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1. 发明授权

US09046192B2 Membrane-based fluid control in microfluidic devices 有权
标题翻译：微流体装置中基于膜的流体控制
公开(公告)号：US09046192B2
公开(公告)日：2015-06-02
申请号：US12023653
申请日：2008-01-31
申请人： Mark J. Mescher , Jason O. Fiering , Erin E. Swan
发明人： Mark J. Mescher , Jason O. Fiering , Erin E. Swan
IPC分类号： F16K99/00 , A61M5/142 , G05D7/01 , A61M5/14 , A61M5/168
CPC分类号： F16K99/0015 , A61M5/141 , A61M5/14276 , A61M5/16809 , A61M5/16813 , A61M31/002 , A61M39/22 , A61M2039/226 , A61M2205/0244 , A61M2206/22 , F16K99/0001 , F16K99/0034 , F16K99/0042 , F16K99/0055 , F16K2099/0069 , F16K2099/0076 , F16K2099/008 , F16K2099/0088 , G05D7/0113 , G05D7/012 , Y10T137/0318 , Y10T137/0396
摘要： A microfluidic device may include a substrate that defines a flow-control cavity and first and second channels in fluid communication with the flow-control cavity. A compliant membrane for regulating fluid flow through the flow-control cavity may surround at least a portion of the flow-control cavity.
摘要翻译：微流体装置可以包括限定流量控制腔的衬底和与流量控制腔流体连通的第一和第二通道。用于调节通过流动控制腔的流体流动的柔性膜可以围绕流动控制腔的至少一部分。

2. 发明授权

US07826144B2 High speed piezoelectric optical system with tunable focal length 有权
标题翻译：具有可调谐焦距的高速压电光学系统
公开(公告)号：US07826144B2
公开(公告)日：2010-11-02
申请号：US12115142
申请日：2008-05-05
申请人： Mark J. Mescher
发明人： Mark J. Mescher
IPC分类号： G02B1/06
CPC分类号： G02B3/14 , G02B26/0825 , G02B26/0875
摘要： A varifocal optical system includes a substantially circular membrane deposited on a substrate, and a ring-shaped PZT thin film deposited on the outer portion of the circular membrane. The membrane may be a MEMS-micromachined membrane, made of thermal oxide, polysilicon, ZrO2 and SiO2. The membrane is initially in a buckled state, and may function as a mirror or a lens. Application of an electric voltage between an inner and outer electrode on the piezoelectric thin film induces a lateral strain on the PZT thin film, thereby altering the curvature of the membrane, and thus its focal length. Focal length tuning speeds as high as 1 MHz have been demonstrated. Tuning ranges of several hundred microns have been attained. The varifocal optical system can be used in many applications that require rapid focal length tuning, such as optical switching, scanning confocal microscopy, and vibration compensation in optical storage disks.
摘要翻译：变焦光学系统包括沉积在基底上的基本圆形的膜和沉积在圆形膜的外部上的环形PZT薄膜。膜可以是由热氧化物，多晶硅，ZrO 2和SiO 2制成的MEMS微加工膜。膜最初处于弯曲状态，并且可以用作镜子或透镜。在压电薄膜上的内部和外部电极之间的电压施加在PZT薄膜上引起横向应变，从而改变膜的曲率，从而改变其焦距。焦距调谐速度高达1 MHz已被证明。达到数百微米的调谐范围。变焦光学系统可用于需要快速焦距调谐的许多应用中，例如光学切换，扫描共焦显微镜和光学存储盘中的振动补偿。

