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1. 发明授权

US08247181B2 Borrelia diagnostics and screening methods 有权
标题翻译：疏螺旋体诊断和筛选方法
公开(公告)号：US08247181B2
公开(公告)日：2012-08-21
申请号：US12676794
申请日：2008-09-08
申请人： Alan G. Barbour , Philip L. Felgner
发明人： Alan G. Barbour , Philip L. Felgner
IPC分类号： G01N33/53
CPC分类号： G01N33/56911 , C12Q1/689 , G01N33/6893 , G01N2333/20 , G01N2469/20 , Y02A50/57 , Y10T436/143333
摘要： Compositions and methods of detecting Borrelia proteins, nucleic acid sequences encoding these proteins, and subject antibodies to these proteins in a sample are disclosed.
摘要翻译：公开了组合物和方法，其中检测到疏螺旋体蛋白，编码这些蛋白质的核酸序列以及受试者中这些蛋白质的抗体。

2. 发明授权

US07319012B2 Protein arrays and methods and systems for producing the same 有权
标题翻译：蛋白质阵列及其制备方法和系统
公开(公告)号：US07319012B2
公开(公告)日：2008-01-15
申请号：US10159428
申请日：2002-05-29
申请人： Philip L. Felgner , Denise L. Doolan
发明人： Philip L. Felgner , Denise L. Doolan
IPC分类号： G01N33/53 , C12Q1/70 , C12Q1/68 , C40B30/04
CPC分类号： C12N15/1086 , C07K2319/21 , C07K2319/23 , C07K2319/42 , C07K2319/43 , C07K2319/60 , C12N15/10 , C12N15/1093 , C12N15/66 , C40B30/04 , G01N33/6845 , G01N2500/00
摘要： Methods of rapidly generating and analyzing a plurality of polypeptides are disclosed. More specifically, libraries and arrays of polypeptides are assayed in order to determine their individual immunogenic effect. Based on the immunogenic effect of polypeptides, specific subunit vaccines can be developed.
摘要翻译：公开了快速产生和分析多种多肽的方法。更具体地，测定多肽的文库和阵列以确定它们的各自的免疫原性效应。基于多肽的免疫原性作用，可以开发特异性亚单位疫苗。

3. 发明授权

US06433017B1 Amphiphilic polyamine compounds 失效
标题翻译：两亲多胺化合物
公开(公告)号：US06433017B1
公开(公告)日：2002-08-13
申请号：US09796340
申请日：2001-02-28
申请人： Philip L. Felgner , Xiang Gao , Jing Ling
发明人： Philip L. Felgner , Xiang Gao , Jing Ling
IPC分类号： A61K3116
CPC分类号： C07C271/20 , C07C217/22 , C07C237/22 , C07C311/19 , C07C311/64 , Y02P20/55
摘要： In accordance with the present invention, there are provided amphiphilic polyamine compounds and derivatives thereof having the property of promoting transfection of polynucleotides and polypeptides into cells, and formulations comprising said compounds.
摘要翻译：根据本发明，提供具有促进将多核苷酸和多肽转染入细胞的性质的二亲多胺化合物及其衍生物，以及包含所述化合物的制剂。

