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1. 发明专利

IL292200A Bifunctional molecules containing an e3 ubiquitine ligase binding moiety linked to a bcl6 targeting moiety 未知
公开(公告)号：IL292200A
公开(公告)日：2022-06-01
申请号：IL29220022
申请日：2022-04-12
申请人： ARVINAS OPERATIONS INC , MICHAEL BERLIN , HANQING DONG , DAN SHERMAN , LAWRENCE SNYDER , JING WANG , WEI ZHANG
发明人： MICHAEL BERLIN , HANQING DONG , DAN SHERMAN , LAWRENCE SNYDER , JING WANG , WEI ZHANG
摘要： Bifunctional compounds, which find utility as modulators of B-cell lymphoma 6 protein (BCL6; target protein), are described herein. In particular, the bifunctional compounds of the present disclosure contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand that binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The bifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

2. 发明专利

IL278029D0 User terminal and radio communication method 未知
公开(公告)号：IL278029D0
公开(公告)日：2020-11-30
申请号：IL27802920
申请日：2020-10-13
申请人： NTT DOCOMO INC , YUKI MATSUMURA , KAZUKI TAKEDA , SATOSHI NAGATA , MIN LIU , JING WANG , XIAOLIN HOU
发明人： YUKI MATSUMURA , KAZUKI TAKEDA , SATOSHI NAGATA , MIN LIU , JING WANG , XIAOLIN HOU
IPC分类号： H04L27/26 , H04W16/28 , H04W72/08 , H04W74/08 , H04W76/19 , H04W88/02
摘要： To appropriately perform a beam recovery procedure. A user terminal according to one aspect of the present disclosure includes: a control section that starts a certain timer, based on a beam failure instance counter; and a transmitting section that transmits a random access preamble by using Contention-Free Random Access (CFRA) resources, in a case that the certain timer has not yet expired, and that there is a reference signal for candidate beam identification having Layer 1 Reference Signal Received Power (L1-RSRP) exceeding a certain threshold, and that there are the CFRA resources corresponding to the reference signal.

3. 发明专利

BR112021009222A2 composições que contêm uma população expandida e enriquecida de células t exterminadoras de citocina superativadas e métodos para produção das mesmas 未知
公开(公告)号：BR112021009222A2
公开(公告)日：2021-08-10
申请号：BR112021009222
申请日：2019-11-13
申请人： CN USA BIOTECH HOLDINGS INC , JIAN QING XU , JING WANG , LING YAN ZHU , XIAO YAN ZHANG
发明人： BEVERLY W LUBIT , JIAN QING XU , JING WANG , LING YAN ZHU , XIAO YAN ZHANG
IPC分类号： C12M3/02 , C12N5/0783
摘要： composições que contêm uma população expandida e enriquecida de células t exterminadoras de citocina superativadas e métodos para produção das mesmas. a presente invenção refere-se uma composição farmacêutica que compreende um carreador farmaceuticamente aceitável e um produto celular que compreende uma população expandida e enriquecida de células t exterminadoras de citocina superativadas e métodos para a fabricação do produto celular.

4. 发明专利

IL225406A Therapeutic applications of smad7 未知
公开(公告)号：IL225406A
公开(公告)日：2019-09-26
申请号：IL22540613
申请日：2013-03-21
申请人： UNIV COLORADO REGENTS , XIAO JING WANG , YOSEF REFAELI , QINGHONG ZHANG
发明人： XIAO-JING WANG , YOSEF REFAELI , QINGHONG ZHANG
IPC分类号： A61K38/17 , A61K38/16
摘要： The invention provides methods and compositions for the treatment of inflammatory and/or tissue damage conditions. In particular, the use of Smad7 compositions delivered locally or systemically to a site of inflammation and/or tissue damage is described. Other specific embodiments concern treatment or prevention of side effects caused by radiation and/or chemotherapy, including but not limited to mucositis.

5. 发明专利

IL225406D0 Therapeutic applications of smad7 未知
公开(公告)号：IL225406D0
公开(公告)日：2013-06-27
申请号：IL22540613
申请日：2013-03-21
申请人： UNIV COLORADO REGENTS , XIAO JING WANG , YOSEF REFAELI , QINGHONG ZHANG
IPC分类号： A61K20060101 , A61K38/16
摘要： The invention provides methods and compositions for the treatment of inflammatory and/or tissue damage conditions. In particular, the use of Smad7 compositions delivered locally or systemically to a site of inflammation and/or tissue damage is described. Other specific embodiments concern treatment or prevention of side effects caused by radiation and/or chemotherapy, including but not limited to mucositis.

