专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

JP2009106766A Method for viewing tumor tissue located within a body cavity 审中-公开
标题翻译：用于观察位于体腔内的肿瘤组织的方法
公开(公告)号：JP2009106766A
公开(公告)日：2009-05-21
申请号：JP2008313120
申请日：2008-12-09
申请人： Oncofluor Inc , オンコフルーアインコーポレイテッド
发明人： LUIKEN GEORGE A
IPC分类号： A61B10/00 , G01N21/64 , A61B1/00 , A61B5/00 , A61K49/00 , G01N21/78
CPC分类号： A61K49/0056 , A61B5/0059 , A61B5/416 , A61K49/0052 , A61K49/0058
摘要： PROBLEM TO BE SOLVED: To provide a method for in vivo detection of diseased tissue in a subject, such as tumor tissue located in a body opening, by administering to the subject a biologically compatible fluorescing targeting construct that binds to or is specifically taken up by the diseased tissue. SOLUTION: The observer directly views fluorescence emanating from a fluorescing targeting construct bound to or taken up by the diseased tissue upon irradiation of the targeting construct with excitation light having at least one wavelength in the range from 401 nm to about 495 nm, but preferably lacking light having a wavelength above about 500 nm, so as to determine the location and/or surface area of the diseased tissue in the subject. Since excitation wavelength does not penetrate through tissue, as is the practice in near infra-red diagnosis, the diseased or abnormal tissue is exposed to the excitation light either surgically or by means of an endoscopic device. Preferably a filter is used to filter out any wavelengths in the excitation light greater than about 500 nm. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种用于体内检测受试者中的患病组织的方法，例如位于体内开放的肿瘤组织，通过向受试者施用结合或特异性的生物相容的荧光靶向构建体被病变组织吸收。解决方案：观察者直接观察到荧光的靶向构建物发出的荧光，该荧光的靶向构建体在靶向构建体照射后具有至少一个波长在401nm至约495nm范围内的激发光束结合或被患病组织吸收，但优选地不具有波长高于约500nm的光，以便确定受试者中患病组织的位置和/或表面积。由于激发波长不穿透组织，如近红外诊断中的做法，病变或异常组织通过外科手术或内窥镜装置暴露于激发光。优选地，使用滤光器来滤出大于约500nm的激发光中的任何波长。版权所有（C）2009，JPO＆INPIT

2. 发明专利

AU2006200164B2 Method for viewing tumor tissue located within a body cavity 未知
公开(公告)号：AU2006200164B2
公开(公告)日：2007-03-08
申请号：AU2006200164
申请日：2006-01-16
申请人： ONCOFLUOR INC
发明人： LUIKEN GEORGE A
IPC分类号： A61B10/00

3. 发明专利

AU2012209079A8 Method for combined imaging and treating organs and tissues 未知
公开(公告)号：AU2012209079A8
公开(公告)日：2014-01-23
申请号：AU2012209079
申请日：2012-01-25
申请人： ONCOFLUOR INC
发明人： LUIKEN GEORGE A
IPC分类号： A61B5/00 , A61B8/00
摘要： The present invention provides methods and compositions for detecting and treating malignant tissue, organs or cells in a mammal. The method comprises parenterally injecting a mammalian subject, at a locus or by a route providing access to the tissue or organ, with a composition comprising a monoclonal antibody, partial antibody. Fab Fragment, antibody fragment that is tagged with a fluorophore with or without the addition of a therapeutic chemotherapy molecule, which specifically binds to the targeted organ, tissue or cell. Resection of the primary malignant tissue within the mammalian species provides the advantage of identifying all bulk tumor as fluorescent at the time of the original tumor resection. Additional therapy is provided by the chemotherapy molecule that is bound to the fluorescent-tagged monoclonal antibody.

4. 发明专利

CA2699912A1 METHOD FOR IMAGING AND TREATING ORGANS AND TISSUES 未知
公开(公告)号：CA2699912A1
公开(公告)日：2009-03-26
申请号：CA2699912
申请日：2008-09-17
申请人： ONCOFLUOR INC
发明人： LUIKEN GEORGE A
IPC分类号： A61B5/00 , A61K51/00
摘要： The present invention provides methods and compositions for detecting and treating malignant tissue, organs or cells in a mammal. The method comprises parenterally injecting a mammalian subject, at a locus or by a route providing access to the tissue or organ, with a composition comprising an antibody/fragment that is tagged with a fluorophore and a therapeutic isotope molecule, which specifically binds to the targeted organ, tissue or cell.

