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1. 发明授权

US08646304B2 Grain bin floor panel 有权
标题翻译：谷仓地板面板
公开(公告)号：US08646304B2
公开(公告)日：2014-02-11
申请号：US13037456
申请日：2011-03-01
申请人： Johnny Richard Friesen , Peter W. Friesen
发明人： Johnny Richard Friesen , Peter W. Friesen
IPC分类号： B21D31/00 , B21B15/00
CPC分类号： B21D5/086 , B21D47/01 , B65D88/68 , B65D90/585 , B65D90/66
摘要： In a grain bin floor panel having first and second floor surface extending outwardly from a central support leg to respective first and second side support legs, the central support leg includes first and second upright portions and a lower portion connected between respective lower ends of the first and second upright portion. The first and second upright portions are connected to respective ones of the first and second floor surfaces at the upper ends of the upright portions and are spaced apart from one another at respective lower ends. The lower portion is generally concave such that the lower ends of the first and second upright portions together with the lower portion forms a concave quadrilateral.
摘要翻译：在具有从中央支撑腿向相对于相应的第一和第二侧支撑腿向外延伸的第一和第二底面的粮仓地板面板中，中央支撑腿包括第一和第二直立部分以及连接在第一和第二支撑腿的相应下端之间的下部分和第二直立部分。第一和第二直立部分在直立部分的上端处连接到第一和第二底板表面中的相应的一个，并且在相应的下端处彼此间隔开。下部通常是凹形的，使得第一和第二直立部分的下端与下部形成凹入的四边形。

2. 发明授权

US07960409B2 Pharmaceutical phenylquinoline and chromen-2-one triazole compounds 失效
标题翻译：药用苯基喹啉和色烯-2-酮三唑化合物
公开(公告)号：US07960409B2
公开(公告)日：2011-06-14
申请号：US12012246
申请日：2008-02-01
申请人： Erich L. Grimm , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Helene Juteau , Sebastien Laliberte , Bruce MacKay , Yves Gareau
发明人： Erich L. Grimm , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Helene Juteau , Sebastien Laliberte , Bruce MacKay , Yves Gareau
IPC分类号： A61K31/47 , A61K31/4192 , C07D487/04 , C07D401/06
CPC分类号： C07D401/06 , C07D401/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The instant invention provides compounds of Formula I which are leukotriene biosynthesis inhibitors. Compounds of Formula I are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.
摘要翻译：本发明提供了作为白三烯生物合成抑制剂的式I化合物。式I的化合物可用作抗动脉粥样硬化，抗哮喘，抗过敏，抗炎和细胞保护剂。

3. 发明申请

US20070208017A1 2-(Phenyl or heterocyclic)-1H-phenantrho[9,10-d]imidazoles as mPGES-1 inhibitors 有权
标题翻译：作为mPGES-1抑制剂的2-（苯基或杂环）-1H-苯并[9,10-d]咪唑
公开(公告)号：US20070208017A1
公开(公告)日：2007-09-06
申请号：US11374288
申请日：2005-11-23
申请人： Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Tom Wu
发明人： Anh Chau , Bernard Cote , Yves Ducharme , Richard Frenette , Richard Friesen , Marc Gagnon , Andre Giroux , Evelyn Martins , Hongping Yu , Tom Wu
IPC分类号： A61K31/5377 , A61K31/4439 , A61K31/4245 , A61K31/4188 , C07D403/14 , C07D413/14
CPC分类号： C07D235/02 , C07D235/18 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/04 , C07D413/06
摘要： The invention encompasses novel compounds of Formula I or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.
摘要翻译：本发明包括式I的新化合物或其药学上可接受的盐。这些化合物是微粒体前列腺素E合酶-1（mPGES-1）酶的抑制剂，因此可用于治疗各种疾病或病症如骨关节炎，类风湿性关节炎和急性或慢性疼痛的疼痛和/或炎症。还包括治疗由mPGES-1酶和药物组合物介导的疾病或病症的方法。

4. 发明申请

US20060265319A1 User interface for an electronic trading system 有权
公开(公告)号：US20060265319A1
公开(公告)日：2006-11-23
申请号：US11417546
申请日：2006-05-03
申请人： Richard Friesen , Peter Hart
发明人： Richard Friesen , Peter Hart
IPC分类号： G06Q40/00
CPC分类号： G06Q40/04 , G06Q20/10 , G06Q30/08 , G06Q40/00 , G06Q40/06
摘要： A user interface for an electronic trading exchange is provided which allows a remote trader to view in real time bid orders, offer orders, and trades for an item, and optionally one or more sources of contextual data. Individual traders place orders on remote client terminals, and this information is routed to a transaction server. The transaction server receives order information from the remote terminals, matches a bid for an item to an offer for an item responsive to the bid corresponding with the offer, and communicates outstanding bid and offer information, and additional information (such as trades and contextual data) back to the client terminals. Each client terminal displays all of the outstanding bids and offers for an item, allowing the trader to view trends in orders for an item. A priority view is provided in which orders are displayed as tokens at locations corresponding to the values of the orders. The size of the tokens reflects the quantity of the orders. An alternate view positions order icons at a location which reflects the value and quantity of the order. Additionally, contextual data for the item is also displayed to allow the trader to consider as much information as possible while making transaction decisions. A pit panel view is also provided in which traders connected to the pit are represented by icons, and are displayed corresponding to an activity level of the trader.

