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1. 发明申请

US20060281943A1 Stereoselective synthesis of (E)-vinylboronic esters via a Zr mediated hydroboration of alkynes 失效
标题翻译：（E） - 乙烯基硼酸酯通过Zr介导的炔烃氢化的立体选择性合成
公开(公告)号：US20060281943A1
公开(公告)日：2006-12-14
申请号：US11447486
申请日：2006-06-06
申请人： Yanong Wang
发明人： Yanong Wang
IPC分类号： C07F5/02
CPC分类号： C07F5/025
摘要： There is herein provided a process for Zr-mediated hydroboration of alkynes which offers (E)-vinylboronic esters in high yield with stereoselectivity and regioselectivity.
摘要翻译：本文提供了Zr介导的炔烃氢化方法，其以高收率提供（E） - 乙烯基硼酸酯，具有立体选择性和区域选择性。

2. 发明申请

US20060063784A1 Method of using substituted pyrazolo [1,5-a] pyrimidines 审中-公开
标题翻译：使用取代的吡唑并[1,5-a]嘧啶的方法
公开(公告)号：US20060063784A1
公开(公告)日：2006-03-23
申请号：US11221846
申请日：2005-09-09
申请人： Yanong Wang , Ariamala Gopalsamy , Erick Honores , Lee Jennings , Steven Johnson , Dennis Powell , Fuk-Wah Sum , Hwei-Ru Tsou , Biqi Wu , Nan Zhang
发明人： Yanong Wang , Ariamala Gopalsamy , Erick Honores , Lee Jennings , Steven Johnson , Dennis Powell , Fuk-Wah Sum , Hwei-Ru Tsou , Biqi Wu , Nan Zhang
IPC分类号： A61K31/519 , C07D487/04
CPC分类号： C07D487/04 , A61K31/519
摘要： This invention relates to novel methods of use of certain pyrazolo[1,5-a]pyrimidine compounds and the therapeutically acceptable salts thereof. This invention also relates to novel methods of using these compounds as anti-proliferative agents in mammals, including humans.
摘要翻译：本发明涉及使用某些吡唑并[1,5-a]嘧啶化合物及其治疗上可接受的盐的新方法。本发明还涉及在哺乳动物（包括人）中使用这些化合物作为抗增殖剂的新方法。

3. 发明授权

US06689772B1 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors 失效
标题翻译： 3-氰基喹啉，3-氰基-1,6-萘啶和3-氰基-1,7-萘啶作为蛋白激酶抑制剂
公开(公告)号：US06689772B1
公开(公告)日：2004-02-10
申请号：US10318213
申请日：2002-12-12
申请人： Diane Harris Boschelli , Yanong Wang , Frank Charles Boschelli , Dan Maarten Berger , Nan Zhang , Dennis William Powell , Fei Ye , Ayako Yamashita , Frenel Fils DeMorin , Biqi Wu , Hwei-Ru Tsou , Elsebe Geraldine Overbeek-Klumpers , Allan Wissner
发明人： Diane Harris Boschelli , Yanong Wang , Frank Charles Boschelli , Dan Maarten Berger , Nan Zhang , Dennis William Powell , Fei Ye , Ayako Yamashita , Frenel Fils DeMorin , Biqi Wu , Hwei-Ru Tsou , Elsebe Geraldine Overbeek-Klumpers , Allan Wissner
IPC分类号： A61K3133
CPC分类号： C07D401/04 , C07D215/54 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14
摘要： This invention provides compounds of Formula (I), having the structure where T, Z, X, A, R1, R2a, R2b, R2c, R3, R4, and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of osteoporosis and polycystic kidney disease.
摘要翻译：本发明提供式（I）化合物，其具有其中T，Z，X，A，R 1，R 2a，R 2b，R 2c，R 3，R 4，和n在本文中定义，或其药学上可接受的盐，其可用作抗肿瘤剂并用于治疗骨质疏松症和多囊肾病。

