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1. 发明专利

IL189677D0 PROCESS FOR PREPARING NITROGENOUS AROMATIC RING COMPOUNDS 未知
公开(公告)号：IL189677D0
公开(公告)日：2008-06-05
申请号：IL18967708
申请日：2008-02-21
申请人： YASUHIRO FUNAHASHI , AKIHIKO TSURUOKA , MASAYUKI MATSUKURA , TORU HANEDA , YOSHIO FUKUDA , JUNICHI KAMATA , KEIKO TAKAHASHI , TOMOHIRO MATSUSHIMA , KAZUKI MIYAZAKI , KEN ICHI NOMOTO , TATSUO WATANABE , HIROSHI OBAISHI , ATSUMI YAMAGUCHI , SACHI SUZUKI , KATSUJI NAKAMURA , FUSAYO MIMURA , YUJI YAMAMOTO , JUNJI MATSUI , KENJI MATSUI , TAKAKO YOSHIBA , YASUYUKI SUZUKI , ITARU ARIMOTO , EISAI R&D MAN CO LTD , EISAI CO LTD
IPC分类号： C07D213/74 , A61K20060101 , A61K31/4355 , A61K31/437 , A61K31/4375 , A61K31/4409 , A61K31/4418 , A61K31/4439 , A61K31/4545 , A61K31/455 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/505 , A61K31/519 , A61K31/5377 , A61P20060101 , A61P3/10 , A61P9/00 , A61P9/10 , A61P17/06 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D20100101 , C07D207/34 , C07D213/26 , C07D213/68 , C07D213/73 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/18 , C07D215/22 , C07D215/233 , C07D215/36 , C07D215/38 , C07D215/48 , C07D239/34 , C07D239/42 , C07D239/46 , C07D239/88 , C07D249/04 , C07D261/14 , C07D277/48 , C07D307/68 , C07D319/06 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D495/04
摘要： The present invention concerns a process for preparing a compound represented by the following general formula (a- or a pharmacologically acceptable salt or hydrate thereof, which comprises reacting a compound repr with a compound represented by the following general formula (a-4) : wherein the residues R 1 , R 2 , R sa1 - R sa3 , R 300 , R 301 and Z are as defined in the claims.

2. 发明申请

US20140031384A1 THERAPEUTIC AGENT FOR TUMOR 有权
标题翻译：肿瘤治疗剂
公开(公告)号：US20140031384A1
公开(公告)日：2014-01-30
申请号：US14002018
申请日：2012-04-16
申请人： Yusuke Narita , Junji Matsui , Yasuhiro Funahashi
发明人： Yusuke Narita , Junji Matsui , Yasuhiro Funahashi
IPC分类号： A61K31/47 , A61K31/437
CPC分类号： A61K31/47 , A61K31/437 , C07D215/48 , A61K2300/00
摘要： A therapeutic agent for tumor for combined use of a compound or pharmaceutically acceptable salt thereof represented by Formula (I) and a compound represented by Formula (II): wherein R1 is C1-6 alkyl or C3-8 cycloalkyl, R2 is a hydrogen atom or C1-6 alkoxy, and R3 is a hydrogen atom or a halogen atom, exhibits an excellent antitumor effect compared to cases where these are individually used.
摘要翻译：用于组合使用由式（I）表示的化合物或其药学上可接受的盐和由式（II）表示的化合物的肿瘤治疗剂：其中R 1是C 1-6烷基或C 3-8环烷基，R 2是氢原子或C 1-6烷氧基，并且R 3为氢原子或卤素原子，与单独使用它们的情况相比表现出优异的抗肿瘤效果。

