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1. 发明申请

WO2007144001A2 EMBRYO QUALITY ASSESSMENT BASED ON BLASTOMERE DIVISION AND MOVEMENT 审中-公开
标题翻译：基于BLASTOMERE分部和运动的EMBRYO质量评估
公开(公告)号：WO2007144001A2
公开(公告)日：2007-12-21
申请号：PCT/DK2007000291
申请日：2007-06-15
申请人： UNISENSE FERTILITECH AS , RAMSING NIELS B , BERNTSEN JOERGEN
发明人： RAMSING NIELS B , BERNTSEN JOERGEN
IPC分类号： G01N33/68
CPC分类号： C12Q1/02 , A61B17/435 , C12M21/06 , C12M41/46 , C12M41/48 , C12N5/0604 , G01N33/689 , G01N2800/385
摘要： The invention concerns a system and method for determining embryo quality comprising monitoring the embryo for a time period, said time period having a length sufficient to comprise at least one cell division period and at least a part of an inter-division period, and determining the length of the at least one cell division period; and/or ii) determining the extent and/or spatial distribution of cellular or organelle movement during the cell division period; and/or iii) determining duration of an inter-division period; and/or iv) determining the extent and/or spatial distribution of cellular or organelle movement during the inter-division period thereby obtaining an embryo quality measure. Thus, the selection of optimal embryos to be implanted after in vitro fertilization (IVF) is facilitated based on the timing, duration, spatial distribution, and extent of observed cell divisions and associated cellular and organelle movement.
摘要翻译：本发明涉及一种用于确定胚胎质量的系统和方法，包括在一段时间内监测胚胎，所述时间段具有足以包括至少一个细胞分裂期和至少部分分期间的长度，并且确定至少一个细胞分裂期的长度; 和/或ii）确定细胞分裂期间细胞或细胞器运动的程度和/或空间分布; 和/或iii）确定分期间的持续时间; 和/或iv）在分隔期间确定细胞或细胞器运动的程度和/或空间分布，从而获得胚胎质量测量。因此，基于观察到的细胞分裂的时间，持续时间，空间分布和程度以及相关的细胞和细胞器运动，促进在体外受精（IVF）后植入的最佳胚胎的选择。

2. 发明申请

WO2013004239A1 Adaptive embryo selection criteria optimized through iterative customization and collaboration 审中-公开
标题翻译：通过迭代定制和协作优化的自适应胚胎选择标准
公开(公告)号：WO2013004239A1
公开(公告)日：2013-01-10
申请号：PCT/DK2012/050236
申请日：2012-06-29
申请人： UNISENSE FERTILITECH A/S , RAMSING, Niels, B , GUNDERSEN, Jens, K , HILLIGSØE, Karen Marie , BERNTSEN, Jørgen , AGERHOLM, Inge Errebo
发明人： RAMSING, Niels, B , GUNDERSEN, Jens, K , HILLIGSØE, Karen Marie , BERNTSEN, Jørgen , AGERHOLM, Inge Errebo
IPC分类号： G01N33/50 , G06K9/00
CPC分类号： G06F19/34 , A61B17/435 , C12M21/06 , C12M41/46 , C12M41/48 , G16H50/70
摘要： The present invention relates to a system and a method for determining quality criteria in order to select the most viable embryos after in vitro fertilization. The present invention may further be applied for iteratively adapting embryo quality criteria based on new knowledge, historical selection & fertilization data and cooperation between fertility clinics.
摘要翻译：本发明涉及一种用于确定质量标准以在体外受精后选择最可行的胚胎的系统和方法。本发明还可以应用于基于新知识，历史选择和受精数据以及生育诊所之间的合作来迭代地适应胚胎质量标准。

3. 发明申请

WO2009003487A2 A DEVICE, A SYSTEM AND A METHOD FOR MONITORING AND/OR CULTURING OF MICROSCOPIC OBJECTS 审中-公开
标题翻译：用于监视和/或培养微观物体的装置，系统和方法
公开(公告)号：WO2009003487A2
公开(公告)日：2009-01-08
申请号：PCT/DK2008/050162
申请日：2008-06-27
申请人： UNISENSE FERTILITECH A/S , RAMSING, Niels B. , BERNTSEN, Jørgen , GUNDERSEN, Jens K. , PLOUGSGAARD, Holger Søe
发明人： RAMSING, Niels B. , BERNTSEN, Jørgen , GUNDERSEN, Jens K. , PLOUGSGAARD, Holger Søe
IPC分类号： C12M1/20 , C12M1/22
CPC分类号： G01N33/5005 , C12M21/06 , C12M23/12 , C12M23/50 , C12M41/12
摘要： The present invention relates to a device, a system and a method for performing monitoring and/or cultivation of microscopic objects. Microscopic objects are in particular microscopic organisms like bacteria and cell cultures, such as cultivation objects like tissue samples and embryos, providing optimal and safe cultivation conditions for incubation during embryo development and for facilitating the selection of optimal embryos to be used in in vitro fertilization (IVF) by facilitating embryo handling for automated digital imaging and time-lapse microscopy.
摘要翻译：用于执行微观物体的监测和/或培养的装置，系统和方法技术领域本发明涉及用于执行微观物体的监测和/或培养的装置，系统和方法。微观物体特别是微生物，如细菌和细胞培养物，如组织样品和胚胎等培养物，为胚胎发育期间的孵化提供最佳和安全的培养条件，并促进选择最佳胚胎用于体外受精（ IVF）通过促进自动化数字成像和时间推移显微镜的胚胎处理。

