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1. 发明授权

US09234841B2 Optical time reversal by ultrasonic encoding in biological tissue 有权
标题翻译：通过超声波编码在生物组织中的光学时间反转
公开(公告)号：US09234841B2
公开(公告)日：2016-01-12
申请号：US13574994
申请日：2011-01-24
申请人： Lihong Wang , Xiao Xu
发明人： Lihong Wang , Xiao Xu
IPC分类号： G01B11/02 , G01N21/49 , G01N21/17 , G01N21/64
CPC分类号： G01N21/49 , G01N21/1717 , G01N21/6456 , G01N21/6458 , G01N2021/1708 , G01N2021/1785
摘要： Generating an optical-phase conjugation of ultrasonically-modulated diffuse light emitted by a scattering medium includes illuminating the medium with a light beam from a coherent light source, modulating the diffuse light transmitted through the medium with an ultrasonic wave focused on a region of interest within the medium, and retro-reflectively illuminating the medium using a phase-conjugated copy of the diffuse light that was ultrasonically modulated.
摘要翻译：产生由散射介质发射的超声调制的漫射光的光相位共轭包括用来自相干光源的光束照射介质，通过聚焦在感兴趣区域上的超声波调制透过介质的漫射光，并且使用超声波调制的漫射光的相位共轭复制物反复地照射介质。

2. 发明授权

US08420363B2 Impedance based devices and methods for use in assays 有权
标题翻译：基于阻抗的装置和方法用于测定
公开(公告)号：US08420363B2
公开(公告)日：2013-04-16
申请号：US12325530
申请日：2008-12-01
申请人： Xiaobo Wang , Xiao Xu
发明人： Xiaobo Wang , Xiao Xu
IPC分类号： C12N13/00 , B05D3/00
CPC分类号： G01N27/02 , C12M23/12 , C12M41/36 , G01N27/3276 , Y10T29/49117
摘要： A device for detecting cells and/or molecules on an electrode surface is disclosed. The device detects cells and/or molecules through measurement of impedance changes resulting from the cells and/or molecules. A disclosed embodiment of the device includes a substrate having two opposing ends along a longitudinal axis. A plurality of electrode arrays are positioned on the substrate. Each electrode array includes at least two electrodes, and each electrode is separated from at least one adjacent electrode in the electrode array by an expanse of non-conductive material. The electrode has a width at its widest point of more than about 1.5 and less than about 10 times the width of the expanse of non-conductive material. The device also includes electrically conductive traces extending substantially longitudinally to one of the two opposing ends of the substrate without intersecting another trace. Each trace is in electrical communication with at least one of the electrode arrays.
摘要翻译：公开了一种用于检测电极表面上的电池和/或分子的装置。该装置通过测量由细胞和/或分子产生的阻抗变化来检测细胞和/或分子。所述装置的公开实施例包括具有沿着纵向轴线的两个相对端部的基板。多个电极阵列位于基板上。每个电极阵列包括至少两个电极，并且每个电极由电极阵列中的至少一个相邻的电极通过一片非导电材料分开。电极的最宽点处的宽度大于非导电材料的宽度的大约1.5倍且小于约10倍。该器件还包括基本上纵向延伸到衬底的两个相对端之一的导电迹线，而不与另一迹线相交。每个迹线与至少一个电极阵列电连通。

