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1. 发明申请

US20070073385A1 Eluting, implantable medical device 审中-公开
标题翻译：洗脱，植入式医疗器械
公开(公告)号：US20070073385A1
公开(公告)日：2007-03-29
申请号：US11523797
申请日：2006-09-18
申请人： Darin Schaeffer , David Grewe , Patrick Ruane
发明人： Darin Schaeffer , David Grewe , Patrick Ruane
IPC分类号： A61F2/90
CPC分类号： A61L31/082 , A61F2/91 , A61F2/915 , A61F2002/30322 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2230/0054 , A61F2250/0023 , A61F2250/0026 , A61F2250/0068 , A61L31/146 , A61L31/16 , A61L2300/416
摘要： An intraluminal device is provided with a porous structure. The porous structure may be loaded with a bioactive substance to treat surrounding tissues after the intraluminal device has been implanted. The porous structure may be made by depositing a metal film on a foam structure using chemical vapor deposition. Porous structures may also be made by sintering or applying a ceramic layer to the intraluminal device. An intraluminal device is also provided with a ceramic material applied to generally straight portions of the device structure but not to portions adapted to bend. One advantage is that the ceramic material is less likely to fracture since it is applied to regions that experience less strain.
摘要翻译：管腔内装置具有多孔结构。在植入腔内装置之后，多孔结构可装载生物活性物质以治疗周围组织。多孔结构可以通过使用化学气相沉积在金属泡沫结构上沉积金属膜来制造。也可以通过烧结或将陶瓷层施加到腔内装置来制造多孔结构。管腔内装置还设置有施加到装置结构的大致直线部分的陶瓷材料，但是不适于弯曲的部分。一个优点是陶瓷材料不太可能破裂，因为它被应用于经历较小应变的区域。

2. 发明申请

US20080108824A1 Medical Devices Incorporating a Bioactive and Methods of Preparing Such Devices 审中-公开
标题翻译：纳入生物活性的医疗器械及其制备方法
公开(公告)号：US20080108824A1
公开(公告)日：2008-05-08
申请号：US11862925
申请日：2007-09-27
申请人： Andrew Isch , Patrick Ruane , Waleska Perez-Segarra
发明人： Andrew Isch , Patrick Ruane , Waleska Perez-Segarra
IPC分类号： C07D211/08 , A61F2/02
CPC分类号： A61L31/16 , A61L2300/402
摘要： One embodiment provides a medical device comprising a base material and a bioactive in contact with the base material, the bioactive having a proton binding site with a non-ionic form and an ionic form, the bioactive being less soluble in water when the proton binding site is in the non-ionic form than when the proton binding site is in the ionic form, wherein at least 5% w/w of the bioactive is present with the proton binding site in the non-ionic form and wherein the bioactive is not an anesthetic. Another embodiment provides such a medical device where the bioactive is an anesthetic and where the device is not a ureteral stent. Another aspect provides method of manufacturing such devices.
摘要翻译：一个实施方案提供了包含基础材料和与基底材料接触的生物活性的医疗装置，所述生物活性物质具有非离子形式和离子形式的质子结合位点，当质子结合位点与质子结合位点处于离子形式相比是非离子形式，其中至少5％w / w的生物活性存在于非离子形式的质子结合位点，并且其中生物活性物质不是麻药。另一个实施方案提供了这样的医疗装置，其中生物活性是麻醉剂，并且其中装置不是输尿管支架。另一方面提供了制造这种装置的方法。

