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1. 发明申请

WO2009098476A1 TOPICAL ANTIMICROBIAL COMPOSITIONS 审中-公开
标题翻译：主题抗微生物组合物
公开(公告)号：WO2009098476A1
公开(公告)日：2009-08-13
申请号：PCT/GB2009/000341
申请日：2009-02-06
申请人： RECKITT BENCKISER INC. , BURT, Willard , CLAYTON, James, Steven , KOSTURKO, Richard, John , RECKITT BENCKISER (UK) LIMITED
发明人： BURT, Willard , CLAYTON, James, Steven , KOSTURKO, Richard, John
IPC分类号： A61K8/35 , A61K8/39 , A61K8/42 , A61K31/205 , A61Q17/04 , A61K9/00
CPC分类号： A61K9/0014 , A61K8/35 , A61K8/39 , A61K8/40 , A61K8/416 , A61K8/42 , A61K31/205 , A61Q17/005 , Y02A50/473
摘要： Provided are topical antimicrobial compositions for application to the epidermis, e.g., hands, arms, legs, face, scalp as well as other body areas which are characterized in being free of conventional anionic soaps and conventional anionic surfactants, which preferably exhibits an acidic pH. The compositions exhibit at least 3 log kill efficacy, preferably at least 4 log kill efficacy at 60 seconds contact time of at least two, preferably at least three and most preferably at least four of microorganisms selected from the group consisting of: S. aureus , E. coli, P. aeruginosa and E.hirae , according to the known-art protocols EN 12054 (Chemical Disinfectants and antiseptics - Quantitative suspension test for the evaluation of antimicrobial activity), EN1276 (Evaluation of Bactericidal Activity in Suspension - Dilution Neutralisation Method) and EN 1499 (Chemical Disinfectants and Antiseptics - Hygienic Handwash). The compositions may be provided in solid, pasty or in flowable forms, but preferably are readily flowable and largely aqueous and desirably exhibit a pH of 5-5.5. Methods for the manufacture of the topical antimicrobial compositions and methods for their use are also disclosed.
摘要翻译：提供用于施用于表皮的局部抗微生物组合物，例如手，手臂，腿，面部，头皮以及其它身体区域，其特征在于不含常规阴离子皂和常规阴离子表面活性剂，其优选表现出酸性pH。所述组合物在至少两个，优选至少三个，最优选至少四种选自以下的微生物的60秒接触时间内表现出至少3log的杀伤效力，优选至少4log的杀伤效力：金黄色葡萄球菌，大肠杆菌，铜绿假单胞菌和埃希氏菌，根据已知技术方案EN 12054（化学消毒剂和防腐剂 - 用于评估抗微生物活性的定量悬浮液试验），EN1276（悬浮液中的杀菌活性评估 - 稀释中和法）和EN 1499（化学消毒剂和防腐剂 - 卫生洗手液）。组合物可以以固体，糊状或可流动的形式提供，但优选容易流动并且大部分为水性并且期望地呈现5-5.5的pH。还公开了制备局部抗微生物组合物的方法及其使用方法。

