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1. 发明授权

US09487508B2 SGC stimulators 有权
标题翻译： SGC刺激剂
公开(公告)号：US09487508B2
公开(公告)日：2016-11-08
申请号：US14429028
申请日：2013-09-19
申请人： Takashi Nakai , Nicholas Robert Perl , Joel Moore
发明人： Takashi Nakai , Nicholas Robert Perl , Joel Moore
IPC分类号： C07D403/04 , C07D413/14 , C07D487/04 , A61K31/4155 , A61K31/513 , A61K31/506 , A61K31/5377 , A61K31/519
CPC分类号： A61K31/513 , A61K31/4155 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D403/04 , C07D413/14 , C07D487/04 , A61K2300/00
摘要： The present patent application discloses at least the compounds according to Formula I or Formula Ib shown below, or pharmaceutically acceptable salts thereof, wherein ring B, JB, n, JD, J, o, X, RC and RA are as described herein.
摘要翻译：其中环B，JB，n，JD，J，o，X，RC和RA如本文所述。

2. 发明申请

US20150274712A1 sGC STIMULATORS 有权
标题翻译： sGC刺激者
公开(公告)号：US20150274712A1
公开(公告)日：2015-10-01
申请号：US14428844
申请日：2013-09-18
申请人： G-Yoon Jamie IM , Rajesh IYENGAR , Joel MOORE , Angelika FRETZEN
发明人： G-Yoon Jamie Im , Rajesh Iyengar , Joel Moore , Angelika Fretzen
IPC分类号： C07D413/14 , A61K31/506 , A61K31/513
CPC分类号： A61K31/513 , A61K31/506 , A61K45/06 , C07D407/14 , C07D409/14 , C07D413/14
摘要： Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
摘要翻译：描述式I化合物。它们作为sGC的刺激剂是有用的，特别是NO不依赖于血红素依赖性刺激物。这些化合物可用于治疗，预防或治疗本文公开的各种疾病。

3. 发明申请

US20150232461A1 SGC STIMULATORS 有权
标题翻译： SGC刺激者
公开(公告)号：US20150232461A1
公开(公告)日：2015-08-20
申请号：US14429028
申请日：2013-09-19
申请人： Taakshi NAKAI , Nicholas Robert PERL , Joel MOORE
发明人： Takashi Nakai , Nicholas Robert Perl , Joel Moore
IPC分类号： C07D413/14 , A61K31/519 , A61K31/5377 , C07D487/04 , A61K31/513 , A61K31/506
CPC分类号： A61K31/513 , A61K31/4155 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D403/04 , C07D413/14 , C07D487/04 , A61K2300/00
摘要： The present patent application discloses at least the compounds according to Formula I or Formula Ib shown below, or pharmaceutically acceptable salts thereof, wherein ring B, JB, n, JD, J, o, X, RC and RA are as described herein.
摘要翻译：本专利申请公开了至少下述式I或式Ib化合物或其药学上可接受的盐，其中环B，JB，n，JD，J，o，X，RC和RA如本文所述。

4. 发明授权

US08674115B2 CRTH2 modulators 有权
标题翻译： CRTH2调节剂
公开(公告)号：US08674115B2
公开(公告)日：2014-03-18
申请号：US12969840
申请日：2010-12-16
申请人： Ara Mermerian , Bo Peng , Colleen Hudson , Charles Kim , Joel Moore , Jason Rohde , Kevin Sprott , Regina Graul , Takashi Nakai , James Jia , Wilmin Bartolini
发明人： Ara Mermerian , Bo Peng , Colleen Hudson , Charles Kim , Joel Moore , Jason Rohde , Kevin Sprott , Regina Graul , Takashi Nakai , James Jia , Wilmin Bartolini
IPC分类号： C07D207/30 , A61K31/40
CPC分类号： C07D403/12 , C07D207/325 , C07D401/04 , C07D413/14
摘要： Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed. The compounds fall within a genus described by formula I:
摘要翻译：公开了可用于治疗各种疾病（包括哮喘和呼吸系统疾病）的CRTH2调节剂，特别是CRTH2拮抗剂。化合物属于式I所述的一类：