3. 发明授权

US08372981B2 Nitrogen-containing aromatic derivatives 有权
标题翻译：含氮芳香族衍生物
公开(公告)号：US08372981B2
公开(公告)日：2013-02-12
申请号：US12986638
申请日：2011-01-07
申请人： Yasuhiro Funahashi , Masayuki Matsukura , Tatsuo Watanabe , Hiroshi Obaishi , Junji Matsui
发明人： Yasuhiro Funahashi , Masayuki Matsukura , Tatsuo Watanabe , Hiroshi Obaishi , Junji Matsui
IPC分类号： C07D213/68 , C07D401/04 , C07D215/16 , A61K31/47 , A61P35/04
CPC分类号： C07D213/73 , A61K31/4706 , A61K31/4745 , A61K31/517 , A61K31/519 , C07D207/34 , C07D213/26 , C07D213/68 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/18 , C07D215/233 , C07D215/36 , C07D215/38 , C07D215/48 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/88 , C07D249/04 , C07D261/14 , C07D277/48 , C07D307/68 , C07D319/06 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04
摘要： Compounds represented by the following general formula: wherein Ag is an optionally substituted 5- to 14-membered heterocyclic group, etc.; Xg is —O—, —S—, etc.; Yg is an optionally substituted C6-14 aryl group, an optionally substituted 5- to 14-membered heterocyclic group, etc.; and Tg1 is a group represented by the following general formula: (wherein Eg is a single bond or —N(Rg2)—), Rg1 and Rg2 each independently represent a hydrogen atom, an optionally substituted C1-6 alkyl group, etc. and Zg represents a C1-8 alkyl group, a C3-8 alicyclic hydrocarbon group, a C6-14 aryl group, etc.), salts thereof or hydrates of the foregoing.
摘要翻译：由以下通式表示的化合物：其中Ag是任选取代的5至14元杂环基等; Xg为-O-，-S-等; Yg是任选取代的C 6-14芳基，任选取代的5至14元杂环基等; Tg1为下列通式表示的基团：（其中Eg为单键或-N（Rg2） - ），Rg1和Rg2各自独立地表示氢原子，任意取代的C 1-6烷基等， Zg表示C1-8烷基，C3-8脂环族烃基，C6-14芳基等），其盐或上述的水合物。

4. 发明申请

US20100273990A1 Notch-based fusion proteins and uses thereof 有权
公开(公告)号：US20100273990A1
公开(公告)日：2010-10-28
申请号：US12657573
申请日：2010-01-21
申请人： Jan Kitajewski , Carrie Shawber , Yasuhiro Funahashi
发明人： Jan Kitajewski , Carrie Shawber , Yasuhiro Funahashi
IPC分类号： C07K16/46
CPC分类号： A61K48/00 , A61K9/0019 , A61K38/00 , C07K14/705 , C07K2319/30 , C07K2319/32
摘要： This invention provides a method for treating a subject having a tumor and a method for inhibiting angiogenesis in a subject, both comprising administering to the subject an effective amount of a composition of matter comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety. This invention also provides a composition of matter comprising the extracellular domain of Notch4 receptor protein operably affixed to a half-life-increasing moiety. This invention further provides an article of manufacture. Finally, this invention provides a replicable vector which encodes a polypeptide comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety, a host vector system which comprises such replicable vector and a method of producing such polypeptide.

5. 发明授权

US5781683A Video reproducing apparatus with non-repetitive selecting function 失效
标题翻译：具有非重复选择功能的视频再生装置
公开(公告)号：US5781683A
公开(公告)日：1998-07-14
申请号：US228717
申请日：1994-04-18
申请人： Iwao Sakoguchi , Yasuhiro Funahashi , Yoshiko Sakoguchi
发明人： Iwao Sakoguchi , Yasuhiro Funahashi , Yoshiko Sakoguchi
IPC分类号： G10H1/36 , H04N5/765 , H04N5/93
CPC分类号： G10H1/365 , G10H1/368 , H04N5/765
摘要： A video reproducing apparatus includes a video data memory for storing video data and a video data table for storing information about whether or not given items of the video data in the video data memory have been reproduced. A backup power supply unit backs up the information in the video data table when power is removed. A song category designation input unit is provided for inputting the song category designated, a video reproducing unit is provided for reproducing video data, and a background video control unit is provided for controlling the component units configured. On the basis of the information held in the video data table, the background video control unit determines whether or not any unreproduced video data remains in the video data belonging to the song category designated by the song category designation input unit. If unreproduced video data is found to exist, the control unit instructs the video reproducing unit to reproduce that unreproduced video data.
摘要翻译：视频再现装置包括用于存储视频数据的视频数据存储器和用于存储关于视频数据存储器中的视频数据的给定项目是否已被再现的信息的视频数据表。备用电源单元在掉电时备份视频数据表中的信息。提供用于输入指定的歌曲类别的歌曲类别指定输入单元，提供用于再现视频数据的视频再现单元，并且提供用于控制配置的组件单元的背景视频控制单元。基于视频数据表中保存的信息，背景视频控制单元确定属于由歌曲类别指定输入单元指定的歌曲类别的视频数据中是否存在任何未再现的视频数据。如果发现未再现的视频数据存在，则控制单元指示视频再现单元再现未再现的视频数据。

