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1. 发明专利

JP2015017051A メタボリックシンドローム治療剤审中-公开
标题翻译：代谢综合征治疗剂
公开(公告)号：JP2015017051A
公开(公告)日：2015-01-29
申请号：JP2013144667
申请日：2013-07-10
申请人：和久前田 , Kazuhisa Maeda , 和久前田 , 株式会社アミノアップ化学 , Amino Up Chemical Co Ltd , ロッテ健康産業株式会社 , Lotte Kenko Sangyo:Kk
发明人： MAEDA KAZUHISA , WAKAMEI KOJI , TAKANARI JUN , YASUDA HIDEYUKI , IMAI KEIJI
IPC分类号： A61K36/18 , A61K36/00 , A61P3/04 , A61P3/06 , A61P3/10
摘要：【課題】メタボリックシンドローム治療剤の提供【解決手段】本願発明者らは、マンゴスチン果皮抽出物を含むことを特徴とするメタボリックシンドローム治療剤、さらには、ライチ抽出物を含む治療剤を提供する。【選択図】図1
摘要翻译：要解决的问题：提供代谢综合征治疗剂。解决方案：本发明提供了一种包含绞胃芒果果皮提取物的代谢综合征治疗剂和包含荔枝提取物的治疗剂。

2. 发明专利

JP2014034562A Adiponectin production promoting agent 审中-公开
标题翻译： ADIPONECTIN生产促销代理
公开(公告)号：JP2014034562A
公开(公告)日：2014-02-24
申请号：JP2012177717
申请日：2012-08-10
申请人： Lotte Kenko Sangyo:Kk , ロッテ健康産業株式会社 , Kazuhisa Maeda , 和久前田
发明人： YASUDA HIDEYUKI , IMAI KEIJI , ITAMI TAICHI , MAEDA KAZUHISA
IPC分类号： A61K36/60 , A23L1/30 , A23L2/52 , A61K31/352 , A61K36/25 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/12 , A61P43/00 , C07D311/86
摘要： PROBLEM TO BE SOLVED: To provide a substance that promotes adiponectin production by fat cells, the substance being derived from food or natural plant.SOLUTION: There is provided an agent for promoting adiponectin production which comprises one or more components selected from the group consisting of mulberry leaf extract, mangosteen (Garcinia mangostana L.) exocarp extract, α-mangostin, γ-mangostin, cacao seed extract, cacao shell extract, ginseng extract, and lychee polyphenol.
摘要翻译：要解决的问题：提供脂肪细胞促进脂联素生成的物质，该物质来自食品或天然植物。解决方案：提供一种促进脂联素生产的试剂，其包含一种或多种选自以下的组分：桑叶提取物，山竹（藤黄）外果皮提取物，α-肉豆蔻蛋白，γ-芒果苷，可可种子提取物，可可壳提取物，人参提取物和荔枝多酚。

3. 发明专利

JP2014161629A System for increasing adiponectin in blood 审中-公开
标题翻译：用于增加血液中ADIPONECTIN的系统
公开(公告)号：JP2014161629A
公开(公告)日：2014-09-08
申请号：JP2013037336
申请日：2013-02-27
申请人： Kawasumi Lab Inc , 川澄化学工業株式会社 , Shiga Univ Of Medical Science , 国立大学法人滋賀医科大学 , Kazuhisa Maeda , 和久前田
发明人： MAEDA KAZUHISA , EGUCHI YUTAKA , YAMAMOTO HIROSHI , MUKAI TOMOKAZU , ETSUKI MASASHI
IPC分类号： A61M1/36 , B01D69/08 , B01D71/26 , B01D71/38
摘要： PROBLEM TO BE SOLVED: To provide a system for increasing adiponectin in blood which can increase an adiponectin concentration more quickly and substantially than ever before.SOLUTION: A system 1 for increasing adiponectin in blood employs an extracorporeal circulation module 10 having a membrane with a sieving coefficient of albumin of 0.1 to 0.8 and a sieving coefficient of fibrinogen of 0.1 or less as a principal component, and treats blood by supplying it to the extracorporeal circulation module 10. The membrane is a hollow fiber membrane formed of ethylene-vinyl alcohol copolymers.
摘要翻译：要解决的问题：提供一种增加血液中脂联素的系统，其可以比以往更快速和显着地增加脂连蛋白浓度。解决方案：用于增加血液中脂联素的系统1使用体外循环模块10，其具有筛分筛白蛋白系数为0.1〜0.8，纤维蛋白原筛分系数为0.1以下为主要成分，通过将血液供给到体外循环组件10进行处理。该膜是由乙烯 - 乙烯醇共聚物形成的中空纤维膜。

