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1. 发明授权

US06548270B1 DNA encoding human acid-sensing ion channel BNaC4 (ASIC4) 有权
标题翻译：编码人酸感应离子通道BNaC4（ASIC4）的DNA
公开(公告)号：US06548270B1
公开(公告)日：2003-04-15
申请号：US09518959
申请日：2000-03-03
申请人： Adrienne Elizabeth Dubin , Jayashree Pyati , Rene Huvar , Mark G. Erlander
发明人： Adrienne Elizabeth Dubin , Jayashree Pyati , Rene Huvar , Mark G. Erlander
IPC分类号： C12N1512
CPC分类号： C07K14/705 , A61K38/00
摘要： DNA encoding human acid sensing ion channel BnaC4 has been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
摘要翻译：已经克隆并表征编码人感应离子通道BnaC4的DNA。重组蛋白能够形成生物活性蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。重组蛋白也从重组宿主细胞中纯化。此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。

2. 发明授权

US07186803B2 Human vanilloid receptor VR3 protein 有权
标题翻译：人类香草素受体VR3蛋白
公开(公告)号：US07186803B2
公开(公告)日：2007-03-06
申请号：US10985156
申请日：2004-11-10
申请人： Adrienne Elizabeth Dubin , Arne Huvar , Charles A. Glass , Mark G. Erlander
发明人： Adrienne Elizabeth Dubin , Arne Huvar , Charles A. Glass , Mark G. Erlander
IPC分类号： C07K14/705 , C07K14/435 , A61K38/17 , C12P21/02
CPC分类号： C07K14/705 , A61K38/00
摘要： DNA encoding human VR1 receptor has been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
摘要翻译：编码人VR1受体的DNA已被克隆和表征。重组蛋白能够形成生物活性蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。重组蛋白也从重组宿主细胞中纯化。此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。

3. 发明授权

US06455278B1 DNA encoding human vanilloid receptor VR3 有权
标题翻译：编码人类香草素受体VR3的DNA
公开(公告)号：US06455278B1
公开(公告)日：2002-09-24
申请号：US09500123
申请日：2000-02-08
申请人： Adrienne Elizabeth Dubin , Arne Huvar , Charles A. Glass , Mark G. Erlander
发明人： Adrienne Elizabeth Dubin , Arne Huvar , Charles A. Glass , Mark G. Erlander
IPC分类号： C12N1512
CPC分类号： C07K14/705 , A61K38/00
摘要： DNA encoding human VR1 receptor has been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
摘要翻译：编码人VR1受体的DNA已被克隆和表征。重组蛋白能够形成生物活性蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。重组蛋白也从重组宿主细胞中纯化。此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。

4. 发明授权

US07094877B2 Human vanilloid receptor VR3 protein 有权
标题翻译：人类香草素受体VR3蛋白
公开(公告)号：US07094877B2
公开(公告)日：2006-08-22
申请号：US10090215
申请日：2002-03-04
申请人： Adrienne Elizabeth Dubin , Arne Huvar , Charles A. Glass , Mark G. Erlander
发明人： Adrienne Elizabeth Dubin , Arne Huvar , Charles A. Glass , Mark G. Erlander
IPC分类号： C07K14/00 , A61K38/16 , C12P21/02
CPC分类号： C07K14/705 , A61K38/00
摘要： DNA encoding human VR1 receptor has been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
摘要翻译：编码人VR1受体的DNA已被克隆和表征。重组蛋白能够形成生物活性蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。重组蛋白也从重组宿主细胞中纯化。此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。