3. 发明授权

US07563255B2 Implantable drug delivery device and use thereof 有权
标题翻译：可植入药物输送装置及其用途
公开(公告)号：US07563255B2
公开(公告)日：2009-07-21
申请号：US10139656
申请日：2002-05-02
申请人： Anthony P. Adamis , Joan W. Miller , Evangelos S. Gragoudas , Mark J. Mescher , Christopher E. Dubé , Jeffrey T. Borenstein , Marcie G. Weinstein , Raanan A. Miller , Mitchell L. Hansberry
发明人： Anthony P. Adamis , Joan W. Miller , Evangelos S. Gragoudas , Mark J. Mescher , Christopher E. Dubé , Jeffrey T. Borenstein , Marcie G. Weinstein , Raanan A. Miller , Mitchell L. Hansberry
IPC分类号： A61M35/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61F2250/0067 , A61K9/1647
摘要： The invention provides a miniaturized, implantable drug delivery device and a method of delivering over a prolonged period of time one or more drugs using such a device. The drug delivery device can be adapted for attachment to the outer surface of an eye. Once attached to the outer surface of an eye, the device can deliver one or more drugs directly into the eye for preventing or ameliorating the symptoms of a particular ocular disorder.
摘要翻译：本发明提供了一种小型化的可植入药物递送装置和使用这种装置在一段时间内递送一种或多种药物的方法。药物递送装置可以适于附着到眼睛的外表面。一旦连接到眼睛的外表面，该装置可以将一种或多种药物直接递送到眼睛中，以防止或改善特定眼部疾病的症状。

4. 发明申请

US20080249510A1 MEMBRANE-BASED FLUID CONTROL IN MICROFLUIDIC DEVICES 有权
标题翻译：微流控器件中基于膜的流体控制
公开(公告)号：US20080249510A1
公开(公告)日：2008-10-09
申请号：US12023653
申请日：2008-01-31
申请人： Mark J. Mescher , Jason O. Fiering , Erin E. Swan
发明人： Mark J. Mescher , Jason O. Fiering , Erin E. Swan
IPC分类号： A61M5/148 , B01L3/00 , B81B3/00 , F15C3/04 , F16K7/16 , A61K9/22
CPC分类号： F16K99/0015 , A61M5/141 , A61M5/14276 , A61M5/16809 , A61M5/16813 , A61M31/002 , A61M39/22 , A61M2039/226 , A61M2205/0244 , A61M2206/22 , F16K99/0001 , F16K99/0034 , F16K99/0042 , F16K99/0055 , F16K2099/0069 , F16K2099/0076 , F16K2099/008 , F16K2099/0088 , G05D7/0113 , G05D7/012 , Y10T137/0318 , Y10T137/0396
摘要： A microfluidic device may include a substrate that defines a flow-control cavity and first and second channels in fluid communication with the flow-control cavity. A compliant membrane for regulating fluid flow through the flow-control cavity may surround at least a portion of the flow-control cavity.
摘要翻译：微流体装置可以包括限定流量控制腔的衬底和与流量控制腔流体连通的第一和第二通道。用于调节通过流动控制腔的流体流动的柔性膜可以围绕流动控制腔的至少一部分。

5. 发明授权

US08876795B2 Drug delivery apparatus 有权
标题翻译：药物输送装置
公开(公告)号：US08876795B2
公开(公告)日：2014-11-04
申请号：US13364583
申请日：2012-02-02
申请人： Jason O. Fiering , Mark J. Mescher , Erin E. Pararas , Jeffrey T. Borenstein , William F. Sewell , Sharon G. Kujawa , Michael J. McKenna , Ernest S. Kim
发明人： Jason O. Fiering , Mark J. Mescher , Erin E. Pararas , Jeffrey T. Borenstein , William F. Sewell , Sharon G. Kujawa , Michael J. McKenna , Ernest S. Kim
IPC分类号： A61M31/00 , A61M5/142
CPC分类号： A61M31/002 , A61M5/14276 , A61M2210/0668
摘要： An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a bodily cavity of a patient over a period of time includes a drug supply reservoir to supply drug into a delivery channel and an actuator for delivering the drug to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear. The drug is loaded into the delivery channel while producing substantially negligible flow at an outlet of the delivery channel.
摘要翻译：一种用于在一段时间内将药物输送到患者身体的体液中的可植入药物递送设备包括：药物供应储存器，用于将药物供应到输送通道中;以及致动器，用于将药物输送到患者的预定位置患者的身体腔，例如人耳的耳蜗。药物被装载到输送通道中，同时在输送通道的出口产生基本上可忽略的流动。

