会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 10. 发明授权
    • Intelligent nanomedicine integrating diagnosis and therapy
    • 智能纳米医学综合诊断与治疗
    • US08257918B2
    • 2012-09-04
    • US11631738
    • 2005-07-07
    • Na LiWinny Tan
    • Na LiWinny Tan
    • C12Q1/68C07H21/04C07H21/02
    • C12N15/111A61K47/549A61K47/62C12N2320/50
    • A method of controlling the activity of a biologically active compound. The method concerns an oligonucleotide-based compound, comprising a hairpin-forming oligonucleotide, an effector moiety physically associated with the oligonucleotide, where the effector moiety possesses a biological activity, and a regulating moiety physically associated with the oligonucleotide, where the regulating moiety controls the biological activity of the effector moiety by interacting with the effector moiety. The oligonucleotide can assume a hairpin configuration, where the effector and regulating moieties interact, or an open configuration, where the effector and regulating moieties fail to interact. Depending on the nature of the effector and regulating moieties, either configuration can result in the expression of the biological activity of the effector moiety.
    • 控制生物活性化合物活性的方法。 该方法涉及基于寡核苷酸的化合物,其包含形成发夹的寡核苷酸,与寡核苷酸物理相关的效应部分,其中效应子部分具有生物活性,以及​​与寡核苷酸物理相关的调节部分,其中调节部分控制 通过与效应部分相互作用,效应部分的生物活性。 寡核苷酸可以呈现发夹构型,其中效应物和调节部分相互作用,或者开放构型,其中效应物和调节部分不能相互作用。 取决于效应物和调节部分的性质,任一构型都可以导致效应子部分的生物学活性的表达。