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1. 发明申请

WO2019133690A1 TRANSDERMAL DRUG DELIVERY SYSTEM AND METHOD FOR USING SAME 审中-公开
公开(公告)号：WO2019133690A1
公开(公告)日：2019-07-04
申请号：PCT/US2018/067643
申请日：2018-12-27
申请人： NICHIBAN CO., LTD. , SENJU USA, INC.
发明人： OSAKO, Teppei , KAWAHARA, Koji , OGAWA, Takahiro , ISOWAKI, Akiharu , KIDA, Tetsuo
IPC分类号： A61F9/007 , A61M37/00
摘要： A method for administering a drug to a diseased portion is achieved in a short time and predominantly improves the administration amount (transdermal permeation amount) of the drug in treatment of eyelid disease or palpebral conjunctiva disease. The method for administering a drug for treatment of eyelid disease or palpebral conjunctiva disease includes a step of microneedle perforation by using a microneedle device into a tissue of the eyelid including a meibomian gland of a patient suffering from or suspected of having the disease, in which drug-containing coating is applied to at least a part of a surface of the microneedle, and the drug is a water-soluble drug.

2. 发明申请

WO1982001317A1 ADHESIVE PREPARATION FOR HEART DISEASE AND PROCESS FOR ITS PREPARATION 审中-公开
标题翻译：用于心脏疾病的胶粘剂制剂及其制备方法
公开(公告)号：WO1982001317A1
公开(公告)日：1982-04-29
申请号：PCT/JP1981000291
申请日：1981-10-19
申请人： NICHIBAN CO LTD , NIPPON KAYAKU KK , TAIHO PHARMA CO LTD , ITO TOSHIO
发明人： NICHIBAN CO LTD , NIPPON KAYAKU KK , TAIHO PHARMA CO LTD
IPC分类号： A61K09/70
CPC分类号： A61K9/7061 , A61L15/58 , A61L15/44 , C08L33/10
摘要： Un preparation adhesive pour les maladies du coeur, sensibilisant moins la peau, comprend un materiau de base ayant un revetement d'une composition adhesive contenant un copolymere consistant essentiellement en un monomere de methacrylate de dodecyle et une quantite appropriee de nitroglycerol comme ingredient effectif. Cette composition possede d'excellentes proprietes de liberation du nitroglycerol et un equilibre excellent d'adhesion et de cohesion.

3. 发明申请

WO2018237232A1 ADHESIVE SKIN PATCH WITH SUPPORT LINER AND MANUFACTURING METHOD OF THE SAME 审中-公开
公开(公告)号：WO2018237232A1
公开(公告)日：2018-12-27
申请号：PCT/US2018/038929
申请日：2018-06-22
申请人： NICHIBAN CO., LTD. , SENJU USA, INC.
发明人： HIRAOKA, Takao , MURATA, Atsushi , KAWAHARA, Koji , OGAWA, Takahiro , ISOWAKI, Akiharu
IPC分类号： A61F13/02 , A61K9/70 , A61K39/07 , A61L27/36 , B32B3/26 , B32B7/06 , B32B7/14
摘要： An adhesive skin patch with a support liner comprises at least a strip drug product and a release liner longer than the drug product. The support liner includes a backing film and an adhesive layer; the drug product is quadrilateral with two long sides being straight in parallel and two short sides each elliptical arcs convex outward; a longest interval between the two short sides is 20.0 mm or more and 50.0 mm or less, and an interval between the two long sides is 5.0 mm or more and 37.5 mm or less; and the elliptical arc has: an ellipse major axis of 20.0 mm or more and 50.0 mm or less, an ellipse minor axis of 14.8 mm or more and less than 50.0 mm, and the minor axis of at least 2.0 mm wider than the interval of the two long sides.

4. 发明授权

US11292626B2 Binding device 有权
公开(公告)号：US11292626B2
公开(公告)日：2022-04-05
申请号：US16971880
申请日：2019-02-04
申请人： NICHIBAN CO., LTD. , MICROJENICS INC.
发明人： Masanori Sato , Toru Katada , Masahiko Noda
IPC分类号： B65B13/02 , B65B13/04 , B65B13/18 , A01G17/08 , B65B27/10
摘要： A binding device that prevents damage to binding tape including a biodegradable material as a base material comprises a pressing surface formed on a resin attachment which is detachably mounted on a head of a tape holding plate, and therefore it is possible to mount an attachment of a shape and material suitable for binding tape to be used. Furthermore, because the tape receiving plate is formed by a rubber plate, the tape receiving plate is able to absorb a shock generated by the pointed end of the tape holding plate entering the tape receiving plate. With this arrangement, it possible to prevent damage to fragile binding tape including a biodegradable material as a base material.

