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1. 发明申请

WO2017091200A1 METHOD AND SYSTEM FOR EYE MEASUREMENTS AND CATARACT SURGERY PLANNING USING VECTOR FUNCTION DERIVED FROM PRIOR SURGERIES 审中-公开
标题翻译：使用来自先前手术的矢量功能进行眼睛测量和神经科外科手术计划的方法和系统
公开(公告)号：WO2017091200A1
公开(公告)日：2017-06-01
申请号：PCT/US2015/062225
申请日：2015-11-23
申请人： AMO WAVEFRONT SCIENCES, LLC
发明人： RAYMOND, Thomas, D. , NEAL, Daniel, R. , COPLAND, Richard, J. , XIONG, Wei , PULASKI, Paul , FARRER, Stephen, W. , CANOVAS, Carmen , HAMRICK, Daniel, R.
IPC分类号： A61F9/008 , A61F2/16 , A61B3/00
CPC分类号： A61B3/0025 , A61F9/00802 , A61F9/00806 , A61F9/00825 , A61F2009/00859 , A61F2009/0087 , A61F2009/00872
摘要： Improved devices, systems, and methods for planning cataract surgery on an eye of a patient incorporate results of prior corrective surgeries into a planned cataract surgery of a particular patient by driving an effective surgery vector function based on data from the prior corrective surgeries. The exemplary effective surgery vector employs an influence matrix which may allow improved refractive corrections to be generated so as to increase the overall efficacy of a cataract surgery by specifying one or more parameters of an intraocular lens (IOL) to be implanted during the cataract surgery.
摘要翻译：通过基于数据驱动有效的手术矢量函数，用于在患者的眼睛上计划白内障手术的改进的装置，系统和方法将先前的矫正手术的结果并入特定患者的计划的白内障手术中从以前的矫正手术。示例性有效手术矢量采用影响矩阵，其可以允许产生改善的屈光矫正，从而通过指定在白内障手术期间植入的人工晶状体（IOL）的一个或多个参数来增加白内障手术的总体功效。

2. 发明申请

WO2017019117A8 OPTICAL IMAGING AND MEASUREMENT SYSTEMS AND METHODS FOR CATARACT SURGERY AND TREATMENT PLANNING 审中-公开
标题翻译：光学成像和测量系统和方法的神经外科手术和治疗计划
公开(公告)号：WO2017019117A8
公开(公告)日：2017-02-02
申请号：PCT/US2015/065713
申请日：2015-12-15
申请人： AMO WAVEFRONT SCIENCES, LLC
发明人： NEAL, Daniel , RAYMOND, Thomas, D. , COPLAND, Richard, J. , XIONG, Wei , PULASKI, Paul , FARRER, Stephen , CANOVAS VIDAL, Carmen , HAMRICK, Daniel
IPC分类号： A61B3/10 , A61B3/107 , A61F2/16 , A61F9/008
摘要： An optical measurement system and apparatus for carrying out cataract diagnostics in an eye of a patient includes a Corneal Topography Subsystem, a wavefront aberrometer subsystem, and an eye structure imaging subsystem, wherein the subsystems have a shared optical axis, and each subsystem is operatively coupled to the others via a controller. The eye structure imaging subsystem is preferably a fourierdomain optical coherence tomographer, and more preferably, a swept source OCT.
摘要翻译：用于在患者的眼睛中执行白内障诊断的光学测量系统和设备包括角膜地形子系统，波前像差计子系统和眼结构成像子系统，其中子系统具有共享光学系统轴，并且每个子系统通过控制器可操作地耦合到其他子系统。眼结构成像子系统最好是一个全域光学相干层析成像器，更好的是一个扫频光源OCT。

