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1. 发明授权

US10543356B2 Pain sensory nerve stimulation apparatus 有权
公开(公告)号：US10543356B2
公开(公告)日：2020-01-28
申请号：US13023623
申请日：2011-02-09
申请人： Koji Inui , Yasuyuki Takeshima , Jun Motogi , Yoshinobu Ono , Takeshi Kojima , Ryosuke Ushijima , Katsumi Nakaichi , Kazuwa Shibuya
发明人： Koji Inui , Yasuyuki Takeshima , Jun Motogi , Yoshinobu Ono , Takeshi Kojima , Ryosuke Ushijima , Katsumi Nakaichi , Kazuwa Shibuya
IPC分类号： A61N1/04 , A61N1/36 , A61B5/00
摘要： A pain sensory nerve stimulation apparatus includes: an electrode portion including: a first electrode, a tip end of which is adapted to be inserted into a skin; and at lease one second electrode which is disposed in a circumference of the first electrode without being electrically conductive with the first electrode, and which is adapted to be in contact with a skin; and a stimulation signal supplying unit, supplying a bipolar stimulation signal between the first electrode and the second electrode, the bipolar stimulation signal including a first waveform signal and a second waveform, the first waveform which is convex in a negative direction in the first electrode, the second waveform signal which is convex in a positive direction in the first electrode.

2. 发明授权

US10413717B2 Pain sensory nerve stimulation apparatus 有权
公开(公告)号：US10413717B2
公开(公告)日：2019-09-17
申请号：US12570213
申请日：2009-09-30
申请人： Koji Inui , Yasuyuki Takeshima , Jun Motogi , Yoshinobu Ono , Takeshi Kojima , Ryosuke Ushijima , Katsumi Nakaichi , Kazuwa Shibuya
发明人： Koji Inui , Yasuyuki Takeshima , Jun Motogi , Yoshinobu Ono , Takeshi Kojima , Ryosuke Ushijima , Katsumi Nakaichi , Kazuwa Shibuya
IPC分类号： A61N1/36 , A61N1/04 , A61B5/04 , A61B5/00 , A61N1/05
摘要： A pain sensory nerve stimulation apparatus includes: an electrode portion including: a first electrode, a tip end of which is adapted to be inserted into a skin; and at lease one second electrode which is disposed in a circumference of the first electrode without being electrically conductive with the first electrode, and which is adapted to be in contact with a skin; and a pulse signal supplier, supplying a pulse signal in which an electrical polarity of the first electrode is set as a anode and an electrical polarity of the second electrode is set as a cathode.

3. 发明授权

US09662063B2 Pain sensory nerve stimulation apparatus 有权
公开(公告)号：US09662063B2
公开(公告)日：2017-05-30
申请号：US13587050
申请日：2012-08-16
申请人： Koji Inui , Yasuyuki Takeshima , Jun Motogi , Yoshinobu Ono , Ryosuke Ushijima , Takeshi Kojima
发明人： Koji Inui , Yasuyuki Takeshima , Jun Motogi , Yoshinobu Ono , Ryosuke Ushijima , Takeshi Kojima
IPC分类号： A61N1/05 , A61B5/00 , A61N1/36
CPC分类号： A61B5/4824 , A61N1/0502 , A61N1/36017 , A61N1/36021
摘要： A pain sensory nerve stimulation apparatus includes: a stimulation electrode which is adapted to be attached to a living body, at least one of an exogenous algesic substance and pyrogen which is to be interposed between the living body and the stimulation electrode; and a stimulation power supplier which is configured to supply electric power to the stimulation electrode.

