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1. 发明公开

KR20200124709A EGFR 이량체 붕괴제 및 이의 용도 审中-公开
公开(公告)号：KR20200124709A
公开(公告)日：2020-11-03
申请号：KR20207027147
申请日：2019-02-25
申请人： UNIV MICHIGAN REGENTS
发明人： NYATI MUKESH K , LAWRENCE THEODORE S , WHITEHEAD CHRISTOPHER , RECH JASON CHRISTOPHER , WATCH BRENNAN TAYLOR
IPC分类号： C07D471/10 , A61K31/437 , A61K31/444 , A61K31/4709 , A61P35/00 , C07D233/70 , C07D233/84
摘要： 본원에는 EGFR을조절하는화합물, 및예를들어암을치료하기위해상기화합물을사용하는방법이제공된다.

2. 发明公开

KR20180020964A 내구성 아이스포빅 표면 审中-公开
标题翻译：耐用的眼睛运动表面
公开(公告)号：KR20180020964A
公开(公告)日：2018-02-28
申请号：KR20177034296
申请日：2016-04-27
申请人： UNIV MICHIGAN REGENTS
发明人： ANISH TUTEJA , KEVIN GOLOVIN
IPC分类号： C09K3/18 , C08G18/10 , C08G18/61 , C08G18/73 , C08G18/83 , C08L75/04 , C09D175/04
CPC分类号： C08G18/10 , C08G18/61 , C08G18/73 , C08G18/837 , C08L75/04 , C09D175/04 , C09K3/18
摘要： 내구성아이스포빅물질은비행기, 전력선, 차량, 선박구조, 통신탑, 실외장치등을비롯한다양한기재위에얼음방지코팅을형성한다. 아이스포빅물질은낮은가교밀도(예, 1,300 mol/㎥이하), 및낮은초기얼음접착강도(예, 결빙조건에노출되기전에 100kPa 이하의τ)를가진엘라스토머성중합체를함유할수 있다. 또한, 아이스포빅물질은 10회의결빙/제빙순환후 초기τ의 50% 이상인τ을유지한다. 선택적인혼화성액체의도입은엘라스토머성중합체내에사슬의계면슬리피지를증진시킨다. 낮은τ수준은얼음축적을최소화하고, 정상작동중에수동제거를통해임의의축적된얼음을제거하는필수적인작업을제거한다. 다른아이스포빅물질로는가소제가내부에분포된선형중합체또는 PDMS-실란코팅을포함하고, 이둘 다임의의표면액체층은없는것이다. 이러한아이스포빅물질을제조하는방법도제공된다.
摘要翻译：耐用的等离子材料在各种基材上形成防冰涂层，包括飞机，电力线，车辆，船舶结构，电信塔和户外设备。运动大孩子材料可以包含具有低交联密度（例如，1300摩尔/㎥或更小），和（在100kPa的τ或曝光较少之前到例如，冻结状态），初始低冰粘附强度的弹性体聚合物。此外，疏水材料保留了τ，这是在10次结冰/结冰循环之后初始τ的50％或更多。引入任选的可混溶液体促进了弹性体聚合物内链的界面释放。低τ水平可最大限度地减少积冰，并消除了在正常操作中通过手动清除任何积聚冰块的重要任务。其他疏油材料包括线性聚合物或其中分布有增塑剂的PDMS-硅烷涂层，并且树枝状聚合物没有表面液体层。还提供了生产这种疏油材料的方法。

3. 发明公开

KR20180041155A OFDM 백채널을 사용한 저전력 무선 통신 审中-公开
公开(公告)号：KR20180041155A
公开(公告)日：2018-04-23
申请号：KR20187006813
申请日：2015-08-18
申请人： UNIV MICHIGAN REGENTS
发明人： WENTZLOFF DAVID D , KIM HUN SEOK
IPC分类号： H04L5/00 , H04L1/00 , H04L25/49 , H04L27/26
CPC分类号： H04L5/0044 , H04L25/4902 , H04L27/2634
摘要： 초저전력장치를위한혁신적이고소프트웨어-정의된(software-defined) 백채널통신체계가제공된다. 이기술을사용하면하드웨어를수정하지않고도기존인프라스트럭처로구현할수 있는 WiFi 백채널을통해이기종(heterogeneous) 장치를상호연결할수 있다. 상기백채널통신체계는또한셀룰러 4G LTE와같은다른 OFDM 기반통신시스템으로확장될수 있다.

