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1. 发明授权

US08088330B1 Apparatus and method for preparing sliced specimen 有权
标题翻译：制备切片试样的装置和方法
公开(公告)号：US08088330B1
公开(公告)日：2012-01-03
申请号：US13214900
申请日：2011-08-22
申请人： Daisuke Nakajima , Yoshihiko Isagawa , Hiroaki Iida , Toshiyuki Murakami
发明人： Daisuke Nakajima , Yoshihiko Isagawa , Hiroaki Iida , Toshiyuki Murakami
IPC分类号： G01N21/00
CPC分类号： G01N1/06 , B26D3/28 , B26D5/02 , B26D7/32 , G01N1/312 , G01N35/00029 , G01N35/02 , G01N2001/065 , Y10T83/2074 , Y10T83/536 , Y10T83/6577 , Y10T436/2575
摘要： Sliced specimens can be automatically and continuously prepared and burdens of an operator can be reduced while accuracy required for the sliced specimen is maintained. The sliced specimen is prepared by relatively moving a specimen block transfer section and a cutter, and when a slicing operation to adjust the height position of the specimen block is continuously performed so that the cutting surface of the specimen block is located at a sliceable position, the cutter is moved so that a contacting area of a blade edge of the cutter that firstly contacts the specimen block after the height position adjustment is sequentially changed, every time previously set number of times of slicing operation is completed. Thereafter, the height position of the blade edge of the cutter after the change is measured by a detector, and based on the measurement information of the detector, the sliceable position is corrected and the slicing operation is resumed.
摘要翻译：切片样品可以自动连续地制备，并且可以减少操作者的负担，同时保持切片试样的精度。通过相对移动样品块转移部和切割器来制备切片样品，并且当连续进行调整样品块的高度位置的切片操作，使得样品块的切割面位于切割位置时，移动切割器，使得在每次预先设定的切片操作次数完成之后，在高度位置调整之后，切割器的叶片边缘的接触区域顺序地改变。此后，通过检测器测量切换器的刀刃的高度位置，并且基于检测器的测量信息，校正切片位置并恢复切片操作。

2. 发明申请

US20140041500A1 SLICED SPECIMEN PREPARING APPARATUS 审中-公开
标题翻译： SLIED样品制备设备
公开(公告)号：US20140041500A1
公开(公告)日：2014-02-13
申请号：US14113912
申请日：2012-04-25
申请人： Yoshihiko Isagawa , Hideaki Hikawa , Hiroaki Iida , Yasushi Nakagawa , Toshiyuki Murakami
发明人： Yoshihiko Isagawa , Hideaki Hikawa , Hiroaki Iida , Yasushi Nakagawa , Toshiyuki Murakami
IPC分类号： G01N1/06
CPC分类号： G01N1/06 , Y10T83/8748
摘要： To improve the freedom in material selection of cutter while suppressing increase in loads on the operator, a sliced specimen preparing apparatus of the present invention includes a cutter storage section storing a plurality of cutters, a specimen block cutting unit holding a cutter and slicing a surface layer of a specimen block, and a cutter transfer unit transferring a cutter stored in the cutter storage section to the specimen block cutting unit and replacing the cutter held by the specimen block cutting unit, the specimen block cutting unit is movable between a sliceable position where a blade edge of the cutter is oriented obliquely downward and a replacement position where the blade edge of the cutter is horizontally or oriented obliquely upward, and the cutter transfer unit replaces the cutter held by the specimen block cutting unit when the specimen block cutting unit is located at the replacement position.
摘要翻译：为了提高刀具的材料选择自由度，同时抑制操作者的负担增加，本发明的切片试样制备装置包括：存储多个切割器的切割器存储部分;保持切割器并切割表面的样品块切割装置试样块的层，以及将存储在切割器存储部中的切割器传送到样品块切割单元并更换由样品块切割单元保持的切割器的切割器传送单元，样品块切割单元可在切割位置切割器的刀片边缘倾斜向下取向，并且切割器的刀刃水平或倾斜向上定向的替换位置，并且当样品块切割单元为样品块切割单元时，切割器传送单元替换由样品块切割单元保持的切割器位于更换位置。

