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1. 发明授权

US08473076B2 Lead for stimulating the baroreceptors in the pulmonary artery 有权
标题翻译：用于刺激肺动脉中的压力感受器的铅
公开(公告)号：US08473076B2
公开(公告)日：2013-06-25
申请号：US13225769
申请日：2011-09-06
申请人： Imad Libbus , Ronald W. Heil, Jr. , Avram Scheiner
发明人： Imad Libbus , Ronald W. Heil, Jr. , Avram Scheiner
IPC分类号： A61N1/05 , A61N1/04
CPC分类号： A61N1/0476 , A61N1/05 , A61N1/056 , A61N1/057 , A61N1/36117
摘要： An apparatus includes a flexible lead body extending from a proximal end to a distal end, an expandable electrode coupled proximate the distal end, the expandable electrode having an expanded diameter dimensioned to abut a wall of a pulmonary artery, and an implantable pulse generator electrically coupled to the expandable electrode. The expandable electrode includes a plurality of electrode zones. The plurality of zones can be tested to determine which zone delivers the best baroreflex response. At least one of the electrode zones can be selected to deliver a stimulation signal based on the testing. The implantable pulse generator is adapted to deliver a baroreflex stimulation signal to a baroreceptor in the pulmonary artery via the electrode.
摘要翻译：一种装置包括从近端延伸到远端的柔性引线主体，靠近远端连接的可扩张电极，所述可扩张电极具有尺寸设计成邻接肺动脉壁的扩张直径，以及电耦合的可植入脉冲发生器到可膨胀电极。可膨胀电极包括多个电极区。可以测试多个区域以确定哪个区域提供最佳的压力反射响应。可以选择至少一个电极区域以基于测试传递刺激信号。可植入脉冲发生器适于通过电极将压力反射刺激信号传递给肺动脉中的压力感受器。

2. 发明授权

US08160721B2 Implantable lead with flexible tip features 有权
标题翻译：可植入导线，具有灵活的尖端特征
公开(公告)号：US08160721B2
公开(公告)日：2012-04-17
申请号：US12508322
申请日：2009-07-23
申请人： Daniel J. Cooke , Leslie J. Carion , Shrojalkumar Desai , Brendan E. Koop , Ronald W. Heil, Jr. , Harshad M. Borgaonkar , Matthew S. Finlay
发明人： Daniel J. Cooke , Leslie J. Carion , Shrojalkumar Desai , Brendan E. Koop , Ronald W. Heil, Jr. , Harshad M. Borgaonkar , Matthew S. Finlay
IPC分类号： A61N1/00
CPC分类号： A61N1/057 , A61N1/0568
摘要： A medical electrical lead comprises a flexible, elongate lead body extending along a longitudinal axis and having a proximal end and a distal end. A protective distal tip structure is disposed on the distal end of the lead body. The tip structure includes a plurality of compliant projections each extending distally from the distal end of the body in the direction of the longitudinal axis. The projections are configured to contact and bear against cardiac tissue when the lead is implanted, and are deformable under the action of an axially or radially directed force. The projections optionally include a coating over a substrate. The coating can include a hydrogel material and/or a pharmaceutical agent such as a steroid for reducing inflammation at the implantation site.
摘要翻译：医疗电引线包括沿着纵向轴线延伸并且具有近端和远端的柔性细长引线体。保护性的顶端结构设置在引线体的远端。尖端结构包括多个顺从突起，每个突起从纵向轴线的方向远离主体的远端延伸。突起被配置为当铅被植入时与心脏组织接触并承受，并且在轴向或径向力的作用下可变形。突起任选地包括在基底上的涂层。涂层可以包括水凝胶材料和/或药剂，例如类固醇，用于在植入部位减少炎症。