4. 发明授权

US06413942B1 Methods of delivering a physiologically active polypeptide to a mammal 失效
标题翻译：向哺乳动物递送生理活性多肽的方法
公开(公告)号：US06413942B1
公开(公告)日：2002-07-02
申请号：US09449923
申请日：1999-12-02
申请人： Philip L. Felgner , Jon Asher Wolff , Gary H. Rhodes , Robert Wallace Malone , Dennis A. Carson
发明人： Philip L. Felgner , Jon Asher Wolff , Gary H. Rhodes , Robert Wallace Malone , Dennis A. Carson
IPC分类号： A61N4304
CPC分类号： C07K14/005 , A61K9/1272 , A61K48/00 , C07K14/61 , C12N9/0069 , C12N9/1033 , C12N9/1247 , C12N9/78 , C12N15/87 , C12N2740/16122 , C12Y113/12007
摘要： A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the vertebrate. The method can be used to deliver a therapeutic polypeptide to the cells of the vertebrate, to provide an immune response upon in vivo translation of the polynucleotide, to deliver antisense polynucleotides, to deliver receptors to the cells of the vertebrate, or to provide transitory gene therapy.
摘要翻译：一种用于将分离的多核苷酸递送至脊椎动物细胞内部的方法，包括将分离的多核苷酸间插入脊椎动物的组织中，其中所述多核苷酸被组织的细胞吸收并对其施用治疗效果脊椎动物。该方法可用于将治疗性多肽递送至脊椎动物的细胞，以在多核苷酸的体内翻译中提供免疫应答，递送反义多核苷酸，将受体递送至脊椎动物的细胞，或提供短暂基因治疗。

5. 发明授权

US06387395B1 N-[1, (1-1) -dialkyloxy] - and N- [1, (1-1) -dialkenyloxy]- alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor 失效
标题翻译： N- [1，（1-1） - 二烷氧基] - 和N- [1,1-（1,1-） - 二烯氧基] - 烷-1-基-N，N，N-四取代的铵脂质及其用途
公开(公告)号：US06387395B1
公开(公告)日：2002-05-14
申请号：US08348635
申请日：1994-12-02
申请人： Deborah A. Eppstein , Philip L. Felgner , Thomas R. Gadek , Gordon H. Jones , Richard B. Roman
发明人： Deborah A. Eppstein , Philip L. Felgner , Thomas R. Gadek , Gordon H. Jones , Richard B. Roman
IPC分类号： A61K9127
CPC分类号： C07D453/02 , A61K9/0014 , A61K9/0019 , A61K9/1272 , A61K47/186 , C12N15/88 , Y10S435/829
摘要： This invention relates to compounds of the formula or an optical isomer thereof wherein R1 and R2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R3, R4 and R5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, aralkyl of 7 to 11 carbon atoms, or when two or three of R3, R4, and R5 are taken together to form quinuclidino, piperidino, pyrrolidino, or morpholino; n is 1 to 8; and X is a pharmaceutically acceptable anion.
摘要翻译：本发明涉及式的化合物或其光学异构体，其中R 1和R 2相同或不同，为6至24个碳原子的烷基或烯基; R3，R4和R5相同或不同，为碳原子数为1〜8的烷基，芳基，碳原子数为7〜11的芳烷基，或者当R3，R4，R5中的2个或3个相同时，可以形成奎宁二基，哌啶子基，吡咯烷子基或吗啉代; n为1至8; X是药学上可接受的阴离子。

6. 发明授权

US06348499B1 Amphiphilic polyamide compounds 失效
标题翻译：两亲聚酰胺化合物
公开(公告)号：US06348499B1
公开(公告)日：2002-02-19
申请号：US09448876
申请日：1999-11-24
申请人： Philip L. Felgner , Xiang Gao , Jing Ling
发明人： Philip L. Felgner , Xiang Gao , Jing Ling
IPC分类号： A61K3116
CPC分类号： C07C271/20 , C07C217/22 , C07C237/22 , C07C311/19 , C07C311/64 , Y02P20/55
摘要： Amphiphilic polyamide compounds and derivatives thereof having the property of promoting transfection of polynucleotides and polypeptides into cells, and formulations comprising said compounds.
摘要翻译：具有促进将多核苷酸和多肽转染入细胞的性质的两亲性聚酰胺化合物及其衍生物，以及包含所述化合物的制剂。

