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1. 发明申请

WO2015048804A2 PROTEIN BIOMARKER AND USES THEREOF 审中-公开
标题翻译：蛋白生物标记及其用途
公开(公告)号：WO2015048804A2
公开(公告)日：2015-04-02
申请号：PCT/US2014058460
申请日：2014-09-30
申请人： DAIICHI SANKYO CO LTD , U3 PHARMA GMBH , UNIV KINKI , AMGEN INC
发明人： SCHNEIDER MATTHIAS , BLUM SABINE , YONESAKA KIMIO , NAKAGAWA KAZUHIKO , FREEMAN DANIEL J , BECKMAN ROBERT ALLEN , JIN XIAOPING , MENDELL-HARARY RENEE JEANNE
IPC分类号： G01N33/574 , C07K16/28
CPC分类号： C07K16/32 , A61K31/517 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/10 , C07K16/2863 , C07K16/40 , C07K2317/21 , C07K2317/76 , G01N33/5695 , G01N33/57423 , G01N2333/4756
摘要： The present invention is directed to methods of identifying and treating a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and administering a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as high. The present invention is also directed to methods of identifying a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and withholding a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as low. The invention is also directed to methods of performing an ELISA, including sequential steps of contacting a solid surface with a plurality of solutions each comprising in turn a capture antibody, a blocking agent, a sample suspected of containing an analyte, a detection antibody and an enzyme conjugate, in which the solid surface is subjected to a wash process after each sequential step.
摘要翻译：本发明涉及鉴定和治疗携带肿瘤或其它疾病的人类受试者的方法，包括评估人受试者的蛋白质水平的HRG基因表达，并向人受试者施用包含抗HER3抗体的治疗，其中HRG基因蛋白质水平的表达被评估为高。本发明还涉及鉴定携带肿瘤或其它疾病的人类受试者的方法，其包括在人受试者中评估蛋白质水平的HRG基因表达，并扣留对HRG基因表达的人受试者包含抗HER3抗体的治疗在蛋白质水平被评估为低。本发明还涉及进行ELISA的方法，包括使固体表面与多个溶液接触的顺序步骤，每个溶液各自包含捕获抗体，封闭剂，怀疑含有分析物的样品，检测抗体和酶缀合物，其中固体表面在每个顺序步骤之后进行洗涤过程。

2. 发明申请

WO2018117103A1 COMPOSITION FOR AMELIORATING PERIPHERAL NERVE DISORDERS 审中-公开
公开(公告)号：WO2018117103A1
公开(公告)日：2018-06-28
申请号：PCT/JP2017045547
申请日：2017-12-19
申请人： UNIV KINKI , KOBAYASHI PHARMACEUTICAL CO LTD
发明人： NISHIDA SHOZO , TSUBAKI MASANOBU , TAKEDA TOMOYA , OKUNO KIYOTAKA , WACHI SATOSHI
IPC分类号： A61K36/07 , A23L33/10 , A61P25/02
摘要： There has been no drug for treating peripheral nerve disorders which occur as a side effect of drugs, in particular, of anticancer drugs such as oxaliplatin. This composition for ameliorating peripheral nerve disorders, which is characterized by including an extract of Lentinus edodes mycelia, ameliorates disorders induced by drugs such as anticancer drugs, including: numbness in the limbs, pain in the limbs, diminished deep tendon reflexes, reduced muscle strength, allodynia, hyperalgesia, fine motor function impairment of the fingers, impaired walking, stumbling, falling, flexion impairment (difficulty with or inability to sit on one's knees, cross-legged, sideways, in a chair, or the like), and paralysis of the limbs.

3. 发明申请

WO2005085454A2 METHOD FOR IMPROVING PRODUCTIVITY OF PLANT BY CHLOROPLAST TECHNOLOGY 审中-公开
标题翻译：通过氯仿技术提高植物生产力的方法
公开(公告)号：WO2005085454A2
公开(公告)日：2005-09-15
申请号：PCT/JP2005004037
申请日：2005-03-02
申请人： NAT UNIV CORP NARA INST , RES INST OF INNOVATIVE TECNHOL , UNIV KINKI , YOKOTA AKIHO , SHIGEOKA SHIGERU , TOMIZAWA KEN-ICHI
发明人： YOKOTA AKIHO , SHIGEOKA SHIGERU , TOMIZAWA KEN-ICHI
IPC分类号： C12N9/16 , C12N15/82 , A01H1/00
CPC分类号： C12N15/8214 , C12N9/16 , C12N15/8245 , C12N15/8261 , C12N15/8269 , Y02A40/146
摘要： An object of the present invention is to provide a transformed plant which has high photosynthesis activity, and has promoted growth and productivity as compared with a wild strain, and has no fear of diffusion of an introduced gene by pollens, by expressing a trait of a specified gene by chloroplast technology in a higher plant. According to the present invention, there is provided a transformed plant using a gene recombinant vector having an expression cassette for enhancing photosynthesis activity, containing a DNA fragment comprising a gene encoding a protein having fructose-1,6-bisphosphatase sedoheptulose-1,7-bisphosphatase activities between a nucleotide sequence complementary to the chloroplast gene rbcL and the chloroplast gene aacD.
摘要翻译：本发明的目的是提供一种具有高光合作用活性的转化植物，并且与野生株相比促进了生长和生产力，并且不用担心通过花粉引入的基因的扩散，通过表达一种在高等植物中通过叶绿体技术指定基因。根据本发明，提供了一种使用具有增强光合作用活性的表达盒的基因重组载体的转化植物，其含有包含编码具有果糖-1,6-二磷酸酶沉默性庚糖醇-1,7-二磷酸的蛋白质的DNA的DNA片段，与叶绿体基因rbcL互补的核苷酸序列与叶绿体基因aacD之间的二磷酸酶活性。