3. 发明申请

US20080312100A1 Hybridization Method as Well as Hybridization Microarray and Hybridization Kit 审中-公开
标题翻译：杂交方法以及杂交微阵列和杂交试剂盒
公开(公告)号：US20080312100A1
公开(公告)日：2008-12-18
申请号：US10589497
申请日：2005-02-25
申请人： Isao Miyagawa , Yoshihiko Isagawa , Atsushi Morishita
发明人： Isao Miyagawa , Yoshihiko Isagawa , Atsushi Morishita
IPC分类号： C40B40/00 , C40B50/18
CPC分类号： C12Q1/6837 , C12Q2527/109 , C12Q2527/137
摘要： A method of simply and reliably hybridizing a sample biopolymer using a glass coverslip and a closed vessel by hybridizing the sample biopolymer and a probe biopolymer with each other in a state that a solution containing the sample biopolymer is in contact with only a slide glass to which the probe biopolymer is immobilized in a closed vessel containing a solution having the same vapor pressure as the solution containing the sample biopolymer is provided. A microarray and a kit for hybridization employed for the present invention are also provided.
摘要翻译：通过使样品生物聚合物和探针生物聚合物在含有样品生物聚合物的溶液仅与载玻片玻璃接触的状态下将样品生物聚合物和探针生物聚合物杂交，使用玻璃盖玻片和密闭容器简单可靠地杂交样品生物聚合物的方法，将探针生物聚合物固定在密闭容器中，其中含有与含有样品生物聚合物的溶液具有相同蒸气压的溶液。还提供了用于本发明的微阵列和用于杂交的试剂盒。

4. 发明申请

US20080072723A1 Apparatus and method for preparing sliced specimen 有权
标题翻译：制备切片试样的装置和方法
公开(公告)号：US20080072723A1
公开(公告)日：2008-03-27
申请号：US11902357
申请日：2007-09-20
申请人： Daisuke Nakajima , Yoshihiko Isagawa , Hiroaki Iida , Toshiyuki Murakami
发明人： Daisuke Nakajima , Yoshihiko Isagawa , Hiroaki Iida , Toshiyuki Murakami
IPC分类号： G01N1/06 , G02B21/34
CPC分类号： G01N1/06 , B26D3/28 , B26D5/02 , B26D7/32 , G01N1/312 , G01N35/00029 , G01N35/02 , G01N2001/065 , Y10T83/2074 , Y10T83/536 , Y10T83/6577 , Y10T436/2575
摘要： Sliced specimens can be automatically and continuously prepared and burdens of an operator can be reduced while accuracy required for the sliced specimen is maintained. The sliced specimen is prepared by relatively moving a specimen block transfer section and a cutter, and when a slicing operation to adjust the height position of the specimen block is continuously performed so that the cutting surface of the specimen block is located at a sliceable position, the cutter is moved so that a contacting area of a blade edge of the cutter that firstly contacts the specimen block after the height position adjustment is sequentially changed, every time previously set number of times of slicing operation is completed. Thereafter, the height position of the blade edge of the cutter after the change is measured by a detector, and based on the measurement information of the detector, the sliceable position is corrected and the slicing operation is resumed.
摘要翻译：切片样品可以自动连续地制备，并且可以减少操作者的负担，同时保持切片试样的精度。通过相对移动样品块转移部和切割器来制备切片样品，并且当连续进行调整样品块的高度位置的切片操作，使得样品块的切割面位于切割位置时，移动切割器，使得在每次预先设定的切片操作次数完成之后，在高度位置调整之后，切割器的叶片边缘的接触区域顺序地改变。此后，通过检测器测量切换器的刀刃的高度位置，并且基于检测器的测量信息，校正切片位置并恢复切片操作。

