , Syed Hossainy
发明人： Stephen Pacetti , Jessica DesNoyer , Yung-Ming Chen , Lothar Kleiner , Syed Hossainy
IPC分类号： A61F2/82
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/608 , A61L2420/08
摘要： Embodiments of coatings for implantable medical devices, such as stents, are disclosed. The devices may include at least one structural element having an abluminal side, luminal side, and sidewalls between the abluminal and luminal sides. The coating may include at least two continuous coating layers. In some embodiments, the luminal side, and all or a majority of the sidewalls are free of at least two of the coating layers.

10. 发明申请

US20050271700A1 Poly(ester amide) coating composition for implantable devices 审中-公开
标题翻译：用于可植入装置的聚（酯酰胺）涂料组合物
公开(公告)号：US20050271700A1
公开(公告)日：2005-12-08
申请号：US10750139
申请日：2004-06-03
申请人： Jessica DesNoyer , Syed Hossainy , Stephen Pacetti , Yiwen Tang
发明人： Jessica DesNoyer , Syed Hossainy , Stephen Pacetti , Yiwen Tang
IPC分类号： A61F2/00 , A61L2/00 , A61L31/10 , A61L31/16 , C09D177/12 , C09D187/00
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/602 , C08L77/12
摘要： A poly(ester amide) (PEA) coating with enhanced mechanical and/or release rate for coating an implantable device, such as a drug-eluting stent, is disclosed. A method of forming the PEA coating onto a device and a method of treating a disorder, such as restenosis, are also disclosed.
摘要翻译：公开了用于涂覆可植入装置（例如药物洗脱支架）的具有增强的机械和/或释放速率的聚（酯酰胺）（PEA）涂层。还公开了将PEA涂层形成在器件上的方法和治疗诸如再狭窄的病症的方法。

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