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1. 发明专利

GB586930A Improvements in or relating to the manufacture of penicillin 未知
公开(公告)号：GB586930A
公开(公告)日：1947-04-08
申请号：GB1328844
申请日：1944-07-11
申请人： GLAXO LAB LTD , BRITISH DRUG HOUSES LTD , AUSTIN ERNEST BIDE , THOMAS HOBSON MEAD , ERNEST LESTER SMITH , MAURICE VINCENT STACK
摘要： A process for the manufacture of Penicillin comprises growing Penicillium notatum or other Penicillin producing mould on a synthetic culture medium or a medium comprising corn steep liquor to which has been added a substance of the general formula R.C6H4.CH2Y where R represents a hydrogen atom or a para hydroxyl group and Y is a carboxylic acid, carboxylic acid amide, an aldehyde or an aminomethyl (-CH2NH2) group or some other group which under the prevailing conditions of biological growth is readily convertible into one or other of these groups. Specified substances of this type are b -phenylethylamine, b -para-hydroxyphenylethylamine, b -phenyl-a -alanine, phenyl pyruvic acid, phenylacetronitrile, c-phenyl-acetamidine, phenylacetylglycine, phenylacetic acid, phenyl acetamide and phenyl acetaldehyde, and in the cases in which these are acids or bases they may be added as salts. The culture media may comprise glucose, lactose, or corn steep liquors to which may be added salts such as sodium nitrate, sodium citrate, sodium sulphate, magnesium sulphate, potassium dihydrogen phosphate, potassium iodide, ferrous sulphate, cupric sulphate, zinc sulphate, manganese sulphate, ammonium molybdate and vanadium trichloride, boric acid and also hydrolysates from zinc and casein and cystine, or protein hydrolysates rich in cystine. The process may be applied to tray, bottle, column or submerged culture.

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