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1. 发明授权

US11287396B2 Method and system for simultaneous determination of multiple measurable biomarkers during the development of a communicable disease 有权
公开(公告)号：US11287396B2
公开(公告)日：2022-03-29
申请号：US16894316
申请日：2020-06-05
申请人： PRINCETON BIOCHEMICALS, INC
发明人： Norberto A. Guzman
IPC分类号： G01N27/447 , G01N33/561 , G01N33/543 , G01N1/40
摘要： A diagnostic and prognostic method and system for sequentially analyzing in a biological fluid or tissue extract the presence of an antigenic infectious agent, infectious organism or its toxic product; an antibody response to the antigenic infectious agent, infectious organism or its toxic product; one or more biomarkers formed during infection in response to a communicable disease; and one or more biomarkers to assess the severity of the disease and to monitor the effectiveness of drug therapy or vaccination.

2. 发明申请

US20160123925A1 MULTI-DIMENSIONAL ELECTROPHORESIS APPARATUS 审中-公开
标题翻译：多维电泳装置
公开(公告)号：US20160123925A1
公开(公告)日：2016-05-05
申请号：US14868328
申请日：2015-09-28
申请人： Princeton Biochemicals, Inc.
发明人： Norberto A. GUZMAN
IPC分类号： G01N27/447 , G01N33/561
CPC分类号： G01N27/44756 , G01N1/405 , G01N27/44708 , G01N27/44743 , G01N33/561
摘要： An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus comprises a relatively large-bore transport capillary which intersects with a plurality of small-bore separation capillaries and includes a valve system. Analyte concentrators, having antibody-specific (or related affinity) chemistries, are stationed at the respective intersections of the transport capillary and separation capillaries to bind one or more analytes of interest. The apparatus allows the performance of two or more dimensions for the optimal separation of analytes. The apparatus may also include a plurality of valves surrounding each of the analyte concentrators to localize each of the concentrators to improve the binding of one or more analytes of interest.
摘要翻译：通常公开了电泳装置，用于顺序分析具有高或低浓度的一种或多种分析物的单个样品或多个样品。该装置包括与多个小孔分离毛细管相交并且包括阀系统的相对大的输送毛细管。具有抗体特异性（或相关亲和力）化学物质的分析物浓缩器驻留在运输毛细管和分离毛细管的相应交叉处，以结合一种或多种感兴趣的分析物。该装置允许执行两个或多个维以分析物的最佳分离。该装置还可以包括围绕每个分析物浓缩器的多个阀，以使每个浓缩器定位，以改善一种或多种感兴趣的分析物的结合。

3. 外观设计

USD970041S1 Combined micro valve and pressing member for controlling path of fluids in miniaturized capillary connections 有权
公开(公告)号：USD970041S1
公开(公告)日：2022-11-15
申请号：US29769253
申请日：2021-02-04
申请人： PRINCETON BIOCHEMICALS, INC
设计人： Norberto Guzman , Daniel E. Guzman

4. 发明申请

US20210382003A1 Method and System for Simultaneous Determination of Multiple Measurable Biomarkers During the Development of a Communicable Disease 有权
公开(公告)号：US20210382003A1
公开(公告)日：2021-12-09
申请号：US16894316
申请日：2020-06-05
申请人： PRINCETON BIOCHEMICALS, INC
发明人： Norberto A. GUZMAN
IPC分类号： G01N27/447 , G01N1/40 , G01N33/543 , G01N33/561
摘要： A diagnostic and prognostic method and system for sequentially analyzing in a biological fluid or tissue extract the presence of an antigenic infectious agent, infectious organism or its toxic product; an antibody response to the antigenic infectious agent, infectious organism or its toxic product; one or more biomarkers formed during infection in response to a communicable disease; and one or more biomarkers to assess the severity of the disease and to monitor the effectiveness of drug therapy or vaccination.

