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1. 发明申请

US20120189637A1 METHODS FOR TREATING PSORIASIS 审中-公开
标题翻译：处理PSORIASIS的方法
公开(公告)号：US20120189637A1
公开(公告)日：2012-07-26
申请号：US13267658
申请日：2011-10-06
申请人： Joaquin Mario Valdes , Susan K. Paulson , Elliot K. Chartash , Yanjun Bao , Parvez M . Mulani , Murali Sundaram , Yihua Gu , Michele Olds Heckaman , Tom C. Harris , Martin Kaul , David Allen Williams , Richard G.B. Langley , Kenneth Gordon
发明人： Joaquin Mario Valdes , Susan K. Paulson , Elliot K. Chartash , Yanjun Bao , Parvez M . Mulani , Murali Sundaram , Yihua Gu , Michele Olds Heckaman , Tom C. Harris , Martin Kaul , David Allen Williams , Richard G.B. Langley , Kenneth Gordon
IPC分类号： A61K39/395 , A61P17/06
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/76
摘要： The invention provides methods of treating psoriasis in a subject by administering to a subject an antibody capable of binding to the p40 subunit of IL-12 and/or IL-23.
摘要翻译：本发明提供了通过向受试者施用能够结合IL-12和/或IL-23的p40亚基的抗体来治疗受试者的牛皮癣的方法。

2. 发明申请

US20110206680A1 METHODS FOR TREATING PSORIASIS 有权
标题翻译：处理PSORIASIS的方法
公开(公告)号：US20110206680A1
公开(公告)日：2011-08-25
申请号：US12881902
申请日：2010-09-14
申请人： JOAQUIN MARIO VALDES , ELLIOT K. CHARTASH , WILLIAM T. BARCHUK , SUSAN K. PAULSON , KENNETH B. GORDON , WALID M. AWNI , YANJUN BAO , WILLIAM G. GLASS , YIHUA GU , TOM C. HARRIS , MARTIN KAUL , PARVEZ M. MULANI , PETER NOERTERSHEUSER , MARTIN M. OKUM
发明人： JOAQUIN MARIO VALDES , ELLIOT K. CHARTASH , WILLIAM T. BARCHUK , SUSAN K. PAULSON , KENNETH B. GORDON , WALID M. AWNI , YANJUN BAO , WILLIAM G. GLASS , YIHUA GU , TOM C. HARRIS , MARTIN KAUL , PARVEZ M. MULANI , PETER NOERTERSHEUSER , MARTIN M. OKUM
IPC分类号： A61K39/395 , A61K39/00 , A61P17/06
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/545 , C07K2317/21 , C07K2317/76
摘要： The invention provides methods of treating psoriasis in a subject by administering to a subject an antibody capable of binding to the p40 subunit of IL-12 and/or IL-23.
摘要翻译：本发明提供了通过向受试者施用能够结合IL-12和/或IL-23的p40亚基的抗体来治疗受试者的牛皮癣的方法。

3. 发明授权

US08557239B2 Methods for treating psoriasis using antibodies that bind to the P40 subunit of IL-12 and/or IL-23 有权
标题翻译：使用结合IL-12和/或IL-23的P40亚基的抗体治疗牛皮癣的方法
公开(公告)号：US08557239B2
公开(公告)日：2013-10-15
申请号：US12881902
申请日：2010-09-14
申请人： Joaquin Mario Valdes , Elliot K. Chartash , William T. Barchuk , Susan K. Paulson , Kenneth B. Gordon , Walid M. Awni , Yanjun Bao , William G. Glass , Yihua Gu , Tom C. Harris , Martin Kaul , Parvez M. Mulani , Peter Noertersheuser , Martin M. Okun
发明人： Joaquin Mario Valdes , Elliot K. Chartash , William T. Barchuk , Susan K. Paulson , Kenneth B. Gordon , Walid M. Awni , Yanjun Bao , William G. Glass , Yihua Gu , Tom C. Harris , Martin Kaul , Parvez M. Mulani , Peter Noertersheuser , Martin M. Okun
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/545 , C07K2317/21 , C07K2317/76
摘要： The invention provides methods of treating psoriasis in a subject by administering to a subject an antibody capable of binding to the p40 subunit of IL-12 and/or IL-23.
摘要翻译：本发明提供了通过向受试者施用能够结合IL-12和/或IL-23的p40亚基的抗体来治疗受试者的牛皮癣的方法。