7. 发明授权

US4946787A N-(.omega.,(.omega.-1)-dialkyloxy)- and N-(.omega.,(.omega.-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor 失效
标题翻译： N-（ω，（ω-1） - 二烷氧基） - 和N-（ω，（ω-1） - 二烯氧基） - 烷基-1-基-N，N，N-四取代的铵脂质及其用途
公开(公告)号：US4946787A
公开(公告)日：1990-08-07
申请号：US428815
申请日：1989-10-27
申请人： Deborah A. Eppstein , Philip L. Felgner , Thomas R. Gadek , Gordon H. Jones , Richard B. Roman
发明人： Deborah A. Eppstein , Philip L. Felgner , Thomas R. Gadek , Gordon H. Jones , Richard B. Roman
IPC分类号： A61K9/127 , A61K47/18 , C07D453/02 , C12N15/88
CPC分类号： C12N15/88 , A61K47/186 , A61K9/0014 , A61K9/0019 , A61K9/1272 , C07D453/02
摘要： This invention relates to compounds of the formula ##STR1## or an optical isomer thereof wherein R.sup.1 and R.sup.2 are the same or different and are an alkyl or alkenyl group of 6 to 24 carbon atoms; R.sup.3, R.sup.4 and R.sup.5 are the same or different and are alkyl of 1 to 8 carbon atoms, aryl, aralkyl of 7 to 11 carbon atoms, or when two or three of R.sup.3, R.sup.4, and R.sup.5 are taken together to form quinuclidino, piperidino, pyrrolidino, or morpholino; n is 1 to 8; and X is a pharmaceutically acceptable anion.
摘要翻译：本发明涉及式I的化合物或其旋光异构体，其中R 1和R 2相同或不同，为6至24个碳原子的烷基或烯基; R 3，R 4和R 5相同或不同，为碳原子数为1〜8的烷基，芳基，碳原子数为7〜11的芳烷基，或者当R3，R4，R5中的2个或3个为一起形成亚硝酰基，哌啶子基，吡咯烷子基或吗啉代; n为1至8; X是药学上可接受的阴离子。

8. 发明授权

US07470675B2 Methods for treating cancer using interferon-ω-expressing polynucleotides 失效
标题翻译：使用干扰素-ω-表达多核苷酸治疗癌症的方法
公开(公告)号：US07470675B2
公开(公告)日：2008-12-30
申请号：US11709868
申请日：2007-02-23
申请人： Holly Horton , Suezanne Parker , Marston Manthorpe , Philip L. Felgner , Jukka Hartikka
发明人： Holly Horton , Suezanne Parker , Marston Manthorpe , Philip L. Felgner , Jukka Hartikka
IPC分类号： A01K54/04 , A61K37/715
CPC分类号： A61K48/005 , A61K31/7052 , A61K38/00 , A61K38/2013 , A61K48/00 , A61K48/0075 , A61K48/0091 , C07K14/555 , C07K14/56
摘要： The present invention provides a pharmaceutical composition, comprising a non-infectious, non-integrating polynucleotide construct comprising a polynucleotide encoding an interferon ω and one or more cationic compounds. The present invention also provides methods of treating cancer in a mammal, comprising administering into a tissue of the mammal a non-infectious, non-integrating polynucleotide construct comprising a polynucleotide encoding a cytokine. In addition, the present invention also relates to the methodology for selective transfection of malignant cells with polynucleotides expressing therapeutic or prophylactic molecules in intra-cavity tumor bearing mammals. More specifically, the present invention provides a methodology for the suppression of an intra-cavity dissemination of malignant cells, such as intraperitoneal dissemination. Furthermore, the invention relates to compositions and methods to deliver polynucleotides encoding polypeptides to vertebrate cells in vivo, where the composition comprises an aqueous solution of sodium phosphate.
摘要翻译：本发明提供一种药物组合物，其包含非传染性非整合多核苷酸构建体，其包含编码干扰素ω和一种或多种阳离子化合物的多核苷酸。本发明还提供了治疗哺乳动物癌症的方法，包括向哺乳动物的组织施用包含编码细胞因子的多核苷酸的非感染性非整合多核苷酸构建体。此外，本发明还涉及用于在具有腔内肿瘤的哺乳动物中表达治疗或预防分子的多核苷酸选择性转染恶性细胞的方法。更具体地，本发明提供了抑制恶性细胞的腔内传播的方法，例如腹膜内传播。此外，本发明涉及将体内编码多肽的多核苷酸递送至脊椎动物细胞的组合物和方法，其中组合物包含磷酸钠水溶液。

