专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100331387A1 LYOPHILIZED PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译： LYOPHILIZED药物组合物
公开(公告)号：US20100331387A1
公开(公告)日：2010-12-30
申请号：US12676755
申请日：2008-09-18
申请人： Thitiwan Buranachokpaisan , Wenlei Jiang , Wei-Qin Tong , Joseph Lawrence Zielinski , Jiahao Zhu , Hans-Peter Zobel
发明人： Thitiwan Buranachokpaisan , Wenlei Jiang , Wei-Qin Tong , Joseph Lawrence Zielinski , Jiahao Zhu , Hans-Peter Zobel
IPC分类号： A61K31/4045
CPC分类号： A61K31/4045 , A61K9/0019 , A61K9/0095 , A61K9/19
摘要： Pharmaceutical compositions that include a poorly water-soluble therapeutic compound, an aqueous solvent, an chelator/antioxidant, a buffer or buffer component, and a bulking agent. The pharmaceutical compositions can be orally ingested or administered parenterally. The pharmaceutical compositions can further be lyophilized to form a pharmaceutically acceptable cake that can be administered orally, e.g., as a solid oral dosage form; or reconstituted and administered parenterally, e.g. as a single i.v. bolus or iv infusion, or administered orally, e.g. as a drink solution.
摘要翻译：包含难溶于水的治疗化合物，水性溶剂，螯合剂/抗氧化剂，缓冲剂或缓冲剂组分以及填充剂的药物组合物。药物组合物可以口服摄取或肠胃外给药。药物组合物可以进一步冻干以形成可以口服给药的药学上可接受的蛋糕，例如作为固体口服剂型; 或重组和肠胃外给药，例如作为一个i.v. 推注或静脉输注，或口服给药，例如作为饮料溶液。

2. 发明申请

US20120164218A1 SOLID DOSAGE FORMS OF VALSARTAN, AMLODIPINE AND HYDROCHLOROTHIAZIDE AND METHOD OF MAKING THE SAME 有权
标题翻译：瓦尔塔坦，阿莫迪汀和氢氯酸的固体剂型及其制备方法
公开(公告)号：US20120164218A1
公开(公告)日：2012-06-28
申请号：US13342533
申请日：2012-01-03
申请人： Yu Cao , Yatindra Joshi , Ping Li , Madhusudhan Pudipeddi , Alan Edward Royce , Robert Frank Wagner , Jiahao Zhu
发明人： Yu Cao , Yatindra Joshi , Ping Li , Madhusudhan Pudipeddi , Alan Edward Royce , Robert Frank Wagner , Jiahao Zhu
IPC分类号： A61K31/549 , A61P9/12 , A61P9/04 , A61P9/10 , A61K9/28 , A61P9/00 , A61P7/00 , A61P25/00 , A61P25/28 , A61K9/20 , A61P1/16
CPC分类号： A61K9/2054 , A61K9/209 , A61K31/41 , A61K31/4422 , A61K31/549 , A61K2300/00
摘要： Monolayer, bilayer and trilayer solid dosage forms of a combination of valsartan, amlodipine and hydrochlorothiazide are made.
摘要翻译：制备缬沙坦，氨氯地平和氢氯噻嗪组合的单层，双层和三层固体剂型。

3. 发明申请

US20060121121A1 Hazard-free microencapsulation for structurally delicate agents, an application of stable aqueous-aqueous emulsion 审中-公开
标题翻译：用于结构脆弱剂的无害微囊化，应用稳定的水性乳液
公开(公告)号：US20060121121A1
公开(公告)日：2006-06-08
申请号：US10517122
申请日：2003-06-03
申请人： Tuo Jin , Hua Zhu , Jiahao Zhu
发明人： Tuo Jin , Hua Zhu , Jiahao Zhu
IPC分类号： A61K9/16 , B29C39/10
CPC分类号： A61K9/0043 , A61K9/0024 , A61K9/0073 , A61K9/1075 , A61K9/113 , A61K9/1652 , A61K9/19 , A61K9/5031 , A61K9/5036 , A61K9/5073 , A61K38/00
摘要： This invention provides method for sustained release delivery of structurally delicate agents such as proteins and peptides. Using unique emulsion system (Stable polymer aqueous-aqueous emulsion), proteins and peptides can be microencapsulated in polysacchride glassy particles under a condition free of any chemical or physical hazard such as organic solvents, strong interfacial tension, strong shears, elevated temperature, large amount of surfactants, and cross-linking agents. Proteins loaded in these glassy particles showed strong resistance to organic solvents, prolonged activity in hydrated state, and an excellent sustained release profile with minimal burst and incomplete release when being further loaded in degradable polymer microspheres. This invention provides a simple yet effective approach to address all the technical challenges raised in sustained release delivery of proteins.
摘要翻译：本发明提供结构上精细的试剂例如蛋白质和肽的持续释放递送方法。使用独特的乳液系统（稳定的聚合物水性乳液），蛋白质和肽可以在没有任何化学或物理危害的条件下，在有机溶剂，强界面张力，强剪切，高温，大量的条件下，微囊化在多糖玻璃状颗粒中的表面活性剂和交联剂。装载在这些玻璃状颗粒中的蛋白质显示出对有机溶剂的强烈抗性，水合状态下的延长的活性，以及当进一步负载在可降解聚合物微球体中时具有最小的突发和不完全释放的优异的持续释放特征。本发明提供了一种简单但有效的方法来解决蛋白质持续释放递送中提出的所有技术挑战。

