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1. 发明申请

US20220062191A1 siRNA DELIVERY SYSTEM COMPOUND AS WELL AS PREPARATION METHOD AND APPLICATION THEREOF 有权
公开(公告)号：US20220062191A1
公开(公告)日：2022-03-03
申请号：US17227408
申请日：2021-04-12
申请人： Zhimin Wang , Chengshen Zhu , Wentao Liu , Xiangyang Zhang , Suqin He , Yaohe Wang , Hao Liu , Miaoming Huang , Chenglin Zhang , Bin Qin , Lei Huang
发明人： Zhimin Wang , Chengshen Zhu , Wentao Liu , Xiangyang Zhang , Suqin He , Yaohe Wang , Hao Liu , Miaoming Huang , Chenglin Zhang , Bin Qin , Lei Huang
IPC分类号： A61K9/51 , A61K31/713 , C08B37/08
摘要： The invention relates to the technical field of gene treatment and nano targeted delivery, in particular to a siRNA delivery system compound as well as a preparation method and application thereof. The preparation method comprises the following steps of reacting Boc-protected histidine with cholesterol to generate Boc-protected histidine cholesteryl ester, and removing BOC-released protected amino in trifluoroacetic acid to generate histidine cholesteryl ester; then, enabling amino to react with carboxyl of carboxymethyl chitosan to modify long-chain carboxymethyl chitosan to generate carboxymethyl chitosan modified by histidine cholesteryl ester, and performing targeted labeling on carboxymethyl chitosan modified by histidine cholesteryl ester to generate a carboxymethyl chitosan high-molecular compound modified by histidine cholesteryl ester and a targeted marker together, then forming a stable spherical delivery vector through self-assembly above critical micelle concentration, and mixing the stable spherical delivery vector with siRNA (small interfering ribonucleic acid) to obtain the siRNA delivery system compound.

2. 发明授权

US09683985B2 Methods for assessing and identifying or evolving conditionally active therapeutic proteins 有权
公开(公告)号：US09683985B2
公开(公告)日：2017-06-20
申请号：US13200666
申请日：2011-09-27
申请人： Lalitha Kodandapani , Louis H. Bookbinder , Gregory I. Frost , Philip Lee Sheridan , Harold Michael Shepard , Ge Wei , Lei Huang
发明人： Lalitha Kodandapani , Louis H. Bookbinder , Gregory I. Frost , Philip Lee Sheridan , Harold Michael Shepard , Ge Wei , Lei Huang
IPC分类号： G01N33/50 , C07K16/28 , C07K16/30 , C07K16/44 , G01N33/53
CPC分类号： G01N33/5011 , C07K16/2863 , C07K16/30 , C07K16/44 , C07K2317/34 , G01N33/5014 , G01N33/5088 , G01N33/53 , G01N2333/71
摘要： Methods for evolving or selecting or producing therapeutic proteins that exhibit reduced adverse side-effects and the resulting proteins are provided. For example, provided herein is an in vitro assay to identify conditionally active therapeutic proteins that exhibit better activity within one in vivo environment compared to another in vivo environment. The methods include the steps of a) testing the activity of a protein under conditions in which normal or increased activity is desired; b) testing the activity of the protein under conditions in which reduced activity compared to normal is desired; and c) comparing the activity in a) with b) and selecting/identifying a protein that has greater activity in a) compared to b). The selected/identified protein is a conditionally active protein.

3. 发明申请

US20150236503A1 ELECTRO-STATIC DISCHARGE FILTERING CIRCUIT AND METHOD, RESET CIRCUIT, AND ELECTRONIC DEVICE 审中-公开
标题翻译：电静电放电滤波电路及方法，复位电路及电子设备
公开(公告)号：US20150236503A1
公开(公告)日：2015-08-20
申请号：US14622320
申请日：2015-02-13
申请人： Peng Zhu , Lei Huang , Yongliang Li
发明人： Peng Zhu , Lei Huang , Yongliang Li
IPC分类号： H02H9/04
CPC分类号： H02H9/046
摘要： This document discusses, among other things, an electro-static discharge (EDS) filtering circuit and method, a reset circuit, and an electronic device. The ESD filtering circuit comprises a first current dividing circuit and a second current dividing circuit which respectively share a current of a first power source signal and aggregate the shared currents to form a second power source signal upon filtering, wherein a voltage drop of the first current dividing circuit is constant and the second current dividing circuit is a pure resistor element circuit.
摘要翻译：本文件还讨论了静电放电（EDS）滤波电路和方法，复位电路和电子设备。 ESD滤波电路包括第一分流电路和第二分流电路，其分别共享第一电源信号的电流并聚合共享电流以在滤波时形成第二电源信号，其中第一电流的电压降分频电路是恒定的，第二分流电路是纯电阻元件电路。

