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1. 发明申请

WO2018107415A1 HYDROXY ISOXAZOLE COMPOUNDS USEFUL AS GPR120 AGONISTS 审中-公开
公开(公告)号：WO2018107415A1
公开(公告)日：2018-06-21
申请号：PCT/CN2016/110054
申请日：2016-12-15
申请人： MERCK SHARP & DOHME CORP. , DEBENHAM, John S. , COX, Jason M. , LAN, Ping , SUN, Zhongxiang , FENG, Zhe , SUN, Chunrui , SEGANISH, W. Michael , LAI, Zhong , ZHU, Chen , BARA, Thomas , RAJAGOPANALAN, Murali , DANG, Qun , KIM, Hyunjin M. , HU, Bin , HAO, Jinglai
发明人： DEBENHAM, John S. , COX, Jason M. , LAN, Ping , SUN, Zhongxiang , FENG, Zhe , SUN, Chunrui , SEGANISH, W. Michael , LAI, Zhong , ZHU, Chen , BARA, Thomas , RAJAGOPANALAN, Murali , DANG, Qun , KIM, Hyunjin M. , HU, Bin , HAO, Jinglai
IPC分类号： C07D413/12 , C07D413/04 , C07D261/12 , A61K31/42 , A61K31/422 , A61P3/10 , A61P43/00
摘要： The present invention relates to a compound represented by formula (I) : and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, NASH, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included.

2. 发明申请

WO2011100798A1 NITRIDING OF NIOBIUM STEEL AND PRODUCT MADE THEREBY 审中-公开
标题翻译：氮化铌及其制品
公开(公告)号：WO2011100798A1
公开(公告)日：2011-08-25
申请号：PCT/AU2011/000171
申请日：2011-02-18
申请人： BLUESCOPE STEEL LIMITED , IHI CORPORATION , NUCOR CORPORATION , XIE, Yuxuan , ZHU, Chen , CAIRNEY, Julie M. , RINGER, Simon P. , KILLMORE, Christopher Ronald , BARBARO, Frank , WILLIAMS, James Geoffery
发明人： XIE, Yuxuan , ZHU, Chen , CAIRNEY, Julie M. , RINGER, Simon P. , KILLMORE, Christopher Ronald , BARBARO, Frank , WILLIAMS, James Geoffery
IPC分类号： B22D11/00 , C22C38/02 , C22C38/12 , C21D1/06 , C22C38/04 , C21D8/02 , C22C38/06
CPC分类号： C22C38/02 , C21D1/06 , C21D8/02 , C22C38/001 , C22C38/04 , C22C38/06 , C22C38/12 , C23C8/02 , C23C8/26 , C23C8/38 , C23C8/50
摘要： A nitrided steel product or thin cast steel strip comprising, by weight, less than 0.25 % carbon, between 0.20 and 2.0 % manganese, between 0.05 and 0.50 % silicon, less than 0.01% aluminum, between 0.01 and about 0.20% niobium, and between 0.01 and 0.075 % nitrogen, and having a majority of the microstructure comprised of bainite and acicular ferrite, having more than 70 % niobium in solid solution prior to nitriding and having yield strength between 650 MPa and 800 MPa and tensile strength between 750 MPa and 900 MPa.
摘要翻译：氮化钢产品或薄铸钢带，其包含重量小于0.25％的碳，0.20％至2.0％的锰，0.05％至0.50％的硅，小于0.01％的铝，0.01％至约0.20％的铌，以及 0.01和0.075％的氮，并且具有由贝氏体和针状铁素体组成的大部分微结构，在氮化之前在固溶体中具有超过70％的铌，并且屈服强度在650MPa和800MPa之间，拉伸强度在750MPa和900之间兆帕。