4. 发明申请

WO2005029463A9 A METHOD FOR RECOVERING TARGET SPEECH BASED ON SPEECH SEGMENT DETECTION UNDER A STATIONARY NOISE 审中-公开
标题翻译：一种基于静态噪声下语音段检测的目标语音恢复方法
公开(公告)号：WO2005029463A9
公开(公告)日：2005-07-07
申请号：PCT/JP2004012899
申请日：2004-08-31
申请人： KITAKYUSHU FOUNDATION , UNIV KINKI , GOTANDA HIROMU , KANEDA KEIICHI , KOYA TAKESHI
发明人： GOTANDA HIROMU , KANEDA KEIICHI , KOYA TAKESHI
IPC分类号： G10L15/20 , G10L11/02 , G10L15/04 , G10L21/02 , G10L19/02
CPC分类号： G10L21/0208 , G10L25/78
摘要： Method for recovering target speech by extracting signal components falling in a speech segment, which is determined based on separated signals obtained through the Independent Component Analysis, thereby minimizing the residual noise in the recovered target speech. The present method comprises: the first step of receiving target speech emitted from a sound source and a noise emitted from another sound source and extracting estimated spectra Y* corresponding to the target speech by use of the Independent Component Analysis; the second step of separating from the estimated spectra Y* an estimated spectrum series group y* in which the noise is removed by applying separation judgment criteria based on the kurtosis of the amplitude distribution of each of estimated spectrum series in Y*; the third step of detecting a speech segment and a noise segment of the total sum F of all the estimated spectrum series in y* by applying detection judgment criteria based on a predetermined threshold value T that is determined by the maximum value of F; and the fourth step of extracting components falling in the speech segment from the estimated spectra Y* to generate a recovered spectrum group of the target speech for recovering the target speech.
摘要翻译：用于通过提取落入语音片段中的信号分量来恢复目标语音的方法，该语音片段是基于通过独立分量分析获得的分离信号确定的，由此最小化恢复的目标语音中的残余噪声。本方法包括：第一步骤，接收从声源发射的目标语音和从另一声源发射的噪声，并通过使用独立分量分析提取与目标语音相对应的估计谱Y * 第二步骤，从估计频谱Y *中分离估计频谱序列组y *，其中通过基于Y *中的每个估计频谱序列的振幅分布的峰度应用分离判断标准来去除噪声; 通过基于由F的最大值确定的预定阈值T应用检测判断标准来检测y *中的所有估计谱系列的总和F的语音片段和噪声片段的第三步骤; 以及第四步骤，从估计光谱Y *中提取落在语音片段中的分量，以生成用于恢复目标语音的目标语音的恢复光谱组。

6. 发明公开

EP2348021A4 ROTAXANE COMPOUND AND ANTITUMOR AGENT 有权
标题翻译： ROTAXANVERBINDUNG和抗肿瘤药
公开(公告)号：EP2348021A4
公开(公告)日：2012-03-21
申请号：EP09821794
申请日：2009-10-21
申请人： WAN STATION CO LTD , TOKYO INST TECH , UNIV FUKUOKA , UNIV KINKI
发明人： TAKATA TOSHIKAZU , KOYAMA YASUHITO , NAKAZONO KAZUKO , HASEGAWA TOSHIHIDE , LEE YOUNG-GI , ONO NOBUFUMI , NISHIO KAZUTO , FUJITA YOSHIHIKO
IPC分类号： C07D323/00 , A61K31/357 , A61P35/00
CPC分类号： C07D323/00 , A61K31/357

7. 发明公开

EP2239319A4 METHOD AND BACTERIUM FOR PROMOTING THE GROWTH OF RACOMITRIUM CANESCENS AND SEED PLANTS 有权
标题翻译：方法和细菌，促进Racomitrium四翅滨藜植物和种子的生长
公开(公告)号：EP2239319A4
公开(公告)日：2011-02-09
申请号：EP09703248
申请日：2009-01-23
申请人： UNIV OKAYAMA NAT UNIV CORP , UNIV KINKI
发明人： TANI AKIO , AKITA MOTOMU
IPC分类号： C12N1/20 , A01G1/00 , A01G7/00
CPC分类号： C12N1/20 , Y02A40/234
摘要： Disclosed are bacteria and methods for promoting growth of Racomitrium canescens, tobacco, barley and soybean. The bacteria are selected from the methanol-utilizing bacteria deposited under Accession numbers FERM BP-11078, FERM BP-11079, FERM BP-11080 and FERM BP-11071, respectively which bacteria belong to the genus Methylobacterium. The methods are a method for promoting growth of protonemata of Racomitrium canescens which method is characterized by culturing the protonemata in the presence of the bacteria and a method for promoting growth of a seed plant selected from the group consisting of tobacco, barley and soybean which method is characterized by culturing seeds of the seed plant while contacting the seeds with the bacterium deposited under Accession number FERM BP-11078 which is one of the above-mentioned bacteria.