3. 发明授权

US08131364B2 Sensors having protective eluting coating and method therefor 有权
标题翻译：具有保护性洗脱涂层的传感器及其方法
公开(公告)号：US08131364B2
公开(公告)日：2012-03-06
申请号：US12984161
申请日：2011-01-04
申请人： Qingsheng Zhu , Ronald W. Heil, Jr. , Mudit Jain
发明人： Qingsheng Zhu , Ronald W. Heil, Jr. , Mudit Jain
IPC分类号： A61N1/00
CPC分类号： A61B5/14546 , A61B5/14532 , A61N1/0568
摘要： An apparatus includes an implantable device, such as a chronically implantable device that has a device body. One or more chemical sensors are coupled with the device body. A drug eluting substance is disposed at a location including at least one of on, directly adjacent, or near the one or more chemical sensors, where the drug eluting substance prevents fibrotic growth on the one or more chemical sensors.
摘要翻译：一种装置包括可植入装置，例如具有装置主体的长期可植入装置。一个或多个化学传感器与装置本体结合。药物洗脱物质被布置在包括一个或多个化学传感器中的至少一个，直接相邻或接近的位置，其中药物洗脱物质防止在一个或多个化学传感器上的纤维化生长。

4. 发明授权

US08126560B2 Stimulation lead for stimulating the baroreceptors in the pulmonary artery 有权
标题翻译：刺激肺动脉压力感受器的刺激
公开(公告)号：US08126560B2
公开(公告)日：2012-02-28
申请号：US10746852
申请日：2003-12-24
申请人： Avram Scheiner , Ronald W. Heil, Jr. , Peter T. Kelley
发明人： Avram Scheiner , Ronald W. Heil, Jr. , Peter T. Kelley
IPC分类号： A61N1/18 , A61N1/362
CPC分类号： A61N1/057 , A61N1/36117
摘要： An apparatus includes a flexible lead body extending from a proximal end to a distal end, the distal end having a biased portion having an outer diameter dimensioned to abut a wall of a pulmonary artery, an electrode coupled proximate the distal end, and an implantable pulse generator electrically coupled to the electrode. The implantable pulse generator is adapted to deliver a baroreflex stimulation signal to a baroreceptor in the pulmonary artery via the electrode.
摘要翻译：一种装置包括从近端延伸到远端的柔性引线体，所述远端具有偏压部分，所述偏压部分的外径尺寸设计成邻接肺动脉壁，邻近远端连接的电极和可植入脉冲发电机电耦合到电极。可植入脉冲发生器适于通过电极将压力反射刺激信号传递给肺动脉中的压力感受器。

5. 发明授权

US08017178B2 Coatings for implantable electrodes 有权
标题翻译：可植入电极涂层
公开(公告)号：US08017178B2
公开(公告)日：2011-09-13
申请号：US10738647
申请日：2003-12-16
申请人： Liliana Atanasoska , Ronald W. Heil , David M. Flynn
发明人： Liliana Atanasoska , Ronald W. Heil , David M. Flynn
IPC分类号： B05D5/12 , B05D3/02
CPC分类号： A61N1/0565 , A61N1/0568
摘要： A method includes sandblasting an electrode surface, applying a conductive oxide precursor solution to the electrode surface, and heating the electrode for at least 5 minutes at a temperature between 350 degrees C. and 550 degrees C. to convert the precursor solution into an oxide coating. One method includes applying a composite material including a conductive component and a non-conductive component to an electrode and curing the composite material to form a coating on the electrode. One method includes providing a metallic oxide coating on an electrode surface and applying a galvanostatic treatment to the electrode to increase the effective surface area of the metallic oxide coating.
摘要翻译：一种方法包括喷镀电极表面，将导电氧化物前体溶液施加到电极表面，并在350摄氏度至550摄氏度之间的温度下将电极加热至少5分钟，以将前体溶液转化为氧化物涂层。一种方法包括将包含导电组分和非导电组分的复合材料施加到电极上并固化复合材料以在电极上形成涂层。一种方法包括在电极表面上提供金属氧化物涂层并对电极施加恒电流处理以增加金属氧化物涂层的有效表面积。

