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1. 发明申请

US20130324569A1 PEGYLATED CYCLOPAMINE ANALOGUE, PREPARATION METHOD AND USES THEREOF 有权
标题翻译：聚乙二醇化合物类似物，其制备方法及其用途
公开(公告)号：US20130324569A1
公开(公告)日：2013-12-05
申请号：US13882797
申请日：2011-02-25
申请人： Chun Song , Chengzhi Zhang , Xin Zhao , Zhao Hu , Xiuling Xu , Youzhong Zhang , Mingyi Wang , Zhijun Sun
发明人： Chun Song , Chengzhi Zhang , Xin Zhao , Zhao Hu , Xiuling Xu , Youzhong Zhang , Mingyi Wang , Zhijun Sun
IPC分类号： A61K47/48
CPC分类号： A61K47/48215 , A61K31/133 , A61K47/60 , C08G65/33396 , C08G2650/30 , C08L2203/02
摘要： A PEGylated cyclopamine analog, preparation method, uses thereof and methods for treating proliferative diseases using the same are disclosed. The PEGylated cyclopamine analog is a compound represented by the following formula I, a compound comprising at least one group represented by the following formula I (in formula I, R is straight or branched polyethylene glycol having a molecular weight between 200 and 200,000 Dalton, L and X are linking groups), or their single enantiomers, mixture of enantiomers, mixture of diastereomers, pharmaceutically acceptable salts, solvates, or hydrates.
摘要翻译：公开了聚乙二醇化的环巴胺类似物，其制备方法，其用途和使用其的治疗增殖性疾病的方法。聚乙二醇化环胺类似物是由下式I表示的化合物，包含至少一个由下式I表示的基团的化合物（在式I中，R是分子量为200至200,000道尔顿的直链或支链聚乙二醇，L 和X是连接基团）或其单一对映异构体，对映异构体的混合物，非对映异构体的混合物，药学上可接受的盐，溶剂合物或水合物。

2. 发明授权

US07801138B2 Pseudo wire label reflector, an edge equipment, a two-layer virtual network and a method of providing pseudo wire service 有权
标题翻译：伪线标签反射器，边缘设备，双层虚拟网络和提供伪线服务的方法
公开(公告)号：US07801138B2
公开(公告)日：2010-09-21
申请号：US11632445
申请日：2005-01-04
申请人： Ke Du , Mingyi Wang , Chunhong Huang , Jun Feng , Weidong Zhong
发明人： Ke Du , Mingyi Wang , Chunhong Huang , Jun Feng , Weidong Zhong
IPC分类号： H04L12/56
CPC分类号： H04L12/4641 , H04L45/507
摘要： A pseudo wire label reflector, based on a existing label distribution router, further includes: a mode management unit, for determining the mode for switching and transferring a pseudo wire label message; a first session management unit, for saving the support information that LDP signaling session connection supports the pseudo wire label reflecting capacity; a first pseudo wire label receiving unit, for receiving a pseudo wire label message; a first pseudo wire management unit, for saving the switched pseudo wire state and deciding whether to modify the pseudo wire label message according to the switch and transfer mode determined by the mode management unit; a first pseudo wire label sending unit, for sending the pseudo wire label message. The invention also provides an edge apparatus, a L2 VPN and a method for providing pseudo wire service in PSN. The present invention makes PE equipments participating pseudo wire service to set up PSN tunnel and LDP signaling session connection with the pseudo wire label reflector by introducing the pseudo wire label reflector and extending the capacity that the current edge apparatus supports the pseudo wire label reflector.
摘要翻译：基于现有标签分发路由器的伪线标签反射器还包括：模式管理单元，用于确定用于切换和传送伪线标签消息的模式; 第一会话管理单元，用于保存LDP信令会话连接支持伪线标签反映能力的支持信息; 第一伪线标签接收单元，用于接收伪线标签消息; 第一伪线管理单元，用于保存切换伪线状态，并根据由模式管理单元确定的切换和传送模式来决定是否修改伪线标签消息; 第一伪线标签发送单元，用于发送伪线标签消息。本发明还提供一种边缘设备，L2 VPN和在PSN中提供伪线服务的方法。本发明使PE设备参与伪线业务，通过引入伪线标签反射器并扩展当前边缘设备支持伪线标签反射器的容量，建立伪线标签反射器的PSN隧道和LDP信令会话连接。