5. 发明申请

US20190167568A1 Transdermal Drug Delivery System and Method for Using Same 审中-公开
公开(公告)号：US20190167568A1
公开(公告)日：2019-06-06
申请号：US16313739
申请日：2017-06-29
申请人： SENJU USA, INC. , NICHIBAN CO., LTD.
发明人： Takahiro OGAWA , Akiharu ISOWAKI , Tetsuo KIDA , Koji KAWAHARA , Emiko TESHIMA , Teppei OSAKO
IPC分类号： A61K9/00 , A61K9/70 , A61K31/573
摘要： [PROBLEMS TO BE SOLVED]To provide a method of advantageously improving a transdermal permeation amount of a steroid drug to diseased portions when treating ophthalmic diseases such as chalazion, blepharitis, allergic conjunctivitis, vernal keratoconjunctivitis, and meibomian gland dysfunction.[SOLUTION]To provide the transdermal drug delivery system for administering a drug via the eyelid skins that have been treated with a microneedle array, featured in that the drug is a water-soluble steroid, and the transdermal drug delivery system is a water-containing base adhesive skin patch.

6. 发明申请

US20170152089A1 PACKAGING FOR ADHESIVE PATCH CONTAINING RIVASTIGMINE 审中-公开
公开(公告)号：US20170152089A1
公开(公告)日：2017-06-01
申请号：US15310412
申请日：2015-05-14
申请人： NICHIBAN CO., LTD.
发明人： Shuta NAKANAMI , Kanako INAGAKI
IPC分类号： B65D65/40 , B65B5/04 , B65D81/26 , A61K9/70 , B65B51/10 , B65B31/00 , B65D81/20 , A61K31/27 , A61J1/00 , B65B7/02
CPC分类号： B65D65/40 , A61J1/00 , A61K9/7007 , A61K9/7061 , A61K31/27 , B32B27/28 , B65B5/045 , B65B7/02 , B65B31/00 , B65B31/04 , B65B51/10 , B65D77/00 , B65D77/04 , B65D81/2084 , B65D81/266
摘要： To provide a packaging for a rivastigmine-containing adhesive patch having excellent temporal stability of rivastigmine, an adhesive patch product including the adhesive patch and a packaging bag, and a method for manufacturing the same.An adhesive patch product including a packaging bag formed from a laminate of at least three layers including an ethylene-vinyl alcohol copolymer film and a rivastigmine-containing adhesive patch housed in the packaging bag and having a residual oxygen concentration of 10% by volume or less in the packaging bag, and a method for manufacturing the same are provided. In addition, a packaging for a rivastigmine-containing adhesive patch formed from a laminate including an ethylene-vinyl alcohol copolymer film and having a residual oxygen concentration of 10% by volume or less therein is provided.

7. 发明申请

US20170348246A1 PACKAGING BODY FOR PATCH AND METHOD OF PACKING PATCH 审中-公开
公开(公告)号：US20170348246A1
公开(公告)日：2017-12-07
申请号：US15538179
申请日：2015-11-18
申请人： Nichiban Co., Ltd.
发明人： Yukiko Tohara , Kyohei Matsuo , Ayaka Ohba , Sayaka Naruse , Kanako Inagaki
IPC分类号： A61K9/70 , A61K47/32 , A61K31/27 , A61K31/167 , A61K47/34 , A61K47/14 , A61J1/00
CPC分类号： A61K9/70 , A61J1/00 , A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/167 , A61K31/27 , A61K45/00 , A61K47/14 , A61K47/32 , A61K47/34 , A61P23/02 , A61P25/28
摘要： To provide a packaging body for a patch exhibiting excellent temporal stability of a drug, a patch product equipped with the patch and a packaging bag, and a method of manufacturing the patch product.A patch product equipped with a packaging bag formed of a laminate composed of at least three or more layers including a cyclic polyolefin film and a lidocaine- or rivastigmine-containing patch housed in the packaging bag, a method of the patch product, and a packaging body for a patch formed of a laminate including a cyclic polyolefin film.