4. 发明授权

US5374720A 2-(substituted pyrrolidinylthio)carbapenem derivatives 失效
标题翻译： 2-（取代的吡咯烷硫基）碳青霉烯衍生物
公开(公告)号：US5374720A
公开(公告)日：1994-12-20
申请号：US780142
申请日：1991-10-21
申请人： Susumu Nakagawa , Norikazu Ohtake , Fumio Nakano , Koji Yamada , Ryosuke Ushijima , Satoshi Murase , Hiroshi Fukatsu
发明人： Susumu Nakagawa , Norikazu Ohtake , Fumio Nakano , Koji Yamada , Ryosuke Ushijima , Satoshi Murase , Hiroshi Fukatsu
IPC分类号： C07D477/20 , C07D487/04 , A61K31/40
CPC分类号： C07D477/20
摘要： A compound of the formula: ##STR1## wherein R is a hydrogen atom or a methyl group, R.sup.1 is a hydrogen atom or a negative charge, each of R.sup.2 and R.sup.3 which may be the same or different, is a hydrogen atom, a lower alkyl group, a hydroxy lower alkyl group, a formimidoyl group, an acetoimidoyl group, --COOR.sup.4, --CON(R.sup.5)R.sup.6, --N(R.sup.5)R.sup.6, --CH.sub.2 COOR.sup.4, --CH.sub.2 N(R.sup.5)R.sup.6 or --CH.sub.2 CON(R.sup.5)R.sup.6 (wherein R.sup.4 is a hydrogen atom or a lower alkyl group, each of R.sup.5 and R.sup.6 which may be the same or different, is a hydrogen atom or a lower alkyl group, or R.sup.5 and R.sup.6 form together with the adjacent nitrogen atom a heterocyclic group selected from the group consisting of an aziridinyl group, an azetidinyl group, a pyrrolidinyl group and a piperidyl group), A is .dbd.NR.sup.7, .dbd.N.sup.+ (R.sup.7)R.sup.8, wherein each of R.sup.7 and R.sup.8 which may be the same or different, is a hydrogen atom, a lower alkyl group, a hydroxy lower alkyl group, a formimidoyl group, an acetoimidoyl group, --COOR.sup.4, --CON(R.sup.5)R.sup.6, --N(R.sup.5)R.sup.6, --CH.sub.2 COOR.sup.4, --CH.sub.2 N(R.sup.5)R.sup.6 or --CH.sub.2 CON(R.sup.5)R.sup.6 (wherein R.sup.4, R.sup.5 and R.sup.6 are as defined above), p is an integer of from 0 to 3, and q is an integer of from 1 to 3; or a pharmaceutically acceptable salt or ester thereof.
摘要翻译：下式的化合物：其中R是氢原子或甲基，R 1是氢原子或负电荷，R 2和R 3可以相同或不同，为氢原子，低级烷基，羟基低级烷基，亚氨基，亚氨酰基，-COOR4，-CON（R5）R6，-N（R5）R6，-CH2COOR4，-CH2N（R5）R6或-CH2CON（ R5）R6（其中R4是氢原子或低级烷基，R5和R6各自可以相同或不同，是氢原子或低级烷基，或R5和R6与相邻的氮原子一起形成）选自氮丙啶基，氮杂环丁烷基，吡咯烷基和哌啶基的杂环基），A为= NR 7 = N +（R 7）R 8，其中R 7和R 8可以相同或不同，不同的是氢原子，低级烷基，羟基低级烷基，亚氨基，亚氨代乙酰基，-COOR4，-CON（R5）R6，-N（R5）R6，-CH2COOR4，-CH2N（R5 ）R6或-CH2CON（R5）R6（其中在R4中，R5和R6如上所定义），p是0-3的整数，q是1至3的整数; 或其药学上可接受的盐或酯。