6. 发明授权

US07890171B2 Sensors having protective eluting coating and method therefor 有权
标题翻译：具有保护性洗脱涂层的传感器及其方法
公开(公告)号：US07890171B2
公开(公告)日：2011-02-15
申请号：US11738251
申请日：2007-04-20
申请人： Qingsheng Zhu , Ronald W. Heil, Jr. , Mudit Jain
发明人： Qingsheng Zhu , Ronald W. Heil, Jr. , Mudit Jain
IPC分类号： A61N1/00
CPC分类号： A61B5/14546 , A61B5/14532 , A61N1/0568
摘要： An apparatus includes an implantable device, such as a chronically implantable device that has a device body. One or more chemical sensors are coupled with the device body. A drug eluting substance is disposed at a location including at least one of on, directly adjacent, or near the one or more chemical sensors, where the drug eluting substance prevents fibrotic growth on the one or more chemical sensors.
摘要翻译：一种装置包括可植入装置，例如具有装置主体的长期可植入装置。一个或多个化学传感器与装置本体结合。药物洗脱物质被布置在包括一个或多个化学传感器中的至少一个，直接相邻或接近的位置，其中药物洗脱物质防止在一个或多个化学传感器上的纤维化生长。

7. 发明申请

US20100152608A1 CHRONICALLY IMPLANTED ABDOMINAL PRESSURE SENSOR FOR CONTINUOUS AMBULATORY ASSESSMENT OF RENAL FUNCTIONS 审中-公开
标题翻译：用于连续评估肾功能的CHRONICALLAL IMPADAL ABDOMINAL PRESSURE传感器
公开(公告)号：US20100152608A1
公开(公告)日：2010-06-17
申请号：US12537403
申请日：2009-08-07
申请人： John D. HATLESTAD , Binh C. TRAN , Bin MI , Ronald W. HEIL, JR.
发明人： John D. HATLESTAD , Binh C. TRAN , Bin MI , Ronald W. HEIL, JR.
IPC分类号： A61B5/00 , A61B5/11
CPC分类号： A61B5/0205 , A61B5/0028 , A61B5/0031 , A61B5/03 , A61B5/036 , A61B5/201 , A61B5/416 , A61B5/6846
摘要： An implantable system for ambulatory monitoring of a high-risk heart failure patient includes a first pressure sensor implantable within an abdomen of the patient for sensing and generating an output representative of a baseline intra-abdominal pressure value of the patient and for chronically sensing and generating an output representative of an intra-abdominal pressure value of the patient at periodic intervals. At least one second implantable sensor is provided for sensing and generating an output representative of a second physiological parameter of the patient. Additionally, the system includes a processor for correlating the output of the first pressure sensor and the second physiologic sensor, and for comparing differences between the baseline intra-abdominal pressure value and subsequent intra-abdominal pressure values. The processor can reside in another implantable device or in an external device/system.
摘要翻译：用于高风险心力衰竭患者的动态监测的可植入系统包括可植入患者腹部的第一压力传感器，用于感测和产生代表患者的基线腹内压力值的输出，并且用于长期感测和产生以周期性间隔代表患者的腹内压力值的输出。提供至少一个第二可植入传感器用于感测和产生代表患者的第二生理参数的输出。另外，该系统包括用于将第一压力传感器和第二生理传感器的输出相关联并且用于比较基线腹内压力值和随后的腹内压力值之间的差异的处理器。处理器可以驻留在另一个可植入设备中或外部设备/系统中。

