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    • 5. 发明申请
    • Method of production and use of crotoxin as an analgesic
    • 生产和使用毒素作为镇痛药的方法
    • US20060034823A1
    • 2006-02-16
    • US10917143
    • 2004-08-13
    • Paul ReidZheng Qin
    • Paul ReidZheng Qin
    • A61K38/48A61K31/60
    • A61K38/465A61K31/60C12Y301/01004A61K2300/00
    • Disclosed a pharmaceutical composition including one of crotoxin, mojavetoxin or a related toxin and a carrier for use in the treatment of chronic pain, especially to the treatment of heretofore intractable pain such as that associated with advanced cancer wherein the treatment is independent of the reduction of tumors. The crotoxin is preferably obtained from the snake Crotalus durissus terrificus and the mojavetoxin is obtained from the rattlesnake Crotalus scutulatus scutulatus. Preferably the composition further comprises an effective amount of acetylsalicylic acid whereby the toxin and acetylsalicylic acid together produce a synergistic effect providing enhanced pain relief. The composition of the invention may be delivered in parenteral (i.p.) (intravenous, intramuscular or subcutaneous) applications. Alternatively, the composition may be applied as a topical application. The biological activity of the composition is characterized by its ability to bind to presynaptic and postsynapic receptor sites. This results in an inhibition of aceylcholine release and activity.
    • 本发明公开了一种药物组合物,其中包括一种抗生素,莫霍伊金或相关毒素,以及用于治疗慢性疼痛的载体,特别是治疗与晚期癌症相关的先天难治性疼痛,其中治疗独立于晚期癌症的降低 肿瘤。 该抗氧化蛋白质优选从蛇形龙胆(Crotalus durissus terrificus)中获得,并且鼠尾草毒素是从响尾蛇(Crotalus scutulatus scutulatus)获得的。 优选地,组合物还包含有效量的乙酰水杨酸,由此毒素和乙酰水杨酸一起产生协同效应,提供增强的疼痛缓解。 本发明的组合物可以肠胃外(腹膜内)(静脉内,肌内或皮下)应用递送。 或者,组合物可以作为局部应用施用。 组合物的生物活性的特征在于其与突触前和突触后受体位点结合的能力。 这导致乙酰胆碱释放和活性的抑制。
    • 9. 发明申请
    • FLIP FLASHCARDS
    • US20120052478A1
    • 2012-03-01
    • US13216632
    • 2011-08-24
    • James Paul REID
    • James Paul REID
    • B43L1/02
    • G09B19/22A63F3/02A63F9/0641B42D15/0093G09B1/02
    • A pack or set of four-sided, waterproof flashcards, which facilitates alternating between several subjects such as spelling, math and pattern recognition. One of the two faces of each flashcard is labelled with specific pairings of alpha-numeric characters or specific mathematical symbol pairings, or is substantially blank. Labelled in one of the four corners of the alternate faces of all of the flashcards in the set is a single small shape (for example, an oval shape). The colour of this shape varies, depending upon the information which is labelled on the aforementioned reverse faces of the flashcards. All of the flashcards may display non-permanent information, which can be printed, written or drawn by users onto both faces of the flashcards, with wet or dry erase markers, for many different interrelated learning purposes.
    • 一套或一组四面防水闪卡,有助于在几个主题之间交替,如拼写,数学和图案识别。 每个闪卡的两个面之一标有字母数字字符或特定数学符号配对的特定配对,或基本为空白。 在集合中所有闪卡的交替面的四个角中的一个标记为单个小形状(例如,椭圆形)。 这种形状的颜色根据在闪卡的上述反面上标记的信息而变化。 所有的闪卡可能会显示非永久性信息,用户可以使用湿纸巾或干擦拭标签将用户打印,写入或绘制到两张脸卡上,以获得许多不同相关的学习目的。