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    • 2. 发明专利
    • Method for mass spectrometry
    • 大量光谱法
    • JP2013257332A
    • 2013-12-26
    • JP2013145875
    • 2013-07-11
    • National Sun Yat-Sen Univ国立中山大学National Sun Yat−Sen University
    • SHIEA JENTAIEYUAN CHENG-HUI
    • G01N27/62H01J49/10
    • H01J49/145H01J49/0431H01J49/0463H01J49/165
    • PROBLEM TO BE SOLVED: To provide a method for mass spectrometry capable of conducting direct analysis of mass spectrometry on a liquid sample under atmospheric pressure by using a laser desorption device and a mass spectrometry assembly.SOLUTION: A method for mass spectrometry comprises the step of irradiating a liquid sample with a laser beam such that, upon irradiation, laser energy is passed on to at least one of analytes contained in the solution of the liquid sample via a matrix so that the at least one of the analytes contained in the liquid sample is desorbed to fly along a flying path which intersects the traveling path of multiply-charged liquid drops of an electrospray medium so as to enable the at least one of the analytes to be occluded in the multiply-charged liquid drops, and such that as a result of dwindling in size of the multiply-charged liquid drops when approaching a receiving unit from a nozzle of an electrospray unit along the traveling path, charges of the liquid drops will pass on to the at least one of the analytes occluded therein to form a corresponding one of the ionized analytes. In the method for mass spectrometry, the material serving as the matrix is selected from a group of materials that are non-transmissible by laser.
    • 要解决的问题:提供一种能够通过使用激光解吸装置和质谱装置在大气压下对液体样品进行质谱分析的质谱法的方法。解决方案:质谱法包括以下步骤: 用激光束照射液体样品,使得在照射时,激光能量通过基质通过液体样品溶液中的至少一种分析物,使得液体样品中所含的至少一种分析物 被解吸,沿着与电喷雾介质的多次充液液滴的行进路径相交的飞行路径飞行,以使得至少一种分析物能够被吸入多次充液的液滴中,并且使得作为 当从电喷雾单元的喷嘴沿着行进路径接近接收单元时,多次充液的液滴的尺寸减小的结果,液体的电荷 滴剂将传递到其中封闭的至少一种分析物以形成相应的一种电离分析物。 在质谱法中,用作基质的材料选自不能通过激光传播的一组材料。
    • 4. 发明专利
    • Cycling electrospray ionization device
    • 循环电极离子化装置
    • JP2011191302A
    • 2011-09-29
    • JP2011053452
    • 2011-03-10
    • National Sun Yat-Sen Univナショナル スン イーシエン ユニバーシティNational Sun Yat−Sen University
    • SHIEA JENTAIE
    • G01N27/62B05B5/04B05B5/08B05D1/04
    • H01J49/165
    • PROBLEM TO BE SOLVED: To provide a circulation type electrospray ionization device for solving the problem of relatively-low intensity and stability of signal responsive to analyte obtained by a mass analyzer, after only a portion of ionized analyte reaches the mass analyzer, because the associated position of a nozzle used in spraying electrospray solution is fixed, in conventional types. SOLUTION: The circulation type electrospray ionization device 5 includes a drive mechanism 51 and a nozzle 52. When droplets of electrospray medium are formed sequentially, and potential difference is impressed between the nozzle 52 and a receiving unit 6, in order to provide the droplets with plural electric charges for ionizing the analyte to produce ionized analyte, the nozzle 52 forms a transfer path between a mass spectrometer 2 and the receiving unit 6 so that the electrically-charged droplets are forced to be transferred toward the receiving unit 6, along the transfer path. The nozzle axis is driven by the drive mechanism 51 that should be moved forward a circulation route A centered about a cyclic axis RC. COPYRIGHT: (C)2011,JPO&INPIT
    • 要解决的问题:为了提供一种循环型电喷雾离子化装置,用于解决响应于由质量分析器获得的分析物的信号的相对低的强度和稳定性的问题,在仅一部分电离分析物到达质量分析器之后, 因为在喷雾电喷雾溶液中使用的喷嘴的相关位置是固定的。 解决方案:循环型电喷雾离子化装置5包括驱动机构51和喷嘴52.当顺序地形成电喷雾介质的液滴,并且在喷嘴52和接收单元6之间施加电位差时,为了提供 具有用于电离分析物以产生离子化分析物的多个电荷的液滴,喷嘴52在质谱仪2和接收单元6之间形成传送路径,使得带电液滴被迫朝向接收单元6传送, 沿着传输路径。 喷嘴轴线由驱动机构51驱动,驱动机构51应该以围绕循环轴线RC为中心的循环路径A向前移动。 版权所有(C)2011,JPO&INPIT
    • 7. 发明专利
    • Laser desorption device, mass spectrometer assembly, and environmental liquid mass spectrometry method
    • 激光解吸装置,质谱仪组件和环境液体质谱法
    • JP2008147165A
    • 2008-06-26
    • JP2007253798
    • 2007-09-28
    • National Sun Yat-Sen Univ国立中山大学National Sun Yat−Sen University
    • SHIEA JENTAIEYUAN CHENG-HUI
    • H01J49/16G01N27/62H01J49/26
    • H01J49/145H01J49/0431H01J49/0463H01J49/165
    • PROBLEM TO BE SOLVED: To provide a laser desorption device, a mass spectrometer assembly and a mass spectrometry method in which a mass spectrometry of a liquid test piece can be carried out directly under an atmospheric pressure. SOLUTION: The electro-spray assisted laser desorption device for irradiating laser to a testpiece is provided with an electro-spray unit with a nozzle, a voltage supplying part which is arranged between the nozzle and a receiving unit and in which solvent drops for the electro-spray formed by the nozzle are charged and a potential difference is created forcibly toward the receiving unit from the nozzle alongside a transfer passage. Desorption of an analyzing object contained in the testpiece is conducted when laser is irradiated and it flies alongside a flying passage which crosses the transfer passage and is confined in the polyvalent charged drops and is transferred alongside the transfer passage and a size of the drop becomes smaller gradually, and an electric charge of the drop is transferred to least one of the analyzing objects confined in the drop and an ionized analyzing object is formed. COPYRIGHT: (C)2008,JPO&INPIT
    • 要解决的问题:提供一种激光解吸装置,质谱仪组合和质谱法,其中液体试样的质谱可以在大气压下直接进行。 解决方案:用于向激光束照射激光的电喷激光辅助激光解吸装置设置有具有喷嘴的电喷单元,设置在喷嘴和接收单元之间的电压供给部,其中溶剂滴 对于由喷嘴形成的电喷雾进行充电,并且从传送通道旁边的喷嘴强制地向接收单元产生电位差。 包含在试件中的分析对象的解吸是在激光照射时进行的,并且与穿过传送通道的飞行通道一起飞行并被限制在多价带电的液滴中并且沿传送通道传送并且液滴的尺寸变小 并且将液滴的电荷转移到限制在液滴中的分析对象中的至少一个,并且形成电离分析对象。 版权所有(C)2008,JPO&INPIT