6. 发明申请

US20130053823A1 Drug Delivery Apparatus 有权
标题翻译：药物输送装置
公开(公告)号：US20130053823A1
公开(公告)日：2013-02-28
申请号：US13364583
申请日：2012-02-02
申请人： Jason O. Fiering , Mark J. Mescher , Erin E. Pararas , Jeffrey T. Borenstein , William F. Sewell , Sharon G. Kujawa , Michael J. McKenna , Ernest S. Kim
发明人： Jason O. Fiering , Mark J. Mescher , Erin E. Pararas , Jeffrey T. Borenstein , William F. Sewell , Sharon G. Kujawa , Michael J. McKenna , Ernest S. Kim
IPC分类号： A61M31/00
CPC分类号： A61M31/002 , A61M5/14276 , A61M2210/0668
摘要： An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a bodily cavity of a patient over a period of time includes a drug supply reservoir to supply drug into a delivery channel and an actuator for delivering the drug to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear. The drug is loaded into the delivery channel while producing substantially negligible flow at an outlet of the delivery channel.
摘要翻译：一种用于在一段时间内将药物输送到患者体腔中的体液中的可植入药物递送装置包括：药物供应储存器，用于将药物供给到输送通道中;以及致动器，用于将药物输送到患者的预定位置患者的身体腔，例如人耳的耳蜗。药物被装载到输送通道中，同时在输送通道的出口产生基本上可忽略的流动。

7. 发明授权

US08292083B2 Method and apparatus for separating particles, cells, molecules and particulates 有权
标题翻译：用于分离颗粒，细胞，分子和颗粒的方法和装置
公开(公告)号：US08292083B2
公开(公告)日：2012-10-23
申请号：US12105805
申请日：2008-04-18
申请人： Mathew Varghese , Jason O. Fiering , Donald E. Ingber , Nan Xia , Mark J. Mescher , Jeffrey T. Borenstein , Chong Wing Yung
发明人： Mathew Varghese , Jason O. Fiering , Donald E. Ingber , Nan Xia , Mark J. Mescher , Jeffrey T. Borenstein , Chong Wing Yung
IPC分类号： B03C1/30
CPC分类号： B03C1/0332 , B03C2201/18 , B03C2201/26 , Y10T436/2575
摘要： A method and apparatus for continuously separating or concentrating particles that includes flowing two fluids in laminar flow through a magnetic field gradient which causes target particles to migrate to a waste fluid stream, and collecting each fluid stream after being flowed through the magnetic field gradient.
摘要翻译：一种用于连续分离或浓缩颗粒的方法和装置，其包括使层流中的两种流体流过导致目标颗粒迁移到废流体的磁场梯度，以及在流过磁场梯度之后收集每个流体流。