4. 发明申请

US20130245061A1 PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：药物组合物
公开(公告)号：US20130245061A1
公开(公告)日：2013-09-19
申请号：US13989250
申请日：2011-12-01
申请人： Yu Cao , Wolfgang Hackl , Ping Li , Shoufeng Li , Tahseen Mirza , Hartmut Zehender , Jiahao Zhu
发明人： Yu Cao , Wolfgang Hackl , Ping Li , Shoufeng Li , Tahseen Mirza , Hartmut Zehender , Jiahao Zhu
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1641 , A61K9/1694 , A61K31/00
摘要： A pharmaceutical composition for the oral administration of a therapeutic compound of formula (I), comprising granules that comprise at least therapeutic compound of formula (I) or a tautomer thereof, or a pharmaceutically acceptable salt, or a hydrate or solvate thereof; at least one non-ionic surfactant that is Vitamin E-TPGS in an amount ranging from about 15 to about 80% by weight of the composition; and at least one a dissolution enhancing agent selected from polyethylene glycol, polyethylene oxide, and any combination of the foregoing; processes for making such pharmaceutical compositions; a kit comprising such pharmaceutical composition and the instructions for administration thereof; and related uses and methods of treatment.
摘要翻译：口服给药式（I）治疗性化合物的药物组合物，其包含至少包含治疗性式（I）化合物或其互变异构体或其药学上可接受的盐或其水合物或溶剂合物的颗粒剂; 至少一种非离子表面活性剂，其量为所述组合物的约15至约80重量％的量的维生素E-TPGS; 和至少一种选自聚乙二醇，聚环氧乙烷和前述的任何组合的溶解增强剂; 制备这种药物组合物的方法; 包含该药物组合物的试剂盒及其施用说明书; 及相关用途及治疗方法。

5. 发明授权

US08435563B2 Solid dosage forms of valsartan, amlodipine and hydrochlorothiazide and method of making the same 有权
公开(公告)号：US08435563B2
公开(公告)日：2013-05-07
申请号：US13342533
申请日：2012-01-03
申请人： Yu Cao , Yatindra Joshi , Ping Li , Madhusudhan Pudipeddi , Alan E Royce , Robert F Wagner , Jiahao Zhu
发明人： Yu Cao , Yatindra Joshi , Ping Li , Madhusudhan Pudipeddi , Alan E Royce , Robert F Wagner , Jiahao Zhu
IPC分类号： A61K31/549 , A61K9/28 , A61P9/12 , A61P9/04 , A61P9/10 , A61P9/00
摘要： Monolayer, bilayer and trilayer solid dosage forms of a combination of valsartan, amlodipine and hydrochlorothiazide are made.

6. 发明申请

US20090218714A1 APPARATUS 审中-公开
标题翻译：仪器
公开(公告)号：US20090218714A1
公开(公告)日：2009-09-03
申请号：US12392344
申请日：2009-02-25
申请人： Ping Li , Mark Robert Mecadon , Jiahao Zhu
发明人： Ping Li , Mark Robert Mecadon , Jiahao Zhu
IPC分类号： B29C43/02 , B28B3/00
CPC分类号： B30B15/306 , B29C43/003 , B29C43/06 , B29C43/146 , B29C2043/3618 , B29C2043/561 , B30B11/06
摘要： The invention relates to apparatus for filling a cavity during production of a pharmaceutical dosage form. The apparatus comprises a cavity open at an upper surface and closed at a lower surface. The lower surface is defined by an initial layer of powder. A powder source and a fluid pump are also provided. The fluid pump is arranged to draw gas away from the cavity such that the gas pressure within the cavity is reduced below the ambient gas pressure before the cavity is filled to a predetermined fill level with powder from the powder source.
摘要翻译：本发明涉及在药物剂型生产期间填充空腔的装置。该装置包括在上表面处敞开并在下表面封闭的空腔。下表面由初始粉末层限定。还提供粉末源和流体泵。流体泵布置成将气体从空腔中抽出，使得在将空腔从粉末源中的粉末填充到预定填充水平之前，空腔内的气体压力降低到环境气体压力以下。

