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1. 发明申请

US20060239789A1 Bracket For Retaining Items In A Stored Position 审中-公开
标题翻译：保留物品在保存位置的支架
公开(公告)号：US20060239789A1
公开(公告)日：2006-10-26
申请号：US10908533
申请日：2005-05-16
申请人： John Beals , David Jamieson , Thomas Haynes
发明人： John Beals , David Jamieson , Thomas Haynes
IPC分类号： B61D3/16
CPC分类号： B60P7/0815 , B60P7/15 , F16B5/0614
摘要： A clip or bracket releasably mountable to a rail having elongated perforations to retain one or more items in a stored position when not in use. In a simple embodiment, the clip is formed of a continuous length of metal or plastic rod having a pair of parallel legs for insertion through the mounting rail perforation, and a three-sided enclosure which, in cooperation with the surface of the mounting rail, form a four-sided enclosure for retaining the stored item. In a second, preferred embodiment, a bracket is formed with an integral, three-sided wall with one or more latching members affixed to one of the walls for releasably attaching the bracket to the mounting rail with portions of the latching member(s) extending through one of the perforations. In one form, a pair of three-sided retainers are connected to one another with latching member(s) mounted between adjacent walls of the two retainers. The invention has particular utility in the cargo transportation field where the brackets may be mounted to the conventional mounting rails currently in use in many trucks and trailers for supporting likewise conventional load bars to restrain cargo against movement during transport.
摘要翻译：可释放地安装到轨道的夹子或支架，其具有细长的穿孔，以在不使用时将一个或多个物品保持在存储位置。在简单的实施例中，夹子由具有一对平行腿的连续长度的金属或塑料杆形成，用于插入通过安装轨道穿孔，以及与安装轨道的表面配合的三边外壳，形成用于保存存储的物品的四面外壳。在第二个优选实施例中，支架形成有一体的三面壁，其中一个或多个闩锁构件固定到一个壁上，用于将支架可释放地附接到安装轨道，其中闩锁构件的一部分延伸通过其中一个穿孔。在一种形式中，一对三侧保持器彼此连接，其中锁定构件安装在两个保持器的相邻壁之间。本发明在货物运输领域具有特别的用途，其中托架可以安装到目前在许多卡车和拖车中使用的常规安装轨道，用于支撑同样常规的载重杆，以限制货物在运输过程中运动。

2. 发明申请

US20070100133A1 Erythropoietic compounds 审中-公开
标题翻译：红血球化合物
公开(公告)号：US20070100133A1
公开(公告)日：2007-05-03
申请号：US11521059
申请日：2006-09-14
申请人： John Beals , Wolfgang Glaesner , Radmila Micanovic , Rohn Millican , Derrick Witcher
发明人： John Beals , Wolfgang Glaesner , Radmila Micanovic , Rohn Millican , Derrick Witcher
IPC分类号： C07K14/51
CPC分类号： C07K14/505 , A01K2217/05 , A61K38/1816 , A61K47/60
摘要： The present invention addresses the need for better pharmaceutical agents for teating anemias by providing polymer derivatized non-glycosylated erythropoietic compounds which show stability and bioactivity in vivo. The invention further provides methods for preparing these derivatived proteins which involves the use of a linkerless aldehyde modification process.
摘要翻译：本发明通过提供在体内显示稳定性和生物活性的聚合物衍生的非糖基化的红细胞生成化合物来满足对更好的药剂的需求。本发明还提供了制备这些衍生蛋白质的方法，其涉及使用无接头的醛修饰方法。

3. 发明申请

US20050070692A1 Anti-interleukin-1 beta analogs 审中-公开
标题翻译：抗白细胞介素-1β类似物
公开(公告)号：US20050070692A1
公开(公告)日：2005-03-31
申请号：US10503504
申请日：2003-02-20
申请人： John Beals , Lihua Huang , Jirong Lu , Derrick Witcher
发明人： John Beals , Lihua Huang , Jirong Lu , Derrick Witcher
IPC分类号： C12N15/09 , A61K38/00 , A61P19/02 , A61P19/04 , A61P29/00 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08 , C07K16/44
CPC分类号： C07K16/245 , A61K2039/505 , C07K2317/24 , C07K2317/567 , C07K2317/73 , C07K2317/76
摘要： The present invention encompasses analogs of humanized antibody Hu007 that neutralize IL-1β activity in vivo. These antibodies can be used to treat various diseases such as rheumatoid arthritis and osteoarthritis.
摘要翻译：本发明包括在体内中和IL-1β活性的人源化抗体Hu007的类似物。这些抗体可用于治疗各种疾病，例如类风湿性关节炎和骨关节炎。

4. 发明申请

US20050014679A1 Insulin molecule having protracted time action 审中-公开
标题翻译：胰岛素分子具有延长的时间作用
公开(公告)号：US20050014679A1
公开(公告)日：2005-01-20
申请号：US10496847
申请日：2002-12-12
申请人： John Beals , Michael DeFelippis , Richard DiMarchi , Wayne Kohn , Radmila Micanovic , Sharon Myers , Kingman Ng , Lianshan Zhang
发明人： John Beals , Michael DeFelippis , Richard DiMarchi , Wayne Kohn , Radmila Micanovic , Sharon Myers , Kingman Ng , Lianshan Zhang
IPC分类号： A61K38/28 , A61P3/10 , C07K14/62
CPC分类号： C07K14/62
摘要： The present invention provides an insulin molecule that provides a protracted, even basal duration of action. The insulin molecule comprises a modification at the N-terminus of the A-chain, optionally a modification at the N-terminus of the B-chain, a modification at a B-chain lysine, and optionally a modification at the C-terminus of the A-chain. The present invention also provides a method of treating diabetes mellitus comprising administering the insulin molecule.
摘要翻译：本发明提供了提供持久的，甚至基础持续时间的胰岛素分子。胰岛素分子包含在A链的N末端的修饰，任选地在B链的N末端的修饰，B链赖氨酸的修饰，以及任选地在C末端的修饰 A链。本发明还提供一种治疗糖尿病的方法，包括给予胰岛素分子。

5. 发明申请

US20070142278A1 Muteins of fibroblast growth factor 21 失效
标题翻译：成纤维细胞生长因子21的突变蛋白
公开(公告)号：US20070142278A1
公开(公告)日：2007-06-21
申请号：US10579510
申请日：2004-12-01
申请人： John Beals , Christopher Frye , Wolfgang Glaesner , Shun Li , Radhakrishnan Rathnachalam , Jing Shang , Beth Strifler , Radmila Micanovic
发明人： John Beals , Christopher Frye , Wolfgang Glaesner , Shun Li , Radhakrishnan Rathnachalam , Jing Shang , Beth Strifler , Radmila Micanovic
IPC分类号： A61K38/18 , C07K14/50
CPC分类号： C07K14/50 , A61K38/00
摘要： The present invention relates to novel muteins of human fibroblast growth factor 21 with improved pharmaceutical properties. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for treating type 2 diabetes, obesity, metabolic syndrome, and in reducing the mortality and morbidity of critically ill patients.
摘要翻译：本发明涉及具有改善的药物性质的人成纤维细胞生长因子21的新颖突变蛋白。公开了蛋白质和各自编码的核酸物质。本发明还体现了用于扩增所述核酸序列和产生所述突变蛋白的载体和宿主细胞。还公开了治疗2型糖尿病，肥胖症，代谢综合征以及降低危重病人死亡率和发病率的方法。

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