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1. 发明专利

BR112022013573A2 VACINAS UNIVERSAIS CONTRA IMUNÓGENOS DE ORGANISMOS PATOGÊNICOS QUE CONFEREM PROTEÇÃO ESPECÍFICA PARA ORGANISMO E ENTRE GRUPOS 未知
公开(公告)号：BR112022013573A2
公开(公告)日：2022-09-13
申请号：BR112022013573
申请日：2020-12-18
申请人： CN USA BIOTECH HOLDINGS INC , JIAN QING XU , XIAO YAN ZHANG , JING WANG , LING YAN ZHU , BEVERLY W LUBIT
发明人： JIAN QING XU , XIAO YAN ZHANG , JING WANG , LING YAN ZHU , BEVERLY W LUBIT
IPC分类号： A61K39/12 , A61K39/145 , A61P31/16 , C07K7/06 , C12N5/0783 , C12N15/86
摘要： VACINAS UNIVERSAIS CONTRA IMUNÓGENOS DE ORGANISMOS PATOGÊNICOS QUE CONFEREM PROTEÇÃO ESPECÍFICA PARA ORGANISMO E ENTRE GRUPOS. A presente invenção refere-se, em parte, a uma plataforma com base em vetor de estimulação e reforço para desenvolver vacinas contra patógenos que são adaptadas para provocar uma ampla resposta de células T que têm como alvo epítopos virais conservados. As vacinas universais são preparadas contra um imunógeno de um organismo patogênico infeccioso selecionado a partir de um vírus, uma bactéria, um fungo ou um protozoário que compreende pelo menos um polinucleotídeo de ácido ribonucleico (RNA) que compreende um quadro de leitura aberta que codifica pelo menos um antígeno polipeptídico ou um fragmento imunogênico do mesmo, em que o antígeno polipeptídico, ou fragmento imunogênico do mesmo, compreende uma proteína interna conservada que é enriquecida em antígenos de reconhecimento de células T CD8(mais elevado). A eficácia da plataforma de estimulação e reforço é testada em um modelo de camundongo humanizado que compreende um sistema imune humano totalmente funcional.

2. 发明专利

BR112021009222A2 composições que contêm uma população expandida e enriquecida de células t exterminadoras de citocina superativadas e métodos para produção das mesmas 未知
公开(公告)号：BR112021009222A2
公开(公告)日：2021-08-10
申请号：BR112021009222
申请日：2019-11-13
申请人： CN USA BIOTECH HOLDINGS INC , JIAN QING XU , JING WANG , LING YAN ZHU , XIAO YAN ZHANG
发明人： BEVERLY W LUBIT , JIAN QING XU , JING WANG , LING YAN ZHU , XIAO YAN ZHANG
IPC分类号： C12M3/02 , C12N5/0783
摘要： composições que contêm uma população expandida e enriquecida de células t exterminadoras de citocina superativadas e métodos para produção das mesmas. a presente invenção refere-se uma composição farmacêutica que compreende um carreador farmaceuticamente aceitável e um produto celular que compreende uma população expandida e enriquecida de células t exterminadoras de citocina superativadas e métodos para a fabricação do produto celular.

3. 发明专利

IL292200A Bifunctional molecules containing an e3 ubiquitine ligase binding moiety linked to a bcl6 targeting moiety 未知
公开(公告)号：IL292200A
公开(公告)日：2022-06-01
申请号：IL29220022
申请日：2022-04-12
申请人： ARVINAS OPERATIONS INC , MICHAEL BERLIN , HANQING DONG , DAN SHERMAN , LAWRENCE SNYDER , JING WANG , WEI ZHANG
发明人： MICHAEL BERLIN , HANQING DONG , DAN SHERMAN , LAWRENCE SNYDER , JING WANG , WEI ZHANG
摘要： Bifunctional compounds, which find utility as modulators of B-cell lymphoma 6 protein (BCL6; target protein), are described herein. In particular, the bifunctional compounds of the present disclosure contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand that binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The bifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