4. 发明申请

WO2004113563A2 PROBES, LIBRARIES AND KITS FOR ANALYSIS OF MIXTURES OF NUCLEIC ACIDS AND METHODS FOR CONSTRUCTING THE SAME 审中-公开
标题翻译：用于分析核酸混合物的探针，图书馆和工具箱及其构造方法
公开(公告)号：WO2004113563A2
公开(公告)日：2004-12-29
申请号：PCT/DK2004/000429
申请日：2004-06-18
申请人： EXIQON A/S , RAMSING, Niels, B. , MOURITZEN, Peter , ECHWALD, Søren, Morgenthaler , TOLSTRUP, Niels
发明人： RAMSING, Niels, B. , MOURITZEN, Peter , ECHWALD, Søren, Morgenthaler , TOLSTRUP, Niels
IPC分类号： C12Q1/68
CPC分类号： C40B50/02 , C12Q1/6837 , C12Q1/6851 , G06F19/20
摘要： The invention relates to nucleic acid probes, nucleic acid probe libraries, and kits for detecting, classifying, or quantitating components in a complex mixture of nucleic acids, such as a transcriptome, and methods of using the same. The invention also relates to methods of identifying nucleic acid probes useful in the probe libraries and to methods of identifying a means for detection of a given nucleic acid.
摘要翻译：本发明涉及核酸探针，核酸探针文库和用于检测，分类或定量核酸复合物如转录组的组分的试剂盒及其使用方法。本发明还涉及鉴定在探针文库中有用的核酸探针的方法以及鉴定用于检测给定核酸的手段的方法。

5. 发明申请

WO2013029625A1 APPARATUS FOR MEASURING THE METABOLIC RATE OF MOTILE ORGANISMS 审中-公开
标题翻译：用于测量机体代谢率的装置
公开(公告)号：WO2013029625A1
公开(公告)日：2013-03-07
申请号：PCT/DK2012/050318
申请日：2012-08-29
申请人： UNISENSE RESPIROMETRY A/S , RAMSING, Niels B. , GUNDERSEN, Jens K. , PETERSEN, Bjørn Molt
发明人： RAMSING, Niels B. , GUNDERSEN, Jens K. , PETERSEN, Bjørn Molt
IPC分类号： G01N33/48 , C12M1/34 , C12Q1/02 , A61B10/00
CPC分类号： G01N33/5097 , G01N33/5005
摘要： The present invention relates to an apparatus and a method for measuring the metabolic rate of motile organisms, such as sperm cells or some forms of plankton. One embodiment of the invention discloses an apparatus for measurement of the metabolic rate of motile organisms in a medium comprising at least one compartment capable of accommodating at least a part of the medium, one or more capillary tubes in fluid communication with said compartment, and at least one metabolite detector for measuring the concentration of metabolite inside the compartment. One embodiment of the invention relates to measurement of the oxygen consumption of sperm cells, thereby obtaining a semen quality parameter.
摘要翻译：本发明涉及一种用于测量运动生物体如精子细胞或某些形式的浮游生物的代谢率的装置和方法。本发明的一个实施方案公开了一种用于测量培养基中活动生物体的代谢率的装置，包括至少一个能容纳介质的至少一部分的隔室，一个或多个与所述室流体连通的毛细管，以及至少一种用于测量隔室内代谢物浓度的代谢物检测器。本发明的一个实施方案涉及测量精子细胞的耗氧量，从而获得精液质量参数。