4. 发明公开

KR20180039666A 항바이러스제로서 유용한 피롤로피리미딘 뉴클레오시드 및 그의 유사체 审中-公开
公开(公告)号：KR20180039666A
公开(公告)日：2018-04-18
申请号：KR20187006431
申请日：2016-08-08
申请人： CHIMERIX INC , UNIV MICHIGAN REGENTS
发明人： TOWNSEND LEROY , DRACH JOHN , WARE ROY W , BOUGHER JOHN HENRY III , CHANGALVALA RAMAMURTY V S , DOWNEY AARON LEIGH , LANIER ERNEST RANDALL JR , MCIVER ANDREW LOUIS , ROBERTSON BRADLEY DAVID , SELLESETH DEAN WALLACE , SETHNA PHIROZE BEHRAM
IPC分类号： C07H19/14 , A61P31/14 , C07D239/70 , C07H19/16
CPC分类号： C07H19/14 , A61K31/7052 , A61K31/706 , A61K31/7064 , C07D239/70 , C07H19/16
摘要： 본개시내용은화학식 I, 화학식 IA, 화학식 IB, 또는화학식 II의피롤로피리미딘뉴클레오시드유사체및 그의인지질접합체및 제약조성물을제공하며, 여기서 R및 A는본원에정의되어있다. 또한, 화학식 I, 화학식 IA, 화학식 IB, 또는화학식 II의 1종이상의화합물로바이러스감염및/또는바이러스감염-연관된질환또는장애를치료하고/거나예방하는방법이제시된다.

5. 发明专利

JP2019093208A Ｓ−ニトロソ−Ｎ−アセチルペニシラミン（ＳＮＡＰ）をドープした安定性の向上した血栓形成抵抗性／殺菌性の酸化窒素放出性ポリマー审中-公开
公开(公告)号：JP2019093208A
公开(公告)日：2019-06-20
申请号：JP2019030769
申请日：2019-02-22
申请人： UNIV MICHIGAN
发明人： ELIZABETH J BRISBOIS , HITESH HANDA , MARK E MEYERHOFF
IPC分类号： A61L29/08 , A61L33/14 , C08J5/18
摘要：【課題】S-ニトロソチオール(RSNOという)付加物またはポリマーS-ニトロソチオール付加物のうちの少なくとも1つを有する前記ポリマーマトリックスを含むポリマーフィルムの提供。【解決手段】ポリマーフィルムは、ポリマーマトリックスへの共有結合;ポリマーマトリックス内での分散;またはその両方によりポリマーマトリックスと関連している分離したS-ニトロソチオール付加物またはポリマーS-ニトロソチオール付加物のうちの少なくとも1つを有するポリマーマトリックスを含み、その分離したS-ニトロソチオール付加物またはポリマーS-ニトロソチオール付加物のうちの少なくとも1つは、酸化窒素(NO)を放出することが可能である。ポリマーマトリックスは、ポリウレタンポリマーマトリックス、シリコーンゴムポリマーマトリックス、またはポリウレタンとシリコーンゴムとのコポリマーマトリックスである。【選択図】図1B