8. 发明授权

EP2856999B1 EXPOSURE-PREVENTING CAP 有权
标题翻译： BELICHTUNGSVERHINDERNDE KAPPE
公开(公告)号：EP2856999B1
公开(公告)日：2017-06-21
申请号：EP13797404
申请日：2013-05-15
申请人： UNIV KINKI , GTO LTD , NIPRO CORP
发明人： ISHIWATA SHUNJI , TAGA ATSUSHI , NISHIDA SHOZO , KITA AYAKO , SUGIURA REIKO , FUJITA HIDEKI , HASEGAWA MITSURU
IPC分类号： A61J1/20 , A61J1/14 , B65D51/00
CPC分类号： A61J1/1443 , A61J1/1406 , A61J1/1425 , A61J1/145 , A61J1/1456 , A61J1/1468 , A61J1/2096 , B65D51/002
摘要： Provided is an exposure-preventing cap of a novel and simple structure that, by being mounted on a vial, can more reliably inhibit leaking of drug solution to an outside when pulling out and collecting drug solution in a syringe from the vial. An exposure-preventing cap, which is mounted on a mouth (64) of a vial (16) sealed with a rubber stopper (66), wherein a puncturing hole (34) is formed in a center part of a cap-shaped housing (12) that is attached to a mouth (64) of the vial (16), and a rubber membrane (14) is arranged at the puncturing hole (34) so as to form an internal space (74) between facing surfaces of the rubber membrane (14) and the rubber stopper (66). The rubber membrane (14) has a dome shape that is convex facing the rubber stopper (66).
摘要翻译：本发明提供一种新型且简单的结构的防露罩，其通过安装在小瓶上，能够更可靠地抑制从药瓶中取出注射器内的药液时向外部泄漏药液。一种安装在用橡皮塞（66）密封的小瓶（16）的口部（64）上的防
露盖，其中穿刺孔（34）形成在帽形壳体（16）的中心部分（14），该橡胶膜（14）安装在所述穿刺孔（34）处，以在所述橡胶的相对表面之间形成内部空间（74）膜（14）和橡胶塞（66）。橡胶膜（14）具有朝向橡胶塞（66）凸起的圆顶形状。

9. 发明公开

EP3042949A4 CULTIVATION METHOD FOR BACTERIA BELONGING TO GENUS COLLIMONAS AND STORAGE METHOD 审中-公开
标题翻译： KULTIVIERUNGSVERFAHRENFÜRBAKTERIEN DER GATTUNG COLLIMONAS UND SPEICHERVERFAHREN
公开(公告)号：EP3042949A4
公开(公告)日：2017-05-17
申请号：EP13893103
申请日：2013-09-04
申请人： NEW ENV TECH COUNCIL , UNIV KINKI
发明人： ANO TAKASHI , HIROSE YOICHIRO
IPC分类号： C12N1/20 , A01N25/22 , A01N63/00
CPC分类号： C12N1/20 , A01N63/00 , C12N1/04 , A01N25/22
摘要： Provided are a novel cultivation method and a storage method that are suitable for storing bacteria belonging to the genus Collimonas for a long period of time. The cultivation method for bacteria belonging to the genus Collimonas is characterized in that bacteria belonging to the genus Collimonas are cultivated in a sealed state on a culture medium that includes a rice bran culture medium and/or a soy pulp culture medium. The storage method for bacteria belonging to the genus Collimonas is characterized in that the cultivated bacteria belonging to the genus Collimonas are stored at room temperature.
摘要翻译：本发明提供适合长期保存Collimonas属细菌的新型栽培方法及保存方法。属于Collimonas的细菌的培养方法的特征在于，在包含米糠培养基和/或大豆纸浆培养基的培养基中将属于Collimonas的细菌以密封状态培养。属于Collimonas属的细菌的储存方法的特征在于，属于Collimonas的栽培细菌在室温下储存。

10. 发明公开

EP3015137A4 ANTICANCER AGENT DECOMPOSITION METHOD AND ANTICANCER AGENT DECOMPOSITION DEVICE 有权
标题翻译：方法抗癌剂的变劣抗癌药物的分解和设备
公开(公告)号：EP3015137A4
公开(公告)日：2017-01-18
申请号：EP14817843
申请日：2014-06-18
申请人： TAMURA TECO CO LTD , UNIV KINKI
发明人： TAMURA KOZO , FUKUDA YOSHIYUKI , ISHIWATA SHUNJI , TAGA ATSUSHI
IPC分类号： A62D3/38 , A62D101/22 , A62D101/26 , A62D101/28
CPC分类号： A62D3/38 , A62D2101/22 , A62D2101/26 , A62D2101/28

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