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1. 发明授权

US07868008B2 Substituted isoindolones and their use as metabotropic glutamate receptor potentiators 失效
标题翻译：取代的异吲哚酮及其作为代谢型谷氨酸受体增强剂的用途
公开(公告)号：US07868008B2
公开(公告)日：2011-01-11
申请号：US12063018
申请日：2006-02-15
申请人： Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Joshua Clayton , Ian Egle , James Empfield , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
发明人： Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Joshua Clayton , Ian Egle , James Empfield , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
IPC分类号： C07D209/46 , C07D401/06 , C07D401/14 , A61K31/4035 , A61K31/454
CPC分类号： C07D209/46 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/04 , C07D413/14
摘要： The present invention is directed to compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined for formula I in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.
摘要翻译：本发明涉及式I化合物：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和n如说明书中对式I所定义。本发明还涉及制备化合物的方法和用于制备中的新中间体，含有该化合物的药物组合物，以及该化合物在治疗中的用途。

2. 发明申请

US20090275578A1 Isoindolone compounds and their use as metabotropic glutamate receptor potentiators 有权
标题翻译：异吲哚酮化合物及其作为代谢型谷氨酸受体增强剂的用途
公开(公告)号：US20090275578A1
公开(公告)日：2009-11-05
申请号：US11659149
申请日：2005-08-12
申请人： Joshua Clayton , Fupeng Ma , Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Ian Egle , James Empfield , Methvin Isaac , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
发明人： Joshua Clayton , Fupeng Ma , Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Ian Egle , James Empfield , Methvin Isaac , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/40 , C07D413/02 , C07D401/14 , C07D209/34
CPC分类号： C07D471/04 , C07D209/46 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D471/10 , C07D487/04
摘要： The present invention is directed to compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined for formula I in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.
摘要翻译：本发明涉及式I化合物：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和n如说明书中对式I所定义。本发明还涉及制备化合物的方法和用于制备中的新中间体，含有该化合物的药物组合物，以及该化合物在治疗中的用途。

3. 发明授权

US07968570B2 Isoindolone compounds and their use as metabotropic glutamate receptor potentiators 有权
标题翻译：异吲哚酮化合物及其作为代谢型谷氨酸受体增强剂的用途
公开(公告)号：US07968570B2
公开(公告)日：2011-06-28
申请号：US11659149
申请日：2005-08-12
申请人： Joshua Clayton , Fupeng Ma , Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Ian Egle , James Empfield , Methvin Isaac , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
发明人： Joshua Clayton , Fupeng Ma , Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Ian Egle , James Empfield , Methvin Isaac , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
IPC分类号： A61K31/4409 , C07D401/14
CPC分类号： C07D471/04 , C07D209/46 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D471/10 , C07D487/04
摘要： The present invention is directed to compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined for formula I in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.
摘要翻译：本发明涉及式I化合物：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和n如说明书中对式I所定义。本发明还涉及制备化合物的方法和用于制备中的新中间体，含有该化合物的药物组合物，以及该化合物在治疗中的用途。

4. 发明授权

US08153638B2 Metabotropic glutamate-receptor-potentiating isoindolones 有权
标题翻译：代谢型谷氨酸受体增强异吲哚酮
公开(公告)号：US08153638B2
公开(公告)日：2012-04-10
申请号：US12861336
申请日：2010-08-23
申请人： Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Joshua Clayton , Ian Egle , James R. Empfield , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
发明人： Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Joshua Clayton , Ian Egle , James R. Empfield , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
IPC分类号： A61K31/497 , A61K31/4439 , A61K31/4035 , A61K31/427 , C07D403/14 , C07D403/02 , C07D401/02 , C07D209/44 , C07D417/02
CPC分类号： C07D209/34 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D417/04
摘要： Compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined in the description, processes for the preparing the compounds, new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and uses of the compounds in therapy.
摘要翻译：式I化合物：其中R1，R2，R3，R4，R5，R6，R7，R8，R9和n如说明书中所定义，制备化合物的方法，制备中使用的新中间体，含有化合物和化合物在治疗中的用途。