4. 发明授权

US08987544B2 Article with heat-activatable expandable structures 有权
标题翻译：产品具有可热活化的可扩展结构
公开(公告)号：US08987544B2
公开(公告)日：2015-03-24
申请号：US12971741
申请日：2010-12-17
申请人： Simon Poruthoor , Rebecca Griffin , Lei Huang , Balaji K. Kandadai , Suzanne Murray , Hue Scott Snowden , Herb Velazquez , Dean M. Wydeven , Ali Yahiaoui
发明人： Simon Poruthoor , Rebecca Griffin , Lei Huang , Balaji K. Kandadai , Suzanne Murray , Hue Scott Snowden , Herb Velazquez , Dean M. Wydeven , Ali Yahiaoui
IPC分类号： A61F13/494 , A61L15/42 , A61F13/472 , A61F13/475 , A61F13/00
CPC分类号： A61L15/42 , A61F13/00059 , A61F13/47263 , A61F13/475
摘要： An absorbent article has a longitudinal direction, a transverse direction, a first major surface which forms a body-facing surface of the absorbent article, and a second major surface disposed distally from the first major surface which forms a garment-facing surface of the absorbent article. The article includes an absorbent core positioned between the first major surface and the second major surface. The article also includes at least one heat-activatable expandable structure. The at least one heat-activatable expandable structure is disposed on or below the first major surface. Application of heat to the heat-activatable expandable structure causes the heat-activatable expandable barrier structure to form distinctive designs, barriers and/or channels.
摘要翻译：吸收性物品具有纵向方向，横向方向，形成吸收性物品的面向身体表面的第一主表面和从第一主表面向远侧设置的第二主表面，其形成吸收剂的面向衣服表面文章。该制品包括位于第一主表面和第二主表面之间的吸收芯。该制品还包括至少一种可热激活的可膨胀结构。至少一个可热激活的可膨胀结构设置在第一主表面上或下方。将热量施加到可热激活的可膨胀结构上使热可活化的可扩张的阻挡结构形成独特的设计，阻挡层和/或通道。

5. 发明申请

US20140227332A1 COMPOSITION FOR COLORING SKIN AND METHOD FOR COLORING SKIN 有权
标题翻译：用于着色皮肤的组合物和用于着色皮肤的方法
公开(公告)号：US20140227332A1
公开(公告)日：2014-08-14
申请号：US14349099
申请日：2011-10-08
申请人： Lei Huang , Qiang Qiu , Congling Quan , Sheng Meng
发明人： Lei Huang , Qiang Qiu , Congling Quan , Sheng Meng
IPC分类号： A61K8/31 , A61K8/36 , A61Q1/02 , A61K8/04
CPC分类号： A61K8/04 , A61K8/19 , A61K8/29 , A61K8/31 , A61K8/361 , A61K2800/413 , A61K2800/43 , A61Q1/02 , A61Q17/04
摘要： Compositions for coloring skin are described. The compositions comprise beads that comprise petrolatum and optionally a colorant and the beads have a diameter from about 90 to about 625 microns. When applied topically, the compositions unexpectedly yield long lasting color.
摘要翻译：描述了皮肤着色的组合物。组合物包含珠粒，其包含凡士林和任选的着色剂，并且珠具有约90至约625微米的直径。当局部应用时，组合物意外地产生长久的颜色。

6. 发明申请

US20140170159A9 Conditionally active anti-epidermal growth factor receptor antibodies and methods of use thereof 审中-公开
标题翻译：有条件的活性抗表皮生长因子受体抗体及其使用方法
公开(公告)号：US20140170159A9
公开(公告)日：2014-06-19
申请号：US13815553
申请日：2013-03-08
申请人： Ge Wei , Gregory I. Frost , Lei Huang , H. Michael Shepard , Daniel Edward Vaughn
发明人： Ge Wei , Gregory I. Frost , Lei Huang , H. Michael Shepard , Daniel Edward Vaughn
IPC分类号： C07K16/28
CPC分类号： C07K16/2863 , A61K39/39558 , A61K47/6825 , A61K47/6849 , A61K47/6851 , A61K2039/505 , C07K16/30 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/92 , A61K39/00
摘要： Provided herein are modified anti-EGFR antibodies and nucleic acid molecules encoding modified anti-EGFR antibodies. Also provided are methods of treatment and uses using modified anti-EGFR antibodies.
摘要翻译：本文提供了修饰的抗EGFR抗体和编码修饰的抗EGFR抗体的核酸分子。还提供了使用修饰的抗EGFR抗体的治疗和使用的方法。