5. 发明授权

US06358706B1 DNA encoding human alpha1G-C T-Type calcium channel 有权
标题翻译：编码人α1G-C型T型钙通道的DNA
公开(公告)号：US06358706B1
公开(公告)日：2002-03-19
申请号：US09426998
申请日：1999-10-26
申请人： Adrienne E. Dubin , Jose E. Galindo , Jayashree Pyati , Jessica Y. Zhu , Mark G. Erlander
发明人： Adrienne E. Dubin , Jose E. Galindo , Jayashree Pyati , Jessica Y. Zhu , Mark G. Erlander
IPC分类号： C12N510
CPC分类号： C07K14/705 , A61K38/00 , C12N2799/026
摘要： A DNA molecule encoding a novel isoform of the human T-type low voltage activated calcium channel (alpha1G-c) has been cloned and characterized. The biological and structural properties of this protein is disclosed, as is the amino acid and nucleotide sequence.
摘要翻译：已经克隆并表征了编码人T型低电压活化钙通道（α1G-c）的新型同工型的DNA分子。公开了该蛋白质的生物学和结构性质，以及氨基酸和核苷酸序列。

6. 发明授权

US07109296B2 Human 5-HT3-C protein 有权
标题翻译：人类5-HT3-C蛋白
公开(公告)号：US07109296B2
公开(公告)日：2006-09-19
申请号：US10661378
申请日：2003-09-12
申请人： Adrienne E. Dubin , Mark G. Erlander , Arne Huvar , Rene Huvar , Lukas K. Buehler
发明人： Adrienne E. Dubin , Mark G. Erlander , Arne Huvar , Rene Huvar , Lukas K. Buehler
IPC分类号： C07K14/705
CPC分类号： C07K14/70571 , A61K38/00 , C07K16/286
摘要： DNA encoding human 5-HT3-C has been cloned and characterized. The recombinant protein is capable of forming biologically active human 5-HT3-C protein. The cDNA has been expressed in recombinant host cells that produce active recombinant protein. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
摘要翻译：已经克隆并表征编码人5-HT3-C的DNA。重组蛋白能够形成生物活性的人5-HT3-C蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。

7. 发明授权

US06365370B1 DNA encoding a human subunit 5-HT3-C of the 5-HT3 serotonin receptor 有权
公开(公告)号：US06365370B1
公开(公告)日：2002-04-02
申请号：US09388349
申请日：1999-09-01
申请人： Adrienne E. Dubin , Mark G. Erlander , Arne Huvar , Rene Huvar , Lukas K. Buehler
发明人： Adrienne E. Dubin , Mark G. Erlander , Arne Huvar , Rene Huvar , Lukas K. Buehler
IPC分类号： C12N510
CPC分类号： C07K14/70571 , A61K38/00 , C07K16/286
摘要： DNA encoding human 5-HT3-C has been cloned and characterized. The recombinant protein is capable of forming biologically active human 5-HT3-C protein. The cDNA has been expressed in recombinant host cells that produce active recombinant protein. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.

8. 发明授权

US09447470B2 Tumor grading and cancer prognosis 有权
标题翻译：肿瘤分级和癌症预后
公开(公告)号：US09447470B2
公开(公告)日：2016-09-20
申请号：US12718973
申请日：2010-03-06
申请人： Mark G. Erlander , Xiao-Jun Ma , Dennis C. Sgroi
发明人： Mark G. Erlander , Xiao-Jun Ma , Dennis C. Sgroi
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112
摘要： The disclosure includes the identification and use of gene expression profiles, or patterns, with clinical relevance to cancer. In particular, the disclosure includes the identities of genes that are expressed in correlation with tumor grade. The levels of gene expression are disclosed as a molecular index for determining tumor grade in a patient and predicting clinical outcome, and so prognosis, for the patient. The molecular grading of cancer may optionally be used in combination with a second molecular index for diagnosing cancer and its prognosis. The disclosure further includes methods for predicting cancer recurrence, and/or predicting occurrence of metastatic cancer. For diagnosis or prognosis, the disclosure further includes methods for determining or selecting the treatment of cancer based upon the likelihood of life expectancy, cancer recurrence, and/or cancer metastasis.
摘要翻译：该公开内容包括鉴定和使用与癌症具有临床相关性的基因表达谱或模式。特别地，本公开包括与肿瘤等级相关表达的基因的身份。公开了基因表达水平作为确定患者肿瘤分级的分子指标，并预测了患者的临床结果以及预后。癌症的分子分级可以任选地与用于诊断癌症及其预后的第二分子指数组合使用。本公开还包括用于预测癌症复发和/或预测转移性癌症发生的方法。为了诊断或预后，本公开还包括基于预期寿命，癌症复发和/或癌症转移的可能性来确定或选择癌症治疗的方法。