3. 发明申请

WO2005033144A3 TIM-3 POLYPEPTIDES 审中-公开
标题翻译： TIM-3多糖
公开(公告)号：WO2005033144A3
公开(公告)日：2005-06-16
申请号：PCT/US2004032749
申请日：2004-10-04
申请人： BRIGHAM & WOMENS HOSPITAL , BETH ISRAEL HOSPITAL , KUCHROO VIJAY K , STROM TERRY , CHA EUGENE K , CHAKRAVARTI SUMONE , SABATOS CATHERINE , ZHU CHEN , ZHENG XIN XIAO , SANCHEZ-FUEGO ALBERTO
发明人： KUCHROO VIJAY K , STROM TERRY , CHA EUGENE K , CHAKRAVARTI SUMONE , SABATOS CATHERINE , ZHU CHEN , ZHENG XIN XIAO , SANCHEZ-FUEGO ALBERTO
IPC分类号： C07H21/04 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/28 , C12N5/06 , A61K38/17 , A61P37/02 , C12N15/12
CPC分类号： C07K16/18 , C07K14/4713 , C07K14/70503 , C07K16/28 , C07K2319/30 , G01N33/505
摘要： The invention relates to isolated polypeptides and acids encoding polypeptides which comprise a tim-3 IgV domain and a tim-3 intracellular domain, wherein the polypeptides do not comprise a tim-3 mucin domain or a tim-3 transmembrane domain. In addition, the invention relates to methods of modulating immune responses in a subject, comprising administering to the subject a therapeutically effective amount of an agent that modulates tim-3 activity. Immune responses include, but are not limited to, immune tolerance, transplantation tolerance, Th1 responses and Th2 responses.
摘要翻译：本发明涉及分离的多肽和编码多肽的酸，其包含tim-3 IgV结构域和tim-3细胞内结构域，其中所述多肽不包含tim-3粘蛋白结构域或tim-3跨膜结构域。此外，本发明涉及调节受试者中的免疫应答的方法，包括向受试者施用治疗有效量的调节tim-3活性的药剂。免疫反应包括但不限于免疫耐受性，移植耐受性，Th1应答和Th2应答。

4. 发明申请

WO2005033144A2 TIM-3 LIGANDS AND METHODS THEREOF 审中-公开
标题翻译： TIM-3配体及其方法
公开(公告)号：WO2005033144A2
公开(公告)日：2005-04-14
申请号：PCT/US2004/032749
申请日：2004-10-04
申请人： BRIGHAM AND WOMEN'S HOSPITAL , BETH ISRAEL DEACONESS MEDICAL CENTER , KUCHROO, Vijay, K. , STROM, Terry , CHA, Eugene, K. , CHAKRAVARTI, Sumone , SABATOS, Catherine , ZHU, Chen , ZHENG, Xin, Xiao , SANCHEZ-FUEGO, Alberto
发明人： KUCHROO, Vijay, K. , STROM, Terry , CHA, Eugene, K. , CHAKRAVARTI, Sumone , SABATOS, Catherine , ZHU, Chen , ZHENG, Xin, Xiao , SANCHEZ-FUEGO, Alberto
IPC分类号： C07K16/00
CPC分类号： C07K16/18 , C07K14/4713 , C07K14/70503 , C07K16/28 , C07K2319/30 , G01N33/505
摘要： The invention relates to isolated polypeptides and acids encoding polypeptides which comprise a tim-3 IgV domain and a tim-3 intracellular domain, wherein the polypeptides do not comprise a tim-3 mucin domain or a tim-3 transmembrane domain. In addition, the invention relates to methods of modulating immune responses in a subject, comprising administering to the subject a therapeutically effective amount of an agent that modulates tim-3 activity. Immune responses include, but are not limited to, immune tolerance, transplantation tolerance, Th1 responses and Th2 responses.
摘要翻译：本发明涉及分离的多肽和编码多肽的酸，其包含tim-3 IgV结构域和tim-3细胞内结构域，其中所述多肽不包含tim-3粘蛋白结构域或tim-3跨膜结构域。此外，本发明涉及调节受试者中的免疫应答的方法，包括向受试者施用治疗有效量的调节tim-3活性的药剂。免疫反应包括但不限于免疫耐受性，移植耐受性，Th1应答和Th2应答。