7. 发明授权

US08536900B2 Circuit and method for detecting multiple supply voltages 有权
标题翻译：用于检测多电源电压的电路和方法
公开(公告)号：US08536900B2
公开(公告)日：2013-09-17
申请号：US13458574
申请日：2012-04-27
申请人： Lei Huang
发明人： Lei Huang
IPC分类号： H03K5/22
CPC分类号： G01R19/16552 , G01R19/16595
摘要： An apparatus comprises a supply voltage divider, a state machine, two comparators and a threshold selector. The supply voltage divider divides a VCC into N states SK, and acquires the border voltages VK and VK+1 corresponding to the SK through a resistor divider. The threshold selector acquires a corresponding voltage VK from the supply voltage divider according to the current state SK outputted by the state machine and then sends the acquired VK as VH to a first comparator, and acquires a corresponding voltage VK+1 and sends the acquired VK+1 as VL to a second comparator. The state machine determines whether or not the VH and the VL are matched with the current state SK. If matched, the OSC of the state machine will be turned off, otherwise, the next state Sk+1 or Sk−1 of the SK will be outputted.
摘要翻译：一种装置包括电源分压器，状态机，两个比较器和阈值选择器。电源分压器将VCC分为N态SK，并通过电阻分压器获取与SK对应的边界电压VK和VK + 1。阈值选择器根据由状态机输出的当前状态SK从电源分压器获取相应的电压VK，然后将所获取的VK作为VH发送到第一比较器，并获取相应的电压VK + 1，并将所获取的VK +1作为第二比较器的VL。状态机确定VH和VL是否与当前状态SK匹配。如果匹配，状态机的OSC将被关闭，否则将输出SK的下一个状态Sk + 1或Sk-1。

8. 发明申请

US20130027089A1 CIRCUIT AND METHOD FOR DETECTING MULTIPLE SUPPLY VOLTAGES 有权
标题翻译：用于检测多个电源电压的电路和方法
公开(公告)号：US20130027089A1
公开(公告)日：2013-01-31
申请号：US13458574
申请日：2012-04-27
申请人： Lei Huang
发明人： Lei Huang
IPC分类号： H03K5/153
CPC分类号： G01R19/16552 , G01R19/16595
摘要： An apparatus comprises a supply voltage divider, a state machine, two comparators and a threshold selector. The supply voltage divider divides a VCC into N states SK, and acquires the border voltages VK and VK+1 corresponding to the SK through a resistor divider. The threshold selector acquires a corresponding voltage VK from the supply voltage divider according to the current state SK outputted by the state machine and then sends the acquired VK as VH to a first comparator, and acquires a corresponding voltage VK+1 and sends the acquired VK+1 as VL to a second comparator. The state machine determines whether or not the VH and the VL are matched with the current state SK. If matched, the OSC of the state machine will be turned off, otherwise, the next state Sk+1 or Sk−1 of the SK will be outputted.
摘要翻译：一种装置包括电源分压器，状态机，两个比较器和阈值选择器。电源分压器将VCC分为N态SK，并通过电阻分压器获取与SK对应的边界电压VK和VK + 1。阈值选择器根据由状态机输出的当前状态SK从电源分压器获取相应的电压VK，然后将所获取的VK作为VH发送到第一比较器，并获取相应的电压VK + 1，并将所获取的VK +1作为第二比较器的VL。状态机确定VH和VL是否与当前状态SK匹配。如果匹配，状态机的OSC将被关闭，否则将输出SK的下一个状态Sk + 1或Sk-1。

9. 发明申请

US20130021981A1 BASE STATION, MOBILE STATION, COORDINATED MOBILE STATION, TRANSMISSION METHOD AND RECEPTION METHOD 有权
公开(公告)号：US20130021981A1
公开(公告)日：2013-01-24
申请号：US13638729
申请日：2011-04-20
申请人： Lei Huang , Isamu Yoshii , Daichi Imamura
发明人： Lei Huang , Isamu Yoshii , Daichi Imamura
IPC分类号： H04W72/04
CPC分类号： H04W72/042 , H04W72/005 , H04W72/121 , H04W88/04
摘要： A base station (BS) which communicates with a plurality of mobile stations (MSs) is configured so as to comprise a control signal generation unit which generates control signals showing information on the allocation of resources for each of the plurality of mobile stations (MSs), and a transmission unit which transmits the control signals to the plurality of mobile stations (MSs). A control signal for a given mobile station (MS) includes information relating to another mobile station (MS).

10. 发明授权

US08240488B2 Bearing device 失效
标题翻译：轴承装置
公开(公告)号：US08240488B2
公开(公告)日：2012-08-14
申请号：US12567922
申请日：2009-09-28
申请人： Lei Huang
发明人： Lei Huang
IPC分类号： A47F5/08
CPC分类号： B05B13/0292 , Y10T403/18
摘要： A bearing device comprises a plurality of bearing members and a plurality of connecting members. The length of at least one connecting member having a different length from other connecting members. The connecting members connect the bearing members together, thus adjusting distance between adjacent bearing members by varying the length of the connecting members.
摘要翻译：轴承装置包括多个轴承构件和多个连接构件。至少一个连接件的长度与其它连接件的长度不同。连接构件将轴承构件连接在一起，从而通过改变连接构件的长度来调节相邻轴承构件之间的距离。

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