8. 发明申请

US20100076511A1 BAROREFLEX STIMULATION SYSTEM TO REDUCE HYPERTENSION 有权
标题翻译： BAROREFLEX刺激系统降低高血压
公开(公告)号：US20100076511A1
公开(公告)日：2010-03-25
申请号：US12627562
申请日：2009-11-30
申请人： Ronald W. Heil, JR. , Avram Scheiner , Imad Libbus
发明人： Ronald W. Heil, JR. , Avram Scheiner , Imad Libbus
IPC分类号： A61N1/08 , A61N1/362
CPC分类号： A61N1/36117 , A61N1/3627 , A61N1/36564
摘要： Various aspects of the present subject matter provide an implantable medical device. In various embodiments, the device comprises a pulse generator, a lead, a sensor, and a controller. The pulse generator generates a baroreflex stimulation signal as part of a baroreflex therapy. The lead is adapted to be electrically connected to the pulse generator and to be intravascularly fed into a heart. The lead includes an electrode to be positioned in or proximate to the heart to deliver the baroreflex signal to a baroreceptor region in or proximate to the heart. The sensor senses a physiological parameter regarding an efficacy of the baroreflex therapy and provides a signal indicative of the efficacy. The controller is connected to the pulse generator to control the baroreflex stimulation signal and to the sensor to receive the signal indicative of the efficacy of the baroreflex therapy. Other aspects are provided herein.
摘要翻译：本主题的各个方面提供可植入医疗装置。在各种实施例中，该装置包括脉冲发生器，引线，传感器和控制器。脉冲发生器产生压力反射刺激信号作为压力反射治疗的一部分。引线适于电连接到脉冲发生器并且被血管内馈送到心脏中。引线包括位于心脏中或靠近心脏的电极，以将压力反射信号传递到心脏中或心脏附近的压力感受器区域。传感器感测关于压力反射治疗的功效的生理参数，并提供指示功效的信号。控制器连接到脉冲发生器以控制压力反射刺激信号和传感器以接收指示压力反射治疗功效的信号。本文提供了其他方面。

9. 发明授权

US07551959B2 Cardiac rhythm management for fetal, neonatal, and/or pediatric patients 失效
标题翻译：胎儿，新生儿和/或儿科患者的心律管理
公开(公告)号：US07551959B2
公开(公告)日：2009-06-23
申请号：US11179121
申请日：2005-07-12
申请人： Ronald W. Heil, Jr. , Beverly Mains , Christopher P. Knapp , Kyle Hoecke
发明人： Ronald W. Heil, Jr. , Beverly Mains , Christopher P. Knapp , Kyle Hoecke
IPC分类号： A61N1/39 , A61B5/0448
CPC分类号： A61N1/362
摘要： A method including inserting an electrode into an umbilical vein, and advancing the electrode through the umbilical vein to a location near or in a heart. In an example, the electrode is inserted into an umbilical vein in utero. In another example, the electrode is inserted into an umbilical vein in a child soon after the child is born. In an example, the electrode is connected to a lead. In an example, a lead is inserted through a catheterized umbilicus.
摘要翻译：一种方法，包括将电极插入脐静脉中，并将电极通过脐静脉推进到心脏附近或心脏的位置。在一个例子中，电极在子宫内插入脐静脉。在另一个例子中，在孩子出生后不久，电极被插入到小孩的脐静脉中。在一个示例中，电极连接到引线。在一个例子中，铅通过导管的脐带插入。

10. 发明授权

US07499757B2 Absorbable myocardial lead fixation system 有权
标题翻译：可吸收心肌引导固定系统
公开(公告)号：US07499757B2
公开(公告)日：2009-03-03
申请号：US10971577
申请日：2004-10-22
申请人： M. Sean Coe , Ronald W. Heil, Jr. , Peter T. Kelley , Jason Alan Shiroff , Randy W. Westlund , Donald F. Palme, II
发明人： M. Sean Coe , Ronald W. Heil, Jr. , Peter T. Kelley , Jason Alan Shiroff , Randy W. Westlund , Donald F. Palme, II
IPC分类号： A61N1/05
CPC分类号： A61B17/0469 , A61B5/0492 , A61B17/06109 , A61B2017/0417 , A61B2017/06042 , A61B2017/0608 , A61N1/0568 , A61N1/0587 , A61N2001/0578 , A61N2001/058
摘要： A myocardial lead attachment system for securing a distal end of a lead within a myocardium of a patient's heart. The system includes a lead body, an anchor mechanism formed of a bioabsorbable or biodegradable polymer for engaging a surface of the patient's heart and a surface feature formed on a portion of the lead body for promoting formation of scar tissue around said portion of the lead body.
摘要翻译：用于将铅的远端固定在患者心脏的心肌内的心肌引线附着系统。该系统包括引线体，由生物可吸收或可生物降解的聚合物形成的锚固机构，用于接合患者心脏的表面，以及形成在引线体的一部分上的表面特征，用于促进在引线体的所述部分周围形成瘢痕组织。

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