3. 发明申请

US20070282422A1 Medical devices and methods for local delivery of elastin-stabilizing compounds 审中-公开
标题翻译：用于局部递送弹性蛋白稳定化合物的医疗装置和方法
公开(公告)号：US20070282422A1
公开(公告)日：2007-12-06
申请号：US11800217
申请日：2007-05-04
申请人： David Biggs , Anthony Ragheb , Patrick Ruane
发明人： David Biggs , Anthony Ragheb , Patrick Ruane
IPC分类号： A61F2/82 , A61F2/02
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/432 , A61L2300/602
摘要： This invention relates to medical devices and an elastin-stabilizing compound, such as a phenolic tannin, the medical device being adapted to release the elastin-stabilizing compound within a body of a patient. This invention also relates to medical devices and methods of treatment of disease, such as aneurysms and aortic dissection. Medical devices may include coated stents, grafts, stent grafts, balloons and catheters.
摘要翻译：本发明涉及医疗装置和弹性蛋白稳定化合物，例如酚醛单宁，医疗装置适于将弹性蛋白稳定化合物释放到患者体内。本发明还涉及医疗装置和治疗疾病的方法，例如动脉瘤和主动脉夹层。医疗装置可以包括涂覆支架，移植物，支架移植物，气囊和导管。

4. 发明申请

US20070212394A1 Taxane coatings for implantable medical devices 有权
标题翻译：可植入医疗器械的紫杉烷涂层
公开(公告)号：US20070212394A1
公开(公告)日：2007-09-13
申请号：US11715975
申请日：2007-03-08
申请人： Priscilla Reyes , William Moore , Patrick Ruane , Darin Schaeffer
发明人： Priscilla Reyes , William Moore , Patrick Ruane , Darin Schaeffer
IPC分类号： A61K31/337 , A61F2/02
CPC分类号： A61L27/54 , A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91575 , A61F2230/0054 , A61F2250/0067 , A61F2310/0097 , A61K31/337 , A61L29/16 , A61L31/08 , A61L31/16 , A61L2300/416 , A61L2300/606
摘要： This disclosure relates to implantable medical devices coated with a taxane therapeutic agent, such as paclitaxel, in one or more solid form(s) having varying dissolution rates. Particularly preferred coatings comprise amorphous and/or solvated solid forms of taxane therapeutic agents that provide durable coatings that release the taxane over a desired period of time, which can be varied in the absence of a polymer by selecting the type and amount of solid forms of the taxane therapeutic agent in the coating. Other preferred embodiments relate to methods of coating medical devices and methods of treatment. The coatings can provide a sustained release of the taxane therapeutic agent within a body vessel without containing a polymer to achieve the desired rate of paclitaxel elution.
摘要翻译：本公开涉及涂覆有紫杉烷治疗剂（例如紫杉醇）的可植入医疗装置，其具有不同溶解速率的一种或多种固体形式。特别优选的涂层包括紫杉烷治疗剂的无定形和/或溶剂化固体形式，其提供耐久性涂层，其在期望的时间段内释放紫杉烷，其可以在不存在聚合物的情况下变化，通过选择固体形式的类型和量紫杉烷治疗剂在涂层中。其它优选实施方案涉及涂覆医疗装置的方法和治疗方法。涂层可以在体内容器内提供紫杉烷治疗剂的持续释放而不含聚合物以达到期望的紫杉醇洗脱速率。

5. 发明申请

US20070196423A1 Implantable medical device coatings with biodegradable elastomer and releasable therapeutic agent 审中-公开
标题翻译：可植入医疗器械涂层，具有可生物降解的弹性体和可释放的治疗剂
公开(公告)号：US20070196423A1
公开(公告)日：2007-08-23
申请号：US11599850
申请日：2006-11-15
申请人： Patrick Ruane , Waleska Perez-Segarra , Priscilla Reyes
发明人： Patrick Ruane , Waleska Perez-Segarra , Priscilla Reyes
IPC分类号： A61L33/00
CPC分类号： A61L31/16 , A61L31/10 , A61L31/148 , A61L2300/416 , A61L2420/08 , C08L67/04
摘要： A coated medical device, such as a stent, that elutes a therapeutic agent in a controlled manner is provided. The medical device may be coated with a layer of therapeutic agent and a layer of bioabsorbable elastomer over the layer of therapeutic agent. Methods of manufacturing a coated medical device and of coating a medical device are also provided.
摘要翻译：提供了以受控方式洗脱治疗剂的涂覆医疗装置，例如支架。医疗装置可以在治疗剂层上涂覆有治疗剂层和生物可吸收弹性体层。还提供了制造涂覆的医疗装置和涂覆医疗装置的方法。