6. 发明申请

WO2010003423A3 ONE TO ONE IDENTIFICATION SYSTEM 审中-公开
标题翻译：一对一的身份识别系统
公开(公告)号：WO2010003423A3
公开(公告)日：2010-08-12
申请号：PCT/DK2009050162
申请日：2009-07-03
申请人： UNISENSE FERTILITECH AS , RAMSING NIELS B , BERNTSEN JOERGEN , GUNDERSEN JENS K , PLOUGSGAARD HOLGER SOEE
发明人： RAMSING NIELS B , BERNTSEN JOERGEN , GUNDERSEN JENS K , PLOUGSGAARD HOLGER SOEE
IPC分类号： C12M1/18
CPC分类号： C12N5/0604 , C12M21/06 , C12M23/12 , C12M41/12 , C12M41/26 , C12M41/36 , C12M41/46
摘要： The present invention relates to a system arranged for assisting secure handling of cells in order to minimize the risk of handling mistakes resulting in mix-up of cell samples. The system allows for one to one identification of cells during a whole culturing period. This is obtained by providing a culturing system with loading/exit control means which ensures that only one device is capable of being loaded/removed at a time.
摘要翻译：本发明涉及一种用于辅助安全处理细胞的系统，以便最小化处理导致细胞样本混淆的错误的风险。该系统允许在整个培养期间一对一鉴别细胞。这是通过提供具有加载/退出控制装置的培养系统来获得的，该加载/退出控制装置确保一次只能装载/移除一个装置。

7. 发明申请

WO2009003487A3 A DEVICE, A SYSTEM AND A METHOD FOR MONITORING AND/OR CULTURING OF MICROSCOPIC OBJECTS 审中-公开
标题翻译：用于监测和/或培养微观物体的装置，系统和方法
公开(公告)号：WO2009003487A3
公开(公告)日：2009-05-07
申请号：PCT/DK2008050162
申请日：2008-06-27
申请人： UNISENSE FERTILITECH AS , RAMSING NIELS B , BERNTSEN JOERGEN , GUNDERSEN JENS K , PLOUGSGAARD HOLGER SOEE
发明人： RAMSING NIELS B , BERNTSEN JOERGEN , GUNDERSEN JENS K , PLOUGSGAARD HOLGER SOEE
IPC分类号： C12M3/00
CPC分类号： G01N33/5005 , C12M21/06 , C12M23/12 , C12M23/50 , C12M41/12
摘要： The present invention relates to a device, a system and a method for performing monitoring and/or cultivation of microscopic objects. Microscopic objects are in particular microscopic organisms like bacteria and cell cultures, such as cultivation objects like tissue samples and embryos, providing optimal and safe cultivation conditions for incubation during embryo development and for facilitating the selection of optimal embryos to be used in in vitro fertilization (IVF) by facilitating embryo handling for automated digital imaging and time-lapse microscopy.
摘要翻译：本发明涉及一种用于执行微观物体的监测和/或培养的装置，系统和方法。显微镜物体特别是微生物如细菌和细胞培养物，如培养对象，如组织样本和胚胎，为胚胎发育期间的孵育提供最佳和安全的培养条件，并促进选择用于体外受精的最佳胚胎（ IVF）通过促进自动数字成像和延时显微镜的胚胎处理。

8. 发明申请

WO2007144001A3 EMBRYO QUALITY ASSESSMENT BASED ON BLASTOMERE DIVISION AND MOVEMENT 审中-公开
公开(公告)号：WO2007144001A3
公开(公告)日：2007-12-21
申请号：PCT/DK2007/000291
申请日：2007-06-15
申请人： UNISENSE FERTILITECH A/S , RAMSING, Niels, B. , BERNTSEN, Jørgen
发明人： RAMSING, Niels, B. , BERNTSEN, Jørgen
IPC分类号： C12N5/06 , G01N33/68
摘要： The invention concerns a system and method for determining embryo quality comprising monitoring the embryo for a time period, said time period having a length sufficient to comprise at least one cell division period and at least a part of an inter-division period, and determining the length of the at least one cell division period; and/or ii) determining the extent and/or spatial distribution of cellular or organelle movement during the cell division period; and/or iii) determining duration of an inter-division period; and/or iv) determining the extent and/or spatial distribution of cellular or organelle movement during the inter-division period thereby obtaining an embryo quality measure. Thus, the selection of optimal embryos to be implanted after in vitro fertilization (IVF) is facilitated based on the timing, duration, spatial distribution, and extent of observed cell divisions and associated cellular and organelle movement.

