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1. 发明申请

US20050135655A1 Ultra high throughput microfluidic analytical systems and methods 审中-公开
标题翻译：超高通量微流体分析系统和方法
公开(公告)号：US20050135655A1
公开(公告)日：2005-06-23
申请号：US11036722
申请日：2005-01-13
申请人： Anne Kopf-Sill , Andrea Chow , Peter Jann , Morten Jensen , Michael Spaid , Colin Kennedy , Michael Kennedy
发明人： Anne Kopf-Sill , Andrea Chow , Peter Jann , Morten Jensen , Michael Spaid , Colin Kennedy , Michael Kennedy
IPC分类号： B01L3/00 , B01L7/00 , B01L9/00 , G01N21/05 , G01N21/64 , G01N27/447 , G01N35/00 , G01N37/00 , G01L9/18
CPC分类号： G01N21/6452 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00628 , B01J2219/0063 , B01J2219/00659 , B01J2219/00707 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L7/54 , B01L9/527 , B01L2200/023 , B01L2200/027 , B01L2200/028 , B01L2200/147 , B01L2300/0654 , B01L2300/0816 , B01L2300/0829 , B01L2300/0867 , B01L2300/1822 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , G01N21/05 , G01N21/6428 , G01N21/645 , G01N27/44721 , G01N27/44782 , G01N35/0099 , G01N2021/0346 , G01N2021/6419 , G01N2021/6421
摘要： Analytical systems and methods that use a modular interface structure for providing an interface between a sample substrate and an analytical unit, where the analytical unit typically has a particular interface arrangement for implementing various analytical and control functions. Using a number of variants for each module of the modular interface structure advantageously provides cost effective and efficient ways to perform numerous tests using a particular substrate or class of substrates with a particular analytical and control systems interface arrangement. Improved optical illumination and detection system for simultaneously analyzing reactions or conditions in multiple parallel microchannels are also provided. Increased throughput and improved emissions detection is provided by the present invention by simultaneously illuminating multiple parallel microchannels at a non-normal incidence using an excitation beam including multiple excitation frequencies, and simultaneously detecting emissions from the substances in the microchannels in a direction normal to the substrate using a detection module with multiple detectors.
摘要翻译：分析系统和方法使用模块化接口结构来提供样品基底和分析单元之间的界面，其中分析单元通常具有用于实现各种分析和控制功能的特定界面布置。使用模块化接口结构的每个模块的许多变体有利地提供了使用具有特定分析和控制系统接口布置的特定基板或类别的基板执行大量测试的成本有效和有效的方式。还提供了用于同时分析多个并行微通道中的反应或条件的改进的光学照明和检测系统。通过使用包括多个激发频率的激发束同时照射非法线入射的多个平行微通道并且同时在垂直于衬底的方向上检测来自微通道中的物质的发射，本发明提供了增加的吞吐量和改进的排放物检测使用具有多个检测器的检测模块。

2. 发明申请

US20060188979A1 Method and apparatus for improved temperature control in microfluidic devices 有权
标题翻译：用于改善微流体装置温度控制的方法和装置
公开(公告)号：US20060188979A1
公开(公告)日：2006-08-24
申请号：US11323318
申请日：2005-12-30
申请人： Michael Spaid , Andrea Chow , Yevgeny Yurkovetsky , Seth Stern , Allen Boronkay , Morten Jensen , Carlton Brooks , Ken Swartz
发明人： Michael Spaid , Andrea Chow , Yevgeny Yurkovetsky , Seth Stern , Allen Boronkay , Morten Jensen , Carlton Brooks , Ken Swartz
IPC分类号： C12M1/34 , F25B29/00
CPC分类号： C12Q1/6818 , B01J2219/00364 , B01J2219/00495 , B01J2219/00704 , B01J2219/00722 , C07B2200/11 , C12Q1/6827 , C40B40/06 , C12Q2561/125 , C12Q2565/543 , C12Q2565/629 , C12Q2565/101
摘要： A microfluidic system and method for employing it to control fluid temperatures of fluids residing within microchannels of a microfluidic device. The microfluidic device is provided with a top layer and a bottom layer and microchannels configured therebetween. Temperature of the fluid within the microchannels is controlled in various ways including the use of electrical resistive heating elements and by providing zones located in contact with the top and bottom layers of the microfluidic device for circulating heat transfer of fluid therein.
摘要翻译：一种微流体系统和方法，用于控制微流体装置的微通道内流体的流体温度。微流体装置设置有顶层和底层以及在其间配置的微通道。微通道内的流体的温度以各种方式进行控制，包括使用电阻加热元件，并且通过提供与微流体装置的顶层和底层接触的区域，以循环其中的流体传热。