7. 发明授权

US06998393B2 Aquespheres, their preparation and uses thereof 失效
公开(公告)号：US06998393B2
公开(公告)日：2006-02-14
申请号：US10291327
申请日：2002-11-08
申请人： Tuo Jin , Hua Zhu , Jiahao Zhu
发明人： Tuo Jin , Hua Zhu , Jiahao Zhu
IPC分类号： A61K9/62
CPC分类号： A61K9/0043 , A61K9/0024 , A61K9/0073 , A61K9/1075 , A61K9/113 , A61K9/1652 , A61K9/19 , A61K9/5031 , A61K9/5036 , A61K9/5073 , A61K38/00
摘要： This invention provides method for sustained release delivery of structurally delicate agents such as proteins and peptides. Using a unique emulsion system (Stable polymer aqueous-aqueous emulsion), proteins and peptides can be microencapsulated in polysacchride glassy particles under a condition free of any chemical or physical hazard such as organic solvents, strong interfacial tension, strong shears, elevated temperature, large amount of surfactants, and cross-linking agents. Proteins loaded in these glassy particles showed strong resistance to organic solvents, prolonged activity in hydrated state, and an excellent sustained release profile with minimal burst and incomplete release when being further loaded in degradable polymer microspheres. This invention provides a simple yet effective approach to address all the technical challenges raised in sustained release delivery of proteins.

8. 发明授权

US08475839B2 Solid dosage forms of valsartan, amlodipine and hydrochlorothiazide and method of making the same 有权
标题翻译：缬沙坦，氨氯地平和氢氯噻嗪的固体剂型及其制备方法
公开(公告)号：US08475839B2
公开(公告)日：2013-07-02
申请号：US13342533
申请日：2012-01-03
申请人： Yu Cao , Yatindra Joshi , Ping Li , Madhusudhan Pudipeddi , Alan E Royce , Robert F Wagner , Jiahao Zhu
发明人： Yu Cao , Yatindra Joshi , Ping Li , Madhusudhan Pudipeddi , Alan E Royce , Robert F Wagner , Jiahao Zhu
IPC分类号： A61K31/549 , A61K9/28 , A61P9/12 , A61P9/04 , A61P9/10 , A61P9/00
CPC分类号： A61K9/2054 , A61K9/209 , A61K31/41 , A61K31/4422 , A61K31/549 , A61K2300/00
摘要： Monolayer, bilayer and trilayer solid dosage forms of a combination of valsartan, amlodipine and hydrochlorothiazide are made.
摘要翻译：制备缬沙坦，氨氯地平和氢氯噻嗪组合的单层，双层和三层固体剂型。

9. 发明申请

US20100003321A1 SOLID DOSAGE FORMS OF VALSARTAN, AMLODIPINE AND HYDROCHLOROTHIAZIDE AND METHOD OF MAKING THE SAME 审中-公开
标题翻译：瓦尔塔坦，阿莫迪汀和氢氯酸的固体剂型及其制备方法
公开(公告)号：US20100003321A1
公开(公告)日：2010-01-07
申请号：US11915096
申请日：2007-06-26
申请人： Yu Cao , Yatindra Joshi , Ping Li , Madhusudhan Pudipeddi , Alan E. Royce , Robert F. Wagner , Jiahao Zhu
发明人： Yu Cao , Yatindra Joshi , Ping Li , Madhusudhan Pudipeddi , Alan E. Royce , Robert F. Wagner , Jiahao Zhu
IPC分类号： A61K31/549 , A61K9/20 , A61P9/00 , A61P25/00
CPC分类号： A61K9/2054 , A61K9/209 , A61K31/41 , A61K31/4422 , A61K31/549 , A61K2300/00
摘要： Monolayer, bilayer and trilayer solid dosage forms of a combination of valsartan, amlodipine and hydrochlorothiazide are made.
摘要翻译：制备缬沙坦，氨氯地平和氢氯噻嗪组合的单层，双层和三层固体剂型。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式