9. 发明申请

US20110136680A1 TUMOR GRADING AND CANCER PROGNOSIS 有权
标题翻译：肿瘤分级和癌症预后
公开(公告)号：US20110136680A1
公开(公告)日：2011-06-09
申请号：US12718973
申请日：2010-03-06
申请人： Mark G. Erlander , Xiao-Jun Ma , Dennis Sgroi
发明人： Mark G. Erlander , Xiao-Jun Ma , Dennis Sgroi
IPC分类号： C12Q1/68 , C40B30/00
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112
摘要： The disclosure includes the identification and use of gene expression profiles, or patterns, with clinical relevance to cancer. In particular, the disclosure includes the identities of genes that are expressed in correlation with tumor grade. The levels of gene expression are disclosed as a molecular index for determining tumor grade in a patient and predicting clinical outcome, and so prognosis, for the patient. The molecular grading of cancer may optionally be used in combination with a second molecular index for diagnosing cancer and its prognosis. The disclosure further includes methods for predicting cancer recurrence, and/or predicting occurrence of metastatic cancer. For diagnosis or prognosis, the disclosure further includes methods for determining or selecting the treatment of cancer based upon the likelihood of life expectancy, cancer recurrence, and/or cancer metastasis.
摘要翻译：该公开内容包括鉴定和使用与癌症具有临床相关性的基因表达谱或模式。特别地，本公开包括与肿瘤等级相关表达的基因的身份。公开了基因表达水平作为确定患者肿瘤分级的分子指标，并预测了患者的临床结果以及预后。癌症的分子分级可以任选地与用于诊断癌症及其预后的第二分子指数组合使用。本公开还包括用于预测癌症复发和/或预测转移性癌症发生的方法。为了诊断或预后，本公开还包括基于预期寿命，癌症复发和/或癌症转移的可能性来确定或选择癌症治疗的方法。

10. 发明申请

US20090270271A1 3' Biased Detection of Nucleic Acids 审中-公开
标题翻译： 3'核酸的偏置检测
公开(公告)号：US20090270271A1
公开(公告)日：2009-10-29
申请号：US12210807
申请日：2008-09-15
申请人： Mark G. Erlander , Xiao-Jun Ma , Thomas Baer
发明人： Mark G. Erlander , Xiao-Jun Ma , Thomas Baer
IPC分类号： C40B30/04
CPC分类号： C12Q1/6876 , C12Q1/6809 , C12Q1/6851 , C12Q1/686 , C12Q2565/501
摘要： The invention provides materials and methods for the detection of nucleic acid expression via the 3′ portion of expressed sequences. Embodiments of the invention include the use of microarrays comprising nucleic acid probes that are complementary to the 3′ end of expressed sequences and by the use of quantitative PCR (Q-PCR) based amplification of sequences found at or near the 3′ end of expressed sequences. The invention may be used to detect the presence of expressed nucleic acids encoding particular gene products (sequences present in a “transcriptome”).
摘要翻译：本发明提供了通过表达序列的3'部分检测核酸表达的材料和方法。本发明的实施方案包括使用包含与表达的序列的3'末端互补的核酸探针的微阵列，以及通过使用基于定量PCR（Q-PCR）的扩增在3'末端发现的序列的表达序列。本发明可用于检测编码特定基因产物（“转录组”中存在的序列）的表达的核酸的存在。

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