4. 发明授权

US4536636A Method and machine for electrical resistance roll seam welding with a single electrode-wire 失效
标题翻译：单电极丝电阻辊缝焊接方法及机器
公开(公告)号：US4536636A
公开(公告)日：1985-08-20
申请号：US573666
申请日：1984-01-25
申请人： Paul Opprecht , Wolfgang Weil , Martin Kaul
发明人： Paul Opprecht , Wolfgang Weil , Martin Kaul
IPC分类号： B23K11/06 , B23K11/08 , B23K11/30
CPC分类号： B23K11/309 , B23K11/063 , B23K11/3045
摘要： In a method for electrical resistance roll seam welding with a single electrode-wire, wherein the electrode-wire runs over first and second electrode carrier-rolls urged against each other, and the strength of the electrode-wire is increased by rolling-out before it enters the first electrode carrier-roll, elongations of the electrode-wire which can otherwise arise and lead to a slippage of the electrode-wire at the welding point and therefore, deleteriously affect the weld-quality can be largely prevented by reducing the electrode-wire temperature at the welding-point by cooling with a cooling device (17) the electrode-wire (12) between its rolling-out point (17/18) and its passage onto the first electrode carrier-roll (14) and/or between its departure from electrode carrier-roll (14) and its passage onto the second electrode carrier-roll (15).
摘要翻译：在用单电极线进行电阻辊缝焊接的方法中，其中电极线在彼此推压的第一和第二电极载体辊之间延伸，并且电极丝的强度通过在它进入第一电极载体辊，否则可能出现的电极线的伸长并导致焊点处电极丝的滑动，因此可以通过减少电极来极大地防止焊接质量的有害影响通过用冷却装置（17）将电极线（12）冷却在其熔点处，该电极线（12）在其滚出点（17/18）及其通向第一电极载体辊（14）和/ 或者在其离开电极载体辊（14）和其通向第二电极载体辊（15）之间。

5. 发明授权

US4493962A Apparatus and method to suppress oxidation during resistance welding 失效
标题翻译：电阻焊时抑制氧化的装置和方法
公开(公告)号：US4493962A
公开(公告)日：1985-01-15
申请号：US458754
申请日：1983-01-17
申请人： Wolfgang Weil , Andres Lanz , Max Vogt , Paul Meier , Martin Kaul , Hanspeter Fankhauser
发明人： Wolfgang Weil , Andres Lanz , Max Vogt , Paul Meier , Martin Kaul , Hanspeter Fankhauser
IPC分类号： B23K9/007 , B23K11/08
CPC分类号： B23K9/007
摘要： In an apparatus and a method of at least partially suppressing oxidation of can components or the like during resistance roller welding with the aid of an inert gas, the steps include welding the can components to one another, so as to obtain a hot welding seam, supplying the inert gas to the hot welding seam so as to envelop it at least partially, and to create a region of the inert gas in contact with the surrounding atmosphere, so that oxidation of the hot welding seam is at least partially suppressed.
摘要翻译：在借助于惰性气体的电阻辊焊接期间至少部分地抑制罐部件等的氧化的装置和方法中，步骤包括将罐部件彼此焊接，从而获得热焊缝，将惰性气体供应到热焊缝，以便至少部分地包围惰性气体，并且产生与周围大气接触的惰性气体的区域，从而至少部分地抑制热焊缝的氧化。