5. 发明申请

US20060259410A1 User interface for semi-fungible trading 有权
标题翻译：用于半互换交易的用户界面
公开(公告)号：US20060259410A1
公开(公告)日：2006-11-16
申请号：US11417881
申请日：2006-05-03
申请人： Richard Friesen , Mark Klizas
发明人： Richard Friesen , Mark Klizas
IPC分类号： G06Q40/00
CPC分类号： G06Q40/04 , G06Q20/10 , G06Q40/00 , G06Q40/06
摘要： A user interface and method are disclosed for providing trading between a plurality of semi-fungible and non-fungible goods. A plurality of book axes are displayed in a single interface, each book axis representing a market for a particular good Orders for goods are displayed as marks on the axes to display the relative value of the orders. A value axis is provided that relates the value of the goods from each market to each other. Thus, a single interface provides the means to relate the values of different semi-fungible goods. The value axis may be displayed in units of price, or a custom value designated by a user or pre-defined by the interface. Quantity information is represented in the interface through the display of a dimension of an order icon. Precise information about each order is displayed either in a panel view or a pop-up window.
摘要翻译：公开了用于提供多个半可替换和不可替代商品之间的交易的用户界面和方法。在单个界面中显示多个书籍轴，每个书籍轴表示特定商品的市场，商品订单在轴上显示为标记以显示订单的相对值。提供了一个价值轴，其将来自每个市场的货物的价值相互关联。因此，单一界面提供了将不同的半可替代商品的价值联系起来的手段。价值轴可以以价格或由用户指定或由界面预定义的自定义值来显示。数量信息通过显示订单图标的维度在界面中表示。关于每个订单的精确信息显示在面板视图或弹出窗口中。

6. 发明申请

US20060116406A1 7-(1,3-thiazol-2-yl)thio!-coumarin derivatives and their use as leukotriene biosynthesis inhibitors 失效
标题翻译： 7-（1,3-噻唑-2-基）硫代香豆素衍生物及其作为白三烯生物合成抑制剂的用途
公开(公告)号：US20060116406A1
公开(公告)日：2006-06-01
申请号：US10559885
申请日：2004-06-08
申请人： Yves Gareau , Helene Juteau , D. Bruce MacKay , Richard Friesen , Erich Grimm , Marc Blouin , Sebastien Laliberte
发明人： Yves Gareau , Helene Juteau , D. Bruce MacKay , Richard Friesen , Erich Grimm , Marc Blouin , Sebastien Laliberte
IPC分类号： A61K31/426 , C07D277/00 , A01N43/78
CPC分类号： C07D417/12 , C07D277/36 , C07D417/14
摘要： The instant invention provides compounds of Formula (I) which are leukotriene biosynthesis inhibitors. Compounds of formula (I) are useful as anti-asthmatic, anti-allergic, anti-inflammatory, cytoprotective and anti-artherosclerotic agents.
摘要翻译：本发明提供了作为白三烯生物合成抑制剂的式（I）化合物。式（I）化合物可用作抗哮喘，抗过敏，抗炎，细胞保护和抗动脉粥样硬化剂。

7. 发明申请

US20050289042A1 Auction merger system 审中-公开
标题翻译：拍卖合并制度
公开(公告)号：US20050289042A1
公开(公告)日：2005-12-29
申请号：US10877236
申请日：2004-06-24
申请人： Richard Friesen
发明人： Richard Friesen
IPC分类号： G06Q30/00 , G06F17/60
CPC分类号： G06Q30/08 , G06Q40/04
摘要： Methods and apparatus for creating and displaying a market for auctions. Many users who are connected by a network may participate in a number of different types of simultaneous auctions using a computer or some other terminal or other appliance.
摘要翻译：用于创建和展示拍卖市场的方法和设备。通过网络连接的许多用户可以使用计算机或其他终端或其他设备参与许多不同类型的同步拍卖。

8. 发明授权

US06812346B2 Substituted pyridines as selective cyclooxygenase-2 inhibitors 失效
标题翻译：取代的吡啶作为选择性环氧合酶-2抑制剂
公开(公告)号：US06812346B2
公开(公告)日：2004-11-02
申请号：US10395788
申请日：2003-03-24
申请人： Daniel Dube , Rejean Fortin , Richard Friesen
发明人： Daniel Dube , Rejean Fortin , Richard Friesen
IPC分类号： C07D21322
CPC分类号： C07D213/75 , C07D213/34 , C07D213/61 , C07D213/65 , C07D213/80 , C07D213/85 , C07D213/89
摘要： The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.
摘要翻译：本发明包括式I的新化合物以及治疗COX-2介导的疾病的方法，包括向需要这种治疗无需治疗有效量的式I化合物的患者施用。本发明还包括用于治疗包含式I化合物的COX-2介导的疾病的某些药物组合物。