3. 发明申请

US20060246493A1 Method and apparatus for use in temperature controlled processing of microfluidic samples 审中-公开
标题翻译：用于微流体样品的温度控制处理的方法和装置
公开(公告)号：US20060246493A1
公开(公告)日：2006-11-02
申请号：US11398489
申请日：2006-04-04
申请人： Morten Jensen , Andrea Chow , Colin Kennedy , Stephane Mouradian
发明人： Morten Jensen , Andrea Chow , Colin Kennedy , Stephane Mouradian
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： B01L7/525 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L3/502746 , B01L3/50851 , B01L7/5255 , B01L2300/0609 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0877 , B01L2300/1822 , B01L2300/1827 , B01L2400/0418 , B01L2400/0487
摘要： Embodiments of the invention comprise microfluidic devices, instrumentation interfacing with those devices, processes for fabricating that device, and methods of employing that device to perform PCR amplification. Embodiments of the invention are also compatible with quantitative Polymerase Chain Reaction (“qPCR”) processes. Microfluidic devices in accordance with the invention may contain a plurality of parallel processing channels. Fully independent reactions can take place in each of the plurality of parallel processing channels. The availability of independent processing channels allows a microfluidic device in accordance with the invention to be used in a number of ways. For example, separate samples could be processed in each of the independent processing channels. Alternatively, different loci on a single sample could be processed in multiple processing channels.
摘要翻译：本发明的实施方案包括微流体装置，与这些装置接口的装置，用于制造该装置的方法以及使用该装置进行PCR扩增的方法。本发明的实施方案也与定量聚合酶链式反应（“qPCR”）方法相容。根据本发明的微流体装置可以包含多个并行处理通道。在多个并行处理通道的每一个中可以发生完全独立的反应。独立处理通道的可用性允许按照本发明的微流体装置以多种方式使用。例如，可以在每个独立处理通道中处理单独的样本。或者，可以在多个处理通道中处理单个样品上的不同基因座。

4. 发明申请

US20110024296A1 Analyte Injection System 审中-公开
标题翻译：分析物注射系统
公开(公告)号：US20110024296A1
公开(公告)日：2011-02-03
申请号：US12902006
申请日：2010-10-11
申请人： Charles Park , Persefoni Kechagia , Michael Spaid , Morten Jensen , Irina G. Kazakova , Josh Molho
发明人： Charles Park , Persefoni Kechagia , Michael Spaid , Morten Jensen , Irina G. Kazakova , Josh Molho
IPC分类号： G01N27/447
CPC分类号： B01L3/502753 , B01L3/502715 , B01L3/502746 , B01L2200/0673 , B01L2200/16 , B01L2300/0816 , B01L2400/0415 , B01L2400/084 , G01N27/44743 , G01N27/44773 , G01N27/44791
摘要： This invention provides methods and systems for injection of analytes into a separation channel for resolution and detection. Samples can be preconditioned and concentrated by isotachophoresis (ITP) before the injection is triggered by a detected voltage event. Separation of analytes from other sample constituents can be enhanced using skewing channel ITP.
摘要翻译：本发明提供了用于将分析物注入到用于分辨和检测的分离通道中的方法和系统。样品可以通过等速电泳（ITP）进行预处理和浓缩，然后通过检测到的电压事件触发注射。使用偏斜通道ITP可以提高分析物与其他样品成分的分离。

5. 发明申请

US20050121324A1 Analyte injection system 审中-公开
标题翻译：分析物注射系统
公开(公告)号：US20050121324A1
公开(公告)日：2005-06-09
申请号：US10936159
申请日：2004-09-07
申请人： Charles Park , Persefoni Kechagia , Michael Spaid , Morten Jensen , Irina Kazakova , Josh Molho
发明人： Charles Park , Persefoni Kechagia , Michael Spaid , Morten Jensen , Irina Kazakova , Josh Molho
IPC分类号： B01L3/00 , G01N27/447 , G01N27/453
CPC分类号： B01L3/502753 , B01L3/502715 , B01L3/502746 , B01L2200/0673 , B01L2200/16 , B01L2300/0816 , B01L2400/0415 , B01L2400/084 , G01N27/44743 , G01N27/44773 , G01N27/44791
摘要： This invention provides methods and systems for injection of analytes into a separation channel for resolution and detection. Samples can be preconditioned and concentrated by isotachophoresis (ITP) before the injection is triggered by a detected voltage event. Separation of analytes from other sample constituents can be enhanced using skewing channel ITP.
摘要翻译：本发明提供了用于将分析物注入到用于分辨和检测的分离通道中的方法和系统。样品可以通过等电泳（ITP）进行预处理和浓缩，然后通过检测到的电压事件触发注射。使用偏斜通道ITP可以提高分析物与其他样品成分的分离。