3. 发明申请

WO2012170518A1 METHOD OF LOCATING VALID LIGHT SPOTS FOR OPTICAL MEASUREMENT AND OPTICAL MEASUREMENT INSTRUMENT EMPLOYING METHOD OF LOCATING VALID LIGHT SPOTS 审中-公开
标题翻译：定位有效光源的光学测量方法和光学测量仪器使用定位有效光源的方法
公开(公告)号：WO2012170518A1
公开(公告)日：2012-12-13
申请号：PCT/US2012/041085
申请日：2012-06-06
申请人： AMO WAVEFRONT SCIENCES, LLC. , FARRER, Stephen W. , RAYMOND, Thomas D. , XIONG, Wei , DIXSON, John , NEAL, Daniel R.
发明人： FARRER, Stephen W. , RAYMOND, Thomas D. , XIONG, Wei , DIXSON, John , NEAL, Daniel R.
IPC分类号： G01J1/42
CPC分类号： G01J1/4228 , A61B3/1015
摘要： An algorithm locates valid light spots produced on an image detector by a wavefront of interest. The algorithm includes sequentially examining pixels of the image detector to determine for each of the pixels whether the light intensity detected by the pixel is greater than a threshold, When the pixel's detected light intensity is determined to be greater than the threshold, the algorithm includes: determining whether the pixel belongs to a valid light spot; and when the pixel is determined to belong to a valid light spot; saving data indicating a location for the valid light spot; and masking out a group of pixels of the image detector at the determined location such that the masked pixels are considered to have a light intensity less than the threshold for a remainder of the sequential examination.
摘要翻译：算法通过感兴趣的波阵面定位在图像检测器上产生的有效光点。该算法包括顺序检查图像检测器的像素，以确定每个像素是否由像素检测的光强度是否大于阈值。当确定像素的检测光强度大于阈值时，该算法包括：确定像素是否属于有效光点; 并且当像素被确定为属于有效光点时; 保存指示有效光点位置的数据; 并且在确定的位置处掩蔽图像检测器的一组像素，使得被掩盖的像素被认为具有小于该顺序检验的其余部分的阈值的光强度。

4. 发明申请

WO2017180914A1 APPARATUS, SYSTEM, AND METHOD FOR INTRAOCULAR LENS POWER CALCULATION USING A REGRESSION FORMULA INCORPORATING CORNEAL SPHERICAL ABERRATION 审中-公开
标题翻译：使用包含角膜球差异的回归公式的用于眼内透镜功率计算的装置，系统和方法
公开(公告)号：WO2017180914A1
公开(公告)日：2017-10-19
申请号：PCT/US2017/027489
申请日：2017-04-13
申请人： AMO WAVEFRONT SCIENCES, LLC
发明人： NEAL, Daniel R. , RAYMOND, Thomas D. , COPLAND, Richard J. , XIONG, Wei , FARRER, Stephen W. , PULASKI, Paul D. , HAMRICK, Daniel R. , CANOVAS VIDAL, Carmen , ARTAL, Pablo
IPC分类号： A61B3/00
CPC分类号： A61B3/0025 , A61F2/1637 , A61F2240/002
摘要： A system for predicting optical power for an intraocular lens based upon measured biometric parameters in a patient's eye includes: a biometric reader capable of measuring at least one biometric parameter and a representation of a corneal topography of the patient's eye; a processor coupled to a computer readable medium having stored thereon a program that upon execution causes the processor to receive the at least one biometric parameter and obtain corneal spherical aberration based upon the representation of the corneal topography, and the processor calculates an optimized optical power to obtain a desired postoperative condition by applying the received value and obtained corneal spherical aberration to a modified regression, wherein the modified regression is of the form: optical power=Regression+constant0*(corneal spherical aberration) or optical power=constant1*(biometric parameter)+constant0*(corneal spherical aberration). Constant1 and constant0 comprise an empirically derived factor across other eyes. The Regression comprises a classical regression and biometric parameter is related to the values of the at least one measured eye's parameter.
摘要翻译：用于基于患者眼睛中的测量的生物参数预测人工晶状体的光焦度的系统包括：生物测量读取器，其能够测量至少一个生物测定参数和患者的角膜地形图的表示眼; 耦合到计算机可读介质的处理器，所述计算机可读介质上存储有程序，所述程序在执行时使所述处理器接收所述至少一个生物测定参数并基于所述角膜形貌的表示获得角膜球面像差，并且所述处理器计算通过将所接收的值和获得的角膜球面像差应用于修正的回归来获得期望的术后状况，其中修改的回归具有以下形式：光学功率=回归+常数0 *（角膜球面像差）或光学功率=常数1 *（生物统计学参数）+常数0 *（角膜球差）。常数1和常数0包括跨越其他眼睛的经验导出因子。回归包括经典回归和生物参数与至少一个测量的眼睛参数的值有关。