5. 发明申请

US20140363373A1 METHOD FOR COMBINED IMAGING AND TREATING ORGANS AND TISSUES 审中-公开
标题翻译：组合成像和处理组织和组织的方法
公开(公告)号：US20140363373A1
公开(公告)日：2014-12-11
申请号：US14468151
申请日：2014-08-25
申请人： ONCOFLUOR, INC.
发明人： George A. Luiken
IPC分类号： A61K49/00 , A61K47/48 , A61K51/10
CPC分类号： A61K49/0058 , A61B1/00165 , A61B1/043 , A61B1/0638 , A61B1/0669 , A61B1/0692 , A61B5/0071 , A61B18/20 , A61K47/6807 , A61K51/1045 , A61K51/1051 , A61K51/1054 , A61K51/106 , A61K51/1063 , A61K51/1066 , A61K51/1072
摘要： The present invention provides methods and compositions for detecting and treating malignant tissue, organs or cells in a mammal. The method comprises parenterally injecting a mammalian subject, at a locus or by a route providing access to the tissue or organ, with a composition comprising a monoclonal antibody (chimeric, humanized, fully human), partial antibody, Fab Fragment, antibody fragment that is tagged with a fluorophore with or without the addition of a therapeutic chemotherapy molecule, which specifically binds to the targeted organ, tissue or cell. Resection of the primary malignant tissue within the mammalian species (using the fluorescence of the fluorescing targeting construct) provides the advantage of identifying all bulk tumor as fluorescent at the time of the original tumor resection. Additional (adjuvant) therapy is provided by the chemotherapy molecule that is bound to the fluorescent-tagged monoclonal antibody (or antibody part thereof that is bound to small, microscopic clusters of cells (circulating tumor cells or tissue bound small microscopic clusters of cells) that are not visible to the naked eye and that could not be seen with the aid of the excitation light source and a magnification device. Chemotherapy molecules bound to the fluorescent-tagged monoclonal antibody construct provide the additional benefit of killing off the malignant cells that might be undetected using just the excitation light source for surgical resection.
摘要翻译：本发明提供用于检测和治疗哺乳动物的恶性组织，器官或细胞的方法和组合物。该方法包括在包含单克隆抗体（嵌合，人源化，完全人），部分抗体，Fab片段，抗体片段的组合物的组织或器官进入的场所或通过途径的肠胃外注射哺乳动物受试者用含有或不添加特异性结合靶向器官，组织或细胞的治疗性化疗分子的荧光团标记。切除哺乳动物物种内的原发性恶性组织（使用荧光靶向构建体的荧光）提供了在原始肿瘤切除时将所有体积肿瘤识别为荧光的优点。附加（辅助）治疗由结合到荧光标记的单克隆抗体（或其结合于小的，微观的细胞簇（循环肿瘤细胞或组织结合的细微小细胞簇））的荧光标记的单克隆抗体（或其抗体部分）提供，肉眼看不到，在激发光源和放大装置的帮助下无法看到。结合荧光标记的单克隆抗体构建体的化疗分子提供了杀死恶性细胞的另外的好处，可能是仅用激发光源检测不到手术切除。

6. 发明申请

WO2013158683A1 LIGHT EMITTING DIODE ENDOSCOPIC DEVICES FOR VISUALIZATION OF DISEASED TISSUE IN HUMANS AND ANIMALS 审中-公开
标题翻译：用于可视化人体和动物中的疾病组织的发光二极管内窥镜装置
公开(公告)号：WO2013158683A1
公开(公告)日：2013-10-24
申请号：PCT/US2013/036840
申请日：2013-04-16
申请人： ONCOFLUOR, INC.
发明人： LUIKEN, George, A.
IPC分类号： A61B1/06 , A61B1/05
CPC分类号： A61B1/0638 , A61B1/00186 , A61B1/00193 , A61B1/005 , A61B1/041 , A61B1/043 , A61B1/05 , A61B1/0646 , A61B1/0684 , A61B5/0071 , A61B5/0084 , A61B5/1112 , A61K49/0043 , A61K49/0052 , A61K49/0056 , A61K49/0058 , G01T1/18
摘要： Endoscopic devices and methods for imaging and treating organs and tissues are described. The endoscopic devices described herein include flexible endoscopes, rigid endoscopes, and capsule endoscopes. The endoscopic device may comprise one or more cameras and one or more light sources. In some embodiments, the endoscopic device comprises at least one white light camera, at least one blue light camera, at least one white light source, and at least one blue light source. In some embodiments, fluorescent targeting constructs can be injected into the subject and bound to and/or taken up by a tumor or diseased tissue. Diseased tissue can be identified by viewing the fluorescence emanating from the fluorescent targeting constructs by illuminating an in vivo body part of the subject with light having at least one excitation wavelength in the range from 400 nm to about 510 nm.
摘要翻译：描述了用于成像和治疗器官和组织的内窥镜装置和方法。本文所述的内窥镜装置包括柔性内窥镜，刚性内窥镜和胶囊内窥镜。内窥镜装置可以包括一个或多个照相机和一个或多个光源。在一些实施例中，内窥镜装置包括至少一个白光照相机，至少一个蓝光照相机，至少一个白光源和至少一个蓝光源。在一些实施方案中，荧光靶向构建体可以注射到受试者中并且被肿瘤或患病组织结合和/或被其吸收。通过使用具有400nm至约510nm范围内的至少一个激发波长的光照射受试者的体内身体部分，可以通过观察从荧光靶向构建体发出的荧光来鉴定疾病组织。