6. 发明专利

JP2006109844A Improved method for transfecting t cell 审中-公开
标题翻译：改进T细胞的方法
公开(公告)号：JP2006109844A
公开(公告)日：2006-04-27
申请号：JP2005372607
申请日：2005-12-26
申请人： Univ Michigan , Usa Government , アメリカ合衆国The United States Of America , ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガンThe Regents Of The University Of Michigan
发明人： JUNE CARL H , THOMPSON CRAIG B , KIM SUIL
IPC分类号： C12N5/10 , C12N15/09 , A61K31/70 , A61K35/14 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/12 , A61P37/00 , C07K16/28 , C12N15/87 , C12P21/02 , C12R1/91
CPC分类号： C07K16/2818 , A61K48/00 , C07K16/2809 , C12N15/87
摘要： PROBLEM TO BE SOLVED: To provide an improved method for transfecting T cell with a nucleic acid molecule comprising a gene, which method is improved in expression of T cell in the gene in comparison with the classic transfecting technology. SOLUTION: The method comprises contacting the growing T cell with one or more active substances stimulating the growing cell prior to introduction of the nucleic acid molecule. One of the embodiment is contacting the T cell with a combination of the first active substance giving first activation signal to the T cell and the second acting substance giving costimulatory signal so as to be stimulated. The method is usable especially for various applications in gene therapy. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：与经典转染技术相比，提供一种用包含基因的核酸分子转染T细胞的改进方法，该方法与T细胞在基因中的表达有所改善。解决方案：该方法包括使生长的T细胞与在引入核酸分子之前刺激生长细胞的一种或多种活性物质接触。本实施方案之一是将T细胞与第一活性物质的组合接触，给予第一激活信号至T细胞，第二作用物质提供共刺激信号以便被刺激。该方法特别适用于基因治疗中的各种应用。版权所有（C）2006，JPO＆NCIPI

7. 发明专利

JP2003034137A Method and device for suppressing light aging of skin 审中-公开
标题翻译：用于抑制皮肤光老化的方法和装置
公开(公告)号：JP2003034137A
公开(公告)日：2003-02-04
申请号：JP2002071908
申请日：2002-03-15
申请人： Univ Michigan , リージェンツオブザユニバーシティオブミシガン
发明人： FISHER GARY J , VOORHEES JOHN J , KANG SEWON
IPC分类号： A61K8/00 , A61K20060101 , A61K8/31 , A61K8/33 , A61K8/35 , A61K8/36 , A61K8/368 , A61K8/37 , A61K8/42 , A61K8/44 , A61K8/49 , A61K8/64 , A61K8/67 , A61K8/97 , A61K9/06 , A61K9/08 , A61K9/10 , A61K31/035 , A61K31/07 , A61K31/198 , A61K31/20 , A61K31/203 , A61K31/341 , A61K31/352 , A61K31/375 , A61K31/65 , A61K38/00 , A61P17/16 , A61P43/00 , A61Q17/04 , A61Q19/00 , A61Q19/08 , B60J1/00 , B60J3/00 , C03C4/08 , G02B1/10 , G02B5/22 , A61K7/42
CPC分类号： A61K8/498 , A61K8/35 , A61K8/368 , A61K8/37 , A61K8/42 , A61K8/447 , A61K8/4973 , A61K8/64 , A61K8/671 , A61K8/676 , A61K8/678 , A61K31/404 , A61K2800/522 , A61K2800/782 , A61Q17/04 , A61Q19/08
摘要： PROBLEM TO BE SOLVED: To provide a method for suppressing light aging of skin and a device used for this method. SOLUTION: This method for protecting a passenger within a vehicle having a transparent or translucent window from solar UV radiation comprises providing a window coated with a UVA blocker or a UVB blocker or having it dispersed therein. This vehicle or other device for transporting a person having a window for passing the solar UV radiation and radiating it to the person is an improved vehicle or device comprising the window structure.
摘要翻译：要解决的问题：提供一种抑制皮肤光老化的方法和用于该方法的装置。解决方案：用于保护具有来自太阳UV辐射的透明或半透明窗口的车辆内的乘客的方法包括提供涂覆有UVA阻断剂或UVB阻断剂或将其分散在其中的窗口。用于运送具有用于通过太阳紫外线辐射并将其辐射到人的窗口的人的该车辆或其他设备是包括窗户结构的改进的车辆或设备。