6. 发明授权

US09539574B2 Analyte injection system 有权
标题翻译：分析物注射系统
公开(公告)号：US09539574B2
公开(公告)日：2017-01-10
申请号：US12902006
申请日：2010-10-11
申请人： Charles Park , Persefoni Kechagia , Michael Spaid , Morten Jensen , Irina G. Kazakova , Josh Molho
发明人： Charles Park , Persefoni Kechagia , Michael Spaid , Morten Jensen , Irina G. Kazakova , Josh Molho
IPC分类号： G01N27/447 , B01L3/00
CPC分类号： B01L3/502753 , B01L3/502715 , B01L3/502746 , B01L2200/0673 , B01L2200/16 , B01L2300/0816 , B01L2400/0415 , B01L2400/084 , G01N27/44743 , G01N27/44773 , G01N27/44791
摘要： This invention provides methods and systems for injection of analytes into a separation channel for resolution and detection. Samples can be preconditioned and concentrated by isotachophoresis (ITP) before the injection is triggered by a detected voltage event. Separation of analytes from other sample constituents can be enhanced using skewing channel ITP.
摘要翻译：本发明提供了用于将分析物注入到用于分辨和检测的分离通道中的方法和系统。样品可以通过等速电泳（ITP）进行预处理和浓缩，然后通过检测到的电压事件触发注射。使用偏斜通道ITP可以提高分析物与其他样品成分的分离。

7. 发明申请

US20050133370A1 Analyte injection system 审中-公开
标题翻译：分析物注射系统
公开(公告)号：US20050133370A1
公开(公告)日：2005-06-23
申请号：US10865959
申请日：2004-06-12
申请人： Charles Park , Persefoni Kechagia , Michael Spaid , Morten Jensen , Irina Kazakova , Josh Molho , Tomohisa Kawabata , Mitsuo Watanabe
发明人： Charles Park , Persefoni Kechagia , Michael Spaid , Morten Jensen , Irina Kazakova , Josh Molho , Tomohisa Kawabata , Mitsuo Watanabe
IPC分类号： B01L3/00 , C12Q1/68 , G01N27/447 , G01N27/453
CPC分类号： G01N27/44791 , B01L3/502715 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L2200/0673 , B01L2400/0415 , C12Q1/6804 , C12Q1/6883 , G01N27/44773 , C12Q2565/629 , C12Q2565/125 , C12Q2563/179
摘要： This invention provides methods and devices for spatially separating at least first and second components in a sample which in one exemplary embodiment comprises introducing the first and second components into a first microfluidic channel of a microfluidic device in a carrier fluid comprising a spacer electrolyte solution and stacking the first and second components by isotachophoresis between a leading electrolyte solution and a trailing electrolyte solution, wherein the spacer electrolyte solution comprises ions which have an intermediate mobility in an electric field between the mobility of the ions present in the leading and trailing electrolyte solutions and wherein the spacer electrolyte solution comprises at least one of the following spacer ions MOPS, MES, Nonanoic acid, D-Glucuronic acid, Acetylsalicyclic acid, 4-Ethoxybenzoic acid, Glutaric acid, 3-Phenylpropionic acid, Phenoxyacetic acid, Cysteine, hippuric acid, p-hydroxyphenylacetic acid, isopropylmalonic acid, itaconic acid, citraconic acid, 3,5-dimethylbenzoic acid, 2,3-dimethylbenzoic acid, p-hydroxycinnamic acid, and 5-br-2,4-dihydroxybenzoic acid, and wherein the first component comprises a DNA-antibody conjugate and the second component comprises a complex of the DNA-antibody conjugate and an analyte.
摘要翻译：本发明提供了用于空间分离样品中的至少第一和第二组分的方法和装置，其在一个示例性实施方案中包括将第一和第二组分引入载体流体中的微流体装置的第一微流体通道，所述载体流体包括间隔电解质溶液和层叠所述第一和第二组分通过在前导电解质溶液和尾部电解质溶液之间的等速电泳，其中所述间隔电解质溶液包含在电场中具有中间迁移率的离子，所述离子存在于所述前导和后续电解质溶液中的离子的迁移率之间，间隔电解质溶液包含以下间隔离子MOPS，MES，壬酸，D-葡糖醛酸，乙酰水杨酸，4-乙氧基苯甲酸，戊二酸，3-苯基丙酸，苯氧基乙酸，半胱氨酸，马尿酸，p 羟基苯乙酸，异丙基丙二酸，衣康酸a cid，柠康酸，3,5-二甲基苯甲酸，2,3-二甲基苯甲酸，对羟基肉桂酸和5-溴-2,4-二羟基苯甲酸，其中第一组分包含DNA-抗体缀合物，第二组分包含第二组分包含DNA抗体缀合物和分析物的复合物。