5. 发明申请

US20080227794A1 Metabotropic Glutamate-Receptor-Potentiating Isoindolones 有权
标题翻译：代谢型谷氨酸受体 - 加强异吲哚酮
公开(公告)号：US20080227794A1
公开(公告)日：2008-09-18
申请号：US12063007
申请日：2006-02-15
申请人： Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Joshua Clayton , Ian Egle , James R. Empfield , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
发明人： Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Joshua Clayton , Ian Egle , James R. Empfield , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
IPC分类号： A61K31/404 , A61P25/00 , C07D209/34 , C07D401/12 , C07D403/02 , C07D417/02 , A61K31/497 , A61K31/4439 , A61K31/427
CPC分类号： C07D209/34 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D417/04
摘要： Compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined in the description, processes for the preparing the compounds, new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and uses of the compounds in therapy.
摘要翻译：式I化合物：其中R 1，R 2，R 3，R 4，R 4， 5，R 6，R 7，R 8，R 9和n如上定义在描述中，制备化合物的方法，制备中使用的新中间体，含有该化合物的药物组合物以及该化合物在治疗中的用途。

6. 发明申请

US20100317674A1 Metabotropic Glutamate-Receptor-Potentiating Isoindolones 有权
标题翻译：代谢型谷氨酸受体 - 加强异吲哚酮
公开(公告)号：US20100317674A1
公开(公告)日：2010-12-16
申请号：US12861336
申请日：2010-08-23
申请人： Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Joshua Clayton , Ian Egle , James R. Empfield , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
发明人： Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Joshua Clayton , Ian Egle , James R. Empfield , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
IPC分类号： A61K31/497 , C07D209/44 , C07D401/12 , C07D401/02 , C07D403/02 , C07D403/14 , C07D417/02 , A61K31/4035 , A61K31/4439 , A61K31/427 , A61P25/28 , A61P25/00 , A61P25/30 , A61P25/18 , A61P25/22 , A61P25/24 , A61P29/00 , A61P25/16 , A61P25/08 , A61P25/06 , A61P9/00 , A61P9/10
CPC分类号： C07D209/34 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D417/04
摘要： Compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined in the description, processes for the preparing the compounds, new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and uses of the compounds in therapy.
摘要翻译：式I化合物：其中R1，R2，R3，R4，R5，R6，R7，R8，R9和n如说明书中所定义，制备化合物的方法，制备中使用的新中间体，含有化合物和化合物在治疗中的用途。

7. 发明授权

US07807706B2 Metabotropic glutamate-receptor-potentiating isoindolones 有权
标题翻译：代谢型谷氨酸受体增强异吲哚酮
公开(公告)号：US07807706B2
公开(公告)日：2010-10-05
申请号：US12063007
申请日：2006-02-15
申请人： Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Joshua Clayton , Ian Egle , James R. Empfield , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
发明人： Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Joshua Clayton , Ian Egle , James R. Empfield , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
IPC分类号： A61K31/4035 , C07D209/46
CPC分类号： C07D209/34 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D417/04
摘要： Compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined in the description, processes for the preparing the compounds, new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and uses of the compounds in therapy.
摘要翻译：式I化合物：其中R1，R2，R3，R4，R5，R6，R7，R8，R9和n如说明书中所定义，制备化合物的方法，制备中使用的新中间体，含有化合物和化合物在治疗中的用途。

8. 发明申请

US20090111830A1 SUBSTITUTED ISOINDOLONES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS 失效
标题翻译：取代的葡聚糖及其作为代谢谷氨酸受体电位的用途
公开(公告)号：US20090111830A1
公开(公告)日：2009-04-30
申请号：US12063018
申请日：2006-02-15
申请人： Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Joshua Clayton , Ian Egle , James R. Empfield , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
发明人： Bradford Van Wagenen , Radhakrishnan Ukkiramapandian , Joshua Clayton , Ian Egle , James R. Empfield , Methvin Isaac , Fupeng Ma , Abdelmalik Slassi , Gary Steelman , Rebecca Urbanek , Sally Walsh
IPC分类号： A61K31/496 , C07D209/34 , C07D401/14 , A61P25/00 , A61K31/4015
CPC分类号： C07D209/46 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/04 , C07D413/14
摘要： The present invention is directed to compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined for formula I in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.
摘要翻译：本发明涉及式I化合物：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和n如说明书中对式I所定义。本发明还涉及制备化合物的方法和用于制备中的新中间体，含有该化合物的药物组合物，以及该化合物在治疗中的用途。