5. 发明授权

US5373002A 2-(substituted pyrrolidinylthio) carbapenem derivatives 失效
标题翻译： 2-（取代的吡咯烷硫基）碳青霉烯衍生物
公开(公告)号：US5373002A
公开(公告)日：1994-12-13
申请号：US950717
申请日：1992-09-25
申请人： Susumu Nakagawa , Norikazu Ohtake , Fumio Nakano , Koji Yamada , Ryosuke Ushijima , Satoshi Murase , Hiroshi Fukatsu
发明人： Susumu Nakagawa , Norikazu Ohtake , Fumio Nakano , Koji Yamada , Ryosuke Ushijima , Satoshi Murase , Hiroshi Fukatsu
IPC分类号： C07D477/20 , A01N43/00 , A61K31/395 , C07D487/04
CPC分类号： C07D477/20
摘要： A compound of the formula: ##STR1## wherein R is a hydrogen atom or a methyl group, R.sup.1 is a hydrogen atom or a negative charge, R.sup.2 is a lower alkyl group, a lower alkyl group substituted with a hydroxyl group or --COOR.sup.3 (wherein R.sup.3 is a hydrogen atom or a lower alkyl group), A is .dbd.NH, .dbd.NR.sup.4 or .dbd.N(R.sup.4)R.sup.5 (wherein each of R.sup.4 and R.sup.5 which may be the same or different, is a lower alkyl group or a lower alkyl group substituted with a hydroxyl group), p is an integer of from 0 to 3, and each of q and r which may be the same or different, is an integer of from 0 to 5, provided that q and r are not simultaneously 0 and q +r.ltoreq.6; or a pharmaceutically acceptable salt or ester thereof.
摘要翻译：下式的化合物：其中R是氢原子或甲基，R1是氢原子或负电荷，R2是低级烷基，被羟基取代的低级烷基或 -COOR 3（其中R 3为氢原子或低级烷基），A为= NH，= NR 4或= N（R 4）R 5（其中R 4和R 5可以相同或不同，为低级烷基或被羟基取代的低级烷基），p为0〜3的整数，q和r可以相同或不同，为0〜5的整数，条件是q和r 不同时为0和q + r为6; 或其药学上可接受的盐或酯。

6. 发明授权

US5225406A 1-carboxy-1-vinyloxyimino aminothiazole cephalosporin derivatives 失效
标题翻译： 1-羧基-1-乙烯氧基亚氨基氨基噻唑头孢菌素衍生物
公开(公告)号：US5225406A
公开(公告)日：1993-07-06
申请号：US753943
申请日：1991-09-03
申请人： Susumu Nakagawa , Ryuji Mitomo , Koji Yamada , Norikazu Otake , Fumio Nakano , Akira Asai , Satoru Kuroyanagi , Yoshiharu Tanaka , Moriaki Ishikawa , Ryosuke Ushijima
发明人： Susumu Nakagawa , Ryuji Mitomo , Koji Yamada , Norikazu Otake , Fumio Nakano , Akira Asai , Satoru Kuroyanagi , Yoshiharu Tanaka , Moriaki Ishikawa , Ryosuke Ushijima
IPC分类号： C07D235/28 , C07D263/46 , C07D263/58 , C07D271/10 , C07D271/113 , C07D277/20 , C07D277/36 , C07D277/56 , C07D285/12 , C07D285/125 , C07D501/20 , C07D501/36 , C07D501/46 , C07D501/59
CPC分类号： C07D263/58 , C07D235/28 , C07D263/46 , C07D271/113 , C07D277/36 , C07D277/56 , C07D277/587 , C07D285/125 , Y02P20/55
摘要： The present invention relates to a compound having the formula: ##STR1## wherein R is a hydrogen atom, a carboxyl-protecting group or a negative charge and Q is a hydrogen atom, a halogen atom, a hydroxyl group, an acetoxy group, a carbamoyloxy group, an azide group, a substituted or unsubstituted quarternary ammonio group or a substituted or unsubstituted heterocyclic thio group having at least one hetero atom selected from the group consisting of a nitrogen atom, an oxygen atom, and a sulfur atom, or a non-toxic salt or physiologically hydrolyzable non-toxic ester thereof; a process for producing it; and an antibacterial agent comprising it as an active ingredient.Further, the present invention also relates to a compound having the formula: ##STR2## wherein R.sup.3 is a hydrogen atom or an amino-protecting group, and each of R.sup.4 and R.sup.5 which may be the same or different is a hydrogen atom or a carboxyl-protecting group, or a salt thereof; and a process for producing it.
摘要翻译：本发明涉及具有下式的化合物：其中R是氢原子，羧基保护基或负电荷，Q是氢原子，卤原子，羟基，乙酰氧基基团，氨基甲酰氧基，叠氮基，取代或未取代的季铵基或具有至少一个选自氮原子，氧原子和硫原子的杂原子的取代或未取代的杂环硫基，或其无毒盐或其生理上可水解的无毒酯; 一个生产过程; 和含有它作为活性成分的抗菌剂。此外，本发明还涉及具有下式的化合物：其中R 3是氢原子或氨基保护基，并且R 4和R 5可以相同或不同的是氢原子或羧基保护基，或其盐; 及其生产工艺。