5. 发明申请

US20130292523A1 Display 审中-公开
标题翻译：显示
公开(公告)号：US20130292523A1
公开(公告)日：2013-11-07
申请号：US13783212
申请日：2013-03-01
申请人： Joel Moore , James William Reddick, III , Jessica Moreland , Christopher Trunek , Joel Beebe
发明人： Joel Moore , James William Reddick, III , Jessica Moreland , Christopher Trunek , Joel Beebe
IPC分类号： F16M13/02 , A47F7/06
CPC分类号： F16M13/02 , A47F7/06 , A47G25/06 , A47G25/0671 , A47G25/10 , A47G2200/106
摘要： Devices having a magnet disposed thereon are disclosed. The devices are operatively configured for suspending and displaying articles, such as tags, signage, clothing, and baseball caps containing ferrous elements.
摘要翻译：公开了具有设置在其上的磁体的装置。这些装置可操作地构造用于悬挂和展示诸如标签，标牌，衣服和含有铁元素的棒球帽的物品。

6. 发明申请

US20130178475A1 sGC STIMULATORS 审中-公开
公开(公告)号：US20130178475A1
公开(公告)日：2013-07-11
申请号：US13635597
申请日：2011-03-10
申请人： Joel Moore , James Jia , Takashi Nakai , Charles Kim , Thomas Wai-Ho Lee , Jane Yang
发明人： Joel Moore , James Jia , Takashi Nakai , Charles Kim , Thomas Wai-Ho Lee , Jane Yang
IPC分类号： C07D495/04 , C07D401/14 , C07D403/04 , C07D413/14 , C07D471/04 , C07D401/04
CPC分类号： C07D495/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/14 , C07D413/14 , C07D471/04
摘要： Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.

7. 发明申请

US20120184516A1 sGC Stimulators 有权
标题翻译： sGC刺激器
公开(公告)号：US20120184516A1
公开(公告)日：2012-07-19
申请号：US13174676
申请日：2011-06-30
申请人： Charles Kim , Takashi Nakai , Thomas Wai-Ho Lee , Joel Moore , Nicholas Robert Perl , Jason Rohde , Rajesh R. Iyengar , Ara Mermerian
发明人： Charles Kim , Takashi Nakai , Thomas Wai-Ho Lee , Joel Moore , Nicholas Robert Perl , Jason Rohde , Rajesh R. Iyengar , Ara Mermerian
IPC分类号： A61K31/56 , A61K31/444 , C07D403/04 , A61K31/506 , C07D401/04 , A61K31/4439 , C07D409/14 , C07D403/14 , C07D417/14 , C07D491/048 , A61K31/497 , C07D413/14 , C07D405/14 , C07D473/34 , A61K31/52 , A61K31/522 , C07D498/04 , A61K31/5365 , A61K31/5377 , A61P9/00 , A61P9/12 , A61P7/02 , A61P11/00 , A61P7/00 , A61P19/04 , A61P11/08 , A61P9/10 , A61P13/12 , A61P9/04 , A61P9/06 , A61P29/00 , A61P1/16 , A61P15/00 , A61P13/00 , A61P13/08 , A61P3/06 , A61P11/06 , A61P37/06 , A61P3/10 , C07D401/14
CPC分类号： C07D401/04 , A61K31/4155 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/522 , A61K31/5365 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D473/34 , C07D491/048 , C07D498/04 , A61K2300/00
摘要： Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
摘要翻译：描述式I化合物。它们作为sGC的刺激剂是有用的，特别是NO不依赖于血红素依赖性刺激物。这些化合物可用于治疗，预防或治疗本文公开的各种疾病。