5. 发明申请

WO2003045306A2 PHENOXY AMINE COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS 审中-公开
标题翻译：苯氧胺化合物和组合物用于递送活性剂
公开(公告)号：WO2003045306A2
公开(公告)日：2003-06-05
申请号：PCT/US2002/036552
申请日：2002-11-13
申请人： EMISPHERE TECHNOLOGIES, INC. , GSCHNEIDNER, David , KRAFT, Kelly , ZHU, Chen , CHEN, Yi
发明人： GSCHNEIDNER, David , KRAFT, Kelly , ZHU, Chen , CHEN, Yi
IPC分类号： A61K
CPC分类号： A61K9/0095 , A61K47/18 , A61K47/22 , C07D233/56 , C07D233/64 , C07D295/088
摘要： Phenoxy amine compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
摘要翻译：提供了用于递送活性剂的苯氧基胺化合物和组合物。还提供了给药方法和制剂。

6. 发明申请

WO2015051725A1 ANTIDIABETIC TRICYCLIC COMPOUNDS 审中-公开
标题翻译：抗菌三环化合物
公开(公告)号：WO2015051725A1
公开(公告)日：2015-04-16
申请号：PCT/CN2014/087857
申请日：2014-09-30
申请人： MERCK SHARP & DOHME CORP. , BIFTU, Tesfaye , BIJU, Purakkatle , COLLETTI, Steven L. , CUI, Mingxiang , HAGMANN, William K. , HU, Bin , JOSIEN, Hubert , KAR, Nam Fung , NAIR, Anilkumar , NARGUND, Ravi , SPERBECK, Donald M. , ZHU, Chen
发明人： BIFTU, Tesfaye , BIJU, Purakkatle , COLLETTI, Steven L. , CUI, Mingxiang , HAGMANN, William K. , HU, Bin , JOSIEN, Hubert , KAR, Nam Fung , NAIR, Anilkumar , NARGUND, Ravi , SPERBECK, Donald M. , ZHU, Chen
IPC分类号： C07D221/16 , C07D401/12 , C07D401/14 , A61K31/444 , A61K31/438 , A61P3/10
CPC分类号： C07D221/16 , A61K31/435 , A61K31/444 , A61K45/06 , C07D401/12 , C07D405/12
摘要： Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
摘要翻译：结构式（I）的新型化合物及其药学上可接受的盐是G蛋白偶联受体40（GPR40）的激动剂，可用于治疗，预防和抑制G蛋白偶联受体受体40.本发明的化合物可用于治疗2型糖尿病，以及通常与该疾病相关的病症，包括肥胖症和脂质疾病，例如混合或糖尿病性血脂异常，高脂血症，高胆固醇血症和高甘油三酯血症。

7. 发明申请

WO03045306A3 PHENOXY AMINE COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS 审中-公开
标题翻译：苯甲酸化合物和用于递送活性剂的组合物
公开(公告)号：WO03045306A3
公开(公告)日：2003-09-04
申请号：PCT/US0236552
申请日：2002-11-13
申请人： EMISPHERE TECH INC , GSCHNEIDNER DAVID , KRAFT KELLY , ZHU CHEN , CHEN YI
发明人： GSCHNEIDNER DAVID , KRAFT KELLY , ZHU CHEN , CHEN YI
IPC分类号： C07D295/08 , A61K9/00 , A61K31/517 , A61K38/00 , A61K38/21 , A61K38/22 , A61K38/28 , A61K38/46 , A61K47/18 , A61K47/22 , C07C217/20 , C07C217/22 , C07D233/54 , C07D233/60 , C07D233/64 , C07D295/092 , C07D265/30 , A01N33/02 , A01N43/50 , A61K31/135 , C07C215/54 , C07D265/32
CPC分类号： A61K9/0095 , A61K47/18 , A61K47/22 , C07D233/56 , C07D233/64 , C07D295/088
摘要： Phenoxy amine compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
摘要翻译：提供了苯氧胺化合物和用于递送活性剂的组合物。也提供给药和制备方法。