5. 发明申请

WO2017019117A1 OPTICAL IMAGING AND MEASUREMENT SYSTEMS AND METHODS FOR CATARACT SURGERY AND TREATMENT PLANNING 审中-公开
标题翻译：光学成像和测量系统和方法用于卡式手术和治疗计划
公开(公告)号：WO2017019117A1
公开(公告)日：2017-02-02
申请号：PCT/US2015/065713
申请日：2015-12-15
申请人： AMO WAVEFRONT SCIENCES, LLC
发明人： NEAL, Daniel , RYAMOND, Thomas, D. , COPLAND, Richard, J. , XIONG, Wei , PULASKI, Paul , FARRER, Stephen , CANOVAS VIDAL, Carmen , HAMRICK, Daniel
IPC分类号： A61B3/10 , A61B3/107 , A61F2/16 , A61F9/008
CPC分类号： A61B3/102 , A61B3/0025 , A61B3/0091 , A61B3/1005 , A61B3/1015 , A61B3/107 , A61B3/112 , A61B3/117 , A61B3/1173 , A61B3/1225 , A61B3/18 , A61F9/008 , A61F2009/0087 , A61F2009/00887 , G02B5/3083 , G02B27/286
摘要： An optical measurement system and apparatus for carrying out cataract diagnostics in an eye of a patient includes a Corneal Topography Subsystem, a wavefront aberrometer subsystem, and an eye structure imaging subsystem, wherein the subsystems have a shared optical axis, and each subsystem is operatively coupled to the others via a controller. The eye structure imaging subsystem is preferably a fourierdomain optical coherence tomographer, and more preferably, a swept source OCT.
摘要翻译：用于在患者眼中执行白内障诊断的光学测量系统和装置包括角膜地形子系统，波前像差计子系统和眼睛结构成像子系统，其中子系统具有共享光轴，并且每个子系统可操作地耦合通过控制器给其他人。眼睛结构成像子系统优选地是四维域光学相干断层摄影器，更优选地是扫描光源OCT。