4. 发明专利

JP2005287478A Human fat precursor cell line and method for using the same 审中-公开
标题翻译：人体脂肪前体细胞系及其使用方法
公开(公告)号：JP2005287478A
公开(公告)日：2005-10-20
申请号：JP2004134825
申请日：2004-03-31
申请人： Kazuhisa Maeda , 和久前田
发明人： MAEDA KAZUHISA
IPC分类号： G01N33/15 , C12N5/07 , C12N5/074 , C12N5/0775 , C12Q1/02 , C12N5/06
摘要： PROBLEM TO BE SOLVED: To provide a human fat precursor cell line susceptible to differentiation into fat cells. SOLUTION: A method for producing the human fat precursor cell line is provided, comprising repeating subculture of fat precursor cells extracted from human fat cell. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供易于分化成脂肪细胞的人体脂肪前体细胞系。解决方案：提供一种生产人脂肪前体细胞系的方法，包括重复从人体脂肪细胞提取的脂肪前体细胞的传代培养。版权所有（C）2006，JPO＆NCIPI

5. 发明专利

JP2011121959A Endotoxin neutralizer 审中-公开
标题翻译：内毒素中和剂
公开(公告)号：JP2011121959A
公开(公告)日：2011-06-23
申请号：JP2011003377
申请日：2011-01-11
申请人： Kazuhisa Maeda , Hiroshi Yamamoto , 和久前田 , 寛山本
发明人： MAEDA KAZUHISA , YAMAMOTO HIROSHI
IPC分类号： A61K38/00 , A61K38/11 , A61P31/04 , A61P43/00 , G01N33/53 , G01N33/68 , G01N33/76
CPC分类号： G01N33/74 , A61K38/2264
摘要： PROBLEM TO BE SOLVED: To provide an efficient endotoxin neutralizer effective for treatment of such as septicemia, an internal disease or a multiple organ failure.
SOLUTION: The endotoxin neutralizer including an effective dose of a human adiponectin to inhibit the endotoxin activity is used.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供对于诸如败血症，内部疾病或多器官功能衰竭的治疗有效的高效内毒素中和剂。解决方案：使用包含有效剂量的人类脂联素以抑制内毒素活性的内毒素中和剂。版权所有（C）2011，JPO＆INPIT

6. 发明专利

JP2005278617A Arteriosclerosis developing type double knockout mouse and method for utilizing the same 审中-公开
标题翻译：发展型双重闭锁小鼠的ARTERIOSCLEROSIS及其使用方法
公开(公告)号：JP2005278617A
公开(公告)日：2005-10-13
申请号：JP2004129037
申请日：2004-03-29
申请人： Kazuhisa Maeda , 和久前田
发明人： MAEDA KAZUHISA
IPC分类号： A01K67/027 , C12N15/00 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50
摘要： PROBLEM TO BE SOLVED: To provide a technique for efficiently and effectively performing a search for a therapeutic method for arteriosclerosis by using a mouse. SOLUTION: A method is to determine and screen therapeutic effects on the arteriosclerosis and metabolic syndrome with a factor derived from a fat tissue. The method comprising (A) a step of providing an arteriosclerosis developing type double knockout mouse obtained by mating an adiponectin knockout mouse with an apoE knockout mouse and (B) a step of determining the therapeutic effects on the mouse with a drug, food ingredients, or the like, is provided. The arteriosclerosis developing type double knockout mouse, a system, or the like, used in the method are further provided. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种通过使用小鼠有效且有效地进行动脉硬化治疗方法的检测的技术。解决方案：一种方法是用来自脂肪组织的因子确定和筛选对动脉硬化和代谢综合征的治疗效果。该方法包括（A）提供通过将脂联素敲除小鼠与apoE敲除小鼠交配获得的动脉硬化发育型双重敲除小鼠的步骤，（B）用药物，食品成分确定对小鼠的治疗效果的步骤，或类似物。还提供了该方法中使用的动脉硬化发育型双敲除小鼠，系统等。版权所有（C）2006，JPO＆NCIPI