3. 发明授权

US08252822B2 Heterocyclic compounds and uses as anticancer agents 有权
标题翻译：杂环化合物和用作抗癌剂
公开(公告)号：US08252822B2
公开(公告)日：2012-08-28
申请号：US12175154
申请日：2008-07-17
申请人： Haoyun An , Biao Xi , Yama Abassi , Xiaobo Wang , Xiao Xu
发明人： Haoyun An , Biao Xi , Yama Abassi , Xiaobo Wang , Xiao Xu
IPC分类号： A61K31/429 , C07D513/04
CPC分类号： C07D487/04 , C07D498/04 , C07D513/04
摘要： Novel compounds having a fused bicyclic heteroaromatic ring system substituted with a heteroaryl five-membered ring are disclosed. The compounds inhibit growth of a variety of types of cancer cells, and are thus useful for treating cancer. Efficacy of these compounds is demonstrated with a system for monitoring cell growth/migration, which shows they are potent inhibitors of growth and/or migration of cancer cells. In addition, compounds of the invention were shown to stop growth of tumors in vivo, and to reduce the size of tumors in vivo. Compositions comprising these compounds, and methods to use these compounds and compositions for treatment of cancers, are disclosed.
摘要翻译：公开了具有被杂芳基五元环取代的稠合双环杂芳环系的新型化合物。这些化合物抑制多种类型的癌细胞的生长，因此可用于治疗癌症。通过用于监测细胞生长/迁移的系统来证明这些化合物的功效，这表明它们是癌细胞的生长和/或迁移的有效抑制剂。此外，本发明的化合物被证明可以在体内停止肿瘤生长，并减少体内肿瘤的大小。公开了包含这些化合物的组合物，以及使用这些化合物和用于治疗癌症的组合物的方法。

4. 发明申请

US20110039294A1 SYSTEM AND METHOD FOR MONITORING CARDIOMYOCYTE BEATING, VIABILITY AND MORPHOLOGY AND FOR SCREENING FOR PHARMACOLOGICAL AGENTS WHICH MAY INDUCE CARDIOTOXICITY OR MODULATE CARDIOMYOCYTE FUNCTION 审中-公开
标题翻译：用于监测心脏病发作，病变和形态学以及可能引起心脏病毒或调节心肌细胞功能的药物代谢筛选的系统和方法
公开(公告)号：US20110039294A1
公开(公告)日：2011-02-17
申请号：US12774709
申请日：2010-05-05
申请人： Xiaobo Wang , Wei Ouyang , Nan Li , Biao Xi , Yama A. Abassi , Xiao Xu
发明人： Xiaobo Wang , Wei Ouyang , Nan Li , Biao Xi , Yama A. Abassi , Xiao Xu
IPC分类号： C12Q1/02 , C12M1/34
CPC分类号： G01N33/48735
摘要： Devices and methods for performing extracellular recording of cells, such as excitable cells, cardiomyocytes, and cardiomyocyte precursor cells is provided. An exemplary device includes a nonconductive substrate forming or provided as a base of one or more wells; a recording electrode positioned on the substrate within the well, wherein the recording electrode is accessible to cells when a cell sample is added to the device; and a reference electrode positioned within the well in a cell-free zone, the cell-free zone characterized as free from contact with cells when the cell sample is added to the device, thereby preventing contact between cells and the reference electrode.
摘要翻译：提供了用于进行细胞的细胞外记录的装置和方法，例如可兴奋细胞，心肌细胞和心肌细胞前体细胞。示例性装置包括形成或提供为一个或多个孔的基底的非导电基底; 记录电极，其位于所述阱内的所述衬底上，其中当将细胞样品添加到所述装置时，所述记录电极可接近细胞; 以及位于无细胞区域内的阱内的参比电极，当将细胞样品添加到器件时，无细胞区域表征为不与细胞接触，从而防止细胞与参比电极之间的接触。

5. 发明申请

US20110007790A1 METHOD AND APPARATUS FOR OPTIMIZING TARGET ERROR RATES FOR LINK ADAPTATION IN A COMMUNICATION SYSTEM 有权
标题翻译：用于优化通信系统中链路适配的目标误差率的方法和装置
公开(公告)号：US20110007790A1
公开(公告)日：2011-01-13
申请号：US12499400
申请日：2009-07-08
申请人： Xiao Xu , Hua Xu
发明人： Xiao Xu , Hua Xu
IPC分类号： H04B17/00
CPC分类号： H04L1/0001 , H04L1/0003 , H04L1/0009 , H04L1/0041 , H04L1/1887 , Y02D50/10
摘要： A method and apparatus for optimizing target error rates for link adaptation in a communication system. The method includes estimating a data rate associated with transmission of a data stream over a communication link. A required target error rate is then selected from a plurality of pre-defined target error rate values based on whether the estimated data rate is within a range of at least one of a plurality of pre-defined threshold values, where each of the pre-defined target error rate values maps to one of the plurality of pre-defined threshold values. A link adaptation parameter associated with the communication link is then selected or updated to maintain the required target error rate and the data stream is transmitted over the communication link using the selected/updated link adaptation parameter.
摘要翻译：一种用于优化通信系统中的链路自适应的目标误码率的方法和装置。该方法包括估计通过通信链路传输数据流的数据速率。然后基于所估计的数据速率是否在多个预定义阈值中的至少一个的范围内，从多个预定义的目标错误率值中选择所需的目标错误率，定义的目标错误率值映射到多个预定义阈值之一。然后选择或更新与通信链路相关联的链路自适应参数以维持所需的目标错误率，并且使用所选择/更新的链路自适应参数通过通信链路传输数据流。

