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1. 发明专利

AU2019202205A1 Method to Discovery of Potential Bioactive Compounds in Herbals with Regrouping after Chromatography 未知
公开(公告)号：AU2019202205A1
公开(公告)日：2019-10-31
申请号：AU2019202205
申请日：2019-03-29
申请人： ZHANG JIANYI DR
发明人： ZHANG JIANYI
IPC分类号： G01N1/18
摘要： A Method of Discovery of Potential Bioactive Compounds in Herbals by Regrouping after Chromatography Abstract The invention discloses a method by which potential bioactive compounds from herbals can be identified by regrouping after chromatography. The method comprises the steps of: selecting herbals with reports of therapeutic effects according to previous experience, extracting compounds by boiling or chemical methods, and separating compounds with the chromatography. The separated compounds are regrouped with different portions, which are further tested in vivo and/or in vitro to remove the inactive portions and repeating the same process until no more compounds can be removed, and the remaining compounds are synthesized or purified, which are made into various forms and utilized to treat diseases.

2. 发明专利

AU2016233772A1 Method of discovery of effective components in herbals based on evidences by reversed-directed analysis 未知
公开(公告)号：AU2016233772A1
公开(公告)日：2017-08-17
申请号：AU2016233772
申请日：2016-03-03
申请人： ZHANG JIANYI
发明人： ZHANG JIANYI
IPC分类号： G16H10/60
摘要： Conventional methods in this field include identifying and screening compounds in a laboratory setting with cells and animals, and then moving on to clinical trials with a promising compound. To complicate the issue with these methods, effective compounds might not exist in the original herbals, multiple compounds might be involved with outcomes, long study period and high cost. The method described above might bypass bottlenecks such as, 1) promising compounds are identified from test patients who demonstrate preferred and safe results; 2) more than one compound might be identified; 3) safe and effective compounds might be metabolites and not exist in herbals. The process includes a website to collect clinical information. The promising compounds can be determined by analyzing common components from patients. Information for potential compounds are directly obtained from human being, application of the invention will tremendously reduce the time and costs involved in research and development of new drugs.

3. 发明专利

CA3039954A1 METHOD OF IDENTIFYING BIOACTIVE COMPOUNDS IN HERBALS 未知
公开(公告)号：CA3039954A1
公开(公告)日：2019-10-14
申请号：CA3039954
申请日：2019-04-10
申请人： ZHANG JIANYI
发明人： ZHANG JIANYI
IPC分类号： G01N33/48 , G01N1/34
摘要： The invention discloses a method by which potential bioactive compounds from herbals can be identified by regrouping after chromatography. The method comprises the steps of: selecting herbals with reports of therapeutic effects according to previous experience, extracting compounds by boiling or chemical methods, and separating compounds with the chromatography. The separated compounds are regrouped with different portions, which are further tested in vivo and/or in vitro to remove the inactive portions and repeating the same process until no more compounds can be removed, and the remaining compounds are synthesized or purified, which are made into various forms and utilized to treat diseases.

4. 发明公开

EP3268926A1 METHOD OF DISCOVERY OF EFFECTIVE COMPONENTS IN HERBALS BASED ON EVIDENCES BY REVERSED-DIRECTED ANALYSIS 审中-公开
标题翻译：反证法分析证据发现有效成分的方法
公开(公告)号：EP3268926A1
公开(公告)日：2018-01-17
申请号：EP16765419.3
申请日：2016-03-03
申请人： Zhang, Jianyi
发明人： Zhang, Jianyi
IPC分类号： G06Q50/24
CPC分类号： G06F19/3475 , A61B5/021 , A61B5/4848 , A61B5/4854 , G06F19/00 , G06F19/24 , G16H10/20 , G16H10/40 , G16H10/60 , Y02A90/26
摘要： A method of proving safety and efficacy of herbal compounds by clinical information obtained by physicians in daily practice by implementation of network technology, chemical analysis, statistics, and clinical trials. Data for potential therapeutic compounds are directly obtained from human being in daily practice setting, application of the invention will tremendously reduce the time and costs involved in research and development of drugs.

5. 发明公开

EP3553517A1 METHOD OF IDENTIFYING BIOACTIVE COMPOUNDS IN HERBALS 审中-公开
公开(公告)号：EP3553517A1
公开(公告)日：2019-10-16
申请号：EP19160162.4
申请日：2019-02-28
申请人： Zhang, Jianyi
发明人： Zhang, Jianyi
IPC分类号： G01N33/50
摘要： The invention discloses a method by which potential bioactive compounds from herbals can be identified by regrouping after chromatography. The method comprises the steps of: selecting herbals with reports of therapeutic effects according to previous experience, extracting compounds by boiling or chemical methods, and separating compounds with the chromatography. The separated compounds are regrouped with different portions, which are further tested in vivo and/or in vitro to remove the inactive portions and repeating the same process until no more compounds can be removed, and the remaining compounds are synthesized or purified, which are made into various forms and utilized to treat diseases.