7. 发明专利

JP2012177670A Method for evaluating effect of preventing wrinkle due to ultraviolet rays and skin external preparation for displaying effect of preventing wrinkle 审中-公开
标题翻译：用于评估预防皱纹的效果的方法，以及用于显示预防皱纹的效果的皮肤外用制剂
公开(公告)号：JP2012177670A
公开(公告)日：2012-09-13
申请号：JP2011057204
申请日：2011-02-25
申请人： Kazuhisa Maeda , 憲寿前田
发明人： MAEDA KAZUHISA
IPC分类号： G01N33/50 , A61Q17/04 , A61Q19/08 , G01N33/68
摘要： PROBLEM TO BE SOLVED: To provide a simple and excellent method for evaluating effect of preventing wrinkles due to ultraviolet rays and a skin external preparation for displaying the effect of preventing wrinkles.SOLUTION: A skin external preparation like a cosmetic, a quasi-drugs, or a medicine is provided which can display reduction in elasticity of collagen due to ultraviolet rays, namely, the effect of preventing wrinkles due to ultrasonic rays on the basis of a method which evaluates the effect of preventing the reduction in elasticity of collagen due to ultrasonic rays by directly or indirectly applying an ultraviolet protective product or an ultrasonic protective component to a collagen gel, an extracted skin, and/or a reconstituted skin and then radiating ultraviolet rays to measure hardness and/or elasticity, and results of the method. Furthermore, a wrinkle prevention effect display article based on the simple and excellent method for evaluating the effect of preventing wrinkles is provided.
摘要翻译：要解决的问题：提供一种评价防止紫外线引起的皱纹的效果的简单而优异的方法，以及用于显示防止皱纹的效果的皮肤外用剂。提供一种皮肤外用剂，如化妆品，准药物或药物，其可以显示由紫外线引起的胶原蛋白弹性的降低，即基于超声波的防止皱纹的效果通过直接或间接地将紫外线防护产品或超声波保护成分施加到胶原凝胶，提取的皮肤和/或重构皮肤上来评估防止由于超声波引起的胶原蛋白弹性降低的效果的方法，然后辐射紫外线以测量硬度和/或弹性，以及该方法的结果。此外，提供了一种基于用于评价防止皱纹的效果的简单而优异的方法的抗皱效果显示品。版权所有（C）2012，JPO＆INPIT

8. 发明专利

JP2012097081A Improving agent for vascular endothelial function for transdermal administration and blood sugar level reducer for transdermal administration 有权
标题翻译：改善血管内皮功能用于转导管理和血糖降低剂用于转移性管理
公开(公告)号：JP2012097081A
公开(公告)日：2012-05-24
申请号：JP2011223886
申请日：2011-10-11
申请人： Kazuhisa Maeda , 和久前田
发明人： MAEDA KAZUHISA
IPC分类号： A61K36/18 , A61K9/70 , A61P3/10 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To improve a vascular endothelial function and to lower a blood sugar level, by using a macadamia nut oil that is used as a carrier oil and contains many kinds of fatty acid.SOLUTION: There are provided an improving agent of a vascular endothelial function for transdermal administration and a blood sugar level reducer for transdermal administration that contain at least the macadamia nut oil, and also provided a patch sheet for living bodies containing the improving agent of a vascular endothelial function for transdermal administration and the blood sugar level reducer for transdermal administration.
摘要翻译：要解决的问题：通过使用用作载体油并含有多种脂肪酸的澳洲坚果油来改善血管内皮功能并降低血糖水平。提供一种用于经皮给药的血管内皮功能改善剂和至少含有澳洲坚果油的透皮给药用血糖降低剂，并且还提供了含有改善剂的活体贴片用于透皮给药的血管内皮功能和用于透皮给药的血糖水平降低剂。版权所有（C）2012，JPO＆INPIT