3. 发明授权

US08553694B2 Pseudo wire label reflector, an edge equipment, and a two-layer virtual network 有权
标题翻译：伪线标签反射器，边缘设备和双层虚拟网络
公开(公告)号：US08553694B2
公开(公告)日：2013-10-08
申请号：US12854584
申请日：2010-08-11
申请人： Ke Du , Mingyi Wang , Chunhong Huang , Jun Feng , Weidong Zhong
发明人： Ke Du , Mingyi Wang , Chunhong Huang , Jun Feng , Weidong Zhong
IPC分类号： H04L12/56
CPC分类号： H04L12/4641 , H04L45/507
摘要： A pseudo wire label reflector, based on a existing label distribution router, further includes: a mode management unit, for determining the mode for switching and transferring a pseudo wire label message; a first session management unit, for saving the support information that LDP signaling session connection supports the pseudo wire label reflecting capacity; a first pseudo wire label receiving unit, for receiving a pseudo wire label message; a first pseudo wire management unit, for saving the switched pseudo wire state and deciding whether to modify the pseudo wire label message according to the switch and transfer mode determined by the mode management unit; a first pseudo wire label sending unit, for sending the pseudo wire label message. The invention also provides an edge apparatus and a L2 VPN. The present invention makes PE equipments participating pseudo wire service to set up PSN tunnel and LDP signaling session connection with the pseudo wire label reflector by introducing the pseudo wire label reflector and extending the capacity that the current edge apparatus supports the pseudo wire label reflector.
摘要翻译：基于现有标签分发路由器的伪线标签反射器还包括：模式管理单元，用于确定用于切换和传送伪线标签消息的模式; 第一会话管理单元，用于保存LDP信令会话连接支持伪线标签反映能力的支持信息; 第一伪线标签接收单元，用于接收伪线标签消息; 第一伪线管理单元，用于保存切换伪线状态，并根据由模式管理单元确定的切换和传送模式来决定是否修改伪线标签消息; 第一伪线标签发送单元，用于发送伪线标签消息。本发明还提供边缘设备和L2 VPN。本发明使PE设备参与伪线业务，通过引入伪线标签反射器并扩展当前边缘设备支持伪线标签反射器的容量，建立伪线标签反射器的PSN隧道和LDP信令会话连接。

4. 发明申请

US20110026530A1 PSEUDO WIRE LABEL REFLECTOR, AN EDGE EQUIPMENT, AND A TWO-LAYER VIRTUAL NETWORK 有权
标题翻译： PSEUDO线标签反射器，边缘设备和两层虚拟网络
公开(公告)号：US20110026530A1
公开(公告)日：2011-02-03
申请号：US12854584
申请日：2010-08-11
申请人： Ke Du , Mingyi Wang , Chunhong Huang , Jun Feng , Weidong Zhong
发明人： Ke Du , Mingyi Wang , Chunhong Huang , Jun Feng , Weidong Zhong
IPC分类号： H04L12/28
CPC分类号： H04L12/4641 , H04L45/507
摘要： A pseudo wire label reflector, based on a existing label distribution router, further includes: a mode management unit, for determining the mode for switching and transferring a pseudo wire label message; a first session management unit, for saving the support information that LDP signaling session connection supports the pseudo wire label reflecting capacity; a first pseudo wire label receiving unit, for receiving a pseudo wire label message; a first pseudo wire management unit, for saving the switched pseudo wire state and deciding whether to modify the pseudo wire label message according to the switch and transfer mode determined by the mode management unit; a first pseudo wire label sending unit, for sending the pseudo wire label message. The invention also provides an edge apparatus and a L2 VPN. The present invention makes PE equipments participating pseudo wire service to set up PSN tunnel and LDP signaling session connection with the pseudo wire label reflector by introducing the pseudo wire label reflector and extending the capacity that the current edge apparatus supports the pseudo wire label reflector.
摘要翻译：基于现有标签分发路由器的伪线标签反射器还包括：模式管理单元，用于确定用于切换和传送伪线标签消息的模式; 第一会话管理单元，用于保存LDP信令会话连接支持伪线标签反映能力的支持信息; 第一伪线标签接收单元，用于接收伪线标签消息; 第一伪线管理单元，用于保存切换伪线状态，并根据由模式管理单元确定的切换和传送模式来决定是否修改伪线标签消息; 第一伪线标签发送单元，用于发送伪线标签消息。本发明还提供边缘设备和L2 VPN。本发明使PE设备参与伪线业务，通过引入伪线标签反射器并扩展当前边缘设备支持伪线标签反射器的容量，建立伪线标签反射器的PSN隧道和LDP信令会话连接。