6. 发明授权

US07640145B2 Automated model configuration and deployment system for equipment health monitoring 有权
标题翻译：自动化模型配置和部署系统，用于设备健康监控
公开(公告)号：US07640145B2
公开(公告)日：2009-12-29
申请号：US11409920
申请日：2006-04-24
申请人： Stephan W. Wegerich , Andre Wolosewicz , Xiao Xu , James P. Herzog , Robert Matthew Pipke
发明人： Stephan W. Wegerich , Andre Wolosewicz , Xiao Xu , James P. Herzog , Robert Matthew Pipke
IPC分类号： G06F7/60 , G06F17/10
CPC分类号： G05B23/0254 , G05B17/02
摘要： A method for systematically configuring and deploying an empirical model used for fault detection and equipment health monitoring. The method is driven by a set of data preprocessing and model performance metrics subsystems that when applied to a raw data set, produce an optimal empirical model.
摘要翻译：一种用于系统地配置和部署用于故障检测和设备健康监测的经验模型的方法。该方法由应用于原始数据集的一组数据预处理和模型性能指标子系统驱动，产生最佳经验模型。

7. 发明申请

US20090192146A1 SUBSTITUTED ORGANOSULFUR COMPOUNDS AND METHODS OF USING THEREOF 有权
标题翻译：取代的有机骨架化合物及其使用方法
公开(公告)号：US20090192146A1
公开(公告)日：2009-07-30
申请号：US12368206
申请日：2009-02-09
申请人： Xiao XU , Haoyun An , Xiaobo Wang
发明人： Xiao XU , Haoyun An , Xiaobo Wang
IPC分类号： A61K31/549 , A61K31/522 , A61K31/506 , A61K31/497 , A61K31/498
CPC分类号： C07C323/07 , C07C321/20 , C07C323/16 , C07C323/20
摘要： The present invention provides substituted di-, tri-, tetra- and penta-sulfide compounds and compositions, and methods of using the same for the treatment and/or prevention of a cell proliferative disorder. The present invention also provides methods for preparing trisulfide compounds and compositions.
摘要翻译：本发明提供取代的二，三，四和五硫化物化合物和组合物，及其用于治疗和/或预防细胞增殖性疾病的方法。本发明还提供了制备三硫化物和组合物的方法。

8. 发明申请

US20080124703A1 Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents 有权
标题翻译：使用基于阻抗的细胞学分析来分类暴露于生物活性剂时的细胞反应谱
公开(公告)号：US20080124703A1
公开(公告)日：2008-05-29
申请号：US11903454
申请日：2007-09-20
申请人： Xiaobo Wang , Yama A. Abassi , Wenfu Zhang , Xiao Xu
发明人： Xiaobo Wang , Yama A. Abassi , Wenfu Zhang , Xiao Xu
IPC分类号： C12Q1/02 , C12Q1/68 , C12Q1/70
CPC分类号： G01N33/502
摘要： The present invention provides methods of multi-dimensional profiling of biologically active agents and determining their effects on biological systems. The methods of the present invention include real-time impedance monitoring of cellular responses to biologically active agents and categorization of cellular kinetic profiles into mechanism specific cellular response profile groups. The grouping of similar cellular response profiles allows the correlation between agent and mechanism, thus allowing for the identification of potential therapeutic applications of agents or further study of cellular responses or mechanisms.
摘要翻译：本发明提供生物活性剂的多维轮廓化方法，并确定其对生物系统的影响。本发明的方法包括对生物活性剂的细胞反应的实时阻抗监测和细胞动力学特征分类到机制特异性细胞应答谱组中。类似的细胞反应谱的分组允许试剂和机制之间的相关性，从而允许鉴定试剂的潜在治疗应用或进一步研究细胞应答或机制。