6. 发明授权

US4160892A Method and apparatus for seam welding overlapped edges 失效
标题翻译：缝焊重叠边的方法和装置
公开(公告)号：US4160892A
公开(公告)日：1979-07-10
申请号：US668312
申请日：1976-03-18
申请人： Paul Opprecht , Martin Kaul
发明人： Paul Opprecht , Martin Kaul
IPC分类号： B23K11/08 , B23K11/06 , B23K11/30
CPC分类号： B23K11/309 , B23K11/063
摘要： Method and apparatus for longitudinally seam welding overlapped edges of metal sheets with continuously renewable flat wire electrodes in which the edges are overlapped a distance of from three to no more than six times the thickness of the edges and the flat wire electrodes have a width from about two to three times the width of the overlap.
摘要翻译：用于连续可再生的扁平电极纵向缝焊金属片的重叠边缘的方法和装置，其中边缘与边缘厚度的三至六倍的距离重叠，扁平线电极的宽度约为两到三倍的宽度重叠。

7. 发明申请

US20140079714A1 METHODS FOR TREATING PSORIASIS 审中-公开
标题翻译：处理PSORIASIS的方法
公开(公告)号：US20140079714A1
公开(公告)日：2014-03-20
申请号：US14023590
申请日：2013-09-11
申请人： Joaquin Mario Valdes , Elliot K. Chartash , William T. Barchuk , Susan K. Paulson , Kenneth B. Gordon , Walid M. Awni , Yanjun Bao , William G. Glass , Yihua Gu , Thomas C. Harris , Martin Kaul , Parvez M. Mulani , Peter A. Noertersheuser , Martin M. Okun
发明人： Joaquin Mario Valdes , Elliot K. Chartash , William T. Barchuk , Susan K. Paulson , Kenneth B. Gordon , Walid M. Awni , Yanjun Bao , William G. Glass , Yihua Gu , Thomas C. Harris , Martin Kaul , Parvez M. Mulani , Peter A. Noertersheuser , Martin M. Okun
IPC分类号： C07K16/24
CPC分类号： C07K16/244 , A61K2039/505 , A61K2039/545 , C07K2317/21 , C07K2317/76
摘要： The invention provides methods of treating psoriasis in a subject by administering to a subject an antibody capable of binding to the p40 subunit of IL-12 and/or IL-23.
摘要翻译：本发明提供了通过向受试者施用能够结合IL-12和/或IL-23的p40亚基的抗体来治疗受试者的牛皮癣的方法。

8. 发明授权

US06235281B1 Use of anti-TNF antibodies as drugs for the treatment of disorders with an elevated serum level of interleukin-6 失效
标题翻译：使用抗TNF抗体作为治疗血清白细胞介素-6升高的疾病的药物
公开(公告)号：US06235281B1
公开(公告)日：2001-05-22
申请号：US08687328
申请日：1996-08-07
申请人： Roswitha Stenzel , Martin Kaul , Lothar Daum , Joachim Kempeni , Christa Raab , Sibylle Schaefer
发明人： Roswitha Stenzel , Martin Kaul , Lothar Daum , Joachim Kempeni , Christa Raab , Sibylle Schaefer
IPC分类号： A61K39395
CPC分类号： C07K16/241 , A61K38/00
摘要： The invention relates to the use of TNF antagonists for producing drugs for the treatment of disorders characterized by elevated serum levels of interleukin-6.
摘要翻译：本发明涉及TNF拮抗剂用于制备用于治疗特征为白细胞介素-6血清水平升高的疾病的药物的用途。

9. 发明授权

US4395614A Apparatus to suppress oxidation during resistance welding 失效
公开(公告)号：US4395614A
公开(公告)日：1983-07-26
申请号：US212593
申请日：1980-12-03
申请人： Wolfgang Weil , Andres Lanz , Max Vogt , Paul Meier , Martin Kaul , Hanspeter Fankhauser
发明人： Wolfgang Weil , Andres Lanz , Max Vogt , Paul Meier , Martin Kaul , Hanspeter Fankhauser
IPC分类号： B23K11/06 , B23K11/00 , B23K11/08 , B23K35/38
CPC分类号： B23K11/0006
摘要： In an apparatus and a method of at least partially suppressing oxidation of can components or the like during resistance roller welding with the aid of an inert gas, the steps include welding the can components to one another, so as to obtain a hot welding seam, supplying the inert gas to the hot welding seam so as to envelop it at least partially, and to create a region of the inert gas in contact with the surrounding atmosphere, so that oxidation of the hot welding seam is at least partially suppressed.

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