5. 发明申请

US20100260178A1 METHOD OF FAST-MULTICAST AND A SYSTEM THEREOF 有权
标题翻译：快速多项式及其系统的方法
公开(公告)号：US20100260178A1
公开(公告)日：2010-10-14
申请号：US11909225
申请日：2005-10-17
申请人： Jinhong Huang , Mingyi Wang , Yong Kong , Bo Wu
发明人： Jinhong Huang , Mingyi Wang , Yong Kong , Bo Wu
IPC分类号： H04L12/56
CPC分类号： H04L12/18 , H04L45/16 , H04L45/48 , H04L45/64
摘要： The present invention discloses a method for implementing fast multicast and a system thereof. The system comprises multicast protocol, forwarding plane and fast multicast control plane, and the fast multicast control plane further comprises management module and agent module. The method comprises steps of: determining an edge node of time domain overlapping sub-tree of corresponding multicast tree in the multicast service according to the analysis of time domain; initiating the static multicast member of multicast service on said edge node, so that an interface at which the static multicast member is initiated generates a requirement for multicast service; generating the multicast overlapping sub-tree from said edge node to a multicast root node, so that the multicast service flow is transmitted to said edge node in advance; after sending out the requirement for the multicast service flow through any receiver at said edge node, multicast tree path establishes a multicast forwarding tree from the receiver to the edge node, the multicast service flow will be transmitted from this edge node to the receiver. The present invention can effectively reduce the delay of multicast application.
摘要翻译：本发明公开了一种实现快速组播的方法及其系统。系统包括组播协议，转发平面和快速组播控制平面，快速组播控制平面还包括管理模块和代理模块。该方法包括以下步骤：根据时域分析，确定组播业务中对应组播树的时域重叠子树的边缘节点; 在所述边缘节点上启动组播业务的静态组播成员，使静态组播成员启动的接口生成组播业务的需求; 从所述边缘节点生成组播重叠子树到组播根节点，从而事先将所述组播业务流发送到所述边缘节点; 在通过所述边缘节点的任何接收方发出组播业务流的要求后，组播树路径从接收者到边缘节点建立组播转发树，组播业务流将从边缘节点发送到接收者。本发明可以有效地减少组播应用的延迟。