8. 发明专利

JP2002355088A METHOD FOR PRODUCING MUTANT CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN (CFTR) 审中-公开
公开(公告)号：JP2002355088A
公开(公告)日：2002-12-10
申请号：JP2001402257
申请日：2001-11-29
申请人： HSC RES DEV CORP , UNIV MICHIGAN
发明人： TSUI LAP-CHEE , RIORDAN JOHN R , COLLINS FRANCIS S , ROMMENS JOHANNA M , IANNUZZI MICHAEL C , KEREM BAT-SHEVA , DRUMM MITCHELL L , BUCHWALD MANUAL
IPC分类号： A01K67/027 , A61K38/00 , A61K48/00 , A61P1/18 , A61P3/00 , A61P5/00 , A61P11/00 , A61P43/00 , C07H21/04 , C07K1/22 , C07K14/00 , C07K14/47 , C07K16/00 , C07K16/18 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/85 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/53 , G01N33/566 , G01N33/577
摘要： PROBLEM TO BE SOLVED: To provide a technique for screening and detection of a cystic fibrosis(CF) carrier, CF diagnosis and therapy. SOLUTION: The CF protein gene usable for screening and detection of the carrier, CF diagnosis and therapy is cloned, isolated and purified.

9. 发明专利

JP2002107494A METHOD AND DEVICE FOR INDUCING NUCLEAR REACTION 失效
公开(公告)号：JP2002107494A
公开(公告)日：2002-04-10
申请号：JP2000295208
申请日：2000-09-27
申请人： CENTRAL RES INST ELECT , UNIV MICHIGAN
发明人： NEMOTO KOSHICHI , NAYUKI TAKUYA , ANATOLY MAXIMCHUK , VALERY YU BAISENKOFU , SUDEEP BANERJEE , SHAOTING GU , KIRK FLIPPO , GERALD MOUROU , DONALD AMUSHUTADDAA
IPC分类号： G21B1/00 , G21B3/00 , G21G4/00 , G21K1/00 , G21K5/04 , G21K5/08 , G21B1/02
摘要： PROBLEM TO BE SOLVED: To easily induce nuclear reaction. SOLUTION: A member to be irradiated is irradiated momentarily with a laser beam having an energy allowing ionization of an irradiation member (step S1) to generate particles of high energy (step S2), and a target material is irradiated with the high-energy particles (step S3) to induce nuclear reaction (step S4).

10. 发明专利

JPH1060652A METHOD FOR PLASMA TREATMENT OF SURFACE AND APPARATUS THEREFOR 失效
公开(公告)号：JPH1060652A
公开(公告)日：1998-03-03
申请号：JP21263696
申请日：1996-08-12
申请人： UNIV MICHIGAN
发明人： G ZANG , JESS ASMUSSEN
IPC分类号： H05H1/46 , B23P15/32 , C23C16/26 , C23C16/27 , C23C16/50 , C23C16/511 , C23F4/00 , H01J37/32 , H01L21/205 , H01L21/302 , H01L21/3065 , H01L21/31
摘要： PROBLEM TO BE SOLVED: To provide a surface treatment apparatus capable of rapidly subjecting article surfaces to a plasma chemical vapor deposition of diamond coatings and further executing the rapid etching of the surfaces and a method therefor. SOLUTION: This plasma generator has a plasma source for which a high frequency is used, a wave coupler member which is made of a metal, couples high-frequency energy to electron cyclotron resonance and acts to confine the ions in the plasma into the electrically insulated chamber member in this wave coupler member, a waveguide member for coupling the high frequency to this coupler member and a stage member for mounting a substrate adjacently to the plasma. In such a case, the apparatus has a conductive plate which is mounted in the aperture of the chamber between the stage member and the chamber and has at least one holes, an inlet and outlet for gas flow which passes the plasma existing in the region between the holes and the stage member and is taken out therefrom and a tuning means which generates the high frequency between the holes and the stage member.

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