4. 发明授权

US06252025B1 Vinyl hyperbranched polymer with photographically useful end groups 失效
标题翻译：具有摄影有用端基的乙烯基超支化聚合物
公开(公告)号：US06252025B1
公开(公告)日：2001-06-26
申请号：US09132045
申请日：1998-08-11
申请人： Jin-Shan Wang , Yanong Wang
发明人： Jin-Shan Wang , Yanong Wang
IPC分类号： C08G6112
CPC分类号： C08G83/005 , G03C1/04 , G03C1/8155 , G03C7/305 , G03C7/327 , G03C7/396
摘要： Photographically useful materials are disclosed comprising a hyperbranched polymer segment and multiple pendant photographically useful groups. Such materials may be prepared by forming an active hyperbranched polymer segment with multiple functionalized end group sites, and reacting the active hyperbranched polymer segment with an active compound comprising a photographically useful group to form a hyperbranched polymer ended with photographically useful groups. The hyperbranched segment may comprise any kind of polymer segment with hyperbranched architecture, and the active end groups may comprise any kind of reactive site. The active hyperbranched polymer may comprise any kind of other functional groups which are located in either backbone or the ends. The hyperbranched polymers containing photographically useful groups obtained in accordance with the invention are particularly advantageous in that they enable polymer structures comprising components exhibiting different photographically useful properties, while maintaining relatively low intrinsic viscosities compared to non-hyperbranched polymers containing photographically useful groups of similar chemical compositions. Additionally, the hyperbranched polymers are advantageous with respect to dendrimer type polymers in that a wide variety of hyperbranched polymer compositions may be synthesized in accordance with commercially acceptable processes.
摘要翻译：公开的照相有用材料包括超支化聚合物链段和多个侧视照相用的基团。可以通过形成具有多个官能化端基位点的活性超支化聚合物链段和使活性超支化聚合物链段与包含照相有用基团的活性化合物反应以形成以照相用的基团结束的超支化聚合物来制备这些材料。超分支链段可以包括具有超支化结构的任何种类的聚合物链段，并且活性末端基团可以包含任何种类的反应性位点。活性超支化聚合物可以包含位于骨架或末端中的任何种类的其它官能团。包含根据本发明获得的具有照相用途基团的超支化聚合物特别有利的是，与含有具有相似化学组成的照相有用基团的非超支化聚合物相比，它们使得包含具有不同照相用性质的组分的聚合物结构同时保持相对低的特性粘度。此外，超支化聚合物对于树枝状聚合物型聚合物是有利的，因为可以根据商业上可接受的方法合成多种超支化聚合物组合物。

5. 发明申请

US20070287708A1 Substituted 3-cyanopyridines as protein kinase inhibitors 有权
标题翻译：取代的3-氰基吡啶作为蛋白激酶抑制剂
公开(公告)号：US20070287708A1
公开(公告)日：2007-12-13
申请号：US11818119
申请日：2007-06-13
申请人： Derek Cole , Diane Boschelli , Yanong Wang , Magda Asselin , Diane Joseph-McCarthy , Amarnauth Prashad , Allan Wissner , Russell Dushin , Biqi Wu , Lawrence Tumey , Chuan Niu , Joan Chen
发明人： Derek Cole , Diane Boschelli , Yanong Wang , Magda Asselin , Diane Joseph-McCarthy , Amarnauth Prashad , Allan Wissner , Russell Dushin , Biqi Wu , Lawrence Tumey , Chuan Niu , Joan Chen
IPC分类号： A61K31/5377 , A61K31/4439 , C07D413/14 , C07D405/14 , C07D409/14 , C07D403/14
CPC分类号： C07D213/85 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present teachings provide compounds of formula I and their pharmaceutically acceptable salts, hydrates, and esters, wherein R1, R2, and X are as defined herein. The present teachings also provide methods of making the compounds of formula I, and methods of treating autoimmune and inflammatory diseases by administering a therapeutically effective amount of a compound or compounds of formula I to a mammal including a human.
摘要翻译：本发明提供式I化合物及其药学上可接受的盐，水合物和酯，其中R 1，R 2和X如本文所定义。本教导还提供制备式I化合物的方法，以及通过向包括人的哺乳动物施用治疗有效量的式I化合物或化合物来治疗自身免疫性和炎性疾病的方法。

6. 发明授权

US06521618B2 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors 失效
标题翻译： 3-氰基喹啉，3-氰基-1,6-萘啶和3-氰基-1,7-萘啶作为蛋白激酶抑制剂
公开(公告)号：US06521618B2
公开(公告)日：2003-02-18
申请号：US09820070
申请日：2001-03-28
申请人： Diane Harris Boschelli , Yanong Wang , Frank Charles Boschelli , Dan Maarten Berger , Nan Zhang , Dennis William Powell , Fei Ye , Ayako Yamashita , Frenel Fils DeMorin , Biqi Wu , Hwei-Ru Tsou , Elsebe Geraldine Overbeek-Klumpers , Allan Wissner
发明人： Diane Harris Boschelli , Yanong Wang , Frank Charles Boschelli , Dan Maarten Berger , Nan Zhang , Dennis William Powell , Fei Ye , Ayako Yamashita , Frenel Fils DeMorin , Biqi Wu , Hwei-Ru Tsou , Elsebe Geraldine Overbeek-Klumpers , Allan Wissner
IPC分类号： A61K315377
CPC分类号： C07D401/04 , C07D215/54 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14
摘要： This invention provides compounds of Formula (I), having the structure where T, Z, X, A, R1, R2a, R2b, R2c, R3, R4, and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of osteoporosis and polycystic kidney disease.
摘要翻译：本发明提供具有其中T，Z，X，A，R 1，R 2a，R 2b，R 2c，R 3，R 4和n如本文所定义的结构的式（I）化合物或其药学上可接受的盐，其可用作抗肿瘤剂药物和治疗骨质疏松症和多囊肾病。