9. 发明申请

US20060050596A1 Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology 有权
标题翻译：使用实时微电子传感技术动态监测活细胞中G蛋白偶联受体（GPCR）和受体酪氨酸激酶（RTK）的活化
公开(公告)号：US20060050596A1
公开(公告)日：2006-03-09
申请号：US11198831
申请日：2005-08-04
申请人： Yama Abassi , Naichen Yu , Josephine Atienza , Xiao Xu , Xiabo Wang
发明人： Yama Abassi , Naichen Yu , Josephine Atienza , Xiao Xu , Xiabo Wang
IPC分类号： G11C8/00
CPC分类号： G01N33/5041 , C12Q1/002 , G01N27/021 , G01N33/5014 , G01N33/5438 , G01N2333/4716 , G01N2333/705 , G01N2333/91205 , G01N2500/04 , G01N2500/10
摘要： The present application includes systems and methods for identifying a compound capable of interacting with a G-Protein Coupled Receptor (GPCR) or Receptor Tyrosine Kinase (RTK) including providing a device capable of measuring cell-substrate impedance operably connected to an impedance analyzer, adding test cells expressing a GPCR or a RTK to wells of the device, measuring first impedances of the wells and optionally determining first cell indices from the first impedances, adding a compound to at least one well containing test cells to form at least one compound well and adding a vehicle control to at least another well containing test cells to form at least one control well, measuring second impedances of the compound well and the control well and optionally determining second cell indices from the second impedances, determining the change in the impedance or cell index for the compound well and the one control well, comparing the change in impedance or cell index between the compound well and the control well, and identifying the compound interacts with the GPCR or RTK if the comparison demonstrates a significant difference between the change in impedance or cell index of the compound well and the control well.
摘要翻译：本申请包括用于鉴定能够与G-蛋白偶联受体（GPCR）或受体酪氨酸激酶（RTK）相互作用的化合物的系统和方法，包括提供能够测量可操作地连接到阻抗分析仪的细胞 - 基底阻抗的装置，将表达GPCR或RTK的测试细胞测量到所述装置的孔中，测量所述孔的第一阻抗并任选地从所述第一阻抗确定第一细胞指数，向至少一个含有测试细胞的孔中加入化合物以形成至少一种化合物，以及向至少另一个含有测试单元的井添加车辆控制以形成至少一个控制井，测量化合物井和控制井的第二阻抗，并且可选地从第二阻抗确定第二细胞指数，确定阻抗或细胞的变化指数为复合井和一个对照孔，比较了阻抗或细胞指数的变化如果比较表明化合物井和对照孔的阻抗变化或细胞指数之间存在显着差异，则鉴定化合物与GPCR或RTK相互作用。

10. 发明申请

US20050261321A1 Substituted organosulfur compounds and methods of using thereof 有权
标题翻译：取代的有机硫化合物及其使用方法
公开(公告)号：US20050261321A1
公开(公告)日：2005-11-24
申请号：US11110203
申请日：2005-04-20
申请人： Xiao Xu , Haoyun An , Xiaobo Wang
发明人： Xiao Xu , Haoyun An , Xiaobo Wang
IPC分类号： A61K31/095 , A61K31/381 , A61K31/444 , A61K31/513
CPC分类号： C07C323/07 , C07C321/20 , C07C323/16 , C07C323/20
摘要： The present invention provides substituted di-, tri-, tetra- and penta-sulfide compounds and compositions, and methods of using the same for the treatment and/or prevention of a cell proliferative disorder. The present invention also provides methods for preparing trisulfide compounds and compositions.
摘要翻译：本发明提供取代的二，三，四和五硫化物化合物和组合物，及其用于治疗和/或预防细胞增殖性疾病的方法。本发明还提供了制备三硫化物和组合物的方法。

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