7. 发明申请

WO2012103255A8 METHOD FOR COMBINED IMAGING AND TREATING ORGANS AND TISSUES 审中-公开
公开(公告)号：WO2012103255A8
公开(公告)日：2012-08-02
申请号：PCT/US2012/022601
申请日：2012-01-25
申请人： ONCOFLUOR, INC. , LUIKEN, George, A.
发明人： LUIKEN, George, A.
IPC分类号： A61B5/00 , A61B8/00
摘要： The present invention provides methods and compositions for detecting and treating malignant tissue, organs or cells in a mammal. The method comprises parenterally injecting a mammalian subject, at a locus or by a route providing access to the tissue or organ, with a composition comprising a monoclonal antibody, partial antibody. Fab Fragment, antibody fragment that is tagged with a fluorophore with or without the addition of a therapeutic chemotherapy molecule, which specifically binds to the targeted organ, tissue or cell. Resection of the primary malignant tissue within the mammalian species provides the advantage of identifying all bulk tumor as fluorescent at the time of the original tumor resection. Additional therapy is provided by the chemotherapy molecule that is bound to the fluorescent-tagged monoclonal antibody.

8. 发明申请

US20150105619A1 LIGHT EMITTING DIODE ENDOSCOPIC DEVICES FOR VISUALIZATION OF DISEASED TISSUE IN HUMANS AND ANIMALS 审中-公开
标题翻译：用于可视化人体和动物中的疾病组织的发光二极管内窥镜装置
公开(公告)号：US20150105619A1
公开(公告)日：2015-04-16
申请号：US14395044
申请日：2013-04-16
申请人： Oncofluor, Inc.
发明人： George A. Luiken
IPC分类号： A61B1/06 , A61B1/04 , A61B5/00 , G01T1/18 , A61B5/11 , A61K49/00 , A61B1/005
CPC分类号： A61B1/0638 , A61B1/00186 , A61B1/00193 , A61B1/005 , A61B1/041 , A61B1/043 , A61B1/05 , A61B1/0646 , A61B1/0684 , A61B5/0071 , A61B5/0084 , A61B5/1112 , A61K49/0043 , A61K49/0052 , A61K49/0056 , A61K49/0058 , G01T1/18
摘要： Endoscopic devices and methods for imaging and treating organs and tissues are described. The endoscopic devices described herein include flexible endoscopes, rigid endoscopes, and capsule endoscopes. The endoscopic device may comprise one or more cameras and one or more light sources. In some embodiments, the endoscopic device comprises at least one white light camera, at least one blue light camera, at least one white light source, and at least one blue light source. In some embodiments, fluorescent targeting constructs can be injected into the subject and bound to and/or taken up by a tumor or diseased tissue. Diseased tissue can be identified by viewing the fluorescence emanating from the fluorescent targeting constructs by illuminating an in vivo body part of the subject with light having at least one excitation wavelength in the range from 400 nm to about 510 nm.
摘要翻译：描述了用于成像和处理器官和组织的内窥镜装置和方法。本文描述的内窥镜装置包括柔性内窥镜，刚性内窥镜和胶囊内窥镜。内窥镜装置可以包括一个或多个相机和一个或多个光源。在一些实施例中，内窥镜装置包括至少一个白光照相机，至少一个蓝光照相机，至少一个白光源和至少一个蓝光源。在一些实施方案中，荧光靶向构建体可以注射到受试者中并且被肿瘤或患病组织结合和/或被其吸收。通过用具有400nm至约510nm范围内的至少一个激发波长的光照射受试者的体内身体部分，可以通过观察从荧光靶向构建体发出的荧光来鉴定疾病组织。