8. 发明授权

US09590253B2 Core-shell structured bifunctional catalysts for metal air battery/fuel cell 有权
标题翻译：用于金属空气电池/燃料电池的核壳结构双功能催化剂
公开(公告)号：US09590253B2
公开(公告)日：2017-03-07
申请号：US13941139
申请日：2013-07-12
申请人： Zhongwei Chen , Zhu Chen
发明人： Zhongwei Chen , Zhu Chen
IPC分类号： H01M4/90 , H01M4/86 , H01M4/96 , H01M12/06
CPC分类号： H01M4/9016 , H01M4/8615 , H01M4/96 , H01M12/06 , Y02E60/50
摘要： The present invention relates to a bifunctional catalyst for use with air metal batteries and fuel cell. The bifunctional catalyst comprising a core and a shell, where the core comprises a metal oxide and the shell comprises a carbon nanostructure. In a further aspect the bifunctional catalyst is catalytically active for oxygen reduction and oxygen evolution reactions.
摘要翻译：本发明涉及一种用于空气金属电池和燃料电池的双功能催化剂。包含核和壳的双功能催化剂，其中芯包含金属氧化物，壳包含碳纳米结构。在另一方面，双功能催化剂对氧还原和析氧反应具有催化活性。

9. 发明授权

US08605442B2 Server cabinet and server structure using the same 失效
标题翻译：服务器机柜和服务器结构使用相同
公开(公告)号：US08605442B2
公开(公告)日：2013-12-10
申请号：US13182650
申请日：2011-07-14
申请人： Hung-Yi Wu , Xiao-Zhu Chen
发明人： Hung-Yi Wu , Xiao-Zhu Chen
IPC分类号： H05K7/16
CPC分类号： H05K7/1489
摘要： A server structure is disclosed including a server cabinet, spaced fixing units, and server groups. Each server unit includes a first server unit and a second server unit fixed to supporting frames of the server cabinet by first fixing plates and the second fixing plates of the fixing units, respectively. The first server unit alternately abuts the second server unit, and the stacked height of each first server unit and the abutting second server unit is equivalent to the height along the supporting frame occupied by the corresponding fixing unit.
摘要翻译：公开了一种服务器结构，包括服务器机柜，间隔的固定单元和服务器组。每个服务器单元包括分别通过固定单元的第一固定板和第二固定板固定到服务器机柜的支撑框架的第一服务器单元和第二服务器单元。第一服务器单元交替地邻接第二服务器单元，并且每个第一服务器单元和邻接的第二服务器单元的堆叠高度等效于沿着由相应的固定单元占据的支撑框架的高度。

10. 发明授权

US08605427B2 Heat dissipation device utilizing fan duct 失效
标题翻译：散热装置利用风机管道
公开(公告)号：US08605427B2
公开(公告)日：2013-12-10
申请号：US13072456
申请日：2011-03-25
申请人： Xiao-Zhu Chen , Lei Liu
发明人： Xiao-Zhu Chen , Lei Liu
IPC分类号： H05K7/20 , F28F7/00 , H01L23/34
CPC分类号： H05K7/20145 , H01L23/467 , H01L2924/0002 , H01L2924/00
摘要： A heat dissipation device includes a heat sink and a fan duct. The fan duct includes a cover and a baffle. The cover includes a top plate, a first sidewall and a second sidewall respectively extending from opposite sides of the top plate. The baffle is located between the first sidewall and the second sidewall of the cover and pivotally contacts the first and second sidewalls. The baffle forms an angle with the top plate and is rotatable relative to the first and second sidewalls to adjust the angle between the baffle and the top plate.
摘要翻译：散热装置包括散热器和风扇导管。风扇导管包括盖和挡板。盖子包括分别从顶板的相对侧延伸的顶板，第一侧壁和第二侧壁。挡板位于盖的第一侧壁和第二侧壁之间，并且枢转地接触第一和第二侧壁。挡板与顶板形成一角度并且可相对于第一和第二侧壁旋转，以调节挡板和顶板之间的角度。

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