8. 发明申请

US20080096260A1 Method of Preparing a Heat-Treated Product 审中-公开
标题翻译：制备热处理产品的方法
公开(公告)号：US20080096260A1
公开(公告)日：2008-04-24
申请号：US11952593
申请日：2007-12-07
申请人： Gitte Budolfsen , Morten Jensen , Hans Heldt-Hansen , Mary Stringer , Lene Lange
发明人： Gitte Budolfsen , Morten Jensen , Hans Heldt-Hansen , Mary Stringer , Lene Lange
IPC分类号： C12P7/62
CPC分类号： A21D8/042 , A23L5/25 , A23L7/117 , A23L19/19 , C12N9/82 , C12P1/00 , C12Y101/01118 , C12Y101/01119 , C12Y101/01124 , C12Y101/01147 , C12Y101/01148 , C12Y101/03009 , C12Y101/9901 , C12Y101/99011 , C12Y101/99018 , C12Y101/99028 , C12Y102/01003 , C12Y102/01004 , C12Y102/01005 , C12Y104/03002 , C12Y110/03002 , C12Y111/01007 , C12Y301/03004 , C12Y301/03005 , C12Y304/13018 , C12Y305/01001 , C12Y305/01002 , C12Y305/01026 , C12Y305/01043 , C12Y305/01052
摘要： The formation of acrylamide during heat treatment in the production of a food product is reduced by treating the raw material with an enzyme before the heat treatment. The enzyme is capable of reacting on asparagine as a substrate.
摘要翻译：通过在热处理前用酶处理原料，可以减少在食品生产过程中热处理过程中丙烯酰胺的形成。该酶能够作为底物在天冬酰胺上反应。

9. 发明授权

US06716394B2 DNA sequencing using multiple fluorescent labels being distinguishable by their decay times 有权
标题翻译：使用多个荧光标记的DNA测序可通过其衰变时间来区分
公开(公告)号：US06716394B2
公开(公告)日：2004-04-06
申请号：US10179686
申请日：2002-06-24
申请人： Morten Jensen , J. Wallace Parce
发明人： Morten Jensen , J. Wallace Parce
IPC分类号： G01N1506
CPC分类号： C12Q1/6869 , C12Q2563/107 , C12Q2561/12
摘要： A method is provided for identifying components of a mixture by labeling the individual components with fluorescent agents having different fluorescence lifetimes. The components are subsequently separated, fluorescent labels detected and their lifetimes measured. Based on the measured fluorescent lifetimes, the components of mixtures of small organic molecules, polymers, peptides, saccharides and nucleic acids can be identified.
摘要翻译：提供了通过用具有不同荧光寿命的荧光剂标记各个组分来鉴定混合物组分的方法。随后分离组分，检测荧光标记物并测定其寿命。基于测量的荧光寿命，可以鉴定小有机分子，聚合物，肽，糖和核酸的混合物的组分。

10. 发明授权

US06447724B1 DNA sequencing using multiple fluorescent labels being distinguishable by their decay times 有权
标题翻译：使用多个荧光标记的DNA测序可通过其衰变时间来区分
公开(公告)号：US06447724B1
公开(公告)日：2002-09-10
申请号：US09213297
申请日：1998-12-15
申请人： Morten Jensen , J. Wallace Parce
发明人： Morten Jensen , J. Wallace Parce
IPC分类号： G01N1506
CPC分类号： G01N15/06 , B01L3/5027 , C12Q1/6869 , G01N21/6408 , G01N2015/0693 , G01N2021/6413 , G01N2021/6441 , C12Q2561/12 , C12Q2565/629
摘要： A method is provided for identifying components of a mixture by labeling the individual components with fluorescent agents having different fluorescence lifetimes. The components are subsequently separated, fluorescent labels detected and their lifetimes measured. Based on the measured fluorescent lifetimes, the components of mixtures of small organic molecules, polymers, peptides, saccharides and nucleic acids can be identified.
摘要翻译：提供了通过用具有不同荧光寿命的荧光剂标记各个组分来鉴定混合物组分的方法。随后分离组分，检测荧光标记物并测定其寿命。基于测量的荧光寿命，可以鉴定小有机分子，聚合物，肽，糖和核酸的混合物的组分。

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