9. 发明申请

WO2004056265A3 DEVICE AND METHOD FOR NON-INVASIVE MEASUREMENT OF THE INDIVIDUAL METABOLIC RATE OF A SUBSTANTIALLY SPHERICAL METABOLIZING PARTICLE 审中-公开
标题翻译：非特异性代谢物代谢特征的个体代谢率的非侵入性测量的装置和方法
公开(公告)号：WO2004056265A3
公开(公告)日：2004-08-12
申请号：PCT/DK0300935
申请日：2003-12-23
申请人： UNISENSE AS , OTTOSEN LARS DITLEV MORCK , RAMSING NIELS B , DAMGAARD LARS R , GUNDERSEN JENS K
发明人： OTTOSEN LARS DITLEV MORCK , RAMSING NIELS B , DAMGAARD LARS R , GUNDERSEN JENS K
IPC分类号： A61B5/00 , A61B5/083 , C12N5/06 , C12N5/12 , G01N33/497 , G01N33/50
CPC分类号： C12M21/06 , C12M41/34 , C12M41/46 , G01N33/5038 , G01N33/5088 , G01N33/5091
摘要： The present invention relates to methods and devices for non-invasive and non-disturbing measurements of metabolizing rates of substantially spherical metabolizing particles, such as an embryo, and to a method and device of controlling oxygen partial pressure at the level of the embryo. Furthermore, the invention relates to a method for regulating supply of metabolites to a substantially spherical metabolizing particle, as well as a method for selecting substantially spherical metabolizing particles of a predetermined quality. The invention is carried out in a device capable of establishing a diffusion gradient of metabolites between the substantially spherical metabolizing particle inside a compartment in the device and the environment outside the compartment. The metabolizing rate is determined based on information of the metabolite diffusion gradient.
摘要翻译：本发明涉及用于非侵入性和非干扰性测量基本上球形代谢颗粒如胚胎的代谢速率的方法和装置，以及控制胚胎水平的氧分压的方法和装置。此外，本发明涉及一种用于调节向基本上球形的代谢颗粒的代谢物供应的方法，以及用于选择具有预定质量的基本上球形的代谢颗粒的方法。本发明在能够在装置中的隔室内的基本上球形的代谢颗粒与隔室外的环境之间建立代谢物的扩散梯度的装置中进行。代谢率根据代谢物扩散梯度的信息确定。

10. 发明申请

WO2012163363A1 EMBRYO QUALITY ASSESSMENT BASED ON BLASTOMERE CLEAVAGE AND MORPHOLOGY 审中-公开
标题翻译：基于BLASTOMERE CLEAVAGE和MORPHOLOGY的EMBRYO质量评估
公开(公告)号：WO2012163363A1
公开(公告)日：2012-12-06
申请号：PCT/DK2012/050188
申请日：2012-05-31
申请人： UNISENSE FERTILITECH A/S , RAMSING, Niels B , HILLIGSØE, Karen Marie , ESCRIVÁ, Marcos Meseguer
发明人： RAMSING, Niels B , HILLIGSØE, Karen Marie , ESCRIVÁ, Marcos Meseguer
IPC分类号： C12N5/073 , G06K9/00 , G01N3/50
CPC分类号： G01N33/5005 , G06K9/0014 , G06T7/0016 , G06T2207/10016 , G06T2207/10056 , G06T2207/20224 , G06T2207/30044
摘要： The present invention relates to a method and to a system for selecting embryos for in vitro fertilization based on the timing, and duration of observed cell cleavages and associated cell morphology. One embodiment of the invention relates to a method for determining embryo quality comprising monitoring the embryo for a time period, and determining one or more quality criteria for said embryo, wherein said one or more quality criteria is based on the extent of irregularity of the timing of cell divisions when the embryo develops from four to eight blastomeres, and/or wherein said one or more quality criteria is based on determining the time of cleavage to a five blastomere embryo (t5) and wherein t5 is between 48.7 hours and 55.6 hours, and/or wherein said one or more quality criteria is based on the ratio of two time intervals, each of said two time intervals determined as the duration of a time period between two morphological events in the embryo development from fertilization to eight blastomeres, and based on said one or more quality criteria determining the embryo quality.
摘要翻译：本发明涉及一种用于基于观察到的细胞切割的时间和持续时间以及相关细胞形态来选择用于体外受精的胚胎的方法和系统。本发明的一个实施方案涉及一种用于确定胚胎质量的方法，其包括在一段时间内监测胚胎，以及确定所述胚胎的一个或多个质量标准，其中所述一个或多个质量标准基于时间的不规则程度当胚胎从四个卵裂球发展到八个卵裂球时，和/或其中所述一个或多个质量标准基于确定切割到五个卵裂球胚胎的时间（t5），并且其中t5在48.7小时至55.6小时之间，和/或其中所述一个或多个质量标准是基于两个时间间隔的比率，所述两个时间间隔中的每一个被确定为从受精到八个卵裂球的胚胎发育中的两个形态事件之间的时间段的持续时间关于确定胚胎质量的一个或多个质量标准。

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