6. 发明申请

US20070150047A1 Implantable medical device with bioabsorbable coating 有权
标题翻译：具有生物可吸收涂层的植入式医疗器械
公开(公告)号：US20070150047A1
公开(公告)日：2007-06-28
申请号：US11599859
申请日：2006-11-15
申请人： Patrick Ruane , Waleska Perez-Segarra , Anthony Ragheb , Neal Fearnot , William Voorhees , Brian Bates , Thomas Osborne
发明人： Patrick Ruane , Waleska Perez-Segarra , Anthony Ragheb , Neal Fearnot , William Voorhees , Brian Bates , Thomas Osborne
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61F2250/0068 , A61K51/1282 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/146 , A61L31/16 , A61L33/022 , A61L2300/602 , A61L2300/608 , A61L2420/08 , A61N5/1002
摘要： Methods of making coated implantable medical devices are provided. The methods include positioning a first layer comprising a bioactive on at least a portion of a structure, and positioning at least one porous layer over the first layer. The at least one porous layer has a thickness adequate to provide a controlled release of the bioactive.
摘要翻译：提供涂覆的可植入医疗装置的方法。所述方法包括将包含生物活性的第一层定位在结构的至少一部分上，并将至少一个多孔层定位在第一层之上。至少一个多孔层具有足以提供生物活性的受控释放的厚度。

7. 发明申请

US20080081829A1 Medical Device Including an Anesthetic and Method of Preparation Thereof 审中-公开
标题翻译：包括麻醉剂及其制备方法的医疗器械
公开(公告)号：US20080081829A1
公开(公告)日：2008-04-03
申请号：US11862937
申请日：2007-09-27
申请人： Andrew Isch , Patrick Ruane , Waleska Perez-Segarra
发明人： Andrew Isch , Patrick Ruane , Waleska Perez-Segarra
IPC分类号： A61K31/164 , A61K47/04 , A61K47/14
CPC分类号： A61L31/10 , A61L31/024 , A61L31/06 , A61L31/16 , A61L2300/402 , C08L75/04
摘要： Non-metallic implantable medical devices including an anesthetic having a proton binding site with a non-ionic form and an ionic form. At least 5% w/w of the anesthetic is present with the proton binding site in the non-ionic form and the remainder of the anesthetic is present with the proton binding site in the ionic form. Methods of preparing such devices are also provided.
摘要翻译：非金属可植入医疗装置包括具有非离子形式的质子结合位点和离子形式的麻醉剂。以非离子形式存在至少5％w / w的麻醉剂质子结合位点，并且剩余的麻醉剂以离子形式存在质子结合位点。还提供了制备这种装置的方法。

8. 发明申请

US20080020013A1 Methods of manufacturing and modifying taxane coatings for implantable medical devices 有权
标题翻译：制造和修饰可植入医疗器械的紫杉烷涂层的方法
公开(公告)号：US20080020013A1
公开(公告)日：2008-01-24
申请号：US11823283
申请日：2007-06-27
申请人： Priscilla Reyes , William Moore , Randy Myers , Patrick Ruane
发明人： Priscilla Reyes , William Moore , Randy Myers , Patrick Ruane
IPC分类号： A61F2/00 , A61K31/335
CPC分类号： A61K31/335 , A61F2/0095 , A61F2/91 , A61F2250/0067 , A61F2250/0091
摘要： This disclosure relates to endolumenal medical devices coated with a taxane therapeutic agent in one or more solid form(s) having varying dissolution rates. Particularly preferred coatings comprise amorphous paclitaxel, dihydrate paclitaxel, or combinations thereof that provide durable coatings that release paclitaxel over a desired period of time, which can be on the order of hours, days or weeks. Preferred embodiments relate to medical device coatings of paclitaxel, or paclitaxel analogs or derivatives, having one or more polymorph solid forms that provide a prolonged release of paclitaxel within a body vessel without requiring a polymer carrier or barrier layer to achieve the desired rate of paclitaxel elution.
摘要翻译：本公开涉及用一种或多种具有不同溶解速率的固体形式涂覆紫杉烷治疗剂的腔内医疗器械。特别优选的涂层包括无定形紫杉醇，二水合紫杉醇或其组合，其提供耐久性涂层，其在期望的时间段内释放紫杉醇，其可以是数小时，数天或数周的数量级。优选实施方案涉及具有一种或多种多晶型固体形式的紫杉醇或紫杉醇类似物或衍生物的医疗器械涂层，其提供紫杉醇在体内容器内的延长释放，而不需要聚合物载体或阻挡层来实现所需的紫杉醇洗脱速率。