9. 发明申请

US20130281845A1 LIGHT EMITTING DIODE ENDOSCOPIC DEVICES FOR VISUALIZATION OF DISEASED TISSUE IN HUMANS AND ANIMALS 审中-公开
公开(公告)号：US20130281845A1
公开(公告)日：2013-10-24
申请号：US13864766
申请日：2013-04-17
申请人： ONCOFLUOR, INC.
发明人： George A. Luiken
IPC分类号： A61B5/00 , A61B1/04
CPC分类号： A61B1/0638 , A61B1/00186 , A61B1/00193 , A61B1/005 , A61B1/041 , A61B1/043 , A61B1/05 , A61B1/0646 , A61B1/0684 , A61B5/0071 , A61B5/0084 , A61B5/1112 , A61K49/0043 , A61K49/0052 , A61K49/0056 , A61K49/0058 , G01T1/18
摘要： Endoscopic devices and methods for imaging and treating organs and tissues are described. The endoscopic devices described herein include flexible endoscopes, rigid endoscopes, and capsule endoscopes. The endoscopic device may comprise one or more cameras and one or more light sources. In some embodiments, the endoscopic device comprises at least one white light camera, at least one blue light camera, at least one white light source, and at least one blue light source. In some embodiments, fluorescent targeting constructs can be injected into the subject and bound to and/or taken up by a tumor or diseased tissue. Diseased tissue can be identified by viewing the fluorescence emanating from the fluorescent targeting constructs by illuminating an in vivo body part of the subject with light having at least one excitation wavelength in the range from 400 nm to about 510 nm.

10. 发明申请

WO2012162318A1 SURGICAL LIGHTING SOURCES FOR USE WITH FLUOPHORE-TAGGED MONOCLONAL ANTIBODIES OR FLUOROPHORE-TAGGED TUMOR AVID COMPOUNDS 审中-公开
标题翻译：使用荧光标记的单克隆抗体或荧光标记肿瘤化合物的外科照明光源
公开(公告)号：WO2012162318A1
公开(公告)日：2012-11-29
申请号：PCT/US2012/038994
申请日：2012-05-22
申请人： ONCOFLUOR, INC. , LUIKEN, George, A.
发明人： LUIKEN, George, A.
IPC分类号： A61K49/00
CPC分类号： A61B5/0071 , A61B1/00039 , A61B1/043 , A61B1/0684 , A61B1/0692 , A61B17/3205 , G01J3/10 , G01N21/6447 , G01N21/6456 , G01N2021/6439
摘要： The present invention describes -light source devices to provide white and blue (401-510 nm) light for the in vivo identification of diseased tissue using fluorescence based tissue targeting. The light source devices are configured with a variety of LED lights capable of emitting white and blue light with at least one excitation wavelength in the range from about 401 nm to about 500 nm (for example, 470 nm to 495 nm) to irradiate an in vivo body part of a subject containing tumor or diseased tissue. The tumor or diseased tissue has fluorophore-tagged targeting constructs attached. The fluorophores used in the targeting constructs have emission spectra greater than 515 nm. The fluorescence emanating from the fluorescent targeting construct in response to the excitation wavelength is directly viewed with long-pass filtered (515 nm) lenses and is used to determine the location and/or surface area of the diseased tissue in the subject. Fluorescence based surgical identification provides more accurate disease resection.
摘要翻译：本发明描述了使用基于荧光的组织靶向来提供白色和蓝色（401-510nm）光用于体内鉴定患病组织的光源装置。光源装置配置有能够发射白光和蓝光的各种LED灯，其具有在约401nm至约500nm（例如，470nm至495nm）范围内的至少一个激发波长以照射受试者的体内部分含有肿瘤或病变组织。肿瘤或病变组织具有连接的荧光团标记的靶向构建体。靶向构建体中使用的荧光团具有大于515nm的发射光谱。从荧光靶向构建体响应于激发波长发出的荧光直接用长通滤波（515nm）透镜观察，并用于确定受试者中病变组织的位置和/或表面积。基于荧光的手术识别提供更准确的疾病切除。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式