9. 发明申请

US20090069340A1 Pyrazolone Compounds As Metabotropic Glutamate Receptor Agonists For The Treatment Of Neurological And Psychiatric Disorders 审中-公开
标题翻译：吡唑啉酮化合物作为代谢型谷氨酸受体激动剂治疗神经和精神疾病
公开(公告)号：US20090069340A1
公开(公告)日：2009-03-12
申请号：US11793050
申请日：2005-12-22
申请人： Michael Balestra , Heather Bunting , Deborah Chen , Ian Egle , Janet Forst , Jennifer Frey , Methvin Isaac , Fupeng Ma , David Nugiel , Abdelmalik Slassi , Gary Steelman , Guang-Ri Sun , Babu Sundar , Radhakrishnan Ukkiramapandian , Rebecca Urbanek , Sally Walsh
发明人： Michael Balestra , Heather Bunting , Deborah Chen , Ian Egle , Janet Forst , Jennifer Frey , Methvin Isaac , Fupeng Ma , David Nugiel , Abdelmalik Slassi , Gary Steelman , Guang-Ri Sun , Babu Sundar , Radhakrishnan Ukkiramapandian , Rebecca Urbanek , Sally Walsh
IPC分类号： A61K31/496 , C07D471/10 , A61K31/438 , C07D401/06 , A61P25/16 , A61P25/28 , A61K31/454 , C07D403/06
CPC分类号： C07D401/14 , C07D211/62 , C07D231/22 , C07D401/06 , C07D401/12 , C07D403/06 , C07D413/14 , C07D417/12 , C07D471/08 , C07D471/10 , C07D491/10
摘要： Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, X, and n are as defined for Formula (I) in the description, processes for the preparation of the compounds and new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and the use of the compounds in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction.
摘要翻译：式（I）化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，X和n如说明书中对于式（I）所定义，用于制备化合物和用于制备的新中间体，含有该化合物的药物组合物，以及该化合物在治疗或预防与谷氨酸功能障碍相关的神经和精神障碍中的用途。

10. 发明申请

US20070147654A1 System and method for translating text to images 审中-公开
标题翻译：用于将文本翻译成图像的系统和方法
公开(公告)号：US20070147654A1
公开(公告)日：2007-06-28
申请号：US11432204
申请日：2006-05-10
申请人： Paul Clatworthy , Sally Walsh , Raymond Walsh
发明人： Paul Clatworthy , Sally Walsh , Raymond Walsh
IPC分类号： G06K9/00
CPC分类号： G06F17/2735
摘要： A method comprises receiving input text; decomposing the input text into segments, e.g., single line segments; using a dictionary to identify at least one object in one of the segments for inclusion in a frame; and using cinematic conventions, e.g., proxemics, to arrange the at least one object in the frame. The input text may be received via a keyboard, via a disk drive, or via a network interface. The dictionary may include a slug line dictionary, a character dictionary, a prop dictionary, an action dictionary, an environment dictionary, etc. The method may further comprise determining the relative importance of the at least one object, and positioning the at least one object in the frame based on its relative importance. The method may further comprise analyzing a segment adjacent to the one of the segments to determine relevant objects for the one of the segments.
摘要翻译：一种方法包括接收输入文本; 将输入文本分解为段，例如单行段; 使用字典来识别其中一个段中的至少一个对象以包括在帧中; 并且使用电影约定（例如，proxemics）将至少一个对象排列在帧中。可以经由键盘，经由盘驱动器或经由网络接口接收输入文本。字典可以包括字幕行字典，字符字典，道具词典，动作词典，环境词典等。该方法还可以包括确定至少一个对象的相对重要性，并且定位至少一个对象在框架中基于其相对重要性。所述方法还可以包括分析与所述片段中的所述片段相邻的片段以确定所述片段之一的相关对象。

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