2. 发明申请

WO2011004175A3 VISCOUS TOPICAL ANTIMICROBIAL COMPOSITIONS 审中-公开
标题翻译：粘性专用抗微生物组合物
公开(公告)号：WO2011004175A3
公开(公告)日：2011-04-21
申请号：PCT/GB2010051027
申请日：2010-06-22
申请人： RECKITT & COLMAN OVERSEAS , BURT WILLARD , CLAYTON JAMES STEVEN , KOSTURKO RICHARD JOHN
发明人： BURT WILLARD , CLAYTON JAMES STEVEN , KOSTURKO RICHARD JOHN
IPC分类号： A61K8/35 , A61K8/39 , A61K8/42 , A61K9/00 , A61K31/205 , A61Q17/04 , C11D1/00
CPC分类号： A61K8/35 , A61K8/42 , A61K8/86 , A61K9/0014 , A61K31/205 , A61Q5/02 , A61Q5/12 , A61Q17/005 , A61Q19/10
摘要： Provided are antimicrobial compositions especially suited for application to the epidermis, e.g., hands, arms, legs, face, scalp as well as other body areas which preferably exhibits an acidic pH. The compositions exhibit at least 3 log kill efficacy, preferably at least 4 log kill efficacy at 60 seconds contact time of at least two, preferably at least three and most preferably at least four of microorganisms selected from the group consisting of: S. aureus, E. coli, P. aeruginosa and E.hirae, according to the protocols of prEN 12054. The compositions are largely aqueous and desirably exhibit a viscosity of at least 500 cPs at 25°C, and desirably exhibit a pH of 4.5-5.5. Methods for the manufacture of the topical antimicrobial compositions and methods for their use are also disclosed. The antimicrobial compositions also find utility in the treatment of inanimate hard surfaces and inanimate soft surfaces.
摘要翻译：提供了特别适用于表皮的抗微生物组合物，例如手，手臂，腿，面部，头皮以及其它优选呈现酸性pH的身体部位。所述组合物在至少两个，优选至少三个，最优选至少四个选自以下的微生物接触时间为60秒时表现出至少3个对数杀死效力，优选至少4个对数杀死效力：金黄色葡萄球菌，大肠杆菌，铜绿假单胞菌和大肠杆菌。根据prEN 12054的方案，所述组合物大部分是水性的，并且期望在25℃下表现出至少500cPs的粘度，并且理想地表现出4.5-5.5的pH。还公开了制备局部用抗微生物组合物的方法和它们的使用方法。该抗微生物组合物还可用于治疗无生命的硬表面和无生命的软表面。

3. 发明申请

WO2011004175A2 VISCOUS TOPICAL ANTIMICROBIAL COMPOSITIONS 审中-公开
标题翻译： VISCOUS主题抗微生物组合物
公开(公告)号：WO2011004175A2
公开(公告)日：2011-01-13
申请号：PCT/GB2010/051027
申请日：2010-06-22
申请人： RECKITT & COLMAN (OVERSEAS) LIMITED , BURT, Willard , CLAYTON, James Steven , KOSTURKO, Richard John
发明人： BURT, Willard , CLAYTON, James Steven , KOSTURKO, Richard John
IPC分类号： A61K9/00
CPC分类号： A61K8/35 , A61K8/42 , A61K8/86 , A61K9/0014 , A61K31/205 , A61Q5/02 , A61Q5/12 , A61Q17/005 , A61Q19/10 , Y02A50/473
摘要： Provided are antimicrobial compositions especially suited for application to the epidermis, e.g., hands, arms, legs, face, scalp as well as other body areas which preferably exhibits an acidic pH. The compositions exhibit at least 3 log kill efficacy, preferably at least 4 log kill efficacy at 60 seconds contact time of at least two, preferably at least three and most preferably at least four of microorganisms selected from the group consisting of: S. aureus, E. coli, P. aeruginosa and E.hirae , according to the protocols of prEN 12054. The compositions are largely aqueous and desirably exhibit a viscosity of at least 500 cPs at 25°C, and desirably exhibit a pH of 4.5-5.5. Methods for the manufacture of the topical antimicrobial compositions and methods for their use are also disclosed. The antimicrobial compositions also find utility in the treatment of inanimate hard surfaces and inanimate soft surfaces.
摘要翻译：提供了特别适合于施用于表皮的抗微生物组合物，例如手，手臂，腿，脸，头皮以及优选显示酸性pH的其它身体区域。所述组合物在至少两个，优选至少三个，最优选至少四种选自以下的微生物的60秒接触时间内表现出至少3log的杀伤效力，优选至少4log的杀伤效力：金黄色葡萄球菌，大肠杆菌，铜绿假单胞菌和埃希氏菌，根据prEN 12054的方案。组合物在很大程度上是水性的，并且希望在25℃下表现出至少500cPs的粘度，并且期望地呈现4.5-5.5的pH。还公开了制备局部抗微生物组合物的方法及其使用方法。抗微生物组合物也用于治疗无生命的硬表面和无生命的软表面。

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