9. 发明申请

US20070299518A1 Device with nanocomposite coating for controlled drug release 审中-公开
标题翻译：具有用于受控药物释放的纳米复合涂层的装置
公开(公告)号：US20070299518A1
公开(公告)日：2007-12-27
申请号：US11698407
申请日：2007-01-26
申请人： Patrick Ruane
发明人： Patrick Ruane
IPC分类号： A61F2/02
CPC分类号： A61L27/34 , A61L27/50 , A61L27/54 , A61L2300/602 , A61L2400/12 , A61L2420/04
摘要： An implantable medical device including a nanocomposite coating deposited on at least a portion of a surface of at least one structural element of the device to provide a controlled release of a bioactive agent in one or more dosages is described. The nanocomposite coating includes a matrix, a bioactive agent and inorganic particles. The inorganic particles respond to a stimulus, preferably by generating heat. The response of the particles to the stimulus causes the matrix of the nanocomposite coating to undergo a volume change by, for example, contracting or swelling, thereby releasing at least a portion of the bioactive agent. A method of providing a controlled release of a bioactive agent from a nanocomposite coating on an implantable medical device is described. A method for providing a nanocomposite coating for the controlled release of a bioactive agent on the implantable medical device is also described.
摘要翻译：描述了一种可植入医疗装置，其包括沉积在装置的至少一个结构元件的表面的至少一部分上以提供一种或多种剂量的生物活性剂的受控释放的纳米复合涂层。纳米复合涂层包括基质，生物活性剂和无机颗粒。无机颗粒对刺激作出反应，优选通过产生热量。颗粒对刺激的反应导致纳米复合涂层的基质通过例如收缩或膨胀而经历体积变化，从而释放至少一部分生物活性剂。描述了从可植入医疗装置上的纳米复合涂层提供生物活性剂的受控释放的方法。还描述了提供用于在可植入医疗装置上控制释放生物活性剂的纳米复合涂层的方法。

10. 发明申请

US20070293937A1 Endoluminal medical device for local delivery of cathepsin inhibitors, method of making and treating 审中-公开
标题翻译：用于组织蛋白酶抑制剂局部递送的腔内医疗装置，制备和治疗方法
公开(公告)号：US20070293937A1
公开(公告)日：2007-12-20
申请号：US11809779
申请日：2007-06-01
申请人： David Biggs , David Grewe , Neal Fearnot , Patrick Ruane , Anthony Ragheb
发明人： David Biggs , David Grewe , Neal Fearnot , Patrick Ruane , Anthony Ragheb
IPC分类号： A61F2/06 , A61K38/00 , A61P9/00
CPC分类号： A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/434 , A61L2300/608
摘要： An endoluminal medical device comprises a drug release system that releases a cathepsin inhibitor at a predetermined location within a lumen of a patient. The endoluminal devices and methods of treatment of disease can treat illnesses such as aneurysms and aortic dissections.
摘要翻译：腔内医疗装置包括药物释放系统，其在组织蛋白酶抑制剂在患者的内腔内的预定位置释放。腔内装置和治疗疾病的方法可以治疗诸如动脉瘤和主动脉夹层的疾病。

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