6. 发明授权

US5654690A Fire alarm system 失效
标题翻译：火警系统
公开(公告)号：US5654690A
公开(公告)日：1997-08-05
申请号：US354668
申请日：1994-12-13
申请人： Seiko Ishikawa , Takayoshi Urano , Kazunori Ikami , Yoshihiko Hibino , Masaru Yasuda , Yasuhiro Funahashi , Naomi Moriguchi , Hiroshi Matsuhashi , Tatsuo Matsuda , Kazuhiro Fujii
发明人： Seiko Ishikawa , Takayoshi Urano , Kazunori Ikami , Yoshihiko Hibino , Masaru Yasuda , Yasuhiro Funahashi , Naomi Moriguchi , Hiroshi Matsuhashi , Tatsuo Matsuda , Kazuhiro Fujii
IPC分类号： G08B25/04 , G08B29/00
CPC分类号： G08B25/04
摘要： Disclosed is an improved fire alarm system for an information providing system having a plurality of terminal devices for providing information to a plurality of operators, respectively. The fire alarm system is provided with a fire detecting sensors. If a fire is detected, a predetermined signal is transmitted to a controller. The controller controls each of the plurality of terminal devices to indicate an alarm information to the operator when the predetermined signal is received.
摘要翻译：公开了一种用于信息提供系统的改进的火灾报警系统，该系统具有分别向多个运营商提供信息的多个终端设备。火灾报警系统配有火灾探测传感器。如果检测到火灾，则将预定的信号发送到控制器。当接收到预定信号时，控制器控制多个终端设备中的每一个以向操作者指示报警信息。

7. 发明授权

US5319452A Control system for concentratively controlling a plurality of music accompanying apparatuses 失效
标题翻译：用于集中控制多个音乐伴奏装置的控制系统
公开(公告)号：US5319452A
公开(公告)日：1994-06-07
申请号：US980764
申请日：1992-11-24
申请人： Yasuhiro Funahashi
发明人： Yasuhiro Funahashi
IPC分类号： G10H1/36 , H04N5/445 , H04N5/78
CPC分类号： G10H1/36 , G10H1/365 , G10H2240/265 , H04N5/445
摘要： The music number is input through the panel switch arranged in the music accompanying apparatus. The modulated music number signal by the modulation-demodulation device is transmitted to the control apparatus through the coaxial cable. In the control apparatus, the music number data signal is received through the coaxial cable, and further demodulated into the music number data by the modulation-demodulation device. The controller reads out the various music data. At the same time, the controller controls the four video disc devices so that the four video picture data each of which is corresponded to the different music genre, are reproduced by the video disc devices. Thereafter, both the various music data and the four video picture data are mutually superimposed through the head amplifier after modulated by each of the modulators and transmitted to each of the music accompanying apparatuses through the coaxial cable. In the music accompanying apparatus, one of the four video picture data is selected by the video tuner based on the song tone data and both the video picture and the song text are displayed on the video monitor at the same time through picture synthesizing circuit.
摘要翻译：音乐编号通过布置在音乐伴奏装置中的面板开关输入。调制解调装置的调制音数信号通过同轴电缆发送到控制装置。在控制装置中，通过同轴电缆接收音乐数据信号，并通过调制解调装置进一步解调成乐曲数据。控制器读出各种音乐数据。同时，控制器控制四个视盘设备，使得与视频盘设备再现每个与不同音乐类型相对应的四个视频图像数据。此后，通过每个调制器调制后，各种音乐数据和四个视频图像数据通过头放大器相互重叠，并通过同轴电缆发送到每个音乐伴随装置。在音乐伴奏装置中，四个视频图像数据中的一个基于歌曲乐曲数据由视频调谐器选择，并且视频图像和歌曲文本都通过图像合成电路同时显示在视频监视器上。