6. 发明授权

US08877928B2 Pegylated cyclopamine analogue, preparation method and uses thereof 有权
标题翻译：聚乙二醇化的环巴胺类似物，其制备方法和用途
公开(公告)号：US08877928B2
公开(公告)日：2014-11-04
申请号：US13882797
申请日：2011-02-25
申请人： Chun Song , Chengzhi Zhang , Xin Zhao , Zhao Hu , Xiuling Xu , Youzhong Zhang , Mingyi Wang , Zhijun Sun
发明人： Chun Song , Chengzhi Zhang , Xin Zhao , Zhao Hu , Xiuling Xu , Youzhong Zhang , Mingyi Wang , Zhijun Sun
IPC分类号： A61K31/133 , C08G65/333 , C08L71/00 , A61P35/00 , A61K47/48
CPC分类号： A61K47/48215 , A61K31/133 , A61K47/60 , C08G65/33396 , C08G2650/30 , C08L2203/02
摘要： A PEGylated cyclopamine analog, preparation method, uses thereof and methods for treating proliferative diseases using the same are disclosed. The PEGylated cyclopamine analog is a compound represented by the following formula I, a compound comprising at least one group represented by the following formula I (in formula I, R is straight or branched polyethylene glycol having a molecular weight between 200 and 200,000 Dalton, L and X are linking groups), or their single enantiomers, mixture of enantiomers, mixture of diastereomers, pharmaceutically acceptable salts, solvates, or hydrates.
摘要翻译：公开了聚乙二醇化的环巴胺类似物，其制备方法，其用途和使用其的治疗增殖性疾病的方法。聚乙二醇化环胺类似物是由下式I表示的化合物，包含至少一个由下式I表示的基团的化合物（在式I中，R是分子量为200至200,000道尔顿的直链或支链聚乙二醇，L 和X是连接基团）或其单一对映异构体，对映异构体的混合物，非对映异构体的混合物，药学上可接受的盐，溶剂合物或水合物。

7. 发明授权

US08392605B2 Method of fast-multicast and a system thereof 有权
标题翻译：快速组播方法及其系统
公开(公告)号：US08392605B2
公开(公告)日：2013-03-05
申请号：US11909225
申请日：2005-10-17
申请人： Jinhong Huang , Mingyi Wang , Yong Kong , Bo Wu
发明人： Jinhong Huang , Mingyi Wang , Yong Kong , Bo Wu
IPC分类号： G06F15/173
CPC分类号： H04L12/18 , H04L45/16 , H04L45/48 , H04L45/64
摘要： The present invention discloses a method for implementing fast multicast and a system thereof. The system comprises multicast protocol, forwarding plane and fast multicast control plane, and the fast multicast control plane further comprises management module and agent module. The method comprises steps of: determining an edge node of time domain overlapping sub-tree of corresponding multicast tree in the multicast service according to the analysis of time domain; initiating the static multicast member of multicast service on said edge node, so that an interface at which the static multicast member is initiated generates a requirement for multicast service; generating the multicast overlapping sub-tree from said edge node to a multicast root node, so that the multicast service flow is transmitted to said edge node in advance; after sending out the requirement for the multicast service flow through any receiver at said edge node, multicast tree path establishes a multicast forwarding tree from the receiver to the edge node, the multicast service flow will be transmitted from this edge node to the receiver. The present invention can effectively reduce the delay of multicast application.
摘要翻译：本发明公开了一种实现快速组播的方法及其系统。系统包括组播协议，转发平面和快速组播控制平面，快速组播控制平面还包括管理模块和代理模块。该方法包括以下步骤：根据时域分析，确定组播业务中对应组播树的时域重叠子树的边缘节点; 在所述边缘节点上启动组播业务的静态组播成员，使静态组播成员启动的接口生成组播业务的需求; 从所述边缘节点生成组播重叠子树到组播根节点，从而事先将所述组播业务流发送到所述边缘节点; 在通过所述边缘节点的任何接收方发出组播业务流的要求后，组播树路径从接收者到边缘节点建立组播转发树，组播业务流将从边缘节点发送到接收者。本发明可以有效地减少组播应用的延迟。