8. 发明申请

US20080008681A1 MACROCYCLIC HEPATITIS C VIRUS SERINE PROTEASE INHIBITORS 有权
标题翻译：大肠杆菌C型病毒丝氨酸蛋白酶抑制剂
公开(公告)号：US20080008681A1
公开(公告)日：2008-01-10
申请号：US11768712
申请日：2007-06-26
申请人： Deqiang Niu , Dong Liu , Joel Moore , Guoyou Xu , Ying Sun , Yonghua Gai , Datong Tang , Yat Sun Or , Zhe Wang
发明人： Deqiang Niu , Dong Liu , Joel Moore , Guoyou Xu , Ying Sun , Yonghua Gai , Datong Tang , Yat Sun Or , Zhe Wang
IPC分类号： A61K38/21 , A61K31/498 , A61P31/12 , C07D245/04
CPC分类号： C07D245/04 , A61K38/212 , A61K38/215 , C07D403/12 , A61K2300/00
摘要： The present invention relates to compounds, including compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
摘要翻译：本发明涉及包括式I化合物或其药学上可接受的盐，酯或前药的化合物，其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。

9. 发明申请

US20050217725A1 Fire safety device for propane cylinders 失效
标题翻译：丙烷气瓶消防安全装置
公开(公告)号：US20050217725A1
公开(公告)日：2005-10-06
申请号：US11093881
申请日：2005-03-30
申请人： Joel Moore , Gregory Reitsma , Robert Jones
发明人： Joel Moore , Gregory Reitsma , Robert Jones
IPC分类号： F16K17/38
CPC分类号： F16K17/383 , Y10T137/1812 , Y10T137/1819
摘要： A fire safety fluid flow device for engagement with a Schrader valve including a sliding valve a housing having a fluid path therethrough and a pressing member. The pressing member presses against the sliding valve of the Schrader valve when engaged therewith to allow fluid flow through the Schrader valve. The pressing member continues to maintain the sliding valve in an open position when the device is below a predetermined temperature and connected to the Schrader valve. The pressing member is configured to no longer press against the sliding valve of the Schrader valve at and above the predetermined temperature to allow the sliding valve of the Schrader valve to thereby stop fluid flow through the Schrader valve.
摘要翻译：一种消防安全流体流动装置，用于与包括滑阀的施拉德阀接合，该壳体具有穿过其中的流体通道的壳体和按压构件。按压构件在与其接合时压靠Schrader阀的滑阀，以允许流体流过Schrader阀。当装置低于预定温度并且连接到施拉德阀时，按压构件继续将滑阀保持在打开位置。按压构件被构造成在预定温度以上不再压入Schrader阀的滑阀，以允许施拉德阀的滑阀阻止流体流过施拉德阀。

10. 发明申请

US20050172949A1 Apparatus for preparing food 审中-公开
标题翻译：食物准备设备
公开(公告)号：US20050172949A1
公开(公告)日：2005-08-11
申请号：US11054223
申请日：2005-02-09
申请人： Joel Moore , Craig Walther , Charles Olds , Brian Yutzy , Mark Hood , Robert Jones , Edward Lee
发明人： Joel Moore , Craig Walther , Charles Olds , Brian Yutzy , Mark Hood , Robert Jones , Edward Lee
IPC分类号： A47J27/00 , A47J27/026 , A47J37/12
CPC分类号： A47J37/1242 , A47J37/1247
摘要： A cooking apparatus for preparing food includes a vessel, a burner, an electrically controllable valve, a thermocouple and a thermally actuated switch. The vessel is configured for containing a fluid and the burner is positioned for providing a gas flame to the vessel. The valve is coupled between the burner and a gas source and the thermocouple is positioned to sense a temperature of the flame provided by the burner. The thermally actuated switch is serially coupled between the valve and the thermocouple. The switch provides a conduction path between the valve and the thermocouple, when a temperature sensed by the thermal switch is less than a predetermined temperature. The switch is integrally mounted to the vessel to sense a temperature of the fluid contained within the vessel.
摘要翻译：用于制备食物的烹饪设备包括容器，燃烧器，电可控阀，热电偶和热致动开关。容器构造成容纳流体，并且燃烧器被定位成为容器提供气体火焰。阀连接在燃烧器和气体源之间，并且热电偶被定位成感测由燃烧器提供的火焰的温度。热致动开关串联在阀和热电偶之间。当热开关感测的温度小于预定温度时，开关提供阀和热电偶之间的传导路径。开关整体地安装到容器以感测容纳在容器内的流体的温度。

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