6. 发明申请

WO2006047743A2 SWINE MULTIPOTENT ADULT PROGENITOR CELLS 审中-公开
公开(公告)号：WO2006047743A2
公开(公告)日：2006-05-04
申请号：PCT/US2005038979
申请日：2005-10-26
申请人： UNIV MINNESOTA , VERFAILLIE CATHERINE M , ZENG LEPENG , ZHANG JIANYI
发明人： VERFAILLIE CATHERINE M , ZENG LEPENG , ZHANG JIANYI
IPC分类号： A61K35/12 , C12N5/074
CPC分类号： A61K35/28 , C12N5/0607 , C12N2501/11 , C12N2501/135
摘要： The present invention provides swine cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple cell types. Also provided are methods of isolation and culture, as well as uses for the cells, such as xenogeneic transplantation and/or tissue repair.
摘要翻译：本发明提供非胚胎来源的猪细胞，其可以维持在未分化状态的培养物中或分化以形成多种细胞类型的细胞。还提供了分离和培养的方法，以及细胞的使用，例如异种移植和/或组织修复。

7. 发明申请

WO2016148936A8 METHOD OF DISCOVERY OF EFFECTIVE COMPONENTS IN HERBALS BASED ON EVIDENCES BY REVERSED-DIRECTED ANALYSIS 审中-公开
标题翻译：通过反向指导分析发现有效成分在草药中的方法
公开(公告)号：WO2016148936A8
公开(公告)日：2017-03-30
申请号：PCT/US2016020789
申请日：2016-03-03
申请人： ZHANG JIANYI
发明人： ZHANG JIANYI
IPC分类号： G06Q50/24
CPC分类号： G06F19/3475 , A61B5/021 , A61B5/4839 , A61B5/4848 , G06F19/24 , G16H10/20 , G16H10/40 , G16H10/60 , Y02A90/26
摘要： A method of proving safety and efficacy of herbal compounds by clinical information obtained by physicians in daily practice by implementation of network technology, chemical analysis, statistics, and clinical trials. Data for potential therapeutic compounds are directly obtained from human being in daily practice setting, application of the invention will tremendously reduce the time and costs involved in research and development of drugs.
摘要翻译：通过实施网络技术，化学分析，统计学和临床试验，通过医生在日常实践中获得的临床信息，证明草药化合物的安全性和有效性的方法。潜在治疗化合物的数据直接从人类在日常实践中获得，本发明的应用将极大地减少药物研发中所涉及的时间和成本。

8. 发明申请

WO2016148936A1 METHOD OF DISCOVERY OF EFFECTIVE COMPONENTS IN HERBALS BASED ON EVIDENCES BY REVERSED-DIRECTED ANALYSIS 审中-公开
标题翻译：通过反向分析发现基于证据的有效成分在草药中的方法
公开(公告)号：WO2016148936A1
公开(公告)日：2016-09-22
申请号：PCT/US2016/020789
申请日：2016-03-03
申请人： ZHANG, Jianyi
发明人： ZHANG, Jianyi
IPC分类号： G06Q50/24
CPC分类号： G06F19/3475 , A61B5/021 , A61B5/4839 , A61B5/4848 , G06F19/00 , G06F19/24 , G16H10/20 , G16H10/40 , G16H10/60 , Y02A90/26
摘要： Conventional methods in this field include identifying and screening compounds in a laboratory setting with cells and animals, and then moving on to clinical trials with a promising compound. To complicate the issue with these methods, effective compounds might not exist in the original herbals, multiple compounds might be involved with outcomes, long study period and high cost. The method described above might bypass bottlenecks such as, 1) promising compounds are identified from test patients who demonstrate preferred and safe results; 2) more than one compound might be identified; 3) safe and effective compounds might be metabolites and not exist in herbals. The process includes a website to collect clinical information. The promising compounds can be determined by analyzing common components from patients. Information for potential compounds are directly obtained from human being, application of the invention will tremendously reduce the time and costs involved in research and development of new drugs.
摘要翻译：该领域的常规方法包括在具有细胞和动物的实验室环境中鉴定和筛选化合物，然后用有希望的化合物进行临床试验。为了使这些方法的问题复杂化，有效的化合物可能不存在于原始草药中，多种化合物可能与结果有关，研究时间长，成本高。上述方法可能会绕过瓶颈，例如：1）有希望的化合物是从测试患者中鉴定出来的，并且表现出优选和安全的结果; 2）可以鉴定多于一种化合物; 3）安全有效的化合物可能是代谢物，不存在于草药中。该过程包括一个收集临床信息的网站。有希望的化合物可以通过分析患者的常见成分来确定。潜在化合物的信息直接从人类获得，本发明的应用将极大地减少研究和开发新药所涉及的时间和成本。

9. 发明申请

WO03093433A2 FIBRIN-BASED BIOMATRIX 审中-公开
标题翻译：基于FIBRIN的生物测定
公开(公告)号：WO03093433A2
公开(公告)日：2003-11-13
申请号：PCT/US0313697
申请日：2003-05-01
申请人： UNIV MINNESOTA , ZHANG JIANYI , WANG ZONG LI
发明人： ZHANG JIANYI , WANG ZONG LI
IPC分类号： A61L24/00 , A61L24/10 , A61L27/22 , A61L27/38 , A61L27/50 , C12N5/0775 , C12N
CPC分类号： A61L27/225 , A61L24/0005 , A61L24/106 , A61L27/3804 , A61L27/3869 , A61L27/3873 , A61L27/3895 , A61L27/50 , C12N5/0663 , C12N2500/25 , C12N2501/11 , C12N2501/135
摘要： The invention involves methods and materials related to fibrin-based biomatrices.
摘要翻译：本发明涉及与基于纤维蛋白的生物基质相关的方法和材料。

10. 发明申请

WO2006047743A3 SWINE MULTIPOTENT ADULT PROGENITOR CELLS 审中-公开
公开(公告)号：WO2006047743A3
公开(公告)日：2006-05-04
申请号：PCT/US2005/038979
申请日：2005-10-26
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , VERFAILLIE, Catherine, M. , ZENG, Lepeng , ZHANG, Jianyi
发明人： VERFAILLIE, Catherine, M. , ZENG, Lepeng , ZHANG, Jianyi
IPC分类号： A01N63/00
摘要： The present invention provides swine cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple cell types. Also provided are methods of isolation and culture, as well as uses for the cells, such as xenogeneic transplantation and/or tissue repair.

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