5. 外观设计

USD919833S1 Micro valve for controlling path of fluids in miniaturized capillary connections 有权
公开(公告)号：USD919833S1
公开(公告)日：2021-05-18
申请号：US29682566
申请日：2019-03-06
申请人： PRINCETON BIOCHEMICALS, INC
设计人： Norberto Guzman , Daniel E. Guzman

6. 发明授权

US11262330B2 Disease detection system and method 有权
公开(公告)号：US11262330B2
公开(公告)日：2022-03-01
申请号：US16459794
申请日：2019-07-02
申请人： PRINCETON BIOCHEMICALS, INC.
发明人： Norberto A. Guzman
IPC分类号： G01N27/447 , G01N33/561 , G01N1/40
摘要： An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus comprises a relatively large-bore transport capillary which intersects with a plurality of small-bore separation capillaries and includes a valve system. Analyte concentrators, having antibody-specific (or related affinity) chemistries, are stationed at the respective intersections of the transport capillary and separation capillaries to bind one or more analytes of interest. The apparatus allows the performance of two or more dimensions for the optimal separation of analytes. The apparatus may also include a plurality of valves surrounding each of the analyte concentrators to localize each of the concentrators to improve the binding of one or more analytes of interest.

7. 发明申请

US20210260590A1 Uniformly Pressing Micro-Valve System for Controlling Path of Fluids in Miniaturized Capillary Connections and Methods of Fabrication 有权
公开(公告)号：US20210260590A1
公开(公告)日：2021-08-26
申请号：US17317184
申请日：2021-05-11
申请人： PRINCETON BIOCHEMICALS, INC
发明人： NORBERTO GUZMAN , Daniel E. GUZMAN
IPC分类号： B01L3/00
摘要： Micro-valve system includes two or more superimposed tubes and a pressing device for fluid control in miniaturized capillary connections. The micro-valve system and method of fabrication can be tailored to the requirements of a wide range of applications; composition, sturdiness and thickness of plastic tubes; and capable of been adapted to the resilient of mechanical pressure and the passing and transport of fluid types.

8. 发明申请

US20190331637A1 DISEASE DETECTION SYSTEM AND METHOD 审中-公开
公开(公告)号：US20190331637A1
公开(公告)日：2019-10-31
申请号：US16459794
申请日：2019-07-02
申请人： PRINCETON BIOCHEMICALS, INC.
发明人： NORBERTO A. GUZMAN
IPC分类号： G01N27/447 , G01N33/561
摘要： An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus comprises a relatively large-bore transport capillary which intersects with a plurality of small-bore separation capillaries and includes a valve system. Analyte concentrators, having antibody-specific (or related affinity) chemistries, are stationed at the respective intersections of the transport capillary and separation capillaries to bind one or more analytes of interest. The apparatus allows the performance of two or more dimensions for the optimal separation of analytes. The apparatus may also include a plurality of valves surrounding each of the analyte concentrators to localize each of the concentrators to improve the binding of one or more analytes of interest.

9. 发明申请

US20220170885A1 Method and System for Simultaneous Determination of Multiple Measurable Biomarkers During the Development of a Communicable Disease 有权
公开(公告)号：US20220170885A1
公开(公告)日：2022-06-02
申请号：US17673247
申请日：2022-02-16
申请人： PRINCETON BIOCHEMICALS, INC.
发明人： NORBERTO A. GUZMAN
IPC分类号： G01N27/447 , G01N33/561 , G01N33/543 , G01N1/40
摘要： A diagnostic and prognostic method and system for sequentially analyzing in a biological fluid or tissue extract the presence of an antigenic infectious agent, infectious organism or its toxic product; an antibody response to the antigenic infectious agent, infectious organism or its toxic product; one or more biomarkers formed during infection in response to a communicable disease; and one or more biomarkers to assess the severity of the disease and to monitor the effectiveness of drug therapy or vaccination.

10. 外观设计

USD923817S1 Analyte concentrator-microreactor device 有权
公开(公告)号：USD923817S1
公开(公告)日：2021-06-29
申请号：US29696763
申请日：2019-07-01
申请人： PRINCETON BIOCHEMICALS, INC
设计人： Norberto Guzman , Daniel E. Guzman

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