8. 发明授权

US07867193B2 Drug delivery apparatus 有权
标题翻译：药物输送装置
公开(公告)号：US07867193B2
公开(公告)日：2011-01-11
申请号：US11046540
申请日：2005-01-28
申请人： Michael J. McKenna , Jason O. Fiering , Mark J. Mescher , Sharon G. Kujawa , William F. Sewell , Anthony A. Mikulec
发明人： Michael J. McKenna , Jason O. Fiering , Mark J. Mescher , Sharon G. Kujawa , William F. Sewell , Anthony A. Mikulec
IPC分类号： A61M29/00 , A61M37/00 , A61M31/00 , A61N1/30
CPC分类号： A61M5/14276 , A61F11/00 , A61M5/14224 , A61M5/1723 , A61M31/002 , A61M2205/0244 , A61M2205/3379 , A61M2210/0662 , A61M2210/0668
摘要： An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a body cavity of a patient over a period of time, which includes a hollow member that defines at least one lumen for facilitating a unidirectional recirculating flow of a therapeutic fluid through the lumen. The fluid can contain a bodily fluid, such as, for example, perilymph, and a drug. The apparatus also includes a pump, for example a single unidirectional pump, to control the flow rate of the therapeutic fluid through the hollow member, and an interface member in communication with at least one lumen of the hollow member. The device thus allows for the controlled delivery of the therapeutic fluid to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear.
摘要翻译：一种可植入药物输送装置，用于将药物输送到患者体腔中的体液一段时间，该时间段包括限定至少一个内腔的中空构件，以便于治疗流体通过内腔的单向循环流动。流体可以包含体液，例如外淋巴液和药物。该装置还包括泵，例如单个单向泵，以控制通过中空构件的治疗流体的流速，以及与中空构件的至少一个内腔连通的界面构件。因此，该装置允许治疗性流体的受控输送到患者体腔中的预定位置，例如人耳的耳蜗。

9. 发明申请

US20090078614A1 METHOD AND APPARATUS FOR SEPARATING PARTICLES, CELLS, MOLECULES AND PARTICULATES 有权
标题翻译：分离颗粒，细胞，分子和颗粒的方法和装置
公开(公告)号：US20090078614A1
公开(公告)日：2009-03-26
申请号：US12105805
申请日：2008-04-18
申请人： Mathew Varghese , Jason O. Fiering , Donald E. Ingber , Nan Xia , Mark J. Mescher , Jeffrey T. Borenstein , Chong Wing Yung
发明人： Mathew Varghese , Jason O. Fiering , Donald E. Ingber , Nan Xia , Mark J. Mescher , Jeffrey T. Borenstein , Chong Wing Yung
IPC分类号： B07C5/344
CPC分类号： B03C1/0332 , B03C2201/18 , B03C2201/26 , Y10T436/2575
摘要： A method and apparatus for continuously separating or concentrating particles that includes flowing two fluids in laminar flow through a magnetic field gradient which causes target particles to migrate to a waste fluid stream, and collecting each fluid stream after being flowed through the magnetic field gradient.
摘要翻译：一种用于连续分离或浓缩颗粒的方法和装置，其包括使层流中的两种流体流过导致目标颗粒迁移到废液流的磁场梯度，以及在流过磁场梯度之后收集每个流体流。

10. 发明授权

US07005946B2 MEMS piezoelectric longitudinal mode resonator 有权
标题翻译： MEMS压电纵模谐振器
公开(公告)号：US07005946B2
公开(公告)日：2006-02-28
申请号：US10631695
申请日：2003-07-31
申请人： Amy E. Duwel , David J. Carter , Mark J. Mescher , Mathew Varghese , Bernard M. Antkowiak , Marc S. Weinberg
发明人： Amy E. Duwel , David J. Carter , Mark J. Mescher , Mathew Varghese , Bernard M. Antkowiak , Marc S. Weinberg
IPC分类号： H03H9/00 , H02N2/00 , H01L41/04 , H01L41/08 , H01L41/18
CPC分类号： H03H3/02 , H03H9/172 , H03H9/564 , H03H9/586 , H03H2003/027 , H03H2009/241 , H04R17/00 , Y10T29/42 , Y10T29/435
摘要： A longitudinal mode resonator that includes a substrate and a bar that is suspended relative to the substrate. The bar is suspended such that it is free to expand and contract longitudinally in response to the application of an electric field across its thickness. The expansion and contraction of the bar achieves resonance in response to the field having a frequency substantially equal to the fundamental frequency of the bar.
摘要翻译：一种纵模式谐振器，其包括相对于衬底悬挂的衬底和棒。该杆被悬挂使得响应于其整个厚度上的电场的应用而使它自由地纵向膨胀和收缩。棒的膨胀和收缩响应于具有与棒的基本频率基本相等的频率的场来实现谐振。

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