8. 发明授权

US09238012B2 Transdermal patch 有权
标题翻译：透皮贴片
公开(公告)号：US09238012B2
公开(公告)日：2016-01-19
申请号：US14496391
申请日：2014-09-25
申请人： NICHIBAN CO., LTD.
发明人： Takao Hiraoka , Shuta Nakanami , Toru Koga
IPC分类号： A61F13/00 , A61K9/14 , A61K31/27 , A61K9/70 , B32B37/12 , B32B37/14 , B65B5/04
CPC分类号： A61K9/7084 , A61K31/27 , B32B37/1284 , B32B37/144 , B32B2309/02 , B32B2333/08 , B32B2333/12 , B32B2405/00 , B32B2535/00 , B65B5/04
摘要： A transdermal patch for the treatment of Alzheimer's disease includes: a backing, a rivastigmine-containing layer, a pressure-sensitive adhesive layer, and a release liner. In the transdermal patch, the rivastigmine-containing layer contains rivastigmine and an alkyl(meth)acrylate resin, the pressure-sensitive adhesive layer is composed of an acrylic pressure-sensitive adhesive containing a (meth)acrylic acid ester having a hydroxyl group, and neither the rivastigmine-containing layer nor the pressure-sensitive adhesive layer contains an anti-oxidizing agent.
摘要翻译：用于治疗阿尔茨海默氏病的透皮贴片包括：背衬，含有伐他斯他明的层，压敏粘合剂层和剥离衬垫。在透皮贴剂中，含有伐罗斯的明和（甲基）丙烯酸烷基酯树脂，该压敏粘合剂层由含有具有羟基的（甲基）丙烯酸酯的丙烯酸系压敏粘合剂构成，利伐斯的明含有层和压敏粘合剂层都不含有抗氧化剂。

9. 发明申请

US20150307216A1 Binding Apparatus 审中-公开
标题翻译：装订装置
公开(公告)号：US20150307216A1
公开(公告)日：2015-10-29
申请号：US14647435
申请日：2013-11-26
申请人： Nichiban Co., Ltd.
发明人： Masanori SATO , Hiroki MATSUSHITA , Eri MORIYAMA
IPC分类号： B65B13/02 , B65B13/20 , B65B13/32 , B65B13/14
CPC分类号： B65B13/025 , A01G17/085 , B65B13/14 , B65B13/20 , B65B13/24 , B65B13/305 , B65B13/327 , B65B27/00
摘要： Provided is a binding apparatus with which the quality of an object to be bound can be ensured and the burden on an operator can be reduced. A binding apparatus includes a pressure bonding mechanism in which pressure is applied by a pair of pressure bonding plates 34 and 35 to a joining portion of a binding tape 8, which is an adhesive tape, to fasten it together by gripping and squeezing a pair of levers 2 and 3 to rotate a pair of arms 4 and 5 around a fulcrum 6. Thereby, any mixing of metal staples into an object to be bound as in a conventional binding apparatus is eliminated, and thus the quality of the object to be bound can be ensured. Further, the need for a strong grip strength like that when ejecting a staple is eliminated, and thus the burden on an operator can be reduced.
摘要翻译：提供了一种能够确保要绑定的对象的质量的装订装置，并且可以减少操作者的负担。捆扎装置包括压接机构，其中压力通过一对压接板34和35施加到作为胶带的粘合带8的接合部分，以通过夹紧和挤压一对杠杆2和3使一对臂4和5围绕支点6旋转。因此，消除了如传统装订装置中任何将金属订书钉混合到待捆扎物体中，从而消除了被约束物体的质量可以确保。此外，消除了在弹出订书钉时具有强力握持力的需要，因此可以降低操作者的负担。

10. 发明申请

US20150090391A1 CHIP-RESISTANT FILM 有权
标题翻译：抗阻膜
公开(公告)号：US20150090391A1
公开(公告)日：2015-04-02
申请号：US14564799
申请日：2014-12-09
申请人： NICHIBAN CO., LTD.
发明人： Syuji ICHIMURA , Masataka SUDO , Tomohisa KATO
IPC分类号： B32B37/12 , C09J5/00
CPC分类号： B32B37/12 , B32B27/32 , C09J5/00 , C09J7/29 , C09J133/02 , C09J2201/162 , C09J2423/006 , C09J2433/00 , Y10T156/10 , Y10T428/2848
摘要： A chip-resistant film includes a composite substrate having an ionomer layer and a polyolefin-based polymer layer, with a strength at upper yield point of 10 to 40 N/10 mm, wherein a pressure-sensitive adhesive, which may be an acrylic pressure-sensitive adhesive, is placed over the polyolefin-based polymer layer. The chip-resistant film may also include an intermediate adhesive layer positioned between the ionomer layer and the polyolefin-based polymer layer. The chip resistance of an object to which the chip-resistant film has been applied is improved.
摘要翻译：耐芯片膜包括具有离聚物层和聚烯烃类聚合物层的复合基材，其强度在10〜40N / 10mm的上屈服点，其中压敏粘合剂可以是丙烯酸压力敏感粘合剂，放置在聚烯烃基聚合物层上。耐芯片膜还可以包括位于离聚物层和聚烯烃基聚合物层之间的中间粘合剂层。提高了抗切屑膜的物体的耐芯片电阻。

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