6. 发明申请

WO2016089395A1 MODEL EYE PRODUCING A SPECKLE PATTERN HAVING A REDUCED BRIGHT-TO-DARK RATIO FOR USE WITH OPTICAL MEASUREMENT SYSTEM FOR CATARACT DIAGNOSTICS 审中-公开
标题翻译：产生具有降低亮度到深度比例的谱图的模型眼睛用于具有用于CATARACT诊断的光学测量系统
公开(公告)号：WO2016089395A1
公开(公告)日：2016-06-09
申请号：PCT/US2014/068412
申请日：2014-12-03
申请人： AMO WAVEFRONT SCIENCES, LLC. , COPLAND, Richard, J. , NEAL, Daniel, R. , RAYMOND, Thomas, D. , XIONG, Wei , PULASKI, Paul, D. , FARRER, Stephen, W. , VIDAL, Carmen, Canovas
发明人： COPLAND, Richard, J. , NEAL, Daniel, R. , RAYMOND, Thomas, D. , XIONG, Wei , PULASKI, Paul, D. , FARRER, Stephen, W. , VIDAL, Carmen, Canovas
IPC分类号： A61B3/00 , A61F9/008 , G09B23/34
CPC分类号： A61B3/00 , A61B3/0025 , A61B3/1015 , A61B2017/00716 , A61B2560/0233 , G09B23/34
摘要： A system includes a model eye and an optical measurement instrument, which includes: a corneal topography subsystem; a wavefront sensor subsystem; and an eye structure imaging subsystem. The subsystems may have a common fixation axis, and be operatively coupled to each other via a controller. The optical measurement instrument may perform measurements of the model eye to verify correct operation of the optical measurement instrument for measuring one or more characteristics of a subject's eye. The model eye may include an optically transmissive structure having a front curved surface and an opposite rear planar surface, and a material structure provided at the rear planar surface of the optically transmissive structure and having a characteristic to cause a speckle pattern of a portion of a coherent light beam that is directed back out the front curved surface of the optically transmissive structure to have a bright-to-dark ratio of less than 2: 1.
摘要翻译：一种系统包括模型眼和光学测量仪器，其包括：角膜地形子系统; 波前传感器子系统; 和眼睛结构成像子系统。子系统可以具有共同的固定轴，并且经由控制器可操作地彼此耦合。光学测量仪器可以执行模型眼睛的测量，以验证用于测量受试者眼睛的一个或多个特征的光学测量仪器的正确操作。模型眼可以包括具有前曲面和相对的后平面的光学透射结构，以及设置在光学透射结构的后平面处的材料结构，并且具有导致一部分的散斑图案的特性相干光束被引导回光学透射结构的前曲面以具有小于2:1的亮暗比。

7. 发明申请

WO2018156805A1 METHOD AND SYSTEM FOR DYNAMICALLY MEASURING TEAR FILM BREAKUP AND IRREGULARITY USING CORNEAL TOPOGRAPHY AND WAVEFRONT ABERROMETRY 审中-公开
公开(公告)号：WO2018156805A1
公开(公告)日：2018-08-30
申请号：PCT/US2018/019284
申请日：2018-02-22
申请人： AMO WAVEFRONT SCIENCES, LLC
发明人： NEAL, Daniel R. , COPLAND, Richard J. , HOY, Jason , XIONG, Wei
IPC分类号： A61B3/10 , A61B3/103 , A61B3/107
摘要： An optical measurement instrument performs a series of wavefront measurements to obtain a plurality of sets of wavefront aberrometry data for an eye, and performs a series of corneal topography measurements to obtain a plurality of sets of corneal topography data for the eye. Each set of wavefront aberrometry data is obtained at a corresponding different point in time, and each set of corneal topography data is obtained at a corresponding different point in time. The wavefront aberrometry data and the corneal topography data are processed to produce combined tear film breakup data as a function of time. The combined tear film breakup data may be employed as a metric for evaluating a level of tear film breakup of the eye as a function of time.

8. 发明申请

WO2009089387A1 SYSTEMS AND METHODS FOR MEASURING SURFACE SHAPE 审中-公开
标题翻译：用于测量表面形状的系统和方法
公开(公告)号：WO2009089387A1
公开(公告)日：2009-07-16
申请号：PCT/US2009/030493
申请日：2009-01-08
申请人： AMO WAVEFRONT SCIENCES LLC , FARRER, Stephen, W. , COPLAND, James , RAYMOND, Thomas, D. , XIONG, Wei
发明人： FARRER, Stephen, W. , COPLAND, James , RAYMOND, Thomas, D. , XIONG, Wei
IPC分类号： G01B11/25 , A61B3/107 , G01M11/02
CPC分类号： G01B11/2513 , A61B3/107 , G01M11/005 , G01M11/025 , G01M11/0264
摘要： A system for determining a surface shape of a test object includes a pattern having a plurality of first elements dispose about a central axis and defining an aperture containing the central axis. The first elements includes a plurality of common elements having a common form and a reference element having a reference form that is different than the common form. The system further comprises a detector array and an optical system. The optical system is adapted to provide an image of the first elements when light reflects off a surface of a test object, passes through the aperture, and is received by the detector array. The reference form may be configured to facilitate an association between the common elements and the spot images of the common elements.
摘要翻译：用于确定测试对象的表面形状的系统包括具有围绕中心轴布置并且限定包含中心轴线的孔的多个第一元件的图案。第一元件包括具有共同形式的多个公共元件和具有不同于通用形式的参考形式的参考元件。该系统还包括检测器阵列和光学系统。当光从测试对象的表面反射出来时，光学系统适于提供第一元件的图像，通过该孔并由检测器阵列接收。参考表格可以被配置为便于公共元素与公共元素的斑点图像之间的关联。