7. 发明授权

US07365197B2 Method for the regioselective preparation of substituted benzo[g]quinoline-3-carbonitriles and benzo[g]quinazolines 失效
标题翻译：取代苯并[g]喹啉-3-腈和苯并[g]喹唑啉的区域选择性制备方法
公开(公告)号：US07365197B2
公开(公告)日：2008-04-29
申请号：US10250376
申请日：2001-12-11
申请人： Dan Maarten Berger , Gary Harold Birnberg , Yanong Wang
发明人： Dan Maarten Berger , Gary Harold Birnberg , Yanong Wang
IPC分类号： C07D265/30 , C07D295/12 , C07D295/22 , C07D255/00 , C07C229/00
CPC分类号： C07D221/08 , C07C227/16 , C07C253/30 , C07C255/59 , C07D239/70 , C07C229/70 , C07C255/47
摘要： This invention relates to a method for the regioselective synthesis of 4,6,7,8-substituted benzo[g]quinoline-3-carbonitriles and 4,6,7,8-substituted benzo[g]quinazolines as well as intermediates thereof. The compounds derived from this invention are useful for the treatment of a variety of diseases that are a result of deregulation of these PTK's, and more specifically, are anti-cancer agents and are useful for the treatment of cancer in mammals. In addition, the compounds derived from this invention are useful for the treatment of polycystic kidney disease in mammals.
摘要翻译：本发明涉及用于区域选择性合成4,6,7,8-取代的苯并[g]喹啉-3-腈和4,6,7,8-取代的苯并[g]喹唑啉的方法及其中间体。衍生自本发明的化合物可用于治疗由于这些PTK的失调而导致的各种疾病，更具体地，是抗癌剂，并且可用于治疗哺乳动物的癌症。此外，衍生自本发明的化合物可用于治疗哺乳动物的多囊肾病。

8. 发明申请

US20060063785A1 Substituted pyrazolo[1,5-a] pyrimidines and process for making same 审中-公开
标题翻译：取代的吡唑并[1,5-a]嘧啶及其制备方法
公开(公告)号：US20060063785A1
公开(公告)日：2006-03-23
申请号：US11221847
申请日：2005-09-09
申请人： Yanong Wang , Ariamala Gopalsamy , Dennis Powell , Hwei-Ru Tsou , Nan Zhang
发明人： Yanong Wang , Ariamala Gopalsamy , Dennis Powell , Hwei-Ru Tsou , Nan Zhang
IPC分类号： A61K31/519 , C07D487/04
CPC分类号： C07D487/04
摘要： This invention relates to novel pyrazolo[1,5-a]pyrimidine compounds and the therapeutically acceptable salts thereof. These compounds are useful as anti-proliferative agents in mammals, including humans.
摘要翻译：本发明涉及新的吡唑并[1,5-a]嘧啶化合物及其治疗上可接受的盐。这些化合物可用作哺乳动物（包括人）中的抗增殖剂。

9. 发明申请

US20060041127A1 Method for the regioselective preparation of substituted benzo[g]quinoline-3-carbonitriles and benzo[g]quinazolines 失效
标题翻译：取代苯并[g]喹啉-3-腈和苯并[g]喹唑啉的区域选择性制备方法
公开(公告)号：US20060041127A1
公开(公告)日：2006-02-23
申请号：US10250376
申请日：2001-12-11
申请人： Dan Berger , Gary Birnberg , Yanong Wang
发明人： Dan Berger , Gary Birnberg , Yanong Wang
IPC分类号： C07D221/06 , C07D239/70
CPC分类号： C07D221/08 , C07C227/16 , C07C253/30 , C07C255/59 , C07D239/70 , C07C229/70 , C07C255/47
摘要： This invention relates to a method for the regioselective synthesis of 4,6,7,8-substituted benzo[g]quinoline-3-carbonitriles and 4,6,7,8-substituted benzo[g]quinazolines as well as intermediates thereof. The compounds derived from this invention are useful for the treatment of a variety of diseases that are a result of deregulation of these PTK's, and more specifically, are anti-cancer agents and are useful for the treatment of cancer in mammals. In addition, the compounds derived from this invention are useful for the treatment of polycystic kidney disease in mammals.
摘要翻译：本发明涉及用于区域选择性合成4,6,7,8-取代的苯并[g]喹啉-3-腈和4,6,7,8-取代的苯并[g]喹唑啉的方法及其中间体。衍生自本发明的化合物可用于治疗由于这些PTK的失调而导致的各种疾病，更具体地，是抗癌剂，并且可用于治疗哺乳动物的癌症。此外，衍生自本发明的化合物可用于治疗哺乳动物的多囊肾病。

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