9. 发明专利

JP2005287479A Method for extracting tissue stem cell and device using the method 审中-公开
标题翻译：使用该方法提取组织干细胞和装置的方法
公开(公告)号：JP2005287479A
公开(公告)日：2005-10-20
申请号：JP2004134826
申请日：2004-03-31
申请人： Kazuhisa Maeda , 和久前田
发明人： MAEDA KAZUHISA
IPC分类号： C12M3/06 , C12M3/08 , C12N5/07 , C12N5/074 , C12N5/0775 , C12N5/0789 , C12N5/06
摘要： PROBLEM TO BE SOLVED: To provide a method for easily extracting tissue stem cells, and to provide a device using the method. SOLUTION: The method for obtaining specific tissue stem cells from tissue pieces extracted from a biological tissue with a puncturing needle comprises, in a closed system, the step (1) of passing the tissue pieces through a filter 200-300 μm in pore size to remove a hemocyte component therefrom, the step (2) of cleansing the resultant tissue pieces with an antibiotic-containing phosphate buffer solution, the step (3) of subjecting the resultant tissue pieces to enzyme treatment into a cell suspension, the step (4) of separating the aimed cells from cells of smaller specific gravity by making the lighter cells float, the step (5) of passing a suspension containing the aimed cells through a filter 250-300 μm in pore size again, the step (6) of further passing the suspension through a filter 20-40 μm in pore size, and the step (7) of either centrifuging or passing the suspension through a filter 400-500 nm in pore size to obtain the objective cells from the cell suspension. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种容易地提取组织干细胞的方法，并提供使用该方法的装置。解决方案：用于从具有穿刺针的生物组织提取的组织片中获得特定组织干细胞的方法包括在封闭系统中的步骤（1）将组织块通过200-300μm的过滤器用于从其中除去血细胞成分的孔径，使用含抗生素的磷酸盐缓冲溶液清洗所得组织片的步骤（2），将所得组织片进行酶处理的细胞悬浮液的步骤（3），步骤（4）通过使较轻的细胞浮起来将目标细胞与较小比重的细胞分离;将含有靶细胞的悬浮液再次通过孔径为250-300微米的步骤（5），步骤（6））将悬浮液进一步通过孔径为20-40μm的过滤器，以及步骤（7）将悬浮液离心或通过孔径为400-500nm的过滤器，从细胞悬浮液中获得目标细胞。版权所有（C）2006，JPO＆NCIPI

10. 发明申请

US20160195551A1 METHOD FOR EVALUATING SALIVARY ADIPONECTIN LEVEL AND KIT FOR MEASURING SALIVARY ADIPONECTIN LEVEL 审中-公开
标题翻译：评估唾液酸补体水平的方法和用于测量唾液腺苷水平的试剂盒
公开(公告)号：US20160195551A1
公开(公告)日：2016-07-07
申请号：US14916183
申请日：2014-09-03
申请人： Kazuhisa MAEDA , NIPRO CORPORATION
发明人： Kazuhisa Maeda , Hsiaoyun Lin , Hiroshi Yoshida , Mitsuhiro Morita
IPC分类号： G01N33/74 , C07K16/26
CPC分类号： G01N33/74 , C07K16/26 , G01N2333/575 , G01N2800/22 , G01N2800/32
摘要： A method for evaluating a salivary adiponectin level, comprising evaluating the salivary adiponectin level by the level of multimeric adiponectin of 280 kDa or more. A method for evaluating a salivary adiponectin level, wherein a saliva sample is fractionated into human multimeric adiponectin of 280 kDa or more and human multimeric adiponectin of less than 280 kDa. A kit for measuring a salivary adiponectm level, comprising a reagent of an anti-adiponectin antibody which reacts specifically with multimeric adiponectin of 280 kDa or more in the collected saliva, wherein the salivary adiponectin level is evaluated by the level of the multimeric adiponectin of 280 kDa or more, by the reagent.
摘要翻译：一种评估唾液脂联素水平的方法，包括通过280kDa或更多个多聚体脂联素水平评价唾液脂联素水平。一种用于评估唾液脂联素水平的方法，其中将唾液样品分成280kDa以上的人多聚体脂联素和小于280kDa的人多聚体脂联素。一种用于测量唾液脂肪含量的试剂盒，其包含与收集的唾液中280kDa以上的多聚体脂联素特异性反应的抗脂联素抗体的试剂，其中唾液脂联素水平由多聚体脂联素的水平评估为280 kDa以上。

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