9. 发明授权

US07250404B2 Lipid-mediated polynucleotide administration to deliver a biologically active peptide and to induce a cellular immune response 失效
标题翻译：脂质介导的多核苷酸施用以递送生物活性肽并诱导细胞免疫应答
公开(公告)号：US07250404B2
公开(公告)日：2007-07-31
申请号：US10202858
申请日：2002-07-26
申请人： Philip L Felgner , Jon A Wolff , Gary H Rhodes , Robert Wallace Malone , Dennis A. Carson
发明人： Philip L Felgner , Jon A Wolff , Gary H Rhodes , Robert Wallace Malone , Dennis A. Carson
IPC分类号： A61K48/00 , A61K9/127 , C12N15/88
CPC分类号： C07K14/005 , A61K9/1272 , A61K48/00 , C07K14/61 , C12N9/0069 , C12N9/1033 , C12N9/1247 , C12N9/78 , C12N15/87 , C12N2740/16122 , C12Y113/12007
摘要： A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the vertebrate. The method can be used to deliver a therapeutic polypeptide to the cells of the vertebrate, to provide an immune response upon in vivo translation of the polynucleotide, to deliver antisense polynucleotides, to deliver receptors to the cells of the vertebrate, or to provide transitory gene therapy.
摘要翻译：一种用于将分离的多核苷酸递送至脊椎动物细胞内部的方法，包括将分离的多核苷酸间插入脊椎动物的组织中，其中所述多核苷酸被组织的细胞吸收并对其施用治疗效果脊椎动物。该方法可用于将治疗性多肽递送至脊椎动物的细胞，以在多核苷酸的体内翻译中提供免疫应答，递送反义多核苷酸，将受体递送至脊椎动物的细胞，或提供短暂基因治疗。

10. 发明授权

US06936470B2 Rapid and enzymeless cloning of nucleic acid fragments 失效
标题翻译：快速和无酶克隆的核酸片段
公开(公告)号：US06936470B2
公开(公告)日：2005-08-30
申请号：US10125789
申请日：2002-04-16
申请人： Xiaowu Liang , Andy Teng , Shizhong Chen , Dongyuan Xia , Philip L. Felgner
发明人： Xiaowu Liang , Andy Teng , Shizhong Chen , Dongyuan Xia , Philip L. Felgner
IPC分类号： C12N15/00 , C12N15/10 , C12N15/66 , C12N15/85 , C12P19/34 , C12N15/63 , C12N15/09 , C12N15/87
CPC分类号： C12N15/66 , C07K2319/21 , C07K2319/23 , C07K2319/42 , C07K2319/43 , C07K2319/60 , C12N15/10
摘要： A method for cloning a nucleic acid fragment into a vector by flanking the fragment with first and second adapter sequences, and contacting the fragment with the vector having sequences homologous to the first and second adapter sequences under conditions such that the nucleic acid fragment is incorporated into the vector by homologous recombination in vivo in a host cell. Additionally, a method for selecting for a successful transformation of a vector by a nucleic acid insert. Also, systems for cloning a nucleic acid fragment into a vector without at least one of a restriction enzyme, a ligase, a gyrase, a single stranded DNA binding protein, or other DNA modifying enzymes. Further, a kit for cloning a nucleic acid fragment into a vector.
摘要翻译：一种通过用第一和第二衔接子序列侧接该片段将核酸片段克隆到载体中的方法，并使该片段与具有与第一和第二衔接子序列同源的序列的载体接触，使得将该核酸片段并入载体通过宿主细胞中的体内同源重组。另外，用于通过核酸插入物成功转化载体的方法。而且，用于将核酸片段克隆到载体中而不具有限制酶，连接酶，促旋酶，单链DNA结合蛋白或其它DNA修饰酶中的至少一种的系统。另外，用于将核酸片段克隆入载体的试剂盒。

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