9. 发明申请

WO2010056997A3 METHOD OF QUALIFYING LIGHT SPOTS FOR OPTICAL MEASUREMENTS AND MEASUREMENT INSTRUMENT EMPLOYING METHOD OF QUALIFYING LIGHT SPOTS 审中-公开
公开(公告)号：WO2010056997A3
公开(公告)日：2010-05-20
申请号：PCT/US2009/064390
申请日：2009-11-13
申请人： AMO WAVEFRONT SCIENCES, LLC. , RAYMOND, Thomas, D. , DIXSON, John, Grant , FARRER, Stephen, W. , XIONG, Wei , NEAL, Daniel, R.
发明人： RAYMOND, Thomas, D. , DIXSON, John, Grant , FARRER, Stephen, W. , XIONG, Wei , NEAL, Daniel, R.
IPC分类号： G01B11/25 , A61B3/107 , G01M11/02 , A61B3/10 , A61B3/103 , A61B3/117
摘要： A method of determining a wavefront of a received light beam includes: (a) receiving a light beam; (b) producing a group of light spots from the light beam; (c) qualifying a set of the light spots for use in determining a wavefront of the received light beam; and (d) determining the wavefront of the received light beam using the qualified set of light spots. Qualifying the set of light spots includes, for each light spot: calculating a first calculated location of the light spot using a first calculation algorithm; calculating a second calculated location of the light spot using a second calculation algorithm; and when a difference between the first and second calculated locations for the light spot is greater than an agreement threshold, excluding the light spot from the set of light spots and/or from being employed in determining the wavefront of the received light beam.

10. 发明公开

EP3328265A1 OPTICAL IMAGING AND MEASUREMENT SYSTEMS AND METHODS FOR CATARACT SURGERY AND TREATMENT PLANNING 审中-公开
公开(公告)号：EP3328265A1
公开(公告)日：2018-06-06
申请号：EP15820404.0
申请日：2015-12-15
申请人： AMO WaveFront Sciences, LLC
发明人： NEAL, Daniel , RAYMOND, Thomas, D. , COPLAND, Richard, J. , XIONG, Wei , PULASKI, Paul , FARRER, Stephen , CANOVAS VIDAL, Carmen , HAMRICK, Daniel
IPC分类号： A61B3/10 , A61B3/107 , A61F2/16 , A61F9/008
CPC分类号： A61B3/102 , A61B3/0025 , A61B3/0091 , A61B3/1005 , A61B3/1015 , A61B3/107 , A61B3/112 , A61B3/117 , A61B3/1173 , A61B3/1225 , A61B3/18 , A61F9/008 , A61F2009/0087 , A61F2009/00887 , G02B5/3083 , G02B27/286
摘要： An optical measurement system and apparatus for carrying out cataract diagnostics in an eye of a patient includes a Corneal Topography Subsystem, a wavefront aberrometer subsystem, and an eye structure imaging subsystem, wherein the subsystems have a shared optical axis, and each subsystem is operatively coupled to the others via a controller. The eye structure imaging subsystem is preferably a fourierdomain optical coherence tomographer, and more preferably, a swept source OCT.

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