8. 发明申请

US20080291921A1 Pseudo Wire Label Reflector, an Edge Equipment, a Two-Layer Virtual Network and a Method of Providing Pseudo Wire Service 有权
标题翻译：伪线标签反射器，边缘设备，双层虚拟网络和提供伪线服务的方法
公开(公告)号：US20080291921A1
公开(公告)日：2008-11-27
申请号：US11632445
申请日：2005-01-04
申请人： Ke Du , Mingyi Wang , Chunhong Huang , Jun Feng , Weidong Zhong
发明人： Ke Du , Mingyi Wang , Chunhong Huang , Jun Feng , Weidong Zhong
IPC分类号： H04L12/56
CPC分类号： H04L12/4641 , H04L45/507
摘要： A pseudo wire label reflector, based on a existing label distribution router, further includes: a mode management unit, for determining the mode for switching and transferring a pseudo wire label message; a first session management unit, for saving the support information that LDP signaling session connection supports the pseudo wire label reflecting capacity; a first pseudo wire label receiving unit, for receiving a pseudo wire label message; a first pseudo wire management unit, for saving the switched pseudo wire state and deciding whether to modify the pseudo wire label message according to the switch and transfer mode determined by the mode management unit; a first pseudo wire label sending unit, for sending the pseudo wire label message. The invention also provides an edge apparatus, a L2 VPN and a method for providing pseudo wire service in PSN. The present invention makes PE equipments participating pseudo wire service to set up PSN tunnel and LDP signaling session connection with the pseudo wire label reflector by introducing the pseudo wire label reflector and extending the capacity that the current edge apparatus supports the pseudo wire label reflector.
摘要翻译：基于现有标签分发路由器的伪线标签反射器还包括：模式管理单元，用于确定用于切换和传送伪线标签消息的模式; 第一会话管理单元，用于保存LDP信令会话连接支持伪线标签反映能力的支持信息; 第一伪线标签接收单元，用于接收伪线标签消息; 第一伪线管理单元，用于保存切换伪线状态，并根据由模式管理单元确定的切换和传送模式来决定是否修改伪线标签消息; 第一伪线标签发送单元，用于发送伪线标签消息。本发明还提供一种边缘设备，L2 VPN和在PSN中提供伪线服务的方法。本发明使PE设备参与伪线业务，通过引入伪线标签反射器并扩展当前边缘设备支持伪线标签反射器的容量，建立伪线标签反射器的PSN隧道和LDP信令会话连接。

9. 发明申请

US20120004133A1 METHOD FOR THE DIAGNOSIS OF AGE-ASSOCIATED VASCULAR DISORDERS 审中-公开
标题翻译：用于诊断与年龄相关的血管疾病的方法
公开(公告)号：US20120004133A1
公开(公告)日：2012-01-05
申请号：US13202319
申请日：2010-02-19
申请人： Mingyi Wang , Zongming Fu , Edward G. Lakatta , Jennifer Van Eyk
发明人： Mingyi Wang , Zongming Fu , Edward G. Lakatta , Jennifer Van Eyk
IPC分类号： C40B30/04 , G01N33/53 , G01N27/447 , C12Q1/68
CPC分类号： G01N33/6893 , G01N2333/485 , G01N2800/32 , G01N2800/323 , G01N2800/324 , G01N2800/325
摘要： Methods for determining if a subject has or is susceptible to having an age-associated vascular disorder are disclosed. The method includes determining if the subject exhibits altered expression of a product of one or more of the genes listed in Table 1 relative to a control level of expression of the gene product. Altered expression of one or more of the genes listed in Table 1 indicates that the subject has or is susceptible to having an age-associated vascular disorder. In specific examples the gene product is a product of the MFG-E8 and an increase in expression indicates the subject has or is susceptible to having an age-associated vascular disorder.
摘要翻译：公开了确定受试者是否具有或具有年龄相关性血管疾病的方法。该方法包括确定受试者是否表现出相对于基因产物的表达的对照水平，表1中列出的一种或多种基因的产物的表达改变。表1中列出的一种或多种基因的改变的表达表明受试者具有或易患有年龄相关的血管疾病。在具体实例中，基因产物是MFG-E8的产物，并且表达增加表示受试者具有或易于患有年龄相关的血管疾病。

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