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1. 发明申请

WO2010047838A1 DEVICE AND METHOD FOR INCREASING EVAPORATION RATES OF BLOW-DOWN APPARATUS 审中-公开
标题翻译：用于增加吹扫装置的蒸发速率的装置和方法
公开(公告)号：WO2010047838A1
公开(公告)日：2010-04-29
申请号：PCT/US2009/005806
申请日：2009-10-26
申请人： MODULAR SFC, LLC , HEDBERG, Herbert, J. , KANGAS, Brian, A. , BURNS, Michael, A.
发明人： HEDBERG, Herbert, J. , KANGAS, Brian, A. , BURNS, Michael, A.
IPC分类号： G01N1/40
CPC分类号： G01N1/40 , B01D1/14 , B01D1/30 , B01L3/5082 , B01L2200/0678 , B01L2300/0609 , G01N2001/4027
摘要： This disclosure reveals a combination of embodiments that increase the evaporation rate of liquid solutions when subjected to blow-down gas flows. Certain gas flow separator baffles or framed inserts with vanes may be especially effective to enhance evaporation when combined with aggressive blow-down flow rates and centrifugal force. The centrifugal force applied to the evaporating liquid protects sample integrity by preventing the solution(s) from splashing out of the drying container. Such splashing, when high blow-down gas flow rates are directed into the sample containers, affects yield and purity.
摘要翻译：本公开揭示了当经受排气气流时增加液体溶液的蒸发速率的实施方案的组合。当与积极的排污流量和离心力相结合时，某些气流分离器挡板或具有叶片的框架插入件可能特别有效地增强蒸发。施加到蒸发液体上的离心力通过防止溶液溅出干燥容器来保护样品的完整性。当高的吹扫气体流量被引导到样品容器中时，这种飞溅会影响产量和纯度。

2. 发明申请

WO2006017737A2 MICROTITER PLATE SCRUBBING DEVICE 审中-公开
标题翻译：微型板式搅拌装置
公开(公告)号：WO2006017737A2
公开(公告)日：2006-02-16
申请号：PCT/US2005/027900
申请日：2005-08-05
申请人： CETEK CORPORATION , HEDBERG, Herbert, J. , LITTLE, Matthew, S. , KANGAS, Brian, A.
发明人： HEDBERG, Herbert, J. , LITTLE, Matthew, S. , KANGAS, Brian, A.
IPC分类号： A46B13/04
CPC分类号： B08B9/28 , B01L99/00 , B01L2300/0829 , B08B9/08 , G01N35/028 , G01N2035/0425
摘要： Au automated high throughput microtiter plate scrubber device that cleans used microtiter plates of previous sample material, allowing their economical reuse as an alternative to using new plates is disclosed. Operated by a suitable programmable controller, the scrubber user time and sequenced applications of hot water, detergent, de-ionized water and compressed air to reduce quantities of previous sample materials in plate sample wells to undetectable levels. An automated embodiment of the device includes vertical hoppers for used (dirty) plates on the input side and clean plates on the output side of a scrubber head assembly, which has a distinct pair of liquid and air ports on a plurality of nozzles corresponding to each sample well in the plate. A sequence of wash liquids applied at public water supply pressures combined with a compressed air source produces significant scrubbing action within each well. A shuttle mechanism receives a used plate from the input hopper and slides it from the input hopper assembly, across the nozzles of the scrubber head assembly and to the out put hopper assembly. An array of air nozzles inserted into every well of the cleaned plate blows excess water from the wells as it is stored in the output side hopper.
摘要翻译： Au自动化高通量微量滴定板洗涤器装置，其清洁以前的样品材料的使用的微量滴定板，允许其经济的再利用作为使用新的板的替代方案。由合适的可编程控制器操作，洗涤器用户可以对热水，洗涤剂，去离子水和压缩空气进行时间和排序，以减少板样品井中先前样品的数量，使其不可检测。该装置的自动化实施例包括用于输入侧上的已使用（脏）板和在洗涤器头组件的输出侧上的清洁板的垂直料斗，其在与每个喷嘴对应的多个喷嘴上具有不同的一对液体和空气端口样品在板中很好。在公共供水压力下与压缩空气源结合使用的一系列洗涤液体在每个孔内产生显着的洗涤作用。穿梭机构从输入料斗接收使用过的板，并将其从输入料斗组件中滑过洗涤器头部组件的喷嘴和出料斗组件。插入清洁板的每个孔中的空气喷嘴阵列在储存在输出侧料斗中时从井中吹过多余的水。