6. 发明专利

BR112022013573A2 VACINAS UNIVERSAIS CONTRA IMUNÓGENOS DE ORGANISMOS PATOGÊNICOS QUE CONFEREM PROTEÇÃO ESPECÍFICA PARA ORGANISMO E ENTRE GRUPOS 未知
公开(公告)号：BR112022013573A2
公开(公告)日：2022-09-13
申请号：BR112022013573
申请日：2020-12-18
申请人： CN USA BIOTECH HOLDINGS INC , JIAN QING XU , XIAO YAN ZHANG , JING WANG , LING YAN ZHU , BEVERLY W LUBIT
发明人： JIAN QING XU , XIAO YAN ZHANG , JING WANG , LING YAN ZHU , BEVERLY W LUBIT
IPC分类号： A61K39/12 , A61K39/145 , A61P31/16 , C07K7/06 , C12N5/0783 , C12N15/86
摘要： VACINAS UNIVERSAIS CONTRA IMUNÓGENOS DE ORGANISMOS PATOGÊNICOS QUE CONFEREM PROTEÇÃO ESPECÍFICA PARA ORGANISMO E ENTRE GRUPOS. A presente invenção refere-se, em parte, a uma plataforma com base em vetor de estimulação e reforço para desenvolver vacinas contra patógenos que são adaptadas para provocar uma ampla resposta de células T que têm como alvo epítopos virais conservados. As vacinas universais são preparadas contra um imunógeno de um organismo patogênico infeccioso selecionado a partir de um vírus, uma bactéria, um fungo ou um protozoário que compreende pelo menos um polinucleotídeo de ácido ribonucleico (RNA) que compreende um quadro de leitura aberta que codifica pelo menos um antígeno polipeptídico ou um fragmento imunogênico do mesmo, em que o antígeno polipeptídico, ou fragmento imunogênico do mesmo, compreende uma proteína interna conservada que é enriquecida em antígenos de reconhecimento de células T CD8(mais elevado). A eficácia da plataforma de estimulação e reforço é testada em um modelo de camundongo humanizado que compreende um sistema imune humano totalmente funcional.

7. 发明专利

IL292200D0 Bifunctional molecules containing an e3 ubiquitine ligase binding moiety linked to a bcl6 targeting moiety 未知
公开(公告)号：IL292200D0
公开(公告)日：2022-06-01
申请号：IL29220022
申请日：2022-04-12
申请人： ARVINAS OPERATIONS INC , MICHAEL BERLIN , HANQING DONG , DAN SHERMAN , LAWRENCE SNYDER , JING WANG , WEI ZHANG
发明人： MICHAEL BERLIN , HANQING DONG , DAN SHERMAN , LAWRENCE SNYDER , JING WANG , WEI ZHANG
IPC分类号： A61K45/06 , A61K47/64 , A61P35/00
摘要： Bifunctional compounds, which find utility as modulators of B-cell lymphoma 6 protein (BCL6; target protein), are described herein. In particular, the bifunctional compounds of the present disclosure contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand that binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The bifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

8. 发明专利

AP01041S1 CHARGER 未知
公开(公告)号：AP01041S1
公开(公告)日：2019-04-11
申请号：AP2018001260
申请日：2018-03-28
申请人： JING WANG , BEIJING HANERGY SOLAR POWER INVEST CO LTD , DAPENG ZHANG , MAOYU LIAO
发明人： WANG JING , ZHANG DAPENG , LIAO MAOYU

9. 发明专利

IL271566D0 User terminal and radio communication method 未知
公开(公告)号：IL271566D0
公开(公告)日：2020-02-27
申请号：IL27156619
申请日：2019-12-19
申请人： NTT DOCOMO INC , HIROKI HARADA , SATOSHI NAGATA , JING WANG
发明人： HIROKI HARADA , SATOSHI NAGATA , JING WANG
IPC分类号： H04W20090101
摘要： Measurement is efficiently performed while suppressing an increase in a processing load of a network side and/or a signaling overhead. A user terminal according to the present invention includes: a reception section that receives synchronization signal (SS) block transmission information indicating an SS block transmitted by a serving cell; and a control section that controls measurement of the serving cell in a measurement period of a predetermined periodicity based on the SS block transmission information.

10. 实用新型

TWM274947U 溫灸按摩裝置失效
简体标题：温灸按摩设备
公开(公告)号：TWM274947U
公开(公告)日：2005-09-11
申请号：TW094204722
申请日：2005-03-28
申请人：晶旺奈米科技股份有限公司 JING WANG NANO TECHNOLOGY CO., LTD.
发明人：馮源鳳 FENG, YUAN FENG
IPC分类号： A61H
摘要：本創作係為一種溫灸按摩裝置，其包括一控制單元、一工作單元、一震動單元及一溫灸單元；其中：此控制單元係至少設有：一電力輸入部，係用來提供此控制單元動力；一開關，係與此電力輸入部電性聯結，並控制此電力輸入部啟/閉；此工作單元，係設於此控制單元前面，其供此震動單元軸向伸出；此震動單元，係驅動一偏心工作端轉動，進而震動此溫灸單元；此溫灸單元，係至少設有：一溫灸端部；一遠紅外線生成部，係位於此溫灸端部內，且可將遠紅外線穿透出此溫灸端部；一加熱部，係設於此溫灸單元後面；一加熱元件，係位於加熱部上，導熱給遠紅外線生成部，且加熱元件對遠紅外線生成部的加熱，乃產生穿透出此溫灸端部之遠紅外線。
简体摘要：本创作系为一种温灸按摩设备，其包括一控制单元、一工作单元、一震动单元及一温灸单元；其中：此控制单元系至少设有：一电力输入部，系用来提供此控制单元动力；一开关，系与此电力输入部电性联结，并控制此电力输入部启/闭；此工作单元，系设于此控制单元前面，其供此震动单元轴向伸出；此震动单元，系驱动一偏心工作端转动，进而震动此温灸单元；此温灸单元，系至少设有：一温灸端部；一远红外线生成部，系位于此温灸端部内，且可将远红外线穿透出此温灸端部；一加热部，系设于此温灸单元后面；一加热组件，系位于加热部上，导热给远红外线生成部，且加热组件对远红外线生成部的加热，乃产生穿透出此温灸端部之远红外线。

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