9. 发明授权

US6114132A Prosphatase binding assay 失效
标题翻译： Prosphatase结合测定
公开(公告)号：US6114132A
公开(公告)日：2000-09-05
申请号：US964313
申请日：1997-11-04
申请人： Sylvie Desmarais , Michael Gresser , Richard Friesen , Brian Kennedy , Don Nicholson , Kathryn Skorey , Chidambaran Ramachandran , Anthony Ford-Hutchinson
发明人： Sylvie Desmarais , Michael Gresser , Richard Friesen , Brian Kennedy , Don Nicholson , Kathryn Skorey , Chidambaran Ramachandran , Anthony Ford-Hutchinson
IPC分类号： G01N33/573 , C07K5/08 , C07K5/083 , C07K5/087 , C07K5/09 , C07K5/093 , C07K5/097 , C12N11/00 , C12N15/09 , C12Q1/34 , C12Q1/37 , C12Q1/42 , C12Q1/48 , C12N9/96
CPC分类号： G01N33/573 , C07K5/0827 , C12Q1/34 , C12Q1/37 , C12Q1/42 , G01N2333/96466
摘要： Disclosed is a binding assay for proteases and phosphatases, which contain cysteine in their binding sites or as a necessary structural component for enzymatic binding. The sulfhydryl group of cysteine is the nucleophilic group in the enzyme's mechanistic proteolytic and hydrolytic properties. The assay can be used to determine the ability of new, unknown ligands and mixtures of compounds to competitively bind with the enzyme versus a known binding agent for the enzyme, e.g., a known enzyme inhibitor. By the use of a mutant form of the natural or native wild-type enzyme, in which serine, or another amino acid, e.g., alanine, replaces cysteine, the problem of interference from extraneous oxidizing and alkylating agents in the assay procedure is overcome. The interference arises because of oxidation or alkylation of the sulfhydryl, --SH (or --S.sup.-), in the cysteine, which then adversely affects the binding ability of the enzyme. Specifically disclosed is an assay for tyrosine phosphatases and cysteine proteases, including caspases and cathepsins, e.g., Cathepsin K(O2), utilizing scintillation proximity assay (SPA) technology. The assay has important applications in the discovery of compounds for the treatment and study of, for example, diabetes, immunosuppression, cancer, Alzheimer's disease and osteoporosis. The novel feature of the use of a mutant enzyme can be extended to its use in a wide variety of conventional colorimetric, photometric, spectrophotometric, radioimmunoassay and ligand-binding competitive assays.
摘要翻译：公开了蛋白酶和磷酸酶的结合测定法，其在其结合位点含有半胱氨酸或作为酶结合的必需结构组分。半胱氨酸的巯基是酶的机理蛋白水解和水解性质中的亲核基团。该测定法可用于测定新的未知配体和化合物的混合物与酶竞争性结合的能力，与酶的已知结合剂，例如已知的酶抑制剂。通过使用天然或天然野生型酶的突变形式，其中丝氨酸或另一氨基酸例如丙氨酸取代半胱氨酸，克服了测定程序中来自外来氧化和烷化剂的干扰问题。干扰是由于半胱氨酸中巯基-SH（或-S-）的氧化或烷基化而产生的，其然后不利地影响酶的结合能力。具体公开的是利用闪烁近邻测定（SPA）技术的酪氨酸磷酸酶和半胱氨酸蛋白酶的测定法，包括胱天蛋白酶和组织蛋白酶，例如组织蛋白酶K（O 2）。该测定在发现用于治疗和研究例如糖尿病，免疫抑制，癌症，阿尔茨海默氏病和骨质疏松症的化合物中具有重要应用。使用突变酶的新颖特征可以扩展到其在各种常规比色，光度，分光光度，放射免疫测定和配体结合竞争性测定中的用途。

10. 发明授权

US6001843A Substituted pyridines as selective cyclooxygenase-2 inhibitors 有权
公开(公告)号：US6001843A
公开(公告)日：1999-12-14
申请号：US181887
申请日：1998-10-29
申请人： Daniel Dube , Rejean Fortin , Richard Friesen , Zhaoyin Wang , Jacques Yves Gauthier
发明人： Daniel Dube , Rejean Fortin , Richard Friesen , Zhaoyin Wang , Jacques Yves Gauthier
IPC分类号： A61K31/44 , A61K31/444 , A61K31/655 , C07D213/04 , C07D213/22 , C07D213/26 , C07D213/34 , C07D213/36 , C07D213/44 , C07D213/54 , C07D213/61 , C07D213/65 , C07D213/75 , C07D213/80 , C07D213/85 , C07D213/89 , A61K31/535 , C07D211/70 , C07D211/72 , C07D211/78
CPC分类号： C07D213/75 , C07D213/34 , C07D213/61 , C07D213/65 , C07D213/80 , C07D213/85 , C07D213/89
摘要： The invention encompasses the novel compound of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. The invention also encompasses certain pharmaceutical compositions for treatment of COX-2 mediated diseases comprising compounds of Formula I.

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