4. 发明专利

IL278029D0 User terminal and radio communication method 未知
公开(公告)号：IL278029D0
公开(公告)日：2020-11-30
申请号：IL27802920
申请日：2020-10-13
申请人： NTT DOCOMO INC , YUKI MATSUMURA , KAZUKI TAKEDA , SATOSHI NAGATA , MIN LIU , JING WANG , XIAOLIN HOU
发明人： YUKI MATSUMURA , KAZUKI TAKEDA , SATOSHI NAGATA , MIN LIU , JING WANG , XIAOLIN HOU
IPC分类号： H04L27/26 , H04W16/28 , H04W72/08 , H04W74/08 , H04W76/19 , H04W88/02
摘要： To appropriately perform a beam recovery procedure. A user terminal according to one aspect of the present disclosure includes: a control section that starts a certain timer, based on a beam failure instance counter; and a transmitting section that transmits a random access preamble by using Contention-Free Random Access (CFRA) resources, in a case that the certain timer has not yet expired, and that there is a reference signal for candidate beam identification having Layer 1 Reference Signal Received Power (L1-RSRP) exceeding a certain threshold, and that there are the CFRA resources corresponding to the reference signal.

5. 发明专利

IL271566D0 User terminal and radio communication method 未知
公开(公告)号：IL271566D0
公开(公告)日：2020-02-27
申请号：IL27156619
申请日：2019-12-19
申请人： NTT DOCOMO INC , HIROKI HARADA , SATOSHI NAGATA , JING WANG
发明人： HIROKI HARADA , SATOSHI NAGATA , JING WANG
IPC分类号： H04W20090101
摘要： Measurement is efficiently performed while suppressing an increase in a processing load of a network side and/or a signaling overhead. A user terminal according to the present invention includes: a reception section that receives synchronization signal (SS) block transmission information indicating an SS block transmitted by a serving cell; and a control section that controls measurement of the serving cell in a measurement period of a predetermined periodicity based on the SS block transmission information.

6. 发明专利

IL292200D0 Bifunctional molecules containing an e3 ubiquitine ligase binding moiety linked to a bcl6 targeting moiety 未知
公开(公告)号：IL292200D0
公开(公告)日：2022-06-01
申请号：IL29220022
申请日：2022-04-12
申请人： ARVINAS OPERATIONS INC , MICHAEL BERLIN , HANQING DONG , DAN SHERMAN , LAWRENCE SNYDER , JING WANG , WEI ZHANG
发明人： MICHAEL BERLIN , HANQING DONG , DAN SHERMAN , LAWRENCE SNYDER , JING WANG , WEI ZHANG
IPC分类号： A61K45/06 , A61K47/64 , A61P35/00
摘要： Bifunctional compounds, which find utility as modulators of B-cell lymphoma 6 protein (BCL6; target protein), are described herein. In particular, the bifunctional compounds of the present disclosure contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand that binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The bifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

7. 发明申请

US20090152646A1 Structure and method for manufacturing device with planar halo profile 有权
标题翻译：具有平面光晕轮廓的制造装置的结构和方法
公开(公告)号：US20090152646A1
公开(公告)日：2009-06-18
申请号：US11955515
申请日：2007-12-13
申请人： HUILONG ZHU , JING WANG
发明人： HUILONG ZHU , JING WANG
IPC分类号： H01L29/94 , H01L21/425
CPC分类号： H01L29/66553 , H01L21/26586 , H01L29/665 , H01L29/66583 , H01L29/7833
摘要： A semiconductor device and method for manufacturing the device with a planar halo profile is provided. The semiconductor device can be a MOSFET. The method of forming the structure includes forming an angled spacer adjacent a gate structure and implanting a halo implant at an angle to form a halo profile having low dopant concentration near a gate dielectric under the gate structure. The structure includes an underlying wafer or substrate and an angled gate spacer having an upper portion and an angled lower portion. The upper portion is structured to prevent halo dopants from penetrating an inversion layer of the structure. The structure further includes a low concentration halo dopant within a channel of a gate structure.
摘要翻译：提供了一种用于制造具有平面晕轮廓的器件的半导体器件和方法。半导体器件可以是MOSFET。形成结构的方法包括在栅极结构附近形成一个倾斜的间隔物，并以一定的角度注入一个晕轮注入，以形成栅极结构附近的栅极电介质附近具有低掺杂浓度的晕轮廓。该结构包括下面的晶片或衬底以及具有上部和成角度的下部的成角度的栅极间隔件。上部构造成防止晕轮掺杂物穿透该结构的反转层。该结构还包括在栅极结构的沟道内的低浓度卤素掺杂剂。

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