7. 发明授权

US4988687A Cephalosporin derivatives, and antibacterial agents 失效
标题翻译：头孢菌素衍生物和抗菌剂
公开(公告)号：US4988687A
公开(公告)日：1991-01-29
申请号：US401747
申请日：1989-09-01
申请人： Susumu Nakagawa , Ryuji Mitomo , Ryosuke Ushijima
发明人： Susumu Nakagawa , Ryuji Mitomo , Ryosuke Ushijima
IPC分类号： C07D501/00 , C07D501/36
CPC分类号： C07D501/00
摘要： A compound having the formula: ##STR1## wherein R is a vinyl, phenyl or aralkyl group which may be substituted; or a pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof.

8. 发明授权

US4987235A Isoindoline derivatives and processes for their preparation 失效
标题翻译：异二氢吲哚衍生物及其制备方法
公开(公告)号：US4987235A
公开(公告)日：1991-01-22
申请号：US267094
申请日：1988-11-03
申请人： Ryosuke Ushijima , Susumu Nakagawa , Eiichi Mano
发明人： Ryosuke Ushijima , Susumu Nakagawa , Eiichi Mano
IPC分类号： C07D209/44 , C07D491/056 , C07D501/08
CPC分类号： C07D209/44 , Y02P20/55
摘要： A compound having the formula: ##STR1## wherein R is a hydrogen atom, a lower alkyl group, an alkanoyl group, an aralkyl group, an alkylsulfonyl group or an arylsulfonyl group, and R.sup.1 is a hydrogen atom or a protecting group for a hydroxyl group, or a salt thereof.
摘要翻译：具有下式的化合物：其中R是氢原子，低级烷基，烷酰基，芳烷基，烷基磺酰基或芳基磺酰基，R 1是氢原子或保护基羟基或其盐。

9. 发明授权

US4782155A Cephalosporin derivatives, processes for their preparation and antibacterial agents 失效
标题翻译：头孢菌素衍生物，其制备方法和抗菌剂
公开(公告)号：US4782155A
公开(公告)日：1988-11-01
申请号：US29903
申请日：1987-03-25
申请人： Susumu Nakagawa , Norikazu Otake , Ryosuke Ushijima
发明人： Susumu Nakagawa , Norikazu Otake , Ryosuke Ushijima
IPC分类号： C07D217/02
CPC分类号： C07D217/02
摘要： The compound having the formula: ##STR1## wherein R.sup.6 is a hydrogen atom or an alkanoyl group, or a salt thereof and a process thereof.
摘要翻译：具有下式的化合物：其中R6是氢原子或烷酰基，或其盐及其制备方法。

10. 发明申请

US20130053933A1 PAIN SENSORY NERVE STIMULATION APPARATUS 有权
标题翻译：疼痛感觉神经刺激装置
公开(公告)号：US20130053933A1
公开(公告)日：2013-02-28
申请号：US13587050
申请日：2012-08-16
申请人： Koji INUI , Yasuyuki TAKESHIMA , Jun MOTOGI , Yoshinobu ONO , Ryosuke USHIJIMA , Takeshi KOJIMA
发明人： Koji INUI , Yasuyuki TAKESHIMA , Jun MOTOGI , Yoshinobu ONO , Ryosuke USHIJIMA , Takeshi KOJIMA
IPC分类号： A61N1/05 , A61N1/04
CPC分类号： A61B5/4824 , A61N1/0502 , A61N1/36017 , A61N1/36021
摘要： A pain sensory nerve stimulation apparatus includes: a stimulation electrode which is adapted to be attached to a living body, at least one of an exogenous algesic substance and pyrogen which is to be interposed between the living body and the stimulation electrode; and a stimulation power supplier which is configured to supply electric power to the stimulation electrode.
摘要翻译：疼痛感觉神经刺激装置包括：刺激电极，其适于附着到生物体上，要包含在生物体和刺激电极之间的至少一种外源性的酸痛物质和热原; 以及被配置为向所述刺激电极提供电力的刺激电力供给器。

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