3. 发明申请

WO0244703A9 HIGH THROUGHPUT CAPILLARY ELECTROPHORESIS SYSTEM 审中-公开
标题翻译：高通量毛细管电泳系统
公开(公告)号：WO0244703A9
公开(公告)日：2003-01-23
申请号：PCT/US0146504
申请日：2001-12-03
申请人： CETEK CORP , HEDBERG HERBERT J , KANGAS BRIAN , WATERS JAMES L
发明人： HEDBERG HERBERT J , KANGAS BRIAN , WATERS JAMES L
IPC分类号： G01N27/26 , G01N27/447 , G01N27/00
CPC分类号： G01N27/44782 , G01N27/44721
摘要： The invention is directed to a high throughput capillary electrophoresis (CE) system, which comprises multiple mobile CE detector modules that are transportable by a programmable fluid-handling arm assembly to fixed samples in microtiter plate wells for analysis. The CE system of the invention is capable of simultaneously automating sample preparation and multiple CE analysis of the sample in continuous timely process. The CE detector modules of the invention may be equipped with any suitable detection method, such as an ultraviolet (UV) absorbance or a laser-induced fluorescence (LIF) detector.
摘要翻译：本发明涉及一种高通量毛细管电泳（CE）系统，其包括多个移动CE检测器模块，所述多个移动CE检测器模块可由可编程流体处理臂组件运输以将样品固定在微量滴定板孔中用于分析。本发明的CE系统能够在连续及时的过程中同时自动化样品制备和样品的多重CE分析。本发明的CE检测器模块可以配备有任何合适的检测方法，例如紫外（UV）吸光度或激光诱导荧光（LIF）检测器。

4. 发明申请

WO2020206410A1 METHODS OF USING MUSCARINIC ANTAGONISTS IN THE TREATMENT OF DEPRESSION 审中-公开
公开(公告)号：WO2020206410A1
公开(公告)日：2020-10-08
申请号：PCT/US2020/026820
申请日：2020-04-06
申请人： UNIVERSITY OF MARYLAND, BALTIMORE , THE REGENTS OF THE UNIVERSITY OF MICHIGAN , THE MCLEAN HOSPITAL CORPORATION , UNIVERSITY OF TEXAS, SAN ANTONIO , COOP, Andrew , JOHNSON, Chad R. , BERGMAN, Jack , KANGAS, Brian D. , WOODS, James H. , JUITKIEWICZ, Emily M. , WINGER, Gail
发明人： COOP, Andrew , JOHNSON, Chad R. , BERGMAN, Jack , KANGAS, Brian D. , WOODS, James H. , JUITKIEWICZ, Emily M. , WINGER, Gail
IPC分类号： C07D413/04 , A61K31/445 , A61K31/44
摘要： Muscarinic antagonist are provided that are used in the treatment of depression in a subject, such as humans. The muscarinic antagonist of the invention can relieve depression without effecting cognitive functions in the treated subject.

5. 发明申请

WO2009088459A3 APPARATUS AND METHOD FOR DRYING A SOLID OR LIQUID SAMPLE 审中-公开
公开(公告)号：WO2009088459A3
公开(公告)日：2009-07-16
申请号：PCT/US2008/014079
申请日：2008-12-29
申请人： MODULAR SFC, LLC , HEDBERG, Herbert, J. , KANGAS, Brian
发明人： HEDBERG, Herbert, J. , KANGAS, Brian
IPC分类号： F26B5/08 , F26B21/00
摘要： This disclosure describes a sample drying system and method that provides a high rates of evaporation and sublimation that is commonly employed in compound processing procedures. The drying increases the sample- solute concentration and removes the solvent completely to produce the dried sample as a non-volatile solute precipitate. Re-circulating of drying gas is disclosed along with a solvent cold trap.