8. 发明授权

US5233438A Entertainment apparatus for producing orchestral music accompaniment and a selected background video 失效
标题翻译：用于制作管弦乐伴奏的娱乐装置和选定的背景视频
公开(公告)号：US5233438A
公开(公告)日：1993-08-03
申请号：US663672
申请日：1991-03-04
申请人： Yasuhiro Funahashi , Yasutada Aoyama , Toshinori Taniuchi , Ryuji Sekiya
发明人： Yasuhiro Funahashi , Yasutada Aoyama , Toshinori Taniuchi , Ryuji Sekiya
IPC分类号： G09B15/00 , G10H1/36 , G11B7/0037 , G11B20/10 , G11B27/00 , G11B27/10 , G11B31/02 , H04N5/93
CPC分类号： H04N5/93 , G09B15/00 , G10H1/363 , G10H1/368 , G11B20/10527 , G11B27/002 , G11B27/10 , G11B31/02 , G11B7/0037 , G11B2220/20 , G11B2220/213 , G11B2220/2545 , G11B2220/2587 , G11B2220/90 , G11B27/105 , G11B27/107
摘要： An entertainment apparatus includes a loudspeaker for producing an orchestral background for singer's accompaniment and a TV monitor for displaying a background video relevant to a song sang by the singer. In a compact disk, accompaniment data and corresponding song text data are recorded with respect to each of a plurality of songs, and in a video disk, stored are a plurality of background video data each being used in conjunction with a song selected. When a desired song is selected, its accompaniment data and the corresponding song text data are read from the compact disk and one of the plurality of background video data is read from the video disk. The song text data is superimposed on the background video data so that the song text and the background video are superimposedly displayed on the TV monitor. In synchronous with the display on the TV monitor, the accompaniment data is reproduced from the loudspeaker to give an orchestral background for singers.
摘要翻译：娱乐装置包括用于产生歌手伴奏的管弦乐背景的扬声器和用于显示与歌手唱歌相关的背景视频的电视监视器。在光盘中，相对于多个歌曲中的每一个记录伴奏数据和对应的歌曲文本数据，并且在视频盘中存储有多个背景视频数据，每个背景视频数据与所选择的歌曲结合使用。当选择期望的歌曲时，从该光盘读取其伴奏数据和对应的歌曲文本数据，并从视频盘中读取多个背景视频数据中的一个。将歌曲文本数据叠加在背景视频数据上，使得歌曲文本和背景视频被叠加在TV监视器上。与电视显示器上的显示同步，从扬声器再现伴奏数据，为歌手提供管弦乐背景。

9. 发明授权

US09945862B2 Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds 有权
公开(公告)号：US09945862B2
公开(公告)日：2018-04-17
申请号：US14122339
申请日：2012-05-31
申请人： Yasuhiro Funahashi , Tadashi Kadowaki , Junji Matsui , Jason S. Simon , Lucy Xu
发明人： Yasuhiro Funahashi , Tadashi Kadowaki , Junji Matsui , Jason S. Simon , Lucy Xu
IPC分类号： A61K31/47 , G01N33/574 , C12Q1/68
CPC分类号： G01N33/57407 , A61K31/47 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , G01N33/57438
摘要： Biomarkers are provided that are predictive of a subject's responsiveness to a therapy comprising lenvatinib or a pharmaceutically acceptable salt thereof (e.g., lenvatinib mesylate). The biomarkers, compositions, and methods described herein are useful in selecting appropriate treatment modalities for a subject having cancer (e.g., thyroid cancer, kidney cancer), suspected of having cancer, or at risk of developing cancer.

10. 发明授权

US08993725B2 Notch-based fusion proteins and uses thereof 有权
标题翻译：基于Notch的融合蛋白及其用途
公开(公告)号：US08993725B2
公开(公告)日：2015-03-31
申请号：US12657573
申请日：2010-01-21
申请人： Jan Kitajewski , Carrie Shawber , Yasuhiro Funahashi
发明人： Jan Kitajewski , Carrie Shawber , Yasuhiro Funahashi
IPC分类号： A61K38/00 , C07K14/00 , A61K48/00 , C07K14/705 , A61K9/00
CPC分类号： A61K48/00 , A61K9/0019 , A61K38/00 , C07K14/705 , C07K2319/30 , C07K2319/32
摘要： This invention provides a method for treating a subject having a tumor and a method for inhibiting angiogenesis in a subject, both comprising administering to the subject an effective amount of a composition of matter comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety. This invention also provides a composition of matter comprising the extracellular domain of Notch4 receptor protein operably affixed to a half-life-increasing moiety. This invention further provides an article of manufacture. Finally, this invention provides a replicable vector which encodes a polypeptide comprising the extracellular domain of a Notch receptor protein operably affixed to a half-life-increasing moiety, a host vector system which comprises such replicable vector and a method of producing such polypeptide.
摘要翻译：本发明提供了治疗患有肿瘤的受试者的方法和用于抑制受试者血管生成的方法，所述方法包括向受试者施用有效量的包含Notch受体蛋白的细胞外结构域的物质组合物，生命增加部分。本发明还提供了包含Notch4受体蛋白的细胞外结构域的物质组合物，其可操作地附着于半衰期增加的部分。本发明还提供了一种制造品。最后，本发明提供了可复制载体，其编码包含可操作地附着于半衰期增加部分的Notch受体蛋白的细胞外结构域的多肽，包含该可复制载体的宿主载体系统和产生该多肽的方法。

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