5. 发明申请

US20110303352A1 APPARATUS AND METHOD FOR PREPARING SLICED SPECIMEN 有权
标题翻译：用于制备图形样本的装置和方法
公开(公告)号：US20110303352A1
公开(公告)日：2011-12-15
申请号：US13214900
申请日：2011-08-22
申请人： Daisuke Nakajima , Yoshihiko Isagawa , Hiroaki Iida , Toshiyuki Murakami
发明人： Daisuke Nakajima , Yoshihiko Isagawa , Hiroaki Iida , Toshiyuki Murakami
IPC分类号： B32B38/10
CPC分类号： G01N1/06 , B26D3/28 , B26D5/02 , B26D7/32 , G01N1/312 , G01N35/00029 , G01N35/02 , G01N2001/065 , Y10T83/2074 , Y10T83/536 , Y10T83/6577 , Y10T436/2575
摘要： Sliced specimens can be automatically and continuously prepared and burdens of an operator can be reduced while accuracy required for the sliced specimen is maintained. The sliced specimen is prepared by relatively moving a specimen block transfer section and a cutter, and when a slicing operation to adjust the height position of the specimen block is continuously performed so that the cutting surface of the specimen block is located at a sliceable position, the cutter is moved so that a contacting area of a blade edge of the cutter that firstly contacts the specimen block after the height position adjustment is sequentially changed, every time previously set number of times of slicing operation is completed. Thereafter, the height position of the blade edge of the cutter after the change is measured by a detector, and based on the measurement information of the detector, the sliceable position is corrected and the slicing operation is resumed.
摘要翻译：切片样品可以自动连续地制备，并且可以减少操作者的负担，同时保持切片试样的精度。通过相对移动样品块转移部和切割器来制备切片样品，并且当连续进行调整样品块的高度位置的切片操作，使得样品块的切割面位于切割位置时，移动切割器，使得在每次预先设定的切片操作次数完成之后，在高度位置调整之后，切割器的叶片边缘的接触区域顺序地改变。此后，通过检测器测量切换器的刀刃的高度位置，并且基于检测器的测量信息，校正切片位置并恢复切片操作。

6. 发明授权

US08025842B2 Apparatus and method for preparing sliced specimen 有权
标题翻译：制备切片试样的装置和方法
公开(公告)号：US08025842B2
公开(公告)日：2011-09-27
申请号：US11902357
申请日：2007-09-20
申请人： Daisuke Nakajima , Yoshihiko Isagawa , Hiroaki Iida , Toshiyuki Murakami
发明人： Daisuke Nakajima , Yoshihiko Isagawa , Hiroaki Iida , Toshiyuki Murakami
IPC分类号： G01N21/00
CPC分类号： G01N1/06 , B26D3/28 , B26D5/02 , B26D7/32 , G01N1/312 , G01N35/00029 , G01N35/02 , G01N2001/065 , Y10T83/2074 , Y10T83/536 , Y10T83/6577 , Y10T436/2575
摘要： Sliced specimens can be automatically and continuously prepared and burdens of an operator can be reduced while accuracy required for the sliced specimen is maintained. The sliced specimen is prepared by relatively moving a specimen block transfer section and a cutter, and when a slicing operation to adjust the height position of the specimen block is continuously performed so that the cutting surface of the specimen block is located at a sliceable position, the cutter is moved so that a contacting area of a blade edge of the cutter that firstly contacts the specimen block after the height position adjustment is sequentially changed, every time previously set number of times of slicing operation is completed. Thereafter, the height position of the blade edge of the cutter after the change is measured by a detector, and based on the measurement information of the detector, the sliceable position is corrected and the slicing operation is resumed.
摘要翻译：切片样品可以自动连续地制备，并且可以减少操作者的负担，同时保持切片试样的精度。通过相对移动样品块转移部和切割器来制备切片样品，并且当连续进行调整样品块的高度位置的切片操作，使得样品块的切割面位于切割位置时，移动切割器，使得在每次预先设定的切片操作次数完成之后，在高度位置调整之后，切割器的叶片边缘的接触区域顺序地改变。此后，通过检测器测量切换器的刀刃的高度位置，并且基于检测器的测量信息，校正切片位置并恢复切片操作。

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