6. 发明申请

WO0244703A3 HIGH THROUGHPUT CAPILLARY ELECTROPHORESIS SYSTEM 审中-公开
标题翻译：高通电毛细管电泳系统
公开(公告)号：WO0244703A3
公开(公告)日：2003-04-03
申请号：PCT/US0146504
申请日：2001-12-03
申请人： CETEK CORP , HEDBERG HERBERT J , KANGAS BRIAN , WATERS JAMES L
发明人： HEDBERG HERBERT J , KANGAS BRIAN , WATERS JAMES L
IPC分类号： G01N27/26 , G01N27/447
CPC分类号： G01N27/44782 , G01N27/44721
摘要： The invention is directed to a high throughput capillary electrophoresis (CE) system, which comprises multiple mobile CE detector modules that are transportable by a programmable fluid-handling arm assembly to fixed samples in microtiter plate wells for analysis. The CE system of the invention is capable of simultaneously automating sample preparation and multiple CE analysis of the sample in continuous timely process. The CE detector modules of the invention may be equipped with any suitable detection method, such as an ultraviolet (UV) absorbance or a laser-induced fluorescence (LIF) detector.
摘要翻译：本发明涉及高通量毛细管电泳（CE）系统，其包括多个移动CE检测器模块，其可由可编程流体处理臂组件运送到微量滴定板孔中的固定样品用于分析。本发明的CE系统能够连续及时地对样品进行自动化样品制备和多次CE分析。本发明的CE检测器模块可以配备任何合适的检测方法，例如紫外（UV）吸光度或激光诱导荧光（LIF）检测器。

7. 发明申请

WO2009088459A2 APPARATUS AND METHOD FOR DRYING A SOLID OR LIQUID SAMPLE 审中-公开
标题翻译：用于干燥固体或液体样品的装置和方法
公开(公告)号：WO2009088459A2
公开(公告)日：2009-07-16
申请号：PCT/US2008014079
申请日：2008-12-29
申请人： MODULAR SFC LLC , HEDBERG HERBERT J , KANGAS BRIAN
发明人： HEDBERG HERBERT J , KANGAS BRIAN
IPC分类号： F26B5/08 , F26B21/00
CPC分类号： B01D1/14 , B01D3/346 , B04B5/0414 , B04B15/08 , F26B5/08 , F26B21/006 , F26B25/006 , G01N1/4022 , G01N2001/4027
摘要： This disclosure describes a sample drying system and method that provides a high rates of evaporation and sublimation that is commonly employed in compound processing procedures. The drying increases the sample- solute concentration and removes the solvent completely to produce the dried sample as a non-volatile solute precipitate. Re-circulating of drying gas is disclosed along with a solvent cold trap.
摘要翻译：本公开描述了提供在化合物处理程序中通常使用的高速蒸发和升华的样品干燥系统和方法。干燥会增加样品溶质浓度，并完全除去溶剂，以产生干燥的样品作为非挥发性溶质沉淀物。公开了干燥气体的再循环以及溶剂冷阱。

8. 发明申请

WO2006017737A3 MICROTITER PLATE SCRUBBING DEVICE 审中-公开
标题翻译：微型板式搅拌装置
公开(公告)号：WO2006017737A3
公开(公告)日：2006-09-21
申请号：PCT/US2005027900
申请日：2005-08-05
申请人： CETEK CORP , HEDBERG HERBERT J , LITTLE MATTHEW S , KANGAS BRIAN A
发明人： HEDBERG HERBERT J , LITTLE MATTHEW S , KANGAS BRIAN A
IPC分类号： B08B3/02 , B08B5/02 , B08B9/00
CPC分类号： B08B9/28 , B01L99/00 , B01L2300/0829 , B08B9/08 , G01N35/028 , G01N2035/0425
摘要： Au automated microtiter plate scrubber device includes vertical hoppers for dirty plates on the input side (12) and clean plates on the out side (16) of the scrubber head assembly (14). The scrubber head (14) has distinct pair of liquid and air ports on a plurality of nozzles corresponding to each sample well on the plate. A shuttle mechanism receives a used plate from the input hopper (12) and slides it from the input hopper assembly (12), across the nozzles of the scrubber head assembly (14) and to the output hopper assembly (16). An array of air nozzles inserted into every well of the cleaned plate blows excess water from the wells as it is stored in the output side hopper (16).
摘要翻译： Au自动微量滴定板洗涤器装置包括用于输入侧（12）上的脏板的垂直料斗和洗涤器头组件（14）的外侧（16）上的清洁板。洗涤器头（14）在对应于板上的每个样品阱的多个喷嘴上具有不同的一对液体和空气端口。穿梭机构从输入料斗（12）接收使用过的板，并将其从输入料斗组件（12）滑动穿过洗涤器头部组件（14）的喷嘴和输出料斗组件（16）。插入清洁板的每个孔中的空气喷嘴阵列在存储在输出侧料斗（16）中时，从井中吹出多余的水。

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